JP2010511039A5 - - Google Patents
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- Publication number
- JP2010511039A5 JP2010511039A5 JP2009539202A JP2009539202A JP2010511039A5 JP 2010511039 A5 JP2010511039 A5 JP 2010511039A5 JP 2009539202 A JP2009539202 A JP 2009539202A JP 2009539202 A JP2009539202 A JP 2009539202A JP 2010511039 A5 JP2010511039 A5 JP 2010511039A5
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- dnase
- preparation
- drug
- tissues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 102000016911 Deoxyribonucleases Human genes 0.000 claims description 8
- 108010053770 Deoxyribonucleases Proteins 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 108020004414 DNA Proteins 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 102000053602 DNA Human genes 0.000 claims description 4
- 210000001723 extracellular space Anatomy 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 claims description 4
- 229940112822 chewing gum Drugs 0.000 claims description 3
- 235000015218 chewing gum Nutrition 0.000 claims description 3
- 239000006190 sub-lingual tablet Substances 0.000 claims description 3
- 229940098466 sublingual tablet Drugs 0.000 claims description 3
- 230000000975 bioactive effect Effects 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 239000010409 thin film Substances 0.000 claims description 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 206010007882 Cellulitis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 201000006747 infectious mononucleosis Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 230000019100 sperm motility Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
- 239000002552 dosage form Substances 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000006215 rectal suppository Substances 0.000 description 1
- 229940100618 rectal suppository Drugs 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/RU2006/000642 WO2008066403A1 (fr) | 2006-11-28 | 2006-11-28 | Procédé de traitement de maladies humaines accompagnées d'une teneur plus élevée d'adn dans des espaces intercellulaires et préparation médicamenteuse destinée à sa mise en oeuvre |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010511039A JP2010511039A (ja) | 2010-04-08 |
| JP2010511039A5 true JP2010511039A5 (OSRAM) | 2013-09-12 |
| JP5372769B2 JP5372769B2 (ja) | 2013-12-18 |
Family
ID=39468110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539202A Expired - Fee Related JP5372769B2 (ja) | 2006-11-28 | 2006-11-28 | 組織の細胞外間隙においてデオキシリボ核酸の量が増量することに関連するヒトの病気の治療方法及び該方法を実施するための医薬製剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8871200B2 (OSRAM) |
| EP (1) | EP2095825B8 (OSRAM) |
| JP (1) | JP5372769B2 (OSRAM) |
| KR (1) | KR20090087095A (OSRAM) |
| AT (1) | ATE513557T1 (OSRAM) |
| ES (1) | ES2369547T3 (OSRAM) |
| IL (1) | IL199005A (OSRAM) |
| PL (1) | PL2095825T3 (OSRAM) |
| WO (1) | WO2008066403A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8710012B2 (en) | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
| US8388951B2 (en) | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
| US8431123B2 (en) | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
| EP1880733A4 (en) * | 2005-04-25 | 2009-08-12 | Genkin Dmitry Dmitrievich | METHOD FOR EXTENDING THE LIFE OF A HUMAN AND ANIMALS |
| KR20090087095A (ko) | 2006-11-28 | 2009-08-14 | 드미트리 드미트리에비치 겐킨 | 조직의 세포외공간에서 증가된 데옥시리보핵산 함량과 관련된 인간 질병을 치료하는 방법 및 이 방법을 수행하기 위한 약학 제제 |
| US20130053595A1 (en) | 2009-09-18 | 2013-02-28 | Arkema France | Catalyst and process for preparing acrolein and/or acrylic acid by dehydration reaction of glycerin |
| US10617743B2 (en) | 2014-06-19 | 2020-04-14 | Cls Therapeutics Limited | Method to improve safety and efficacy of anti-cancer therapy |
| RU2017125957A (ru) | 2015-01-04 | 2019-02-04 | Проталикс Лтд. | Модифицированная днказа и ее применения |
| JP6745873B2 (ja) * | 2015-05-22 | 2020-08-26 | ドミトリエヴィッチ ゲンキン，ドミトリー | 神経変性における治療標的としての細胞外ｄｎａ |
| EP3708660A3 (en) | 2015-10-07 | 2020-12-30 | Novozymes A/S | Polypeptides |
| WO2018197547A1 (en) | 2017-04-25 | 2018-11-01 | Lipoxen Technologies Limited | Methods of treating diseases related to net formation with parenteral administration of polysialylated dnase i |
| JP2021510539A (ja) | 2018-01-16 | 2021-04-30 | シーエルエス セラピューティクス リミテッドＣＬＳ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | デオキシリボヌクレアーゼ（ＤＮａｓｅ）活性を有する酵素の肝臓発現による疾患の処置 |
| EP3813555A4 (en) * | 2018-06-29 | 2022-03-30 | Tets, Viktor, Veniaminovich | COMPOSITIONS FOR MODULATION OF INTESTINAL FLORA |
| US20200046809A1 (en) * | 2018-08-07 | 2020-02-13 | Bradley G. Thompson | Methods for regulating endogenous production of dnase1 |
| US12478571B2 (en) | 2018-12-17 | 2025-11-25 | Pontis Biologics, Inc. | Enzyme based compositions and methods for removing dental calculi |
| WO2020131952A1 (en) * | 2018-12-17 | 2020-06-25 | Mynarcik Dennis C | Compositions and methods for removing dental calculi |
| EP4225903A1 (en) | 2020-10-07 | 2023-08-16 | Protalix Ltd. | Long-acting dnase |
| CN117999086A (zh) * | 2021-05-24 | 2024-05-07 | 普利纳斯技术公司 | 使用dna酶的治疗方案 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3224942A (en) | 1962-01-15 | 1965-12-21 | Rorer Inc William H | Anti-inflammatory, anti-edema and anti-thrombi drug |
| US3324002A (en) | 1962-09-17 | 1967-06-06 | Armour Pharma | Anti-inflammatory preparations containing proteolytic enzymes and adrenal glucocorticoids |
| JPS5826822A (ja) * | 1981-08-10 | 1983-02-17 | Kaken Pharmaceut Co Ltd | 慢性腎炎治療剤 |
| JPS61293927A (ja) | 1986-06-18 | 1986-12-24 | Kaken Pharmaceut Co Ltd | 肝臓疾患予防治療剤 |
| US4985243A (en) | 1988-01-20 | 1991-01-15 | Ml Technology Ventures, L.P. | Composition and method for protecting against diseases caused by microorganisms |
| DE68928934T2 (de) * | 1988-12-23 | 1999-08-05 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur herstellung von menschlicher dnase |
| US5464817A (en) * | 1990-04-11 | 1995-11-07 | Brigham And Women's Hospital | Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I |
| DE4024530A1 (de) | 1990-08-02 | 1992-02-06 | Klinger & Co Dr | Verfahren zur bekaempfung von viren |
| FR2666096B1 (fr) * | 1990-08-21 | 1993-12-31 | Sfri Sa | Nouveau procede de dosage d'acide desoxyribonucleique present en position extracellulaire dans un milieu. |
| WO1993003709A1 (en) | 1991-08-16 | 1993-03-04 | Vical, Inc. | Composition and method for treating cystic fibrosis |
| US5484589A (en) * | 1992-04-20 | 1996-01-16 | Rufeld, Inc. | Anti-viral methods using RNAse and DNAse |
| NZ299257A (en) | 1992-06-08 | 2000-08-25 | Genentech Inc | Treating purulent material (eg pulmonary disease) accumulation in patients using deamidated DNase |
| AU7212694A (en) | 1993-06-24 | 1995-01-17 | Rufeld, Inc. | Inhibition of human immunodeficiency virus reproduction by deoxyribonuclease i |
| CH686982A5 (fr) * | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| RU2099080C1 (ru) | 1994-02-11 | 1997-12-20 | Дмитрий Иванович Финько | Способ предотвращения развития рака |
| JP2986215B2 (ja) | 1994-03-04 | 1999-12-06 | ジェネンテック インコーポレイテッド | Ｄｎアーゼ含有医薬製剤 |
| JP3173794B2 (ja) * | 1994-05-20 | 2001-06-04 | 久光製薬株式会社 | タンパク質またはポリペプチド類とその製造法および中間化合物 |
| JP4118334B2 (ja) | 1996-02-05 | 2008-07-16 | ジェネンテック・インコーポレーテッド | ヒトｄｎアーゼ |
| US6156504A (en) * | 1996-03-15 | 2000-12-05 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
| US6391607B1 (en) * | 1996-06-14 | 2002-05-21 | Genentech, Inc. | Human DNase I hyperactive variants |
| US6524578B1 (en) | 1996-07-10 | 2003-02-25 | Scott E. Tackett | Use of nuclease to reduce wrinkles and discolorations in humans |
| US6455250B1 (en) * | 1997-12-11 | 2002-09-24 | The Regents Of The University Of California | Endonuclease compositions and methods of use |
| CN1243545C (zh) | 1998-07-16 | 2006-03-01 | 研究发展基金会 | 切割dna的抗肿瘤剂 |
| US6465177B1 (en) * | 1998-10-26 | 2002-10-15 | John Wayne Cancer Institute | Detection of loss of heterozygosity in tumor and serum of melanoma patients |
| AU2156600A (en) | 1998-11-25 | 2000-06-13 | Cold Spring Harbor Laboratory | Methods and reagents for increasing proliferative capacity and preventing replicative senescence |
| DE60035851D1 (de) * | 1999-08-17 | 2007-09-20 | Tanuma | Deoxyribonuklease, dafür kodierendes gen und verfahren |
| US6428785B1 (en) * | 1999-10-28 | 2002-08-06 | Immunolytics Inc. | Method and composition for treating prostate cancer |
| UA78486C2 (uk) | 1999-12-10 | 2007-04-10 | Хемджен Корпорейшн | Композиція для перорального введення птахам та тваринам для лікування або зниження ризику інфекції травного тракту (варіанти), її застосування (варіанти) та спосіб лікування або зниження ризику інфекцій травного тракту (варіанти) |
| AU4430701A (en) | 2000-04-03 | 2001-10-15 | Antisoma Research Limited | Compounds for targeting |
| RU2202109C1 (ru) | 2001-08-03 | 2003-04-10 | Научно-исследовательский институт неврологии РАН | Способ выявления степени нарушения реологических свойств крови |
| RU2207876C1 (ru) | 2001-11-08 | 2003-07-10 | Ткаченко Виталий Васильевич | Способ комплексно-индивидуализированного воздействия на организм при медленной вирусной инфекции и способ подготовки лабораторного животного для испытания способа такого воздействия |
| ES2527096T3 (es) * | 2002-02-18 | 2015-01-20 | Ockham Biotech Limited | Combinación de ADNasa I y glucosaminoglucanos para su uso en limpieza de ADN extracelular |
| RU2207676C1 (ru) | 2002-04-24 | 2003-06-27 | ООО "Предприятие "Контакт-1" | Плоский радиолокационный отражатель |
| DE10221194B4 (de) | 2002-05-13 | 2005-02-10 | Fryda, Waltraud, Dr.med. | Hyaluronidasehaltiges Hautpflegemittel |
| US20040001817A1 (en) * | 2002-05-14 | 2004-01-01 | Giampapa Vincent C. | Anti-aging nutritional supplement |
| RU2239442C1 (ru) | 2003-05-05 | 2004-11-10 | Красноярская государственная медицинская академия | Способ профилактики внутриутробных инфекций у детей |
| RU2269359C2 (ru) | 2004-03-12 | 2006-02-10 | Дмитрий Дмитриевич Генкин | Способ профилактики развития онкологических заболеваний или инфекций, вызываемых бактериями, грибами и простейшими, или атеросклероза, или сахарного диабета, или заболеваний, связанных с реакцией гиперчувствительности замедленного типа, или заболеваний, развивающихся вследствие мутации генов соматических клеток (варианты) |
| RU2269356C2 (ru) | 2003-07-14 | 2006-02-10 | Дмитрий Дмитриевич Генкин | Способ лечения онкологических заболеваний |
| US8388951B2 (en) * | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
| US8431123B2 (en) * | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
| US8710012B2 (en) * | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
| RU2269358C2 (ru) * | 2003-07-14 | 2006-02-10 | Дмитрий Дмитриевич Генкин | Способ лечения генерализованных инфекций, вызываемых бактериями, или заболеваний, вызываемых грибами и простейшими, или атеросклероза, или сахарного диабета, или заболеваний, связанных с реакцией гиперчувствительности замедленного типа, или заболеваний, обусловленных мутациями генов соматических клеток |
| WO2005004904A1 (en) | 2003-07-14 | 2005-01-20 | Dmitry Dmitrievich Genkin | Method for treating diseases associated with modifications of qualitative and/ quantitative composition of blood extracellular dna (variants) |
| AU2003298972A1 (en) | 2003-07-14 | 2005-02-04 | Dmitry Dmitrievich Genkin | Method for treating oncological, virulent and somatic diseases, method for controlling treatment efficiency, pharmaceutical agents and composition for carrying out said treatment |
| RU2239404C1 (ru) | 2003-09-17 | 2004-11-10 | Бессонов Дмитрий Михайлович | Способ профилактики старения организма человека |
| RU2267329C2 (ru) | 2004-03-12 | 2006-01-10 | Дмитрий Дмитриевич Генкин | Способ лечения заболеваний, сопровождающихся изменениями качественного и/или количественного состава внеклеточной днк крови (варианты) |
| RU2269357C2 (ru) | 2004-03-12 | 2006-02-10 | Дмитрий Дмитриевич Генкин | Способ замедления наступления болезненных состояний, связанных с увеличением возраста человека |
| EP1734991A4 (en) * | 2004-04-14 | 2012-10-24 | Avirid Inc | COMPOSITIONS COMPRISING MODIFIED NUCLEASES DIRECTED AGAINST VIRAL NUCLEIC ACIDS AND METHODS OF USE FOR THE PREVENTION AND TREATMENT OF VIRAL DISEASES |
| JP3989936B2 (ja) | 2005-04-07 | 2007-10-10 | 進 須永 | 抗腫瘍剤及び新規ｄｎアーゼ |
| EP1880733A4 (en) | 2005-04-25 | 2009-08-12 | Genkin Dmitry Dmitrievich | METHOD FOR EXTENDING THE LIFE OF A HUMAN AND ANIMALS |
| BRPI0616012A2 (pt) * | 2005-07-18 | 2011-05-31 | Protalix Ltd | administração via mucosa ou intestino de macromoléculas biologicamente ativas |
| RU2308968C2 (ru) | 2005-07-19 | 2007-10-27 | Дмитрий Дмитриевич Генкин | Способ лечения заболеваний человека, сопровождающихся повышенным содержанием дезоксирибонуклеиновой кислоты во внеклеточных пространствах тканей, и лекарственный препарат для его реализации |
| AU2007311444B2 (en) | 2006-10-18 | 2012-11-29 | Periness Ltd. | Method and pharmacological composition for the diagnosis and treatment of male sub-fertility |
| KR20090087095A (ko) | 2006-11-28 | 2009-08-14 | 드미트리 드미트리에비치 겐킨 | 조직의 세포외공간에서 증가된 데옥시리보핵산 함량과 관련된 인간 질병을 치료하는 방법 및 이 방법을 수행하기 위한 약학 제제 |
| GB0922006D0 (en) | 2009-12-17 | 2010-02-03 | Genome Res Ltd | Diagnostic |
| US20130243794A1 (en) | 2010-12-03 | 2013-09-19 | Beth Israel Deaconess Medical Center, Inc. | Methods for predicting and treating infection-induced illnesses and predicting the severity of infection-induced illnesses |
-
2006
- 2006-11-28 KR KR1020097013352A patent/KR20090087095A/ko not_active Withdrawn
- 2006-11-28 ES ES06843990T patent/ES2369547T3/es active Active
- 2006-11-28 AT AT06843990T patent/ATE513557T1/de not_active IP Right Cessation
- 2006-11-28 WO PCT/RU2006/000642 patent/WO2008066403A1/ru not_active Ceased
- 2006-11-28 EP EP06843990A patent/EP2095825B8/en active Active
- 2006-11-28 US US12/516,440 patent/US8871200B2/en active Active
- 2006-11-28 PL PL06843990T patent/PL2095825T3/pl unknown
- 2006-11-28 JP JP2009539202A patent/JP5372769B2/ja not_active Expired - Fee Related
-
2009
- 2009-05-27 IL IL199005A patent/IL199005A/en active IP Right Grant
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