JP2010509391A5 - - Google Patents
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- JP2010509391A5 JP2010509391A5 JP2009536788A JP2009536788A JP2010509391A5 JP 2010509391 A5 JP2010509391 A5 JP 2010509391A5 JP 2009536788 A JP2009536788 A JP 2009536788A JP 2009536788 A JP2009536788 A JP 2009536788A JP 2010509391 A5 JP2010509391 A5 JP 2010509391A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- azoniabicyclo
- octane
- oxy
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 54
- 125000001424 substituent group Chemical group 0.000 claims 29
- 229910052736 halogen Inorganic materials 0.000 claims 27
- 150000002367 halogens Chemical class 0.000 claims 27
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
- -1 R 21 Chemical compound 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 4
- 150000001450 anions Chemical class 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 229940124750 glucocorticoid receptor agonist Drugs 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000003637 steroidlike Effects 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- OEZCQPCNRTUQAT-WLBKGHODSA-N 2-[(3R)-3-(1-phenylcycloheptanecarbonyl)oxy-1-azoniabicyclo[2.2.2]octan-1-yl]acetate Chemical compound O([C@@H]1C2CC[N+](CC2)(C1)CC(=O)[O-])C(=O)C1(C=2C=CC=CC=2)CCCCCC1 OEZCQPCNRTUQAT-WLBKGHODSA-N 0.000 claims 1
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- NGSBDKFSRILIDF-PSWPWZSKSA-O [(3r)-1-(2-amino-2-oxoethyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(C1)CC(=O)N)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 NGSBDKFSRILIDF-PSWPWZSKSA-O 0.000 claims 1
- CZOWFMAPYKSLAP-YVAFOINJSA-N [(3r)-1-(2-naphthalen-2-ylethyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(CCC=2C=C3C=CC=CC3=CC=2)C1)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 CZOWFMAPYKSLAP-YVAFOINJSA-N 0.000 claims 1
- VYHGUKGXNPWESL-ROTRRZJSSA-N [(3r)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)[N+]21CCOC1=CC=CC=C1 VYHGUKGXNPWESL-ROTRRZJSSA-N 0.000 claims 1
- MFSUMGDKWRMGPT-KGBLJUBMSA-N [(3r)-1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)[N+]21CCC1=CC=CC=C1 MFSUMGDKWRMGPT-KGBLJUBMSA-N 0.000 claims 1
- WUTXCDJSORWIOO-ZYOFUYEDSA-N [(3r)-1-(2-phenylmethoxyethyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)[N+]21CCOCC1=CC=CC=C1 WUTXCDJSORWIOO-ZYOFUYEDSA-N 0.000 claims 1
- FMRJFBVIMHOAPF-GPQFNORQSA-N [(3r)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)[N+]21CCCOC1=CC=CC=C1 FMRJFBVIMHOAPF-GPQFNORQSA-N 0.000 claims 1
- SSVFEKMHMYUHBG-IMYXDSERSA-N [(3r)-1-[(3,4-difluorophenyl)methyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C1=C(F)C(F)=CC=C1C[N+]1(C[C@@H]2OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)CCC2CC1 SSVFEKMHMYUHBG-IMYXDSERSA-N 0.000 claims 1
- GDOMMQSCTLYZNK-ROTRRZJSSA-N [(3r)-1-[(3-methoxyphenyl)methyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound COC1=CC=CC(C[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C=2C=CC=CC=2)=C1 GDOMMQSCTLYZNK-ROTRRZJSSA-N 0.000 claims 1
- HKHCDPDPJFUXPH-SHCORVSCSA-N [(3r)-1-[(4-fluorophenyl)methyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C1=CC(F)=CC=C1C[N+]1(C[C@@H]2OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)CCC2CC1 HKHCDPDPJFUXPH-SHCORVSCSA-N 0.000 claims 1
- ZMDRQLCWQWRLIB-HZCURFCSSA-O [(3r)-1-[2-(1,2-oxazol-3-ylamino)-2-oxoethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(C1)CC(=O)NC1=NOC=C1)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 ZMDRQLCWQWRLIB-HZCURFCSSA-O 0.000 claims 1
- KDSVYWIWPYWJNB-QZLZOZNSSA-N [(3r)-1-[2-(1,3-benzodioxol-5-yl)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(CCC=2C=C3OCOC3=CC=2)C1)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 KDSVYWIWPYWJNB-QZLZOZNSSA-N 0.000 claims 1
- XBQRHDCYAGXODN-WKWZVSMFSA-N [(3r)-1-[2-(1,3-dioxoisoindol-2-yl)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(CCN2C(C3=CC=CC=C3C2=O)=O)C1)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 XBQRHDCYAGXODN-WKWZVSMFSA-N 0.000 claims 1
- OTHHLJYDOFMRSW-JUEZVXFGSA-N [(3r)-1-[2-(3-chloro-4-methoxyphenyl)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C1=C(Cl)C(OC)=CC=C1CC[N+]1(C[C@@H]2OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)CCC2CC1 OTHHLJYDOFMRSW-JUEZVXFGSA-N 0.000 claims 1
- DAQHIIOXIMZCKN-FYKVLBHHSA-N [(3r)-1-[2-(3-chlorophenyl)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound ClC1=CC=CC(CC[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C=2C=CC=CC=2)=C1 DAQHIIOXIMZCKN-FYKVLBHHSA-N 0.000 claims 1
- FLGWQKCYJHVWOP-QUBVCFFMSA-O [(3r)-1-[2-(3-fluoroanilino)-2-oxoethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound FC1=CC=CC(NC(=O)C[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C=2C=CC=CC=2)=C1 FLGWQKCYJHVWOP-QUBVCFFMSA-O 0.000 claims 1
- XRACNWVAPFAPRC-GPQFNORQSA-N [(3r)-1-[2-(3-methoxyphenyl)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound COC1=CC=CC(CC[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C=2C=CC=CC=2)=C1 XRACNWVAPFAPRC-GPQFNORQSA-N 0.000 claims 1
- CTECLDDAHAOOBL-AJXMQQCNSA-N [(3r)-1-[2-(4-cyanophenyl)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)[N+]21CCC1=CC=C(C#N)C=C1 CTECLDDAHAOOBL-AJXMQQCNSA-N 0.000 claims 1
- ACJZKUYZTMXUQR-JOMKWTIYSA-N [(3r)-1-[2-(5-methylthiophen-2-yl)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound S1C(C)=CC=C1CC[N+]1(C[C@@H]2OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)CCC2CC1 ACJZKUYZTMXUQR-JOMKWTIYSA-N 0.000 claims 1
- QEOQOGWJVWUJAX-WITHESGTSA-O [(3r)-1-[2-[(3-methyl-1,2-oxazol-5-yl)amino]-2-oxoethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O1N=C(C)C=C1NC(=O)C[N+]1(C[C@@H]2OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)CCC2CC1 QEOQOGWJVWUJAX-WITHESGTSA-O 0.000 claims 1
- NNCGETNRKRCVCF-CKQYWTFRSA-N [(3r)-1-[2-[3-(trifluoromethyl)phenyl]ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound FC(F)(F)C1=CC=CC(CC[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C=2C=CC=CC=2)=C1 NNCGETNRKRCVCF-CKQYWTFRSA-N 0.000 claims 1
- WWTLDDUPZFPOSZ-AQELMELHSA-O [(3r)-1-[2-oxo-2-(2-phenoxyethylamino)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(C1)CC(=O)NCCOC=1C=CC=CC=1)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 WWTLDDUPZFPOSZ-AQELMELHSA-O 0.000 claims 1
- HBVYYPABZRTBLD-ZGBRQYORSA-O [(3r)-1-[2-oxo-2-(3-phenylpropylamino)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(C1)CC(=O)NCCCC=1C=CC=CC=1)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 HBVYYPABZRTBLD-ZGBRQYORSA-O 0.000 claims 1
- UDWRGWVYJNZRME-HBUOLCFLSA-O [(3r)-1-[2-oxo-2-(pyrazin-2-ylamino)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(C1)CC(=O)NC=1N=CC=NC=1)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 UDWRGWVYJNZRME-HBUOLCFLSA-O 0.000 claims 1
- NKWQBIXNTADYFR-HBUOLCFLSA-O [(3r)-1-[2-oxo-2-(pyridazin-3-ylamino)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(C1)CC(=O)NC=1N=NC=CC=1)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 NKWQBIXNTADYFR-HBUOLCFLSA-O 0.000 claims 1
- VOTFMALLPTVLLS-RZXUQNCUSA-N [(3r)-1-[[1-(4-chlorophenyl)cyclopropyl]methyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C1=CC(Cl)=CC=C1C1(C[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C=2C=CC=CC=2)CC1 VOTFMALLPTVLLS-RZXUQNCUSA-N 0.000 claims 1
- MIRFXUYYLNEELO-BFIOTATESA-N [(3r)-1-[[3-(trifluoromethoxy)phenyl]methyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound FC(F)(F)OC1=CC=CC(C[N+]23CCC(CC2)[C@H](C3)OC(=O)C2(CCCCCC2)C=2C=CC=CC=2)=C1 MIRFXUYYLNEELO-BFIOTATESA-N 0.000 claims 1
- XCULUOASBAQYLD-ZITBFLLYSA-N [(3r)-1-[[5-(trifluoromethyl)furan-2-yl]methyl]-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O1C(C(F)(F)F)=CC=C1C[N+]1(C[C@@H]2OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)CCC2CC1 XCULUOASBAQYLD-ZITBFLLYSA-N 0.000 claims 1
- ADYYIFSAKZORJY-MUZWYTLNSA-N [(3r)-1-benzyl-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C3(CCCCCC3)C=3C=CC=CC=3)[N+]21CC1=CC=CC=C1 ADYYIFSAKZORJY-MUZWYTLNSA-N 0.000 claims 1
- NAJYZLIFKZKXFY-WWAKMMQFSA-N [(3r)-1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl] 1-phenylcycloheptane-1-carboxylate Chemical compound O([C@@H]1C2CC[N+](CC2)(C1)C)C(=O)C1(C=2C=CC=CC=2)CCCCCC1 NAJYZLIFKZKXFY-WWAKMMQFSA-N 0.000 claims 1
- 150000008065 acid anhydrides Chemical class 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86566706P | 2006-11-14 | 2006-11-14 | |
| US60/865,667 | 2006-11-14 | ||
| US86938406P | 2006-12-11 | 2006-12-11 | |
| US60/869,384 | 2006-12-11 | ||
| PCT/GB2007/004350 WO2008059245A1 (en) | 2006-11-14 | 2007-11-13 | Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010509391A JP2010509391A (ja) | 2010-03-25 |
| JP2010509391A5 true JP2010509391A5 (cg-RX-API-DMAC7.html) | 2011-08-18 |
| JP4904402B2 JP4904402B2 (ja) | 2012-03-28 |
Family
ID=39048793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536788A Expired - Fee Related JP4904402B2 (ja) | 2006-11-14 | 2007-11-13 | ムスカリン受容体アンタゴニストとしての（ヘテロ）アリールシクロヘプタンカルボン酸のキヌクリジン誘導体 |
Country Status (29)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010500973A (ja) * | 2006-07-21 | 2010-01-14 | マース インコーポレーテッド | アルギナーゼ濃度／活性の改善 |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| EA017627B1 (ru) * | 2008-05-13 | 2013-01-30 | Астразенека Аб | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора |
| BRPI0912657A2 (pt) * | 2008-05-13 | 2016-01-26 | Astrazeneca Ab | produto farmacêutico compreendendo um antagonista de receptor muscarínico e um agonista beta2-adrenorreceptor |
| GB0808708D0 (en) * | 2008-05-13 | 2008-06-18 | Astrazeneca Ab | New compounds 274 |
| GB0808709D0 (en) * | 2008-05-13 | 2008-06-18 | Astrazeneca Ab | New combination 295 |
| GB0811099D0 (en) * | 2008-06-17 | 2008-07-23 | Astrazeneca Ab | New combination 376 |
| RU2011101664A (ru) * | 2008-06-20 | 2012-07-27 | Астразенека Аб (Se) | Фармацевтическая композиция, содержащая 4-гидрокси-2-оксо-2, 3-дигидро-1, 3-бензотиазол-7-ильное соединение, для модулирования активности бета2- адренорецепторов |
| WO2010008341A1 (en) * | 2008-07-16 | 2010-01-21 | Astrazeneca Ab | A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist |
| GB0814729D0 (en) * | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
| EP2206712A1 (en) * | 2008-12-23 | 2010-07-14 | CHIESI FARMACEUTICI S.p.A. | "Alkaloid aminoester derivatives and medicinal composition thereof" |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| AR076590A1 (es) * | 2009-05-19 | 2011-06-22 | Vivia Biotech Sl | Metodos para proveer pruebas medicinales personalizada ex vivo para neoplasmas hematologicos |
| ES2545812T3 (es) * | 2010-06-22 | 2015-09-16 | Chiesi Farmaceutici S.P.A. | Derivados aminoéster de alcaloides y composición medicinal de estos |
| JP2011195593A (ja) * | 2011-06-30 | 2011-10-06 | Astrazeneca Ab | ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体 |
| AU2013257139B2 (en) | 2012-04-30 | 2018-02-22 | Biothera, Inc. | Beta-glucan immunotherapeutic methods |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TW201617343A (zh) * | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
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| NL62140C (cg-RX-API-DMAC7.html) | 1942-12-16 | |||
| DE2104179C3 (de) | 1971-01-29 | 1980-10-02 | Knoll Ag, 6700 Ludwigshafen | exo-2-Phenyl-bicyclo- [2,2,1] -heptan-2- (N-methylpiperidol-4)-carbonsäureester und dessen Salze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel |
| FR2155927A1 (en) | 1971-10-15 | 1973-05-25 | Synthelabo | 1-phenylcyclo hexane carboxylic acid esters - with antispasmodic and anticholinergic activity |
| FR2168881A1 (en) | 1972-01-25 | 1973-09-07 | Synthelabo | Tropanol 1-phenylcycloalkane carboxylic ester salts - spasmolytics and cholinergics |
| FR2208649A1 (en) | 1972-12-01 | 1974-06-28 | Synthelabo | 1-(2-Thienyl)cycloalkane carboxylic ester salts - with spasmolytic and anticholinergic activity |
| GB8334494D0 (en) | 1983-12-24 | 1984-02-01 | Tanabe Seiyaku Co | Carbostyril derivatives |
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-
2007
- 2007-11-02 TW TW096141387A patent/TW200825084A/zh unknown
- 2007-11-12 SA SA07280616A patent/SA07280616B1/ar unknown
- 2007-11-13 PT PT07824574T patent/PT2094694E/pt unknown
- 2007-11-13 EP EP07824574A patent/EP2094694B1/en active Active
- 2007-11-13 WO PCT/GB2007/004350 patent/WO2008059245A1/en not_active Ceased
- 2007-11-13 HR HR20110178T patent/HRP20110178T1/hr unknown
- 2007-11-13 PL PL07824574T patent/PL2094694T3/pl unknown
- 2007-11-13 AR ARP070105051A patent/AR063804A1/es not_active Application Discontinuation
- 2007-11-13 JP JP2009536788A patent/JP4904402B2/ja not_active Expired - Fee Related
- 2007-11-13 US US12/514,509 patent/US8207193B2/en not_active Expired - Fee Related
- 2007-11-13 CL CL200703260A patent/CL2007003260A1/es unknown
- 2007-11-13 DE DE602007012300T patent/DE602007012300D1/de active Active
- 2007-11-13 RU RU2009115829/04A patent/RU2456286C2/ru not_active IP Right Cessation
- 2007-11-13 MX MX2009004780A patent/MX2009004780A/es active IP Right Grant
- 2007-11-13 EP EP10175910A patent/EP2256117A1/en not_active Withdrawn
- 2007-11-13 CA CA002669326A patent/CA2669326A1/en not_active Abandoned
- 2007-11-13 AT AT07824574T patent/ATE496916T1/de active
- 2007-11-13 MY MYPI20091925A patent/MY148392A/en unknown
- 2007-11-13 PE PE2007001564A patent/PE20081164A1/es not_active Application Discontinuation
- 2007-11-13 NZ NZ576679A patent/NZ576679A/en not_active IP Right Cessation
- 2007-11-13 BR BRPI0718750-5A patent/BRPI0718750A2/pt not_active IP Right Cessation
- 2007-11-13 KR KR1020097009772A patent/KR20090078828A/ko not_active Ceased
- 2007-11-13 RS RS20110126A patent/RS51650B/sr unknown
- 2007-11-13 DK DK07824574.3T patent/DK2094694T3/da active
- 2007-11-13 AU AU2007321019A patent/AU2007321019B2/en not_active Ceased
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2009
- 2009-04-23 IL IL198314A patent/IL198314A/en not_active IP Right Cessation
- 2009-04-24 CO CO09041752A patent/CO6160312A2/es unknown
- 2009-05-15 EC EC2009009338A patent/ECSP099338A/es unknown
- 2009-06-09 NO NO20092224A patent/NO20092224L/no not_active Application Discontinuation
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2011
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2012
- 2012-05-15 US US13/471,912 patent/US20130005695A1/en not_active Abandoned
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