JP2010514720A5 - - Google Patents
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- Publication number
- JP2010514720A5 JP2010514720A5 JP2009543376A JP2009543376A JP2010514720A5 JP 2010514720 A5 JP2010514720 A5 JP 2010514720A5 JP 2009543376 A JP2009543376 A JP 2009543376A JP 2009543376 A JP2009543376 A JP 2009543376A JP 2010514720 A5 JP2010514720 A5 JP 2010514720A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- aryl
- isoquinolin
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BCZPUVXMWIBIRE-UHFFFAOYSA-N Fc(c(Cl)c1)cc2c1cncc2 Chemical compound Fc(c(Cl)c1)cc2c1cncc2 BCZPUVXMWIBIRE-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06026892.7 | 2006-12-27 | ||
| EP06026892 | 2006-12-27 | ||
| PCT/EP2007/011168 WO2008077555A2 (en) | 2006-12-27 | 2007-12-19 | Substituted isoquinolines and their use as rho-kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514720A JP2010514720A (ja) | 2010-05-06 |
| JP2010514720A5 true JP2010514720A5 (cg-RX-API-DMAC7.html) | 2011-02-03 |
| JP5313919B2 JP5313919B2 (ja) | 2013-10-09 |
Family
ID=38015325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543376A Expired - Fee Related JP5313919B2 (ja) | 2006-12-27 | 2007-12-19 | 新規な置換イソキノリン及びイソキノリノン誘導体 |
Country Status (30)
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2443688C2 (ru) | 2005-06-28 | 2012-02-27 | Санофи-Авентис | ПРОИЗВОДНЫЕ ИЗОХИНОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| US7470787B2 (en) | 2005-07-11 | 2008-12-30 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| KR101336678B1 (ko) | 2005-07-26 | 2013-12-04 | 사노피 | Ｒｈｏ-키나제 억제제로서의 사이클로헥실아민 이소퀴놀론유도체 |
| WO2007012421A1 (en) | 2005-07-26 | 2007-02-01 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
| EP2068878B1 (en) | 2006-09-20 | 2019-04-10 | Aerie Pharmaceuticals, Inc. | Rho kinase inhibitors |
| NZ577984A (en) | 2006-12-27 | 2011-03-31 | Sanofi Aventis | Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives |
| KR20090094338A (ko) | 2006-12-27 | 2009-09-04 | 사노피-아벤티스 | 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
| JP5405314B2 (ja) | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノロン誘導体 |
| MY151953A (en) | 2006-12-27 | 2014-07-31 | Sanofi Aventis | Cycloalkylamine substituted isoquinoline derivatives |
| ATE502027T1 (de) | 2006-12-27 | 2011-04-15 | Sanofi Aventis | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren |
| JP5421783B2 (ja) | 2006-12-27 | 2014-02-19 | サノフイ | Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体 |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| PT2303845E (pt) * | 2008-06-24 | 2013-11-25 | Sanofi Sa | Derivados de isoquinolina e isoquinolina substituída com bi- e policíclicos como inibidores de rho-cinase |
| ES2436531T3 (es) | 2008-06-24 | 2014-01-02 | Sanofi | Isoquinolinas e isoquinolinonas sustituidas en posición 6 |
| AU2009262517B2 (en) | 2008-06-24 | 2014-01-09 | Sanofi | Substituted isoquinolines and isoquinolinones as Rho kinase inhibitors |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| US8791102B2 (en) * | 2008-10-17 | 2014-07-29 | Exelixis, Inc. | Acetanilide sphingosine-1-phosphate receptor antagonists |
| CA2929545C (en) | 2009-05-01 | 2019-04-09 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| JP2013507417A (ja) * | 2009-10-13 | 2013-03-04 | エム・エス・ディー・オス・ベー・フェー | アセチルコリン受容体に関連する疾患の処置のための縮合アジン誘導体 |
| HRP20160356T1 (hr) * | 2011-07-08 | 2016-05-06 | Sanofi | Kristalni solvati 6-(piperidin-4-iloksi)-2h-izokinolin-1-on hidroklorida |
| CN102993178A (zh) * | 2012-12-04 | 2013-03-27 | 天津红日药业股份有限公司 | 具有Rho激酶抑制活性的异喹啉类化合物、制备方法及用途 |
| EA036160B1 (ru) * | 2013-03-15 | 2020-10-08 | Селджен Кар Ллс | Гетероарильные соединения и их применение |
| ES2852377T3 (es) | 2013-03-15 | 2021-09-13 | Aerie Pharmaceuticals Inc | Sales dimesilato de 4-(3-amino-1-(isoquinolin-6-ilamino)-1-oxopropan-2-il)bencilo, sus combinaciones con prostaglandinas y el uso de las mismas en el tratamiento de trastornos oculares |
| NZ711376A (en) | 2013-03-15 | 2020-01-31 | Sanofi Sa | Heteroaryl compounds and uses thereof |
| AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
| JP6729963B2 (ja) | 2014-01-31 | 2020-07-29 | 株式会社エーピーアイ コーポレーション | ピペコリン酸４位水酸化酵素およびそれを利用した４−ヒドロキシアミノ酸の製造法 |
| FR3017868A1 (fr) * | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN116396991A (zh) | 2015-10-02 | 2023-07-07 | 株式会社Api | 羟基-l-哌可酸的制造方法 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US10550087B2 (en) | 2015-11-17 | 2020-02-04 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| CN109640966A (zh) | 2016-08-31 | 2019-04-16 | 爱瑞制药公司 | 眼用组合物 |
| EP3609871A4 (en) | 2017-03-31 | 2021-01-06 | Aerie Pharmaceuticals, Inc. | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS |
| WO2020056345A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
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| FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| WO1992002476A1 (en) | 1990-07-31 | 1992-02-20 | E.I. Du Pont De Nemours And Company | Catalytic equilibration of selected halocarbons |
| US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| IL128456A0 (en) | 1996-08-12 | 2000-01-31 | Yoshitomi Pharmaceutical | Compositions containing a Rho kinase inhibitor |
| JPH1087629A (ja) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
| JP2001514259A (ja) | 1997-08-29 | 2001-09-11 | ゼネカ・リミテッド | アミノメチルオキソオキサゾリジニルベンゼン誘導体 |
| TW575567B (en) * | 1998-10-23 | 2004-02-11 | Akzo Nobel Nv | Serine protease inhibitor |
| GB9912701D0 (en) | 1999-06-01 | 1999-08-04 | Smithkline Beecham Plc | Novel compounds |
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| RU2259365C2 (ru) * | 2000-01-20 | 2005-08-27 | Эйсай Ко., Лтд. | Пиперидиновое соединение, способ его получения, фармацевтическая композиция и способ ингибирования натриевых каналов и калиевых каналов |
| US7217722B2 (en) * | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| US20040171533A1 (en) | 2000-02-29 | 2004-09-02 | Barbara Zehentner | Methods and compositions for regulating adiopocytes |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| WO2002034712A1 (en) | 2000-10-27 | 2002-05-02 | Takeda Chemical Industries, Ltd. | Process for preparing substituted aromatic compounds and intermediates therefor |
| EP1351936A1 (en) | 2001-01-15 | 2003-10-15 | Glaxo Group Limited | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression |
| SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
| JP2004534017A (ja) | 2001-04-27 | 2004-11-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｂａｃｅのインヒビター |
| JPWO2002100833A1 (ja) * | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Ｒｈｏキナーゼ阻害剤 |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| WO2003024450A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| CA2493230A1 (en) | 2002-07-22 | 2004-01-29 | Asahi Kasei Pharma Corporation | 5-substituted isoquinoline derivative |
| EP1550660A1 (en) * | 2002-09-12 | 2005-07-06 | Kirin Beer Kabushiki Kaisha | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same |
| US20050014783A1 (en) | 2003-05-29 | 2005-01-20 | Schering Aktiengesellschaft | Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy |
| EP1638939A2 (en) | 2003-06-24 | 2006-03-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| AU2004275720B2 (en) | 2003-09-23 | 2008-04-24 | Merck Sharp & Dohme Corp. | Isoquinoline potassium channel inhibitors |
| EP1667982B1 (en) | 2003-09-23 | 2013-07-31 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| US20050067037A1 (en) | 2003-09-30 | 2005-03-31 | Conocophillips Company | Collapse resistant composite riser |
| WO2005035516A1 (ja) | 2003-10-10 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | 新規縮合複素環化合物およびその用途 |
| EP1689719A1 (en) | 2003-11-25 | 2006-08-16 | Eli Lilly And Company | 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b) |
| JP2005232175A (ja) * | 2004-01-21 | 2005-09-02 | Asahi Kasei Pharma Kk | ５−置換イソキノリン医薬 |
| WO2005074535A2 (en) | 2004-01-30 | 2005-08-18 | Eisai Co., Ltd. | Cholinesterase inhibitors for spinal cord disorders |
| EP1729761A4 (en) | 2004-03-05 | 2008-09-03 | Eisai Co Ltd | TREATMENT OF CADASIL WITH CHOLINESTERASE INHIBITORS |
| SE0400850D0 (sv) | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
| US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| RU2443688C2 (ru) * | 2005-06-28 | 2012-02-27 | Санофи-Авентис | ПРОИЗВОДНЫЕ ИЗОХИНОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| WO2007012421A1 (en) | 2005-07-26 | 2007-02-01 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
| KR101336678B1 (ko) | 2005-07-26 | 2013-12-04 | 사노피 | Ｒｈｏ-키나제 억제제로서의 사이클로헥실아민 이소퀴놀론유도체 |
| TW200745101A (en) * | 2005-09-30 | 2007-12-16 | Organon Nv | 9-Azabicyclo[3.3.1]nonane derivatives |
| TW200738682A (en) | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| US7618985B2 (en) | 2005-12-08 | 2009-11-17 | N.V. Organon | Isoquinoline derivatives |
| US7893088B2 (en) * | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| NZ577984A (en) | 2006-12-27 | 2011-03-31 | Sanofi Aventis | Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives |
| ATE502027T1 (de) | 2006-12-27 | 2011-04-15 | Sanofi Aventis | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren |
-
2007
- 2007-12-19 AT AT07856891T patent/ATE502027T1/de active
- 2007-12-19 AU AU2007338411A patent/AU2007338411B2/en not_active Ceased
- 2007-12-19 CA CA2673921A patent/CA2673921C/en not_active Expired - Fee Related
- 2007-12-19 CN CN200780048335.9A patent/CN101573354B/zh not_active Expired - Fee Related
- 2007-12-19 PT PT07856891T patent/PT2132194E/pt unknown
- 2007-12-19 DE DE602007013295T patent/DE602007013295D1/de active Active
- 2007-12-19 MX MX2009005862A patent/MX2009005862A/es active IP Right Grant
- 2007-12-19 JP JP2009543376A patent/JP5313919B2/ja not_active Expired - Fee Related
- 2007-12-19 RU RU2009128690/04A patent/RU2009128690A/ru not_active Application Discontinuation
- 2007-12-19 DK DK07856891.2T patent/DK2132194T3/da active
- 2007-12-19 KR KR1020097013326A patent/KR101545533B1/ko not_active Expired - Fee Related
- 2007-12-19 WO PCT/EP2007/011168 patent/WO2008077555A2/en not_active Ceased
- 2007-12-19 EP EP07856891A patent/EP2132194B1/en active Active
- 2007-12-19 ES ES07856891T patent/ES2363105T3/es active Active
- 2007-12-19 MY MYPI20092542A patent/MY148902A/en unknown
- 2007-12-19 BR BRPI0720909A patent/BRPI0720909A2/pt not_active IP Right Cessation
- 2007-12-21 AR ARP070105858A patent/AR064493A1/es unknown
- 2007-12-25 TW TW096149802A patent/TWI448286B/zh not_active IP Right Cessation
- 2007-12-26 CL CL200703819A patent/CL2007003819A1/es unknown
-
2009
- 2009-05-20 CR CR10815A patent/CR10815A/es not_active Application Discontinuation
- 2009-05-22 ZA ZA200903554A patent/ZA200903554B/xx unknown
- 2009-06-02 NI NI200900109A patent/NI200900109A/es unknown
- 2009-06-12 CO CO09061598A patent/CO6210690A2/es not_active Application Discontinuation
- 2009-06-18 US US12/487,409 patent/US8772492B2/en not_active Expired - Fee Related
- 2009-06-24 IL IL199538A patent/IL199538A/en active IP Right Grant
- 2009-06-24 SV SV2009003316A patent/SV2009003316A/es unknown
- 2009-06-24 MA MA32039A patent/MA31024B1/fr unknown
- 2009-06-26 TN TNP2009000273A patent/TN2009000273A1/fr unknown
- 2009-06-26 NO NO20092434A patent/NO20092434L/no not_active Application Discontinuation
- 2009-06-26 EC EC2009009469A patent/ECSP099469A/es unknown