ZA200903554B - Substituted isoquinolines and their use as rho-kinase inhibitors - Google Patents

Substituted isoquinolines and their use as rho-kinase inhibitors

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Publication number
ZA200903554B
ZA200903554B ZA200903554A ZA200903554A ZA200903554B ZA 200903554 B ZA200903554 B ZA 200903554B ZA 200903554 A ZA200903554 A ZA 200903554A ZA 200903554 A ZA200903554 A ZA 200903554A ZA 200903554 B ZA200903554 B ZA 200903554B
Authority
ZA
South Africa
Prior art keywords
rho
kinase inhibitors
substituted isoquinolines
isoquinolines
substituted
Prior art date
Application number
ZA200903554A
Other languages
English (en)
Inventor
Oliver Plettenburg
Katrin Lorenz
Jochen Goerlitzer
Matthias Loehn
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ZA200903554B publication Critical patent/ZA200903554B/xx

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

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ZA200903554A 2006-12-27 2009-05-22 Substituted isoquinolines and their use as rho-kinase inhibitors ZA200903554B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06026892 2006-12-27

Publications (1)

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ZA200903554B true ZA200903554B (en) 2010-05-26

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ZA200903554A ZA200903554B (en) 2006-12-27 2009-05-22 Substituted isoquinolines and their use as rho-kinase inhibitors

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US (1) US8772492B2 (cg-RX-API-DMAC7.html)
EP (1) EP2132194B1 (cg-RX-API-DMAC7.html)
JP (1) JP5313919B2 (cg-RX-API-DMAC7.html)
KR (1) KR101545533B1 (cg-RX-API-DMAC7.html)
CN (1) CN101573354B (cg-RX-API-DMAC7.html)
AR (1) AR064493A1 (cg-RX-API-DMAC7.html)
AT (1) ATE502027T1 (cg-RX-API-DMAC7.html)
AU (1) AU2007338411B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0720909A2 (cg-RX-API-DMAC7.html)
CA (1) CA2673921C (cg-RX-API-DMAC7.html)
CL (1) CL2007003819A1 (cg-RX-API-DMAC7.html)
CO (1) CO6210690A2 (cg-RX-API-DMAC7.html)
CR (1) CR10815A (cg-RX-API-DMAC7.html)
DE (1) DE602007013295D1 (cg-RX-API-DMAC7.html)
DK (1) DK2132194T3 (cg-RX-API-DMAC7.html)
EC (1) ECSP099469A (cg-RX-API-DMAC7.html)
ES (1) ES2363105T3 (cg-RX-API-DMAC7.html)
IL (1) IL199538A (cg-RX-API-DMAC7.html)
MA (1) MA31024B1 (cg-RX-API-DMAC7.html)
MX (1) MX2009005862A (cg-RX-API-DMAC7.html)
MY (1) MY148902A (cg-RX-API-DMAC7.html)
NI (1) NI200900109A (cg-RX-API-DMAC7.html)
NO (1) NO20092434L (cg-RX-API-DMAC7.html)
PT (1) PT2132194E (cg-RX-API-DMAC7.html)
RU (1) RU2009128690A (cg-RX-API-DMAC7.html)
SV (1) SV2009003316A (cg-RX-API-DMAC7.html)
TN (1) TN2009000273A1 (cg-RX-API-DMAC7.html)
TW (1) TWI448286B (cg-RX-API-DMAC7.html)
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MX2008001053A (es) 2005-07-26 2008-03-19 Sanofi Aventis Derivados de isoquinolona sustituidos con piperidinilo en calidad de inhibidores de rho-quinasa.
PT1912949E (pt) 2005-07-26 2011-11-23 Sanofi Sa Derivados de ciclo-hexilamina isoquinolona como inibidores da rho-cinase
EP2526948A1 (en) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO kinase inhibitors
MX2009005862A (es) 2006-12-27 2009-06-17 Sanofi Aventis Nuevos derivados de isoquinolina e isoquinolinona sustituidos.
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WO2008077551A1 (en) 2006-12-27 2008-07-03 Sanofi-Aventis Cycloalkylamine substituted isoquinolone derivatives
DK2102164T3 (da) 2006-12-27 2011-03-21 Sanofi Aventis Cycloalkylaminsubstituerede isochinolin- og isochinolinonderivater
KR20090094338A (ko) 2006-12-27 2009-09-04 사노피-아벤티스 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
JP5421783B2 (ja) 2006-12-27 2014-02-19 サノフイ Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体
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KR102350704B1 (ko) * 2013-03-15 2022-01-13 셀젠 카르 엘엘씨 헤테로아릴 화합물 및 이의 용도
EA036160B1 (ru) * 2013-03-15 2020-10-08 Селджен Кар Ллс Гетероарильные соединения и их применение
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