JP2010511621A5 - - Google Patents
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- Publication number
- JP2010511621A5 JP2010511621A5 JP2009539355A JP2009539355A JP2010511621A5 JP 2010511621 A5 JP2010511621 A5 JP 2010511621A5 JP 2009539355 A JP2009539355 A JP 2009539355A JP 2009539355 A JP2009539355 A JP 2009539355A JP 2010511621 A5 JP2010511621 A5 JP 2010511621A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- diazepan
- benzoxazole
- triazol
- benzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2H-1,2,3-triazol-2-yl Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- JYTNQNCOQXFQPK-MRXNPFEDSA-N suvorexant Chemical compound C([C@H]1C)CN(C=2OC3=CC=C(Cl)C=C3N=2)CCN1C(=O)C1=CC(C)=CC=C1N1N=CC=N1 JYTNQNCOQXFQPK-MRXNPFEDSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87239306P | 2006-12-01 | 2006-12-01 | |
| US95974207P | 2007-07-16 | 2007-07-16 | |
| PCT/US2007/024690 WO2008069997A1 (en) | 2006-12-01 | 2007-11-30 | Substituted diazepan compounds as orexin receptor antagonists |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010264812A Division JP5767803B2 (ja) | 2006-12-01 | 2010-11-29 | オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物 |
| JP2010264809A Division JP5335758B2 (ja) | 2006-12-01 | 2010-11-29 | オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010511621A JP2010511621A (ja) | 2010-04-15 |
| JP2010511621A5 true JP2010511621A5 (OSRAM) | 2011-01-20 |
| JP4675427B2 JP4675427B2 (ja) | 2011-04-20 |
Family
ID=39284173
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539355A Active JP4675427B2 (ja) | 2006-12-01 | 2007-11-30 | オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物 |
| JP2010264809A Active JP5335758B2 (ja) | 2006-12-01 | 2010-11-29 | オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物 |
| JP2010264812A Active JP5767803B2 (ja) | 2006-12-01 | 2010-11-29 | オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010264809A Active JP5335758B2 (ja) | 2006-12-01 | 2010-11-29 | オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物 |
| JP2010264812A Active JP5767803B2 (ja) | 2006-12-01 | 2010-11-29 | オレキシンレセプターアンタゴニストとしての置換ジアゼパン化合物 |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US7951797B2 (OSRAM) |
| EP (2) | EP2089382B1 (OSRAM) |
| JP (3) | JP4675427B2 (OSRAM) |
| KR (2) | KR101299426B1 (OSRAM) |
| CN (1) | CN101880276B (OSRAM) |
| AR (2) | AR063979A1 (OSRAM) |
| AU (2) | AU2007328267B2 (OSRAM) |
| BR (1) | BRPI0719361B8 (OSRAM) |
| CA (1) | CA2670892C (OSRAM) |
| CL (2) | CL2007003441A1 (OSRAM) |
| CO (1) | CO6190524A2 (OSRAM) |
| CR (1) | CR10859A (OSRAM) |
| CY (1) | CY1113798T1 (OSRAM) |
| DK (1) | DK2089382T3 (OSRAM) |
| DO (1) | DOP2009000126A (OSRAM) |
| EC (1) | ECSP099374A (OSRAM) |
| ES (1) | ES2397188T3 (OSRAM) |
| HR (1) | HRP20130002T1 (OSRAM) |
| IL (1) | IL198825A0 (OSRAM) |
| MA (1) | MA31016B1 (OSRAM) |
| MX (1) | MX2009005712A (OSRAM) |
| MY (1) | MY161834A (OSRAM) |
| NI (1) | NI200900100A (OSRAM) |
| NO (1) | NO342586B1 (OSRAM) |
| NZ (1) | NZ577334A (OSRAM) |
| PE (1) | PE20081229A1 (OSRAM) |
| PL (1) | PL2089382T3 (OSRAM) |
| PT (1) | PT2089382E (OSRAM) |
| RS (1) | RS52617B (OSRAM) |
| RU (2) | RU2458924C3 (OSRAM) |
| SI (1) | SI2089382T1 (OSRAM) |
| SV (1) | SV2009003276A (OSRAM) |
| TW (2) | TWI515188B (OSRAM) |
| WO (1) | WO2008069997A1 (OSRAM) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2657552A1 (en) * | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | Substituted diazepan orexin receptor antagonists |
| EP2049110B1 (en) * | 2006-07-14 | 2014-08-20 | Merck Sharp & Dohme Corp. | Bridged diazepan orexin receptor antagonists |
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| JP2010527924A (ja) | 2007-05-18 | 2010-08-19 | メルク・シャープ・エンド・ドーム・コーポレイション | オキソ架橋ジアゼパンオレキシン受容体アンタゴニスト |
| WO2008147518A1 (en) * | 2007-05-23 | 2008-12-04 | Merck & Co., Inc. | Pyridyl piperidine orexin receptor antagonists |
| JP2011502146A (ja) | 2007-10-29 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換ジアゼパンオレキシン受容体アンタゴニスト |
| WO2009097995A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2369926B1 (en) * | 2008-06-19 | 2015-04-22 | Takeda Pharmaceutical Company Limited | Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues |
| CA2739927A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | Disubstituted azepan orexin receptor antagonists |
| AU2009307916A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted morpholine orexin receptor antagonists |
| US8853202B2 (en) | 2008-11-04 | 2014-10-07 | Chemocentryx, Inc. | Modulators of CXCR7 |
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| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
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