JP2010511596A5 - - Google Patents

Info

Publication number

JP2010511596A5

JP2010511596A5 JP2009524032A JP2009524032A JP2010511596A5 JP 2010511596 A5 JP2010511596 A5 JP 2010511596A5 JP 2009524032 A JP2009524032 A JP 2009524032A JP 2009524032 A JP2009524032 A JP 2009524032A JP 2010511596 A5 JP2010511596 A5 JP 2010511596A5

Authority

JP

Japan

Prior art keywords

hyaluronic acid

acid derivative

solution

crosslinked hyaluronic

injection solution

Prior art date

2007-12-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000243 solution Substances 0.000 claims description 21
• 238000002347 injection Methods 0.000 claims description 15
• 239000007924 injection Substances 0.000 claims description 15
• 238000004132 cross linking Methods 0.000 claims description 6
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 12
• 229920002674 hyaluronan Polymers 0.000 claims 3
• 229960003160 hyaluronic acid Drugs 0.000 claims 3
• 230000000202 analgesic effect Effects 0.000 claims 2
• 125000000524 functional group Chemical group 0.000 claims 2
• WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 1
• WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims 1
• 208000012659 Joint disease Diseases 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• -1 aminoalkyl alcohol Chemical compound 0.000 claims 1
• 229930016911 cinnamic acid Natural products 0.000 claims 1
• 235000013985 cinnamic acid Nutrition 0.000 claims 1
• 150000001851 cinnamic acid derivatives Chemical class 0.000 claims 1
• 125000000600 disaccharide group Chemical group 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 230000005923 long-lasting effect Effects 0.000 claims 1
• WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 1
• 239000002904 solvent Substances 0.000 claims 1
• 125000006850 spacer group Chemical group 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 description 2
• 239000003814 drug Substances 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1