JP2010514751A5 - - Google Patents

Info

Publication number

JP2010514751A5

JP2010514751A5 JP2009543566A JP2009543566A JP2010514751A5 JP 2010514751 A5 JP2010514751 A5 JP 2010514751A5 JP 2009543566 A JP2009543566 A JP 2009543566A JP 2009543566 A JP2009543566 A JP 2009543566A JP 2010514751 A5 JP2010514751 A5 JP 2010514751A5

Authority

JP

Japan

Prior art keywords

aza

bicyclo

thiazole

hex

ylmethyl

Prior art date

2007-12-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• -1 2,3-dihydro-benzofuranyl- Chemical group 0.000 claims 53
• 125000001424 substituent group Chemical group 0.000 claims 22
• 150000001875 compounds Chemical class 0.000 claims 20
• 125000000217 alkyl group Chemical group 0.000 claims 16
• 125000000623 heterocyclic group Chemical group 0.000 claims 14
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
• 125000003118 aryl group Chemical group 0.000 claims 10
• 229910052736 halogen Inorganic materials 0.000 claims 10
• 150000002367 halogens Chemical class 0.000 claims 10
• 208000035475 disorder Diseases 0.000 claims 9
• 208000002193 Pain Diseases 0.000 claims 8
• 150000003839 salts Chemical class 0.000 claims 8
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 7
• QRDZFPUVLYEQTA-UHFFFAOYSA-N quinoline-8-carboxylic acid Chemical compound C1=CN=C2C(C(=O)O)=CC=CC2=C1 QRDZFPUVLYEQTA-UHFFFAOYSA-N 0.000 claims 7
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 7
• 230000036407 pain Effects 0.000 claims 6
• 208000011580 syndromic disease Diseases 0.000 claims 6
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 5
• 125000003545 alkoxy group Chemical group 0.000 claims 5
• CHDSHBWEGSCEDX-UHFFFAOYSA-N 2,3-dihydro-1-benzofuran-4-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1CCO2 CHDSHBWEGSCEDX-UHFFFAOYSA-N 0.000 claims 4
• 230000004064 dysfunction Effects 0.000 claims 4
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 4
• 208000020016 psychiatric disease Diseases 0.000 claims 4
• 208000019901 Anxiety disease Diseases 0.000 claims 3
• 206010010904 Convulsion Diseases 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 208000004296 neuralgia Diseases 0.000 claims 3
• 201000000980 schizophrenia Diseases 0.000 claims 3
• 230000001568 sexual effect Effects 0.000 claims 3
• VPYXATIIMHQAPR-UHFFFAOYSA-N 1,2-benzoxazole-3-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=NOC2=C1 VPYXATIIMHQAPR-UHFFFAOYSA-N 0.000 claims 2
• VCLSWKVAHAJSFL-UHFFFAOYSA-N 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid Chemical compound O1CCOC2=C1C=CC=C2C(=O)O VCLSWKVAHAJSFL-UHFFFAOYSA-N 0.000 claims 2
• 125000000850 2H-chromenyl group Chemical group O1C(C=CC2=CC=CC=C12)* 0.000 claims 2
• IJEUISLJVBUNRE-UHFFFAOYSA-N 3,5-dimethyl-1,2-oxazole-4-carboxylic acid Chemical compound CC1=NOC(C)=C1C(O)=O IJEUISLJVBUNRE-UHFFFAOYSA-N 0.000 claims 2
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 2
• AVBKMSSLAIKOGM-UHFFFAOYSA-N 4-methoxyquinoline-2-carboxylic acid Chemical compound C1=CC=C2C(OC)=CC(C(O)=O)=NC2=C1 AVBKMSSLAIKOGM-UHFFFAOYSA-N 0.000 claims 2
• VSQMBZXCDDTZAF-UHFFFAOYSA-N 6-methylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid Chemical compound S1C=CN2C(C(O)=O)=C(C)N=C21 VSQMBZXCDDTZAF-UHFFFAOYSA-N 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• 208000000044 Amnesia Diseases 0.000 claims 2
• 208000031091 Amnestic disease Diseases 0.000 claims 2
• 206010002091 Anaesthesia Diseases 0.000 claims 2
• 208000024172 Cardiovascular disease Diseases 0.000 claims 2
• 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 2
• 208000012661 Dyskinesia Diseases 0.000 claims 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• 208000004454 Hyperalgesia Diseases 0.000 claims 2
• 208000012902 Nervous system disease Diseases 0.000 claims 2
• 208000025966 Neurological disease Diseases 0.000 claims 2
• 208000028017 Psychotic disease Diseases 0.000 claims 2
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 2
• 206010046543 Urinary incontinence Diseases 0.000 claims 2
• 206010047700 Vomiting Diseases 0.000 claims 2
• 230000032683 aging Effects 0.000 claims 2
• 125000000304 alkynyl group Chemical group 0.000 claims 2
• 230000006986 amnesia Effects 0.000 claims 2
• 230000037005 anaesthesia Effects 0.000 claims 2
• 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 2
• 208000010877 cognitive disease Diseases 0.000 claims 2
• 125000000753 cycloalkyl group Chemical group 0.000 claims 2
• 230000035622 drinking Effects 0.000 claims 2
• 235000021271 drinking Nutrition 0.000 claims 2
• 235000005686 eating Nutrition 0.000 claims 2
• 206010015037 epilepsy Diseases 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 230000002267 hypothalamic effect Effects 0.000 claims 2
• KMAKOBLIOCQGJP-UHFFFAOYSA-N indole-3-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=CNC2=C1 KMAKOBLIOCQGJP-UHFFFAOYSA-N 0.000 claims 2
• 206010022437 insomnia Diseases 0.000 claims 2
• 230000000302 ischemic effect Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 230000003340 mental effect Effects 0.000 claims 2
• 208000021722 neuropathic pain Diseases 0.000 claims 2
• 201000001119 neuropathy Diseases 0.000 claims 2
• 230000007823 neuropathy Effects 0.000 claims 2
• 208000033808 peripheral neuropathy Diseases 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 229940001470 psychoactive drug Drugs 0.000 claims 2
• 239000004089 psychotropic agent Substances 0.000 claims 2
• 230000001850 reproductive effect Effects 0.000 claims 2
• 230000008673 vomiting Effects 0.000 claims 2
• XYRXQPDMBJNYIU-UHFFFAOYSA-N 1,2-dimethylindole-3-carboxylic acid Chemical compound C1=CC=C2N(C)C(C)=C(C(O)=O)C2=C1 XYRXQPDMBJNYIU-UHFFFAOYSA-N 0.000 claims 1
• XBFRQODQXBMILB-UHFFFAOYSA-N 1,3-benzothiazole-4-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1N=CS2 XBFRQODQXBMILB-UHFFFAOYSA-N 0.000 claims 1
• ORSZGLLQNYSMNO-UHFFFAOYSA-N 1,3-benzothiazole-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1SC=N2 ORSZGLLQNYSMNO-UHFFFAOYSA-N 0.000 claims 1
• KRCCCWVXRVDONW-UHFFFAOYSA-N 1,3-benzoxazole-4-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1N=CO2 KRCCCWVXRVDONW-UHFFFAOYSA-N 0.000 claims 1
• JHTQTAYWCUAENJ-UHFFFAOYSA-N 1,3-benzoxazole-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1OC=N2 JHTQTAYWCUAENJ-UHFFFAOYSA-N 0.000 claims 1
• LJPSRTWIAXVPIS-UHFFFAOYSA-N 1-benzothiophene-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1SC=C2 LJPSRTWIAXVPIS-UHFFFAOYSA-N 0.000 claims 1
• DTJLXXLXQPOQBZ-UHFFFAOYSA-N 1-ethyl-3-methylpyrazole-4-carboxylic acid Chemical compound CCN1C=C(C(O)=O)C(C)=N1 DTJLXXLXQPOQBZ-UHFFFAOYSA-N 0.000 claims 1
• YDGHXEVBZZGFLL-KPFFTGBYSA-N 1-ethyl-n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-methylpyrazole-4-carboxamide Chemical compound CC1=NN(CC)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 YDGHXEVBZZGFLL-KPFFTGBYSA-N 0.000 claims 1
• BHXVYTQDWMQVBI-UHFFFAOYSA-N 1h-indazole-3-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=NNC2=C1 BHXVYTQDWMQVBI-UHFFFAOYSA-N 0.000 claims 1
• ZVXXYWHMRDJFDL-HFTRVMKXSA-N 2,2-difluoro-n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,3-benzodioxole-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OC(F)(F)OC=3C=CC=2)=C1C1=CC=CC(F)=C1 ZVXXYWHMRDJFDL-HFTRVMKXSA-N 0.000 claims 1
• YXXWGZCPGQJCRW-GIWBLDEGSA-N 2,2-dimethyl-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3h-1-benzofuran-7-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OC(C)(C)CC=3C=CC=2)=C1C1=CC=CC(C)=C1 YXXWGZCPGQJCRW-GIWBLDEGSA-N 0.000 claims 1
• QRWZFUBHOQWUGH-UHFFFAOYSA-N 2,5-dimethylpyrazole-3-carboxylic acid Chemical compound CC=1C=C(C(O)=O)N(C)N=1 QRWZFUBHOQWUGH-UHFFFAOYSA-N 0.000 claims 1
• CZKIDVYMBRVQBU-UHFFFAOYSA-N 2-chloro-1,3-benzothiazole-4-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1N=C(Cl)S2 CZKIDVYMBRVQBU-UHFFFAOYSA-N 0.000 claims 1
• RZYJINMBGDAXJP-LQWHRVPQSA-N 2-chloro-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]benzamide Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=CC=C1Cl RZYJINMBGDAXJP-LQWHRVPQSA-N 0.000 claims 1
• KVQVGIGILHSZSU-AABGKKOBSA-N 2-ethyl-5-methyl-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]pyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)[C@H]2C[C@H]2C1 KVQVGIGILHSZSU-AABGKKOBSA-N 0.000 claims 1
• ISNGGIADAFLJMJ-NEWSRXKRSA-N 2-ethyl-n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 ISNGGIADAFLJMJ-NEWSRXKRSA-N 0.000 claims 1
• KDPOFQJHFWJFCB-UHFFFAOYSA-N 2-methyl-1,3-benzoxazole-7-carboxylic acid Chemical compound C1=CC(C(O)=O)=C2OC(C)=NC2=C1 KDPOFQJHFWJFCB-UHFFFAOYSA-N 0.000 claims 1
• QMVZMKJWEQFJDP-UHFFFAOYSA-N 2h-chromene-5-carboxylic acid Chemical compound O1CC=CC2=C1C=CC=C2C(=O)O QMVZMKJWEQFJDP-UHFFFAOYSA-N 0.000 claims 1
• FTOZLHKBGJHVNK-GIVPXCGWSA-N 3-bromo-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]benzamide Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=CC(Br)=C1 FTOZLHKBGJHVNK-GIVPXCGWSA-N 0.000 claims 1
• AZAHJSDNHZYCDQ-DXIQSLLYSA-N 3-chloro-2-methyl-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]benzamide Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=CC(Cl)=C1C AZAHJSDNHZYCDQ-DXIQSLLYSA-N 0.000 claims 1
• DTTGYKRNHMRWHY-GIVPXCGWSA-N 3-iodo-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]benzamide Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=CC(I)=C1 DTTGYKRNHMRWHY-GIVPXCGWSA-N 0.000 claims 1
• AGOAENRCPQZMFP-URVUXULASA-N 3-methoxy-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]benzamide Chemical compound COC1=CC=CC(C(=O)NC[C@H]2N([C@H]3C[C@H]3C2)C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)=C1 AGOAENRCPQZMFP-URVUXULASA-N 0.000 claims 1
• 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
• GCEPRJCFTSFVDA-QYZOEREBSA-N 3-methyl-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[2,1-b][1,3]thiazole-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C2=C(N3C=CN=C3S2)C)=C1C1=CC=CC(C)=C1 GCEPRJCFTSFVDA-QYZOEREBSA-N 0.000 claims 1
• OYOMMXTUBZYEGS-UHFFFAOYSA-N 3-methylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid Chemical compound C1=C(C(O)=O)N2C(C)=CSC2=N1 OYOMMXTUBZYEGS-UHFFFAOYSA-N 0.000 claims 1
• JKEUXKJMBNQDRK-LMNJBCLMSA-N 4-chloro-2-methoxy-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]benzamide Chemical compound COC1=CC(Cl)=CC=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)[C@H]2C[C@H]2C1 JKEUXKJMBNQDRK-LMNJBCLMSA-N 0.000 claims 1
• DFLOUBRTXQQGOE-DYXWJJEUSA-N 4-methoxy-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-(trifluoromethyl)benzamide Chemical compound C1=C(C(F)(F)F)C(OC)=CC=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)[C@H]2C[C@H]2C1 DFLOUBRTXQQGOE-DYXWJJEUSA-N 0.000 claims 1
• ZGWGSEUMABQEMD-UHFFFAOYSA-N 4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound CC=1N=CSC=1C(O)=O ZGWGSEUMABQEMD-UHFFFAOYSA-N 0.000 claims 1
• XNZRBTUVFURPDX-QTEQDKRBSA-N 4-methyl-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzoxazine-8-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C1=CC=CC2=C1OCCN2C)C(=O)C=1N=C(C)SC=1C1=CC=CC(C)=C1 XNZRBTUVFURPDX-QTEQDKRBSA-N 0.000 claims 1
• QXXLUBQLXMROMY-NWSQWKLXSA-N 5-fluoro-1-methyl-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]indole-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N(C3=CC=C(F)C=C3C=2)C)=C1C1=CC=CC(C)=C1 QXXLUBQLXMROMY-NWSQWKLXSA-N 0.000 claims 1
• SQVZFICXVOEKNL-WVBUVRCRSA-N 5-fluoro-n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1h-indole-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2NC3=CC=C(F)C=C3C=2)=C1C1=CC=CC(F)=C1 SQVZFICXVOEKNL-WVBUVRCRSA-N 0.000 claims 1
• JFOACJIGTATYPC-IKGGRYGDSA-N 6-chloro-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CSC3=NC=2Cl)=C1C1=CC=CC(C)=C1 JFOACJIGTATYPC-IKGGRYGDSA-N 0.000 claims 1
• RLHABKYWDKVMLH-AGHHOFFYSA-N 6-fluoro-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-4h-1,3-benzodioxine-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCOCC=3C=C(F)C=2)=C1C1=CC=CC(C)=C1 RLHABKYWDKVMLH-AGHHOFFYSA-N 0.000 claims 1
• BZHUUDQQILZKGO-JJXUHFIVSA-N 6-fluoro-n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-4h-1,3-benzodioxine-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCOCC=3C=C(F)C=2)=C1C1=CC=CC(F)=C1 BZHUUDQQILZKGO-JJXUHFIVSA-N 0.000 claims 1
• NAGXUKYONQYLQK-HBFSDRIKSA-N 6-methyl-n-[[(1s,3s,5s)-2-(2-methyl-4-phenylpyrimidine-5-carbonyl)-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C=1N2C=CSC2=NC=1C)C(=O)C1=CN=C(C)N=C1C1=CC=CC=C1 NAGXUKYONQYLQK-HBFSDRIKSA-N 0.000 claims 1
• WRHNJFXQMMMBGX-GJYPPUQNSA-N 6-methyl-n-[[(1s,3s,5s)-2-(2-pyrazol-1-ylbenzoyl)-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C=1N2C=CSC2=NC=1C)C(=O)C1=CC=CC=C1N1C=CC=N1 WRHNJFXQMMMBGX-GJYPPUQNSA-N 0.000 claims 1
• BBILWLLJFSWYFO-QYZOEREBSA-N 6-methyl-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CSC3=NC=2C)=C1C1=CC=CC(C)=C1 BBILWLLJFSWYFO-QYZOEREBSA-N 0.000 claims 1
• SNISEKWZQSWMSM-AABGKKOBSA-N 6-methyl-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]pyrrolo[2,1-b][1,3]thiazole-7-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C2=C3SC=CN3C=C2C)=C1C1=CC=CC(C)=C1 SNISEKWZQSWMSM-AABGKKOBSA-N 0.000 claims 1
• GVOZOHSZUJYIQL-UHFFFAOYSA-N 7-chloro-1-benzofuran-4-carboxylic acid Chemical compound OC(=O)C1=CC=C(Cl)C2=C1C=CO2 GVOZOHSZUJYIQL-UHFFFAOYSA-N 0.000 claims 1
• VFCOHQGGTMMONH-ZZGJPJSFSA-N 7-chloro-2-methoxy-n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C1=CC=C(Cl)C2=C1CC(O2)OC)C(=O)C=1N=C(C)SC=1C1=CC=CC(C)=C1 VFCOHQGGTMMONH-ZZGJPJSFSA-N 0.000 claims 1
• KELIAGSOLXPTAY-UHFFFAOYSA-N 7-fluoro-1-benzofuran-4-carboxylic acid Chemical compound OC(=O)C1=CC=C(F)C2=C1C=CO2 KELIAGSOLXPTAY-UHFFFAOYSA-N 0.000 claims 1
• OPXMVZLSLQAXPQ-MMOPVJDHSA-N 7-fluoro-n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1h-indole-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2NC3=C(F)C=CC=C3C=2)=C1C1=CC=CC(F)=C1 OPXMVZLSLQAXPQ-MMOPVJDHSA-N 0.000 claims 1
• 206010000599 Acromegaly Diseases 0.000 claims 1
• 208000003200 Adenoma Diseases 0.000 claims 1
• 206010001233 Adenoma benign Diseases 0.000 claims 1
• 208000007848 Alcoholism Diseases 0.000 claims 1
• 201000000736 Amenorrhea Diseases 0.000 claims 1
• 206010001928 Amenorrhoea Diseases 0.000 claims 1
• 206010002383 Angina Pectoris Diseases 0.000 claims 1
• 208000008035 Back Pain Diseases 0.000 claims 1
• 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
• 208000020925 Bipolar disease Diseases 0.000 claims 1
• 208000002381 Brain Hypoxia Diseases 0.000 claims 1
• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010007556 Cardiac failure acute Diseases 0.000 claims 1
• 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
• 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
• 208000017164 Chronobiology disease Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000019736 Cranial nerve disease Diseases 0.000 claims 1
• 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
• 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
• 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
• 208000014311 Cushing syndrome Diseases 0.000 claims 1
• 206010011878 Deafness Diseases 0.000 claims 1
• 206010012218 Delirium Diseases 0.000 claims 1
• 206010012289 Dementia Diseases 0.000 claims 1
• 208000016192 Demyelinating disease Diseases 0.000 claims 1
• 201000004624 Dermatitis Diseases 0.000 claims 1
• 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
• 208000025967 Dissociative Identity disease Diseases 0.000 claims 1
• 206010013883 Dwarfism Diseases 0.000 claims 1
• 208000032928 Dyslipidaemia Diseases 0.000 claims 1
• 208000030814 Eating disease Diseases 0.000 claims 1
• 206010014733 Endometrial cancer Diseases 0.000 claims 1
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
• 208000020564 Eye injury Diseases 0.000 claims 1
• 208000002091 Febrile Seizures Diseases 0.000 claims 1
• 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
• 208000011688 Generalised anxiety disease Diseases 0.000 claims 1
• 201000005569 Gout Diseases 0.000 claims 1
• 206010019233 Headaches Diseases 0.000 claims 1
• 206010019280 Heart failures Diseases 0.000 claims 1
• 208000032843 Hemorrhage Diseases 0.000 claims 1
• 208000016988 Hemorrhagic Stroke Diseases 0.000 claims 1
• 208000035154 Hyperesthesia Diseases 0.000 claims 1
• 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 206010020843 Hyperthermia Diseases 0.000 claims 1
• 206010058359 Hypogonadism Diseases 0.000 claims 1
• 208000001953 Hypotension Diseases 0.000 claims 1
• 208000028482 Hypothalamic disease Diseases 0.000 claims 1
• 206010070511 Hypoxic-ischaemic encephalopathy Diseases 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• 201000006347 Intellectual Disability Diseases 0.000 claims 1
• 208000032382 Ischaemic stroke Diseases 0.000 claims 1
• 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 208000007177 Left Ventricular Hypertrophy Diseases 0.000 claims 1
• 201000006792 Lennox-Gastaut syndrome Diseases 0.000 claims 1
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
• 208000019695 Migraine disease Diseases 0.000 claims 1
• 206010061296 Motor dysfunction Diseases 0.000 claims 1
• 208000016285 Movement disease Diseases 0.000 claims 1
• 208000008238 Muscle Spasticity Diseases 0.000 claims 1
• 208000029578 Muscle disease Diseases 0.000 claims 1
• 206010028813 Nausea Diseases 0.000 claims 1
• NNXMEKCQTGLZKA-JQSLRTAOSA-N O1CCC=2C1=CC=CC2C(=O)O.CC=2C=C(C=C(C2)C)C2=C(N=C(S2)C)C(=O)N2[C@H]1C[C@H]1C[C@H]2CNC(=O)C=2C=CC=C1C2CCO1 Chemical compound O1CCC=2C1=CC=CC2C(=O)O.CC=2C=C(C=C(C2)C)C2=C(N=C(S2)C)C(=O)N2[C@H]1C[C@H]1C[C@H]2CNC(=O)C=2C=CC=C1C2CCO1 NNXMEKCQTGLZKA-JQSLRTAOSA-N 0.000 claims 1
• 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
• 102000002512 Orexin Human genes 0.000 claims 1
• 208000001132 Osteoporosis Diseases 0.000 claims 1
• 206010033664 Panic attack Diseases 0.000 claims 1
• 208000006199 Parasomnias Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 206010034759 Petit mal epilepsy Diseases 0.000 claims 1
• 206010034918 Phobic avoidance Diseases 0.000 claims 1
• 208000014993 Pituitary disease Diseases 0.000 claims 1
• 208000004550 Postoperative Pain Diseases 0.000 claims 1
• 206010036832 Prolactinoma Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 claims 1
• 206010037660 Pyrexia Diseases 0.000 claims 1
• 206010038389 Renal cancer Diseases 0.000 claims 1
• 208000005793 Restless legs syndrome Diseases 0.000 claims 1
• 208000017442 Retinal disease Diseases 0.000 claims 1
• 206010038923 Retinopathy Diseases 0.000 claims 1
• 208000027520 Somatoform disease Diseases 0.000 claims 1
• 208000029033 Spinal Cord disease Diseases 0.000 claims 1
• 208000007107 Stomach Ulcer Diseases 0.000 claims 1
• 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims 1
• 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
• 208000025371 Taste disease Diseases 0.000 claims 1
• 208000011622 Testicular disease Diseases 0.000 claims 1
• 208000009205 Tinnitus Diseases 0.000 claims 1
• 206010044565 Tremor Diseases 0.000 claims 1
• 206010046555 Urinary retention Diseases 0.000 claims 1
• 201000004810 Vascular dementia Diseases 0.000 claims 1
• PLQHTLOAZNLRAD-NRUUGDAUSA-N [(1S,3S,5S)-3-(aminomethyl)-2-azabicyclo[3.1.0]hexan-2-yl]-[5-(2,3-dichlorophenyl)-2-methyl-1,3-thiazol-4-yl]methanone Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CN)=C1C1=CC=CC(Cl)=C1Cl PLQHTLOAZNLRAD-NRUUGDAUSA-N 0.000 claims 1
• OCPFLHDEAUPJKB-SQNIBIBYSA-N [(1s,3s,5s)-3-[[(4,6-dimethoxypyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[2-methyl-5-(3-methylphenyl)-1,3-thiazol-4-yl]methanone Chemical compound COC1=CC(OC)=NC(NC[C@H]2N([C@H]3C[C@H]3C2)C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)=N1 OCPFLHDEAUPJKB-SQNIBIBYSA-N 0.000 claims 1
• MVPBEYORUDQRHJ-NJAFHUGGSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-(2-cyclopropyl-5-phenyl-1,3-thiazol-4-yl)methanone Chemical compound N1=CC(Br)=CN=C1NC[C@H]1N(C(=O)C2=C(SC(=N2)C2CC2)C=2C=CC=CC=2)[C@H]2C[C@H]2C1 MVPBEYORUDQRHJ-NJAFHUGGSA-N 0.000 claims 1
• VXSMUGJLHVKIPB-PVAVHDDUSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-(2-methyl-5-phenyl-1,3-thiazol-4-yl)methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=CC=CC=1)C)NC1=NC=C(Br)C=N1 VXSMUGJLHVKIPB-PVAVHDDUSA-N 0.000 claims 1
• JJYPMUVMTCCHFA-NJAFHUGGSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[2-methyl-5-(3-methylphenyl)-1,3-thiazol-4-yl]methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC1=NC=C(Br)C=N1 JJYPMUVMTCCHFA-NJAFHUGGSA-N 0.000 claims 1
• WSLKOLMTAAYPMR-COXVUDFISA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[2-methyl-5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl]methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C=CC=1)C(F)(F)F)C)NC1=NC=C(Br)C=N1 WSLKOLMTAAYPMR-COXVUDFISA-N 0.000 claims 1
• UTIODKKMBCLUHW-IFIJOSMWSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[5-(3,4-dichlorophenyl)-2-methyl-1,3-thiazol-4-yl]methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(Cl)C(Cl)=CC=1)C)NC1=NC=C(Br)C=N1 UTIODKKMBCLUHW-IFIJOSMWSA-N 0.000 claims 1
• BEXLHINYFZDODT-IFIJOSMWSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[5-(3,4-difluorophenyl)-2-methyl-1,3-thiazol-4-yl]methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(F)C(F)=CC=1)C)NC1=NC=C(Br)C=N1 BEXLHINYFZDODT-IFIJOSMWSA-N 0.000 claims 1
• ZWCXIYNPZUPTJW-NEWSRXKRSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[5-(3,4-dimethylphenyl)-2-methyl-1,3-thiazol-4-yl]methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C)C(C)=CC=1)C)NC1=NC=C(Br)C=N1 ZWCXIYNPZUPTJW-NEWSRXKRSA-N 0.000 claims 1
• MNKSTPMLQGTDKD-MNEFBYGVSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[5-(3,5-dimethylphenyl)-2-methyl-1,3-thiazol-4-yl]methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C)C=C(C)C=1)C)NC1=NC=C(Br)C=N1 MNKSTPMLQGTDKD-MNEFBYGVSA-N 0.000 claims 1
• BVRLEKPFIWDGBN-KCXAZCMYSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[5-(3-chlorophenyl)-1,3-thiazol-4-yl]methanone Chemical compound ClC1=CC=CC(C2=C(N=CS2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC=2N=CC(Br)=CN=2)=C1 BVRLEKPFIWDGBN-KCXAZCMYSA-N 0.000 claims 1
• NODAGFGTEXFBBV-COXVUDFISA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[5-(3-chlorophenyl)-2-methyl-1,3-thiazol-4-yl]methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(Cl)C=CC=1)C)NC1=NC=C(Br)C=N1 NODAGFGTEXFBBV-COXVUDFISA-N 0.000 claims 1
• ULTVXVJJYMVKKB-HFTRVMKXSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[5-(3-fluoro-4-methylphenyl)-2-methyl-1,3-thiazol-4-yl]methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(F)C(C)=CC=1)C)NC1=NC=C(Br)C=N1 ULTVXVJJYMVKKB-HFTRVMKXSA-N 0.000 claims 1
• IHCDQMGOFLPHAI-KMFMINBZSA-N [(1s,3s,5s)-3-[[(5-bromopyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[5-(3-methoxyphenyl)-1,3-thiazol-4-yl]methanone Chemical compound COC1=CC=CC(C2=C(N=CS2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC=2N=CC(Br)=CN=2)=C1 IHCDQMGOFLPHAI-KMFMINBZSA-N 0.000 claims 1
• VIRNIFNUAHJGFC-AABGKKOBSA-N [(1s,3s,5s)-3-[[(5-ethylpyrimidin-2-yl)amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]-[2-methyl-5-(3-methylphenyl)-1,3-thiazol-4-yl]methanone Chemical compound N1=CC(CC)=CN=C1NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(C)C=CC=2)[C@H]2C[C@H]2C1 VIRNIFNUAHJGFC-AABGKKOBSA-N 0.000 claims 1
• BYJKDVRXONVAPA-IKGGRYGDSA-N [2-methyl-5-(3-methylphenyl)-1,3-thiazol-4-yl]-[(1s,3s,5s)-3-[[[4-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]-2-azabicyclo[3.1.0]hexan-2-yl]methanone Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC1=NC=CC(C(F)(F)F)=N1 BYJKDVRXONVAPA-IKGGRYGDSA-N 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 230000005856 abnormality Effects 0.000 claims 1
• 208000028311 absence seizure Diseases 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 206010000496 acne Diseases 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 208000005298 acute pain Diseases 0.000 claims 1
• 208000012826 adjustment disease Diseases 0.000 claims 1
• 230000001919 adrenal effect Effects 0.000 claims 1
• 201000007930 alcohol dependence Diseases 0.000 claims 1
• 125000004414 alkyl thio group Chemical group 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 206010053552 allodynia Diseases 0.000 claims 1
• 231100000540 amenorrhea Toxicity 0.000 claims 1
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
• 230000036592 analgesia Effects 0.000 claims 1
• 230000036506 anxiety Effects 0.000 claims 1
• 230000036528 appetite Effects 0.000 claims 1
• 235000019789 appetite Nutrition 0.000 claims 1
• 230000006793 arrhythmia Effects 0.000 claims 1
• 206010003119 arrhythmia Diseases 0.000 claims 1
• 230000002917 arthritic effect Effects 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 1
• 125000005605 benzo group Chemical group 0.000 claims 1
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
• 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
• 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
• 208000028683 bipolar I disease Diseases 0.000 claims 1
• 230000000740 bleeding effect Effects 0.000 claims 1
• 208000026106 cerebrovascular disease Diseases 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 229910052801 chlorine Inorganic materials 0.000 claims 1
• 239000000460 chlorine Substances 0.000 claims 1
• 208000020832 chronic kidney disease Diseases 0.000 claims 1
• 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 208000029078 coronary artery disease Diseases 0.000 claims 1
• 208000014826 cranial nerve neuropathy Diseases 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 208000031513 cyst Diseases 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 230000006806 disease prevention Effects 0.000 claims 1
• 235000014632 disordered eating Nutrition 0.000 claims 1
• 208000018459 dissociative disease Diseases 0.000 claims 1
• 208000009985 drug-induced dyskinesia Diseases 0.000 claims 1
• 208000024732 dysthymic disease Diseases 0.000 claims 1
• 206010016165 failure to thrive Diseases 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 201000005917 gastric ulcer Diseases 0.000 claims 1
• 208000029364 generalized anxiety disease Diseases 0.000 claims 1
• 230000006589 gland dysfunction Effects 0.000 claims 1
• 231100000869 headache Toxicity 0.000 claims 1
• 230000010370 hearing loss Effects 0.000 claims 1
• 231100000888 hearing loss Toxicity 0.000 claims 1
• 208000016354 hearing loss disease Diseases 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 208000031424 hyperprolactinemia Diseases 0.000 claims 1
• 230000036031 hyperthermia Effects 0.000 claims 1
• 230000036543 hypotension Effects 0.000 claims 1
• DOGXPDFZEQXZDS-UHFFFAOYSA-N imidazo[1,2-a]pyridine-3-carboxylic acid Chemical compound C1=CC=CN2C(C(=O)O)=CN=C21 DOGXPDFZEQXZDS-UHFFFAOYSA-N 0.000 claims 1
• 125000005946 imidazo[1,2-a]pyridyl group Chemical group 0.000 claims 1
• ZGIABSKPSCMXFD-UHFFFAOYSA-N imidazo[2,1-b][1,3]thiazole-5-carboxylic acid Chemical compound S1C=CN2C(C(=O)O)=CN=C21 ZGIABSKPSCMXFD-UHFFFAOYSA-N 0.000 claims 1
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
• 125000001041 indolyl group Chemical group 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 208000014674 injury Diseases 0.000 claims 1
• 208000020658 intracerebral hemorrhage Diseases 0.000 claims 1
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
• 125000000842 isoxazolyl group Chemical group 0.000 claims 1
• 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
• 201000010982 kidney cancer Diseases 0.000 claims 1
• 208000017169 kidney disease Diseases 0.000 claims 1
• 230000003902 lesion Effects 0.000 claims 1
• 208000024714 major depressive disease Diseases 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 206010027599 migraine Diseases 0.000 claims 1
• 230000036651 mood Effects 0.000 claims 1
• 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1
• BBBBXICMCPTHBJ-MSYCTHLASA-N n-[[(1s,3s,5s)-2-(2-methyl-4-phenylpyrimidine-5-carbonyl)-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound N=1C(C)=NC=C(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3C=COC=3C=CC=2)C=1C1=CC=CC=C1 BBBBXICMCPTHBJ-MSYCTHLASA-N 0.000 claims 1
• OVOZTIRKTQGQLV-DXIQSLLYSA-N n-[[(1s,3s,5s)-2-(2-methyl-4-phenylpyrimidine-5-carbonyl)-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound N=1C(C)=NC=C(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)C=1C1=CC=CC=C1 OVOZTIRKTQGQLV-DXIQSLLYSA-N 0.000 claims 1
• IMNKHTQTALTWLQ-URVUXULASA-N n-[[(1s,3s,5s)-2-(2-methyl-5-phenyl-1,3-thiazole-4-carbonyl)-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC=C1 IMNKHTQTALTWLQ-URVUXULASA-N 0.000 claims 1
• ZXNUBKZHCMLXBK-DPLHUUCSSA-N n-[[(1s,3s,5s)-2-(5-methyl-2-phenylfuran-3-carbonyl)-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound O1C(C)=CC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC=C1 ZXNUBKZHCMLXBK-DPLHUUCSSA-N 0.000 claims 1
• MVPMCQDMUCLMIY-WIEQDCTASA-N n-[[(1s,3s,5s)-2-[2-(2-amino-1,3-thiazol-4-yl)benzoyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(N)=NC(C=2C(=CC=CC=2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1 MVPMCQDMUCLMIY-WIEQDCTASA-N 0.000 claims 1
• IYRVYLAWVYZPPZ-SIFCLUCFSA-N n-[[(1s,3s,5s)-2-[2-(2-amino-1,3-thiazol-4-yl)benzoyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(N)=NC(C=2C(=CC=CC=2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1 IYRVYLAWVYZPPZ-SIFCLUCFSA-N 0.000 claims 1
• YORWJYKLNUAMLP-GLJUWKHASA-N n-[[(1s,3s,5s)-2-[2-(2-amino-1,3-thiazol-4-yl)benzoyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C=1N2C=CSC2=NC=1C)C(=O)C1=CC=CC=C1C1=CSC(N)=N1 YORWJYKLNUAMLP-GLJUWKHASA-N 0.000 claims 1
• FGCNGGNPMHRAGA-UZEJHQAJSA-N n-[[(1s,3s,5s)-2-[2-(2-fluorophenyl)benzoyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound FC1=CC=CC=C1C1=CC=CC=C1C(=O)N1[C@H](CNC(=O)C=2C=3C=COC=3C=CC=2)C[C@@H]2C[C@@H]21 FGCNGGNPMHRAGA-UZEJHQAJSA-N 0.000 claims 1
• UHINWWWQPPBTFJ-AOUJKTHWSA-N n-[[(1s,3s,5s)-2-[2-(3-chlorophenyl)benzoyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound ClC1=CC=CC(C=2C(=CC=CC=2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1 UHINWWWQPPBTFJ-AOUJKTHWSA-N 0.000 claims 1
• WRXHACFFYAGOIW-SQNIBIBYSA-N n-[[(1s,3s,5s)-2-[2-(dimethylamino)-5-phenyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(N(C)C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CSC3=NC=2C)=C1C1=CC=CC=C1 WRXHACFFYAGOIW-SQNIBIBYSA-N 0.000 claims 1
• VAATUMGPJZOHDP-KMFMINBZSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,2,3-benzothiadiazole-5-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=C3N=NSC3=CC=2)=C1C1=CC=CC(F)=C1 VAATUMGPJZOHDP-KMFMINBZSA-N 0.000 claims 1
• RYZMMEDSLCCAHE-KMFMINBZSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,2-benzoxazole-3-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3ON=2)=C1C1=CC=CC(F)=C1 RYZMMEDSLCCAHE-KMFMINBZSA-N 0.000 claims 1
• JOIKNOONRUDGRB-MMOPVJDHSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,2-dimethylindole-3-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C1=C(N(C2=CC=CC=C21)C)C)C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 JOIKNOONRUDGRB-MMOPVJDHSA-N 0.000 claims 1
• PYBMNLHPXNANJX-PVAVHDDUSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,3,5-trimethylpyrazole-4-carboxamide Chemical compound CC1=NN(C)C(C)=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 PYBMNLHPXNANJX-PVAVHDDUSA-N 0.000 claims 1
• ZRNCUSLODZTAGF-KMFMINBZSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,3-benzodioxole-4-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCOC=3C=CC=2)=C1C1=CC=CC(F)=C1 ZRNCUSLODZTAGF-KMFMINBZSA-N 0.000 claims 1
• KYSRXVHHVYSPTP-KMFMINBZSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,3-dimethylpyrazole-4-carboxamide Chemical compound CC1=NN(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 KYSRXVHHVYSPTP-KMFMINBZSA-N 0.000 claims 1
• WRVOIYHUVDVRNE-ALKREAHSSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1C1=CC=CC(F)=C1 WRVOIYHUVDVRNE-ALKREAHSSA-N 0.000 claims 1
• FBKAZYQXMOLMMU-HFTRVMKXSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-ethyl-3-methylpyrazole-4-carboxamide Chemical compound CC1=NN(CC)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 FBKAZYQXMOLMMU-HFTRVMKXSA-N 0.000 claims 1
• ADJCWOYNWYOWIM-ZLDLUXBVSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-methyl-5-(trifluoromethyl)pyrazole-4-carboxamide Chemical compound CN1N=CC(C(=O)NC[C@H]2N([C@H]3C[C@H]3C2)C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)=C1C(F)(F)F ADJCWOYNWYOWIM-ZLDLUXBVSA-N 0.000 claims 1
• UDPYNUNNSFKAGE-KUDFPVQQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-methylindole-3-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C1=CN(C2=CC=CC=C21)C)C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 UDPYNUNNSFKAGE-KUDFPVQQSA-N 0.000 claims 1
• LISJIDFCWXAONY-XUWXXGDYSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1h-indazole-3-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3NN=2)=C1C1=CC=CC(F)=C1 LISJIDFCWXAONY-XUWXXGDYSA-N 0.000 claims 1
• KZLZLPNETUUCPZ-IIMJZQEZSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1h-indole-3-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3NC=2)=C1C1=CC=CC(F)=C1 KZLZLPNETUUCPZ-IIMJZQEZSA-N 0.000 claims 1
• RIVJJZYVIMDNKH-INWMFGNUSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,2-difluoro-1,3-benzodioxole-4-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OC(F)(F)OC=3C=CC=2)=C1C1=CC=CC(F)=C1 RIVJJZYVIMDNKH-INWMFGNUSA-N 0.000 claims 1
• YPLIPLLENOEHFJ-KPFFTGBYSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,2-dimethyl-3h-1-benzofuran-7-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C=1C=CC=C2CC(OC2=1)(C)C)C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 YPLIPLLENOEHFJ-KPFFTGBYSA-N 0.000 claims 1
• FSJQWDJNMKMWGA-HFTRVMKXSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1C1=CC=CC(F)=C1 FSJQWDJNMKMWGA-HFTRVMKXSA-N 0.000 claims 1
• CJTMBFBFOHCHNN-ALKREAHSSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=CC(F)=C1 CJTMBFBFOHCHNN-ALKREAHSSA-N 0.000 claims 1
• SXOUZMVBNPCWIL-KBMXLJTQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,5-dimethyl-1,3-oxazole-4-carboxamide Chemical compound O1C(C)=NC(C(=O)NC[C@H]2N([C@H]3C[C@H]3C2)C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)=C1C SXOUZMVBNPCWIL-KBMXLJTQSA-N 0.000 claims 1
• IHBNXFCVHGTHKD-KBMXLJTQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,5-dimethylpyrazole-3-carboxamide Chemical compound CN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 IHBNXFCVHGTHKD-KBMXLJTQSA-N 0.000 claims 1
• FFWZFLVTHJRBRH-PVAVHDDUSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 FFWZFLVTHJRBRH-PVAVHDDUSA-N 0.000 claims 1
• GWZRHORPTRIYPH-KBMXLJTQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C=1N2C=C(SC2=NC=1)C)C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 GWZRHORPTRIYPH-KBMXLJTQSA-N 0.000 claims 1
• YQNTXYIXVCDHDS-ALKREAHSSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2-methylindazole-3-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C1=C2C=CC=CC2=NN1C)C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 YQNTXYIXVCDHDS-ALKREAHSSA-N 0.000 claims 1
• WZMUZXOAZRXIOV-KBMXLJTQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound CC1=NOC(C)=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 WZMUZXOAZRXIOV-KBMXLJTQSA-N 0.000 claims 1
• SWHHAPFYDVAOTR-XBFCOCLRSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-methyl-5-(trifluoromethyl)-1,2-oxazole-4-carboxamide Chemical compound CC1=NOC(C(F)(F)F)=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 SWHHAPFYDVAOTR-XBFCOCLRSA-N 0.000 claims 1
• ZCPJOEXFIVNBSM-KBMXLJTQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C1=C(N2C=CN=C2S1)C)C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 ZCPJOEXFIVNBSM-KBMXLJTQSA-N 0.000 claims 1
• KJPSTUQGVALPNP-KBMXLJTQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-5-ethyl-3-methyl-1,2-oxazole-4-carboxamide Chemical compound O1N=C(C)C(C(=O)NC[C@H]2N([C@H]3C[C@H]3C2)C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)=C1CC KJPSTUQGVALPNP-KBMXLJTQSA-N 0.000 claims 1
• KUNVODKYBAOYPV-BPAFIMBUSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-5-fluoro-1-methylindole-2-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C=1N(C2=CC=C(F)C=C2C=1)C)C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 KUNVODKYBAOYPV-BPAFIMBUSA-N 0.000 claims 1
• QZBPIWQBWWPEHK-PVAVHDDUSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-5-tert-butyl-2-methylpyrazole-3-carboxamide Chemical compound CN1N=C(C(C)(C)C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(N)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 QZBPIWQBWWPEHK-PVAVHDDUSA-N 0.000 claims 1
• VDQAGIQIUIZORQ-FMEYXAORSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-6-fluoro-4h-1,3-benzodioxine-8-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCOCC=3C=C(F)C=2)=C1C1=CC=CC(F)=C1 VDQAGIQIUIZORQ-FMEYXAORSA-N 0.000 claims 1
• DIZQXVPSQFCAJY-KBMXLJTQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C=1N2C=CSC2=NC=1C)C(=O)C=1N=C(N)SC=1C1=CC=CC(F)=C1 DIZQXVPSQFCAJY-KBMXLJTQSA-N 0.000 claims 1
• MUDFTNOBBRYNGR-SNPRPXQTSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CSC3=NC=2)=C1C1=CC=CC(F)=C1 MUDFTNOBBRYNGR-SNPRPXQTSA-N 0.000 claims 1
• YGIUUAOPOXXRJV-KPFFTGBYSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]isoquinoline-1-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3C=CN=2)=C1C1=CC=CC(F)=C1 YGIUUAOPOXXRJV-KPFFTGBYSA-N 0.000 claims 1
• FQQGWKSSBLQNSB-MMOPVJDHSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]isoquinoline-5-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=NC=C3C=CC=2)=C1C1=CC=CC(F)=C1 FQQGWKSSBLQNSB-MMOPVJDHSA-N 0.000 claims 1
• GYNSFMRWLPIVJD-KUDFPVQQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-4-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3N=CC=2)=C1C1=CC=CC(F)=C1 GYNSFMRWLPIVJD-KUDFPVQQSA-N 0.000 claims 1
• JKHPJPIOIGQUSW-KUDFPVQQSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-5-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CN=C3C=CC=2)=C1C1=CC=CC(F)=C1 JKHPJPIOIGQUSW-KUDFPVQQSA-N 0.000 claims 1
• ICZOTUOVKVXDJS-KPFFTGBYSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(N)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC(F)=C1 ICZOTUOVKVXDJS-KPFFTGBYSA-N 0.000 claims 1
• BJUAUMKZWDEZAL-UWVAXJGDSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1 BJUAUMKZWDEZAL-UWVAXJGDSA-N 0.000 claims 1
• UVTNQXCWIQUOAO-UWVAXJGDSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-methylindazole-3-carboxamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3N(C)N=2)=C1 UVTNQXCWIQUOAO-UWVAXJGDSA-N 0.000 claims 1
• JRPGUYFEQYSWLH-AOIWGVFYSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1 JRPGUYFEQYSWLH-AOIWGVFYSA-N 0.000 claims 1
• NDWOXJJCWNRPHY-UWVAXJGDSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1 NDWOXJJCWNRPHY-UWVAXJGDSA-N 0.000 claims 1
• LIELRRIIARUVHU-HBFSDRIKSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-7-carboxamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCC=3C=CC=2)=C1 LIELRRIIARUVHU-HBFSDRIKSA-N 0.000 claims 1
• QRJBVPFDEZXYFL-PMPSAXMXSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C2=C3OCCOC3=CS2)=C1 QRJBVPFDEZXYFL-PMPSAXMXSA-N 0.000 claims 1
• CMNKWJKYFWEVJN-AOIWGVFYSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3,4-dihydro-2h-1,4-benzoxazine-5-carboxamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3NCCOC=3C=CC=2)=C1 CMNKWJKYFWEVJN-AOIWGVFYSA-N 0.000 claims 1
• URYSQMOHKJMWQI-NEWSRXKRSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-bromobenzamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=C(Br)C=CC=2)=C1 URYSQMOHKJMWQI-NEWSRXKRSA-N 0.000 claims 1
• SMSKKKDQSPQPBB-HKBOAZHASA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-ethynylbenzamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=C(C=CC=2)C#C)=C1 SMSKKKDQSPQPBB-HKBOAZHASA-N 0.000 claims 1
• SFSKTVHOJFMXIW-HBFSDRIKSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-methylsulfanylbenzamide Chemical compound CSC1=CC=CC(C(=O)NC[C@H]2N([C@H]3C[C@H]3C2)C(=O)C2=C(SC(N)=N2)C=2C=C(C)C=CC=2)=C1 SFSKTVHOJFMXIW-HBFSDRIKSA-N 0.000 claims 1
• DWTJVHUMWXCHJZ-IKGGRYGDSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound N1([C@H]2C[C@H]2C[C@H]1CNC(=O)C=1N2C=CSC2=NC=1C)C(=O)C=1N=C(N)SC=1C1=CC=CC(C)=C1 DWTJVHUMWXCHJZ-IKGGRYGDSA-N 0.000 claims 1
• YLKCKZJWYQIFJX-DYXWJJEUSA-N n-[[(1s,3s,5s)-2-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound CC1=CC=CC(C2=C(N=C(N)S2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1 YLKCKZJWYQIFJX-DYXWJJEUSA-N 0.000 claims 1
• DGPQYYMFHNHJFI-JLHGSKIFSA-N n-[[(1s,3s,5s)-2-[2-cyclopropyl-5-(2-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound FC1=CC=CC=C1C1=C(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)N=C(C2CC2)S1 DGPQYYMFHNHJFI-JLHGSKIFSA-N 0.000 claims 1
• HLQLEGQHWVBEPG-LZNRXBQRSA-N n-[[(1s,3s,5s)-2-[2-cyclopropyl-5-(4-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound C1=CC(F)=CC=C1C1=C(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)N=C(C2CC2)S1 HLQLEGQHWVBEPG-LZNRXBQRSA-N 0.000 claims 1
• YLLSWNPZCFUPRS-LZNRXBQRSA-N n-[[(1s,3s,5s)-2-[2-cyclopropyl-5-[3-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound FC(F)(F)C1=CC=CC(C2=C(N=C(S2)C2CC2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1 YLLSWNPZCFUPRS-LZNRXBQRSA-N 0.000 claims 1
• VJJRTFROQVBXHH-DXIQSLLYSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1C1=CC=CC(C)=C1 VJJRTFROQVBXHH-DXIQSLLYSA-N 0.000 claims 1
• OLFCCRPHCVZQSG-DYXWJJEUSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1C1=CC=CC(C)=C1 OLFCCRPHCVZQSG-DYXWJJEUSA-N 0.000 claims 1
• KCOANUKFVBJCKP-DXIQSLLYSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=CC(C)=C1 KCOANUKFVBJCKP-DXIQSLLYSA-N 0.000 claims 1
• ZUGBKCDIFFBUIC-SQNIBIBYSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C2=C3OCCOC3=CS2)=C1C1=CC=CC(C)=C1 ZUGBKCDIFFBUIC-SQNIBIBYSA-N 0.000 claims 1
• PEALOQZNTJHOHY-DYXWJJEUSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3,4-dihydro-2h-1,4-benzoxazine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3NCCOC=3C=CC=2)=C1C1=CC=CC(C)=C1 PEALOQZNTJHOHY-DYXWJJEUSA-N 0.000 claims 1
• PBTITHPDWJGISI-QTEQDKRBSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3,4-dihydro-2h-chromene-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCCOC=3C=CC=2)=C1C1=CC=CC(C)=C1 PBTITHPDWJGISI-QTEQDKRBSA-N 0.000 claims 1
• GCMSAOJERLBESS-GIWBLDEGSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3,4-dihydro-2h-chromene-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCCC=3C=CC=2)=C1C1=CC=CC(C)=C1 GCMSAOJERLBESS-GIWBLDEGSA-N 0.000 claims 1
• SINYBNKIDPMQMD-GIVPXCGWSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-(trifluoromethyl)benzamide Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(C)C=CC=1)C)NC(=O)C1=CC=CC(C(F)(F)F)=C1 SINYBNKIDPMQMD-GIVPXCGWSA-N 0.000 claims 1
• ATVUJFCDAHNQKA-IKGGRYGDSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CSC3=NC=2C(F)(F)F)=C1C1=CC=CC(C)=C1 ATVUJFCDAHNQKA-IKGGRYGDSA-N 0.000 claims 1
• YQDLDJGYDZSKNF-GIWBLDEGSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]isoquinoline-1-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3C=CN=2)=C1C1=CC=CC(C)=C1 YQDLDJGYDZSKNF-GIWBLDEGSA-N 0.000 claims 1
• TUYNRWXGOHLKKD-DPLHUUCSSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N=C3C=CC=CC3=CC=2)=C1C1=CC=CC(C)=C1 TUYNRWXGOHLKKD-DPLHUUCSSA-N 0.000 claims 1
• HKBPOHZBBPDWEE-GIWBLDEGSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC(C)=C1 HKBPOHZBBPDWEE-GIWBLDEGSA-N 0.000 claims 1
• CDJYZBZDMPVNPM-XFQAVAEZSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-[2-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1C1=CC=CC=C1C(F)(F)F CDJYZBZDMPVNPM-XFQAVAEZSA-N 0.000 claims 1
• FKOJPPYIJVVNNM-GUXCAODWSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-[2-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1C1=CC=CC=C1C(F)(F)F FKOJPPYIJVVNNM-GUXCAODWSA-N 0.000 claims 1
• LRBPYXXOWQPIQY-CBQOVEMMSA-N n-[[(1s,3s,5s)-2-[2-methyl-5-[3-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC(C(F)(F)F)=C1 LRBPYXXOWQPIQY-CBQOVEMMSA-N 0.000 claims 1
• KJGPKBFNTWFXIY-WWMYMODYSA-N n-[[(1s,3s,5s)-2-[5-(2,3-dichlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC(Cl)=C1Cl KJGPKBFNTWFXIY-WWMYMODYSA-N 0.000 claims 1
• GFZBQTVLLBULSP-DPLHUUCSSA-N n-[[(1s,3s,5s)-2-[5-(2,3-dimethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC(C)=C1C GFZBQTVLLBULSP-DPLHUUCSSA-N 0.000 claims 1
• RRLLDPBLZSIRIN-GJYPPUQNSA-N n-[[(1s,3s,5s)-2-[5-(3,4-dichlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[1,2-a]pyridine-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CC=CC3=NC=2)=C1C1=CC=C(Cl)C(Cl)=C1 RRLLDPBLZSIRIN-GJYPPUQNSA-N 0.000 claims 1
• IRKPOWMQKJCWJT-FGSXEWAUSA-N n-[[(1s,3s,5s)-2-[5-(3,4-dichlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=C(Cl)C(Cl)=C1 IRKPOWMQKJCWJT-FGSXEWAUSA-N 0.000 claims 1
• RZISYTTYCMGRIV-XFQAVAEZSA-N n-[[(1s,3s,5s)-2-[5-(3,4-difluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=C(F)C(F)=C1 RZISYTTYCMGRIV-XFQAVAEZSA-N 0.000 claims 1
• AZDXLOMUOCNXEW-FGSXEWAUSA-N n-[[(1s,3s,5s)-2-[5-(3,4-difluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=C(F)C(F)=C1 AZDXLOMUOCNXEW-FGSXEWAUSA-N 0.000 claims 1
• GUKRKVDEZFQTSH-QTEQDKRBSA-N n-[[(1s,3s,5s)-2-[5-(3,4-dimethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=C(C)C(C)=C1 GUKRKVDEZFQTSH-QTEQDKRBSA-N 0.000 claims 1
• KZQZKNMOTAMKQF-HKBOAZHASA-N n-[[(1s,3s,5s)-2-[5-(3,4-dimethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[1,2-a]pyridine-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CC=CC3=NC=2)=C1C1=CC=C(C)C(C)=C1 KZQZKNMOTAMKQF-HKBOAZHASA-N 0.000 claims 1
• QCPQDWCUHPQQOM-GPXNEJASSA-N n-[[(1s,3s,5s)-2-[5-(3,4-dimethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=C(C)C(C)=C1 QCPQDWCUHPQQOM-GPXNEJASSA-N 0.000 claims 1
• YDFURXOYOVOKJD-SFLYRZDNSA-N n-[[(1s,3s,5s)-2-[5-(3,5-dimethylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC(C)=CC(C)=C1 YDFURXOYOVOKJD-SFLYRZDNSA-N 0.000 claims 1
• FEPGFYIHJOPNSL-XFQAVAEZSA-N n-[[(1s,3s,5s)-2-[5-(3-bromo-4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=C(F)C(Br)=C1 FEPGFYIHJOPNSL-XFQAVAEZSA-N 0.000 claims 1
• JOHGJYPTRQGDGY-GJYPPUQNSA-N n-[[(1s,3s,5s)-2-[5-(3-bromo-4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[1,2-a]pyridine-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CC=CC3=NC=2)=C1C1=CC=C(F)C(Br)=C1 JOHGJYPTRQGDGY-GJYPPUQNSA-N 0.000 claims 1
• ZUEMLXNMUXNLOR-NEWSRXKRSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-ethoxy-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[1,2-a]pyridine-3-carboxamide Chemical compound S1C(OCC)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CC=CC3=NC=2)=C1C1=CC=CC(Cl)=C1 ZUEMLXNMUXNLOR-NEWSRXKRSA-N 0.000 claims 1
• XUHKGEPMDCAIRN-AYBZRNKSSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,2-benzoxazole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3ON=2)=C1C1=CC=CC(Cl)=C1 XUHKGEPMDCAIRN-AYBZRNKSSA-N 0.000 claims 1
• KULMNBBOQJYNOV-RFWXGWTQSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,2-dimethylindole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3N(C)C=2C)=C1C1=CC=CC(Cl)=C1 KULMNBBOQJYNOV-RFWXGWTQSA-N 0.000 claims 1
• MZVIWUMTFZWTSC-KPFFTGBYSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-ethyl-3-methylpyrazole-4-carboxamide Chemical compound CC1=NN(CC)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(Cl)C=CC=2)[C@H]2C[C@H]2C1 MZVIWUMTFZWTSC-KPFFTGBYSA-N 0.000 claims 1
• DLOVGCVIGXHUNF-SYNHAJSKSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1h-indazole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3NN=2)=C1C1=CC=CC(Cl)=C1 DLOVGCVIGXHUNF-SYNHAJSKSA-N 0.000 claims 1
• YIXBQPFPRXJUDG-NRJQMVOHSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1h-indole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3NC=2)=C1C1=CC=CC(Cl)=C1 YIXBQPFPRXJUDG-NRJQMVOHSA-N 0.000 claims 1
• ZHSWDDMSCPEKSE-KPFFTGBYSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1C1=CC=CC(Cl)=C1 ZHSWDDMSCPEKSE-KPFFTGBYSA-N 0.000 claims 1
• PJJFOLAESAPRLI-MMOPVJDHSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=CC(Cl)=C1 PJJFOLAESAPRLI-MMOPVJDHSA-N 0.000 claims 1
• ZWCAZXXGONPGFK-PVAVHDDUSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C2=C3OCCOC3=CS2)=C1C1=CC=CC(Cl)=C1 ZWCAZXXGONPGFK-PVAVHDDUSA-N 0.000 claims 1
• YPFFTZMAJGPYGI-NJAFHUGGSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,5-dimethylpyrazole-3-carboxamide Chemical compound CN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(Cl)C=CC=2)[C@H]2C[C@H]2C1 YPFFTZMAJGPYGI-NJAFHUGGSA-N 0.000 claims 1
• KBSSVCYUMROVTM-NEWSRXKRSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(Cl)C=CC=2)[C@H]2C[C@H]2C1 KBSSVCYUMROVTM-NEWSRXKRSA-N 0.000 claims 1
• WWIBMKSHGULDKS-UXPWSPDFSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-(trifluoromethyl)benzamide Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(Cl)C=CC=1)C)NC(=O)C1=CC=CC(C(F)(F)F)=C1 WWIBMKSHGULDKS-UXPWSPDFSA-N 0.000 claims 1
• CCEVMRIFKIBBST-LMNJBCLMSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-methoxybenzamide Chemical compound COC1=CC=CC(C(=O)NC[C@H]2N([C@H]3C[C@H]3C2)C(=O)C2=C(SC(C)=N2)C=2C=C(Cl)C=CC=2)=C1 CCEVMRIFKIBBST-LMNJBCLMSA-N 0.000 claims 1
• WVEYOGBDDMVQGW-NJAFHUGGSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C2=C(N3C=CN=C3S2)C)=C1C1=CC=CC(Cl)=C1 WVEYOGBDDMVQGW-NJAFHUGGSA-N 0.000 claims 1
• AQHMWVQEGIXGRB-AGHHOFFYSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-5-fluoro-1-methylindole-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N(C3=CC=C(F)C=C3C=2)C)=C1C1=CC=CC(Cl)=C1 AQHMWVQEGIXGRB-AGHHOFFYSA-N 0.000 claims 1
• ABAFUSICQAJYHX-JJXUHFIVSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-6-fluoro-4h-1,3-benzodioxine-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCOCC=3C=C(F)C=2)=C1C1=CC=CC(Cl)=C1 ABAFUSICQAJYHX-JJXUHFIVSA-N 0.000 claims 1
• AMRUTJGNGLZLAU-NEWSRXKRSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[1,2-a]pyridine-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CC=CC3=NC=2)=C1C1=CC=CC(Cl)=C1 AMRUTJGNGLZLAU-NEWSRXKRSA-N 0.000 claims 1
• PYLPTCXZFSJPBQ-CBQOVEMMSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]isoquinoline-1-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3C=CN=2)=C1C1=CC=CC(Cl)=C1 PYLPTCXZFSJPBQ-CBQOVEMMSA-N 0.000 claims 1
• LMXRJZBZNFHGQO-RFWXGWTQSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N=C3C=CC=CC3=CC=2)=C1C1=CC=CC(Cl)=C1 LMXRJZBZNFHGQO-RFWXGWTQSA-N 0.000 claims 1
• NUEKDPUEOHJGRL-CBQOVEMMSA-N n-[[(1s,3s,5s)-2-[5-(3-chlorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=CC(Cl)=C1 NUEKDPUEOHJGRL-CBQOVEMMSA-N 0.000 claims 1
• TVEAFQUZIZCOLS-JLHGSKIFSA-N n-[[(1s,3s,5s)-2-[5-(3-fluoro-2-methylphenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=CC(F)=C1C TVEAFQUZIZCOLS-JLHGSKIFSA-N 0.000 claims 1
• FAELKWNVFKPZTI-AYBZRNKSSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,2,3-benzothiadiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=C3N=NSC3=CC=2)=C1C1=CC=CC(F)=C1 FAELKWNVFKPZTI-AYBZRNKSSA-N 0.000 claims 1
• HAEZTYREHPHRFS-AYBZRNKSSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,2-benzoxazole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3ON=2)=C1C1=CC=CC(F)=C1 HAEZTYREHPHRFS-AYBZRNKSSA-N 0.000 claims 1
• NWDDGUMPWCBBKH-RFWXGWTQSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,2-dimethylindole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3N(C)C=2C)=C1C1=CC=CC(F)=C1 NWDDGUMPWCBBKH-RFWXGWTQSA-N 0.000 claims 1
• RUNJGURNLBVIFZ-AYBZRNKSSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1,3-benzodioxole-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCOC=3C=CC=2)=C1C1=CC=CC(F)=C1 RUNJGURNLBVIFZ-AYBZRNKSSA-N 0.000 claims 1
• IXZDFZYIRMITCC-MMOPVJDHSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1C1=CC=CC(F)=C1 IXZDFZYIRMITCC-MMOPVJDHSA-N 0.000 claims 1
• ZWPHKCYSAULFQP-KMFMINBZSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-methyl-5-(trifluoromethyl)pyrazole-4-carboxamide Chemical compound C([C@@H]1C[C@@H]2C[C@@H]2N1C(=O)C=1N=C(SC=1C=1C=C(F)C=CC=1)C)NC(=O)C=1C=NN(C)C=1C(F)(F)F ZWPHKCYSAULFQP-KMFMINBZSA-N 0.000 claims 1
• GPEXRUVIDUNSOK-FHJLPGHOSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-methylindole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3N(C)C=2)=C1C1=CC=CC(F)=C1 GPEXRUVIDUNSOK-FHJLPGHOSA-N 0.000 claims 1
• ZAKYHOCPQDNYNQ-SYNHAJSKSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1h-indazole-3-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3NN=2)=C1C1=CC=CC(F)=C1 ZAKYHOCPQDNYNQ-SYNHAJSKSA-N 0.000 claims 1
• RANNBCIGXQEKKB-CBQOVEMMSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,2-dimethyl-3h-1-benzofuran-7-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OC(C)(C)CC=3C=CC=2)=C1C1=CC=CC(F)=C1 RANNBCIGXQEKKB-CBQOVEMMSA-N 0.000 claims 1
• OCWKZYWPKWZHHI-KPFFTGBYSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1C1=CC=CC(F)=C1 OCWKZYWPKWZHHI-KPFFTGBYSA-N 0.000 claims 1
• IRSZGAWQARVDBB-MMOPVJDHSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=CC(F)=C1 IRSZGAWQARVDBB-MMOPVJDHSA-N 0.000 claims 1
• LFQJYLUTKWNOSL-NJAFHUGGSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,5-dimethylpyrazole-3-carboxamide Chemical compound CN1N=C(C)C=C1C(=O)NC[C@H]1N(C(=O)C2=C(SC(C)=N2)C=2C=C(F)C=CC=2)[C@H]2C[C@H]2C1 LFQJYLUTKWNOSL-NJAFHUGGSA-N 0.000 claims 1
• HDTURWYGRJKUDY-NJAFHUGGSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CSC3=NC=2C)=C1C1=CC=CC(F)=C1 HDTURWYGRJKUDY-NJAFHUGGSA-N 0.000 claims 1
• YADRBPJUUYWGHU-PVAVHDDUSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CSC3=NC=2)=C1C1=CC=CC(F)=C1 YADRBPJUUYWGHU-PVAVHDDUSA-N 0.000 claims 1
• LZOWHENTMXNRQV-CBQOVEMMSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]isoquinoline-1-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=CC=CC=C3C=CN=2)=C1C1=CC=CC(F)=C1 LZOWHENTMXNRQV-CBQOVEMMSA-N 0.000 claims 1
• LUJFBPBYVPGEBN-RFWXGWTQSA-N n-[[(1s,3s,5s)-2-[5-(3-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-2-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N=C3C=CC=CC3=CC=2)=C1C1=CC=CC(F)=C1 LUJFBPBYVPGEBN-RFWXGWTQSA-N 0.000 claims 1
• ONUYRECGXUHPRC-WWMYMODYSA-N n-[[(1s,3s,5s)-2-[5-(3-methoxyphenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound COC1=CC=CC(C2=C(N=CS2)C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1 ONUYRECGXUHPRC-WWMYMODYSA-N 0.000 claims 1
• PXUCQWLVQLBNHW-MMOPVJDHSA-N n-[[(1s,3s,5s)-2-[5-(4-bromophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=C(Br)C=C1 PXUCQWLVQLBNHW-MMOPVJDHSA-N 0.000 claims 1
• PPHGLFPIIJAYAF-CBQOVEMMSA-N n-[[(1s,3s,5s)-2-[5-(4-bromophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=C(Br)C=C1 PPHGLFPIIJAYAF-CBQOVEMMSA-N 0.000 claims 1
• XPTLYHMSWYFQEP-MMOPVJDHSA-N n-[[(1s,3s,5s)-2-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3C=COC=3C=CC=2)=C1C1=CC=C(F)C=C1 XPTLYHMSWYFQEP-MMOPVJDHSA-N 0.000 claims 1
• AZHMNKZIDLMFPF-KPFFTGBYSA-N n-[[(1s,3s,5s)-2-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)=C1C1=CC=C(F)C=C1 AZHMNKZIDLMFPF-KPFFTGBYSA-N 0.000 claims 1
• QKZBDFUUEJARFX-MMOPVJDHSA-N n-[[(1s,3s,5s)-2-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1-benzofuran-4-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3CCOC=3C=CC=2)=C1C1=CC=C(F)C=C1 QKZBDFUUEJARFX-MMOPVJDHSA-N 0.000 claims 1
• DKKXPZIUGBKRPG-NJAFHUGGSA-N n-[[(1s,3s,5s)-2-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2N3C=CSC3=NC=2C)=C1C1=CC=C(F)C=C1 DKKXPZIUGBKRPG-NJAFHUGGSA-N 0.000 claims 1
• BCXPFLWKUBVZJM-CBQOVEMMSA-N n-[[(1s,3s,5s)-2-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]quinoline-8-carboxamide Chemical compound S1C(C)=NC(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C3=NC=CC=C3C=CC=2)=C1C1=CC=C(F)C=C1 BCXPFLWKUBVZJM-CBQOVEMMSA-N 0.000 claims 1
• JUBVRLXHQKTHJC-UWVAXJGDSA-N n-[[(1s,3s,5s)-2-[5-(4-methoxyphenyl)-1,3-oxazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound C1=CC(OC)=CC=C1C1=C(C(=O)N2[C@@H](C[C@@H]3C[C@@H]32)CNC(=O)C=2C=3OCCOC=3C=CC=2)N=CO1 JUBVRLXHQKTHJC-UWVAXJGDSA-N 0.000 claims 1
• 201000003631 narcolepsy Diseases 0.000 claims 1
• 239000004081 narcotic agent Substances 0.000 claims 1
• 230000008693 nausea Effects 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 108060005714 orexin Proteins 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 125000002971 oxazolyl group Chemical group 0.000 claims 1
• 208000027753 pain disease Diseases 0.000 claims 1
• 230000008533 pain sensitivity Effects 0.000 claims 1
• 208000019906 panic disease Diseases 0.000 claims 1
• 208000030062 persistent idiopathic facial pain Diseases 0.000 claims 1
• 208000022821 personality disease Diseases 0.000 claims 1
• 208000017402 pituitary gland disease Diseases 0.000 claims 1
• 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 201000009395 primary hyperaldosteronism Diseases 0.000 claims 1
• 208000030153 prolactin-producing pituitary gland adenoma Diseases 0.000 claims 1
• 230000001107 psychogenic effect Effects 0.000 claims 1
• 125000003226 pyrazolyl group Chemical group 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• SWVBPJMJJQONPB-UHFFFAOYSA-N pyrrolo[2,1-b][1,3]thiazole-7-carboxylic acid Chemical compound C1=CSC2=C(C(=O)O)C=CN21 SWVBPJMJJQONPB-UHFFFAOYSA-N 0.000 claims 1
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
• 230000004043 responsiveness Effects 0.000 claims 1
• 210000001732 sebaceous gland Anatomy 0.000 claims 1
• 238000005204 segregation Methods 0.000 claims 1
• 230000001953 sensory effect Effects 0.000 claims 1
• 201000002859 sleep apnea Diseases 0.000 claims 1
• 208000019116 sleep disease Diseases 0.000 claims 1
• 210000000278 spinal cord Anatomy 0.000 claims 1
• 208000020431 spinal cord injury Diseases 0.000 claims 1
• 230000002269 spontaneous effect Effects 0.000 claims 1
• 230000035882 stress Effects 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 235000019669 taste disorders Nutrition 0.000 claims 1
• 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
• 125000000335 thiazolyl group Chemical group 0.000 claims 1
• 231100000886 tinnitus Toxicity 0.000 claims 1
• 208000004371 toothache Diseases 0.000 claims 1
• 231100000331 toxic Toxicity 0.000 claims 1
• 230000002588 toxic effect Effects 0.000 claims 1
• 230000001052 transient effect Effects 0.000 claims 1
• 230000008733 trauma Effects 0.000 claims 1
• 230000000472 traumatic effect Effects 0.000 claims 1
• SMBZJSVIKJMSFP-UHFFFAOYSA-N trifluoromethyl hypofluorite Chemical compound FOC(F)(F)F SMBZJSVIKJMSFP-UHFFFAOYSA-N 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
• 208000009935 visceral pain Diseases 0.000 claims 1