JP2010508834A5 - - Google Patents
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- JP2010508834A5 JP2010508834A5 JP2009535633A JP2009535633A JP2010508834A5 JP 2010508834 A5 JP2010508834 A5 JP 2010508834A5 JP 2009535633 A JP2009535633 A JP 2009535633A JP 2009535633 A JP2009535633 A JP 2009535633A JP 2010508834 A5 JP2010508834 A5 JP 2010508834A5
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- Prior art keywords
- core
- cells
- positive
- binding
- antibody
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- 244000005700 microbiome Species 0.000 claims description 138
- 239000000203 mixture Substances 0.000 claims description 117
- 210000004443 dendritic cell Anatomy 0.000 claims description 109
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 84
- 210000004027 cell Anatomy 0.000 claims description 70
- 239000012634 fragment Substances 0.000 claims description 65
- 239000006166 lysate Substances 0.000 claims description 65
- 238000009472 formulation Methods 0.000 claims description 64
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical group OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims description 60
- 238000012360 testing method Methods 0.000 claims description 59
- 210000002865 immune cell Anatomy 0.000 claims description 48
- 230000009089 cytolysis Effects 0.000 claims description 46
- 230000028996 humoral immune response Effects 0.000 claims description 45
- 241001465754 Metazoa Species 0.000 claims description 43
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- 108010028495 asialoglycophorin Proteins 0.000 claims description 40
- 230000028327 secretion Effects 0.000 claims description 40
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 36
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 36
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 36
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 35
- 230000024932 T cell mediated immunity Effects 0.000 claims description 25
- 239000000427 antigen Substances 0.000 claims description 24
- 102000036639 antigens Human genes 0.000 claims description 24
- 108091007433 antigens Proteins 0.000 claims description 24
- 241000606125 Bacteroides Species 0.000 claims description 23
- 238000012258 culturing Methods 0.000 claims description 23
- 210000002381 plasma Anatomy 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- VYZAMTAEIAYCRO-BJUDXGSMSA-N Chromium-51 Chemical compound [51Cr] VYZAMTAEIAYCRO-BJUDXGSMSA-N 0.000 claims description 16
- 229910052693 Europium Inorganic materials 0.000 claims description 16
- 102000028180 Glycophorins Human genes 0.000 claims description 16
- 108091005250 Glycophorins Proteins 0.000 claims description 16
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 claims description 16
- 230000028993 immune response Effects 0.000 claims description 16
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- 235000015872 dietary supplement Nutrition 0.000 claims description 6
- 206010027476 Metastases Diseases 0.000 claims description 5
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- 102000003886 Glycoproteins Human genes 0.000 claims description 4
- 108090000288 Glycoproteins Proteins 0.000 claims description 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 4
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- 239000003814 drug Substances 0.000 claims description 4
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- 150000003839 salts Chemical class 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 241000217846 Bacteroides caccae Species 0.000 claims description 2
- 241000588923 Citrobacter Species 0.000 claims description 2
- 241000193403 Clostridium Species 0.000 claims description 2
- 241000186216 Corynebacterium Species 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241000186394 Eubacterium Species 0.000 claims description 2
- 241001617393 Finegoldia Species 0.000 claims description 2
- 241000186429 Propionibacterium Species 0.000 claims description 2
- 241000194017 Streptococcus Species 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- 239000010839 body fluid Substances 0.000 claims description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000002689 soil Substances 0.000 claims description 2
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- 210000001519 tissue Anatomy 0.000 claims description 2
- 241000194036 Lactococcus Species 0.000 claims 6
- 150000001720 carbohydrates Chemical group 0.000 claims 5
- 238000004090 dissolution Methods 0.000 claims 4
- 230000004044 response Effects 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- 241001569772 Celithemis elisa Species 0.000 claims 1
- 241000853331 Eggerella Species 0.000 claims 1
- 241000604373 Ovatus Species 0.000 claims 1
- 210000000447 Th1 cell Anatomy 0.000 claims 1
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- 125000000837 carbohydrate group Chemical group 0.000 description 3
- 241000193818 Atopobium Species 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 241001657509 Eggerthella Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
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- 244000005709 gut microbiome Species 0.000 description 1
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- 229940039696 lactobacillus Drugs 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06090209A EP1920782A1 (en) | 2006-11-10 | 2006-11-10 | Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof |
| EP06090208.7A EP1920781B1 (en) | 2006-11-10 | 2006-11-10 | Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors |
| PCT/EP2007/009766 WO2008055703A2 (en) | 2006-11-10 | 2007-11-12 | Microorganisms or fractions thereof capable of activating cellular immunity against carbohydrates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075105A Division JP2015134813A (ja) | 2006-11-10 | 2015-04-01 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010508834A JP2010508834A (ja) | 2010-03-25 |
| JP2010508834A5 true JP2010508834A5 (enExample) | 2011-01-06 |
Family
ID=39200183
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535633A Withdrawn JP2010508834A (ja) | 2006-11-10 | 2007-11-12 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
| JP2009535632A Expired - Fee Related JP5771355B2 (ja) | 2006-11-10 | 2007-11-12 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
| JP2015075105A Withdrawn JP2015134813A (ja) | 2006-11-10 | 2015-04-01 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
| JP2015074801A Withdrawn JP2015133979A (ja) | 2006-11-10 | 2015-04-01 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535632A Expired - Fee Related JP5771355B2 (ja) | 2006-11-10 | 2007-11-12 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
| JP2015075105A Withdrawn JP2015134813A (ja) | 2006-11-10 | 2015-04-01 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
| JP2015074801A Withdrawn JP2015133979A (ja) | 2006-11-10 | 2015-04-01 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9494587B2 (enExample) |
| EP (4) | EP1920781B1 (enExample) |
| JP (4) | JP2010508834A (enExample) |
| KR (2) | KR20150054014A (enExample) |
| CN (1) | CN101573138B (enExample) |
| AU (2) | AU2007316819B2 (enExample) |
| BR (2) | BRPI0718796A2 (enExample) |
| CA (2) | CA2668603A1 (enExample) |
| EA (1) | EA025395B1 (enExample) |
| ES (1) | ES2715045T3 (enExample) |
| IL (2) | IL198567A0 (enExample) |
| MX (1) | MX2009005004A (enExample) |
| NO (1) | NO20091748L (enExample) |
| NZ (1) | NZ577559A (enExample) |
| PL (1) | PL1920781T3 (enExample) |
| RU (1) | RU2460074C2 (enExample) |
| WO (2) | WO2008055703A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20150307T1 (hr) | 2006-09-10 | 2015-04-24 | Glycotope Gmbh | Upotreba ljudskih stanica podrijetlom iz ljudske leukemije za eksprimiranje protutijela |
| EP1920781B1 (en) * | 2006-11-10 | 2015-03-04 | Glycotope GmbH | Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors |
| EP2119365B1 (de) | 2008-05-13 | 2017-08-16 | Glycotope GmbH | Fermentationsprozess |
| AR071787A1 (es) * | 2008-05-13 | 2010-07-14 | Glycotope Gmbh | Procedimiento de fermentacion, alimento fermentado producido por dicho procedimiento y auxiliar de procesamiento |
| AU2010281507A1 (en) * | 2009-07-27 | 2012-03-01 | The University Of North Carolina At Chapel Hill | Enterococcus and fecal Bacteroides for rapid water quality assessment |
| GB2475226A (en) | 2009-11-03 | 2011-05-18 | Genetic Analysis As | Universal Prokaryote 16S ribosome PCR primer pair |
| WO2011153226A2 (en) * | 2010-06-01 | 2011-12-08 | Moore Research Enterprises Llc | Cellular constituents from bacteroides, compositions thereof, and therapeutic methods employing bacteroides or cellular constituents thereof |
| US20130259899A1 (en) * | 2010-10-04 | 2013-10-03 | Allen-Vercoe, Emma Molecular And Cellular Biology University Of Guelph | Detection of fusobacterium in a gastrointestinal sample to diagnose gastrointestinal cancer |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| ES2893170T3 (es) * | 2011-08-22 | 2022-02-08 | Te Bios Co Ltd | Microorganismos de la especie Bacteroides xylanisolvens DSM23964 (CTC1) y su uso para la producción de un alimento |
| BR112014004065A2 (pt) | 2011-08-22 | 2017-03-14 | Glycotope Gmbh | micro-organismos carregando um antígeno de tumor |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| PT2877590E (pt) * | 2012-06-26 | 2016-06-23 | Centre Nat De La Rech Scient (Cnrs) | Método de diagnóstico in vitro de uma infeção fúngica invasiva por espectrometria de massa taldi-tof |
| CN102813916B (zh) * | 2012-09-05 | 2015-03-11 | 北京希普生国际生物医学研究院 | 一种快速获取树突状细胞疫苗的制备方法及其应用 |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| EP2818056A1 (en) * | 2013-06-25 | 2014-12-31 | Biosearch S.A. | Probiotic bacteria comprising metals, metal nanoparticles and uses thereof |
| US11155801B2 (en) * | 2013-08-06 | 2021-10-26 | Trustees Of Dartmouth College | Unglycosylated lysostaphin variant protein |
| SG11201607258SA (en) | 2014-04-10 | 2016-10-28 | Obi Pharma Inc | Antibodies, pharmaceutical compositions and uses thereof |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| CN104546933A (zh) * | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 粪拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| CN104546932A (zh) * | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 卵形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| ES2658310T3 (es) | 2014-12-23 | 2018-03-09 | 4D Pharma Research Limited | Una cepa de bacteroides thetaiotaomicron y su uso en la reducción de la inflamación |
| EP3193901B1 (en) * | 2014-12-23 | 2018-04-04 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
| US10076556B2 (en) * | 2015-01-29 | 2018-09-18 | Oxyrase, Inc. | Methods for inhibiting tumor growth |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| PT3307288T (pt) | 2015-06-15 | 2019-10-17 | 4D Pharma Res Ltd | Composições compreendendo estirpes bacterianas |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA55434B1 (fr) | 2015-06-15 | 2022-02-28 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| TWI759266B (zh) | 2015-06-15 | 2022-04-01 | 英商4D製藥研究有限公司 | 包含細菌菌株之組合物之用途 |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA45287A (fr) | 2015-11-20 | 2018-08-22 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| PT3313423T (pt) | 2016-03-04 | 2019-07-10 | 4D Pharma Plc | Composições que compreendem a estirpe blautia bacteriana para tratar a hipersensibilidade visceral |
| AU2017290900A1 (en) * | 2016-07-01 | 2019-01-17 | Infinant Health, Inc | Method for facilitating maturation of the mammalian immune system |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| EP3378949A1 (en) * | 2017-03-22 | 2018-09-26 | Assistance Publique - Hôpitaux de Paris | Method for determining the potential efficacy of anticancer treatment |
| RS61872B1 (sr) | 2017-05-22 | 2021-06-30 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| WO2018215782A1 (en) | 2017-05-24 | 2018-11-29 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| JP6840272B2 (ja) | 2017-06-14 | 2021-03-10 | フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ | 細菌株を含む組成物 |
| RS63393B1 (sr) | 2017-06-14 | 2022-08-31 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| EP3638271B1 (en) | 2017-06-14 | 2020-10-14 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| MA51770A (fr) | 2017-07-05 | 2020-05-13 | Evelo Biosciences Inc | Compositions et méthodes de traitement du cancer à l'aide de bifidobacterium animalis ssp. lactis |
| WO2019217951A1 (en) * | 2018-05-11 | 2019-11-14 | Obi Pharma Inc. | Method for predicting human immune response |
| BR112020023373A2 (pt) | 2018-05-18 | 2021-02-09 | Daiichi Sankyo Company, Limited | conjugado, composição, e, uso de um conjugado ou de uma composição |
| US12144834B2 (en) | 2018-09-13 | 2024-11-19 | Xbiome Inc. | Methods and compositions for treating gastrointestinal and inflammatory disorders |
| EP4588511A3 (en) * | 2019-07-18 | 2025-07-30 | Theriva Biologics, Inc. | Intestinal alkaline phosphatase-based treatments of metabolic disorders |
| EP4100742A4 (en) * | 2020-02-03 | 2024-03-20 | Technion Research & Development Foundation Limited | Method for isolating a microorganism |
| CN115992084A (zh) * | 2022-08-18 | 2023-04-21 | 吉林农业大学 | 表达牛巨噬细胞粒细胞集落刺激因子的重组乳酸菌及应用 |
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-
2006
- 2006-11-10 EP EP06090208.7A patent/EP1920781B1/en active Active
- 2006-11-10 PL PL06090208T patent/PL1920781T3/pl unknown
- 2006-11-10 EP EP06090209A patent/EP1920782A1/en not_active Withdrawn
-
2007
- 2007-11-12 CA CA002668603A patent/CA2668603A1/en not_active Abandoned
- 2007-11-12 ES ES07819755T patent/ES2715045T3/es active Active
- 2007-11-12 KR KR1020157011383A patent/KR20150054014A/ko not_active Abandoned
- 2007-11-12 WO PCT/EP2007/009766 patent/WO2008055703A2/en not_active Ceased
- 2007-11-12 AU AU2007316819A patent/AU2007316819B2/en not_active Ceased
- 2007-11-12 EP EP07819754A patent/EP2101814A1/en not_active Withdrawn
- 2007-11-12 US US12/514,248 patent/US9494587B2/en not_active Expired - Fee Related
- 2007-11-12 EP EP07819755.5A patent/EP2099480B2/en active Active
- 2007-11-12 MX MX2009005004A patent/MX2009005004A/es active IP Right Grant
- 2007-11-12 CN CN200780049283.7A patent/CN101573138B/zh not_active Expired - Fee Related
- 2007-11-12 US US12/514,200 patent/US8592165B2/en not_active Expired - Fee Related
- 2007-11-12 AU AU2007316820A patent/AU2007316820B2/en not_active Ceased
- 2007-11-12 BR BRPI0718796-3A2A patent/BRPI0718796A2/pt not_active IP Right Cessation
- 2007-11-12 NZ NZ577559A patent/NZ577559A/en not_active IP Right Cessation
- 2007-11-12 JP JP2009535633A patent/JP2010508834A/ja not_active Withdrawn
- 2007-11-12 KR KR1020097011972A patent/KR20090080554A/ko not_active Abandoned
- 2007-11-12 JP JP2009535632A patent/JP5771355B2/ja not_active Expired - Fee Related
- 2007-11-12 BR BRPI0719005-0A patent/BRPI0719005A2/pt not_active IP Right Cessation
- 2007-11-12 EA EA200970471A patent/EA025395B1/ru not_active IP Right Cessation
- 2007-11-12 CA CA002668704A patent/CA2668704A1/en not_active Abandoned
- 2007-11-12 RU RU2009122204/10A patent/RU2460074C2/ru not_active IP Right Cessation
- 2007-11-12 WO PCT/EP2007/009765 patent/WO2008055702A1/en not_active Ceased
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2009
- 2009-05-04 NO NO20091748A patent/NO20091748L/no not_active Application Discontinuation
- 2009-05-05 IL IL198567A patent/IL198567A0/en unknown
- 2009-05-07 IL IL198626A patent/IL198626A/en not_active IP Right Cessation
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- 2015-04-01 JP JP2015075105A patent/JP2015134813A/ja not_active Withdrawn
- 2015-04-01 JP JP2015074801A patent/JP2015133979A/ja not_active Withdrawn
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