JP2010508834A5 - - Google Patents
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- JP2010508834A5 JP2010508834A5 JP2009535633A JP2009535633A JP2010508834A5 JP 2010508834 A5 JP2010508834 A5 JP 2010508834A5 JP 2009535633 A JP2009535633 A JP 2009535633A JP 2009535633 A JP2009535633 A JP 2009535633A JP 2010508834 A5 JP2010508834 A5 JP 2010508834A5
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- antibody
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- 244000005700 microbiome Species 0.000 claims description 138
- 239000000203 mixture Substances 0.000 claims description 117
- 210000004443 dendritic cell Anatomy 0.000 claims description 109
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 84
- 210000004027 cell Anatomy 0.000 claims description 70
- 239000012634 fragment Substances 0.000 claims description 65
- 239000006166 lysate Substances 0.000 claims description 65
- 238000009472 formulation Methods 0.000 claims description 64
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical group OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims description 60
- 238000012360 testing method Methods 0.000 claims description 59
- 210000002865 immune cell Anatomy 0.000 claims description 48
- 230000009089 cytolysis Effects 0.000 claims description 46
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- 108010028495 asialoglycophorin Proteins 0.000 claims description 40
- 230000028327 secretion Effects 0.000 claims description 40
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 36
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 36
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 36
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 35
- 230000024932 T cell mediated immunity Effects 0.000 claims description 25
- 239000000427 antigen Substances 0.000 claims description 24
- 102000036639 antigens Human genes 0.000 claims description 24
- 108091007433 antigens Proteins 0.000 claims description 24
- 241000606125 Bacteroides Species 0.000 claims description 23
- 238000012258 culturing Methods 0.000 claims description 23
- 210000002381 plasma Anatomy 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- VYZAMTAEIAYCRO-BJUDXGSMSA-N Chromium-51 Chemical compound [51Cr] VYZAMTAEIAYCRO-BJUDXGSMSA-N 0.000 claims description 16
- 229910052693 Europium Inorganic materials 0.000 claims description 16
- 102000028180 Glycophorins Human genes 0.000 claims description 16
- 108091005250 Glycophorins Proteins 0.000 claims description 16
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 claims description 16
- 230000028993 immune response Effects 0.000 claims description 16
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- 102000003886 Glycoproteins Human genes 0.000 claims description 4
- 108090000288 Glycoproteins Proteins 0.000 claims description 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 4
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- 150000003839 salts Chemical class 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 241000217846 Bacteroides caccae Species 0.000 claims description 2
- 241000588923 Citrobacter Species 0.000 claims description 2
- 241000193403 Clostridium Species 0.000 claims description 2
- 241000186216 Corynebacterium Species 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241000186394 Eubacterium Species 0.000 claims description 2
- 241001617393 Finegoldia Species 0.000 claims description 2
- 241000186429 Propionibacterium Species 0.000 claims description 2
- 241000194017 Streptococcus Species 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- 239000010839 body fluid Substances 0.000 claims description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000002689 soil Substances 0.000 claims description 2
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- 210000001519 tissue Anatomy 0.000 claims description 2
- 241000194036 Lactococcus Species 0.000 claims 6
- 150000001720 carbohydrates Chemical group 0.000 claims 5
- 238000004090 dissolution Methods 0.000 claims 4
- 230000004044 response Effects 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- 241001569772 Celithemis elisa Species 0.000 claims 1
- 241000853331 Eggerella Species 0.000 claims 1
- 241000604373 Ovatus Species 0.000 claims 1
- 210000000447 Th1 cell Anatomy 0.000 claims 1
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- 125000000837 carbohydrate group Chemical group 0.000 description 3
- 241000193818 Atopobium Species 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 241001657509 Eggerthella Species 0.000 description 1
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- 244000005709 gut microbiome Species 0.000 description 1
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- 229940039696 lactobacillus Drugs 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06090209A EP1920782A1 (en) | 2006-11-10 | 2006-11-10 | Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof |
| EP06090208.7A EP1920781B1 (en) | 2006-11-10 | 2006-11-10 | Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors |
| PCT/EP2007/009766 WO2008055703A2 (en) | 2006-11-10 | 2007-11-12 | Microorganisms or fractions thereof capable of activating cellular immunity against carbohydrates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075105A Division JP2015134813A (ja) | 2006-11-10 | 2015-04-01 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010508834A JP2010508834A (ja) | 2010-03-25 |
| JP2010508834A5 true JP2010508834A5 (enExample) | 2011-01-06 |
Family
ID=39200183
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535632A Expired - Fee Related JP5771355B2 (ja) | 2006-11-10 | 2007-11-12 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
| JP2009535633A Withdrawn JP2010508834A (ja) | 2006-11-10 | 2007-11-12 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
| JP2015075105A Withdrawn JP2015134813A (ja) | 2006-11-10 | 2015-04-01 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
| JP2015074801A Withdrawn JP2015133979A (ja) | 2006-11-10 | 2015-04-01 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535632A Expired - Fee Related JP5771355B2 (ja) | 2006-11-10 | 2007-11-12 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075105A Withdrawn JP2015134813A (ja) | 2006-11-10 | 2015-04-01 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
| JP2015074801A Withdrawn JP2015133979A (ja) | 2006-11-10 | 2015-04-01 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8592165B2 (enExample) |
| EP (4) | EP1920782A1 (enExample) |
| JP (4) | JP5771355B2 (enExample) |
| KR (2) | KR20090080554A (enExample) |
| CN (1) | CN101573138B (enExample) |
| AU (2) | AU2007316819B2 (enExample) |
| BR (2) | BRPI0718796A2 (enExample) |
| CA (2) | CA2668704A1 (enExample) |
| EA (1) | EA025395B1 (enExample) |
| ES (1) | ES2715045T3 (enExample) |
| IL (2) | IL198567A0 (enExample) |
| MX (1) | MX2009005004A (enExample) |
| NO (1) | NO20091748L (enExample) |
| NZ (1) | NZ577559A (enExample) |
| PL (1) | PL1920781T3 (enExample) |
| RU (1) | RU2460074C2 (enExample) |
| WO (2) | WO2008055702A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150126730A (ko) | 2006-09-10 | 2015-11-12 | 글리코토페 게엠베하 | 항체 발현을 위한 골수성 백혈병 기원의 인간 세포의 용도 |
| EP1920782A1 (en) | 2006-11-10 | 2008-05-14 | Glycotope Gmbh | Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof |
| US8741365B2 (en) | 2008-05-13 | 2014-06-03 | Glycotope Gmbh | Fermentation process |
| EP2119365B1 (de) | 2008-05-13 | 2017-08-16 | Glycotope GmbH | Fermentationsprozess |
| EP2459752A4 (en) * | 2009-07-27 | 2013-01-23 | Univ North Carolina | ENTEROCOCCUS AND DEPOSIT BACTEROIDS FOR QUICK WATER QUALITY ASSESSMENT |
| GB2475226A (en) | 2009-11-03 | 2011-05-18 | Genetic Analysis As | Universal Prokaryote 16S ribosome PCR primer pair |
| AU2011261528A1 (en) * | 2010-06-01 | 2013-01-10 | Moore Research Enterprises Llc | Cellular constituents from Bacteroides, compositions thereof, and therapeutic methods employing Bacteroides or cellular constituents thereof |
| AU2011313763A1 (en) * | 2010-10-04 | 2013-05-30 | Emma Allen-Vercoe | Detection of Fusobacterium in a gastrointestinal sample to diagnose gastrointestinal cancer |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| CA2844543A1 (en) | 2011-08-22 | 2013-02-28 | Glycotope Gmbh | Microorganisms carrying a tumor antigen |
| CA2844542A1 (en) * | 2011-08-22 | 2013-02-28 | Glycotope Gmbh | Microorganisms of the species bacteroides xylanisolvens |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| PL2877590T3 (pl) * | 2012-06-26 | 2016-11-30 | Sposób diagnozowania in vitro inwazyjnego zakażenia grzybiczego metodą spektrometrii masowej maldi-tof | |
| CN102813916B (zh) * | 2012-09-05 | 2015-03-11 | 北京希普生国际生物医学研究院 | 一种快速获取树突状细胞疫苗的制备方法及其应用 |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| EP2818056A1 (en) * | 2013-06-25 | 2014-12-31 | Biosearch S.A. | Probiotic bacteria comprising metals, metal nanoparticles and uses thereof |
| CN113717964A (zh) * | 2013-08-06 | 2021-11-30 | 达特茅斯学院理事会 | 非糖基化溶葡球菌素变体蛋白 |
| ES2772817T3 (es) | 2014-04-10 | 2020-07-08 | Obi Pharma Inc | Anticuerpos de unión a antígenos de carbohidrato asociados a tumor, composiciones farmacéuticas y sus usos |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| CN104546933A (zh) * | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 粪拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| CN104546932A (zh) * | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 卵形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| KR102523805B1 (ko) | 2014-12-23 | 2023-04-20 | 4디 파마 리서치 리미티드 | 면역 조정 |
| KR20170091157A (ko) * | 2014-12-23 | 2017-08-08 | 4디 파마 리서치 리미티드 | 피린 폴리펩티드 및 면역 조정 |
| EP4548978A3 (en) | 2015-01-29 | 2025-08-06 | Oxyrase, Inc. | Methods for inhibiting tumor growth |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| RS59038B1 (sr) | 2015-06-15 | 2019-08-30 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| JP6426264B2 (ja) | 2015-06-15 | 2018-11-21 | フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ | 細菌株を含む組成物 |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| PL3240554T3 (pl) | 2015-06-15 | 2020-02-28 | 4D Pharma Research Limited | Blautia stercosis i wexlerae do stosowania w leczeniu chorób zapalnych i autoimmunologicznych |
| CA3005781C (en) | 2015-11-20 | 2019-01-22 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| HK1246670B (en) | 2016-03-04 | 2020-05-15 | 4D Pharma Plc | Compositions comprising bacterial blautia strains for treating visceral hypersensitivity |
| EP3478093A4 (en) | 2016-07-01 | 2020-03-04 | Evolve Biosystems, Inc. | Method for facilitating maturation of the mammalian immune system |
| TW201821093A (zh) | 2016-07-13 | 2018-06-16 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| EP3378949A1 (en) * | 2017-03-22 | 2018-09-26 | Assistance Publique - Hôpitaux de Paris | Method for determining the potential efficacy of anticancer treatment |
| EP3630136B1 (en) | 2017-05-22 | 2021-04-21 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| MA41708A (fr) | 2017-05-24 | 2020-04-08 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| WO2018229188A1 (en) | 2017-06-14 | 2018-12-20 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| EP3600363B1 (en) | 2017-06-14 | 2020-12-02 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| HUE052258T2 (hu) | 2017-06-14 | 2021-04-28 | 4D Pharma Res Ltd | Megasphaera nemzetségbe tartozó baktériumtörzset tartalmazó készítmény, és alkalmazása |
| BR112019028301A2 (pt) | 2017-07-05 | 2020-07-14 | Evelo Biosciences, Inc. | composições e métodos para tratar câncer com o uso de bifidobacterium animalis ssp. lactis |
| US20210396759A1 (en) * | 2018-05-11 | 2021-12-23 | Obi Pharma, Inc. | Method for Predicting Human Immune Response |
| HUE067382T2 (hu) | 2018-05-18 | 2024-10-28 | Daiichi Sankyo Co Ltd | Anti-MUC1-exatecan antitest-hatóanyag konjugátum |
| EP3870691A4 (en) | 2018-09-13 | 2022-09-07 | Xbiome Inc. | METHODS AND COMPOSITIONS FOR TREATING GASTROINTESTINAL AND INFLAMMATORY DISORDERS |
| US20220257726A1 (en) * | 2019-07-18 | 2022-08-18 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase-based treatments of metabolic disorders |
| KR20220137045A (ko) * | 2020-02-03 | 2022-10-11 | 테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디. | 미생물을 단리하는 방법 |
| CN115992084A (zh) * | 2022-08-18 | 2023-04-21 | 吉林农业大学 | 表达牛巨噬细胞粒细胞集落刺激因子的重组乳酸菌及应用 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
| US4672316A (en) | 1983-08-19 | 1987-06-09 | Werkzeugmaschinenfabrik Oerlikon-Buhrle Ag | Method for calibrating a muzzle velocity measuring device |
| KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| US4931275A (en) | 1985-12-02 | 1990-06-05 | Yeda Research & Development Co., Ltd. | Anti-tumor vaccines and their preparation |
| US5683674A (en) | 1987-01-07 | 1997-11-04 | Imperial Cancer Research Technology Ltd. | Antibody against human mucin core protein and method of preparing and using same |
| CA1333564C (en) | 1988-08-02 | 1994-12-20 | Thomas Julius Borody | Treatment of gastro-intestinal disorders |
| US5110911A (en) | 1989-11-02 | 1992-05-05 | Biomira, Inc. | Human tumor-associated thomsen-friedenreich antigen |
| DK0573551T3 (da) | 1991-02-27 | 2003-08-04 | Micromet Ag | Serinrige peptidlinkere |
| CA2118010C (en) | 1992-04-13 | 2003-10-28 | Donald Kufe | Antibodies specific for carcinoma-associated antigens |
| US5804187A (en) | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
| ATE301201T1 (de) | 1993-06-07 | 2005-08-15 | Vical Inc | Für die gentherapie verwendbare plasmide |
| DE4329004A1 (de) | 1993-08-28 | 1995-03-09 | Max Delbrueck Centrum | Monoklonale Antikörper gegen das Thomsen-Friedenreich-Antigen, ihre Herstellung und ihre Verwendung zum Tumornachweis |
| US7137011B1 (en) | 1993-09-01 | 2006-11-14 | Sandisk Corporation | Removable mother/daughter peripheral card |
| US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| US5772995A (en) * | 1994-07-18 | 1998-06-30 | Sidney Kimmel Cancer Center | Compositions and methods for enhanced tumor cell immunity in vivo |
| JP2660175B2 (ja) * | 1994-10-19 | 1997-10-08 | 北海道 | キクイモ由来のレクチンおよびその分離精製法 |
| US5739277A (en) * | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| AU723325B2 (en) | 1995-06-23 | 2000-08-24 | President And Fellows Of Harvard College | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
| US5939404A (en) * | 1995-12-27 | 1999-08-17 | Ngk Insulators, Ltd. | Cancer metastasis inhibitor containing a streptococcus agalactiae Ia type or Ib type surface polysaccharide as a main ingredient |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| WO1997040182A1 (de) | 1996-04-19 | 1997-10-30 | Gabriele Pecher | Gentransfizierte humane dendritische zellen, ihre herstellung und ihre verwendung, bevorzugt als vakzine |
| JP2001523480A (ja) | 1997-11-20 | 2001-11-27 | バイカル インコーポレイテッド | サイトカイン発現ポリヌクレオチドおよびそれらの組成物を用いた癌の処置 |
| US5948646A (en) | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
| PT1054693E (pt) * | 1998-02-20 | 2009-01-22 | Genentech Inc | Inibidores da activação do complemento |
| JP2000028599A (ja) * | 1998-04-15 | 2000-01-28 | Ebara Corp | Ｄ―マンノ―ス識別アフィニティ―担体とその使用方法 |
| CA2363297C (en) | 1999-03-02 | 2011-08-09 | Michael J. Betenbaugh | Engineering intracellular sialylation pathways |
| DK1167537T3 (da) | 1999-03-30 | 2008-11-10 | Japan Tobacco Inc | Fremgangsmåde til fremstilling af et monoklonalt antistof |
| US7147850B2 (en) * | 1999-08-18 | 2006-12-12 | Altarex Medical Corp. | Therapeutic binding agents against MUC-1 antigen and methods for their use |
| JP2003519096A (ja) | 1999-08-18 | 2003-06-17 | アルタレックス コーポレーション | Ｍｕｃ−１抗原に対する治療用抗体およびその使用方法 |
| AU7743100A (en) | 1999-09-30 | 2001-04-30 | Corixa Corporation | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| US20030138769A1 (en) * | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| GB0029360D0 (en) | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
| JP2004534088A (ja) * | 2001-07-06 | 2004-11-11 | スローン−ケッタリング・インスティテュート・フォア・キャンサー・リサーチ | 癌のための多価コンジュゲートワクチン |
| EP1419176A2 (en) | 2001-08-17 | 2004-05-19 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Glycoconjugates of sialic acid derivates, methods for their production and use thereof |
| DE10139428A1 (de) | 2001-08-17 | 2003-03-27 | Nemod Immuntherapie Ag | Herstellung und Verwendung von humanen CD124 und CD116 positiven Tumorzelllinien zur Herstellung von allogenen oder semi-allogenen Immuntherapeutika |
| GB0125473D0 (en) | 2001-10-24 | 2001-12-12 | Syngenta Ltd | Chemical process |
| CN1201817C (zh) * | 2001-11-09 | 2005-05-18 | 北京大学肝病研究所 | 一种治疗肝癌的肿瘤ct抗原免疫诱导剂及其制备方法 |
| KR100506766B1 (ko) | 2001-11-20 | 2005-08-05 | (주)에이티젠 | 환경 스트레스에 내성을 부여하는 신규한 펩타이드 및이를 포함하는 융합단백질 |
| AU2003266236A1 (en) | 2002-07-22 | 2004-02-09 | Nemod Immuntherapie Ag | Method for the production of an immunostimulating mucin (muc1) |
| ES2353753T3 (es) | 2002-08-16 | 2011-03-04 | Glycotope Gmbh | Procedimiento para la producción de lisados de células tumorales inducidas por temperatura para usar como compuestos inmunógenos. |
| WO2004029621A2 (en) * | 2002-09-26 | 2004-04-08 | Novartis Ag | Tcell mediator/modulator assay based upon tcell restricted transgenic mouse |
| DE10256900A1 (de) * | 2002-11-29 | 2004-06-24 | Nemod Immuntherapie Ag | Tumorspezifische Erkennungsmoleküle |
| EP1604016B1 (en) * | 2003-02-27 | 2009-01-14 | NorthWest Biotherapeutics, Inc. | Generation of dendritic cells from monocytic dendritic precursor cells with gm-csf in the absence of additional cytokines |
| GB0315991D0 (en) * | 2003-07-08 | 2003-08-13 | Dakocytomation Denmark As | Standard |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| DK1654353T3 (da) | 2003-08-18 | 2013-08-26 | Glycotope Gmbh | Tumorcellelinjerne nm-f9 (dsm acc2606) og nm-d4 (dsm acc2605) samt anvendelser deraf |
| FR2861080B1 (fr) | 2003-10-20 | 2006-02-17 | Lab Francais Du Fractionnement | Anticorps presentant un taux de fucose et de galactose optimise |
| AU2005215889B9 (en) | 2004-02-13 | 2011-11-17 | Glycotope Gmbh | Highly active glycoproteins-process conditions and an efficient method for their production |
| WO2005108423A1 (en) | 2004-05-11 | 2005-11-17 | Atgen Co., Ltd. | Novel peptides conferring environmental stress resistance and fusion proteins including said peptides |
| EP1778280A1 (en) * | 2004-07-01 | 2007-05-02 | Kobenhavns Universitet | Method for multiple sclerosis treatment and prophylaxis by treatment of leptospira infection |
| US7374755B2 (en) * | 2004-07-26 | 2008-05-20 | The Research Foundation Of State University Of New York | Therapeutic use of anti-TF-Antigen antibody |
| AR054603A1 (es) * | 2005-08-01 | 2007-06-27 | Canada Natural Resources | Semillas de canola amarillas que comprenden bajo contenido de aceite linolenico y alto contenido oleico y grano molido de bajo contenido de fibra |
| KR20150126730A (ko) * | 2006-09-10 | 2015-11-12 | 글리코토페 게엠베하 | 항체 발현을 위한 골수성 백혈병 기원의 인간 세포의 용도 |
| EP1920782A1 (en) | 2006-11-10 | 2008-05-14 | Glycotope Gmbh | Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof |
| US8741365B2 (en) * | 2008-05-13 | 2014-06-03 | Glycotope Gmbh | Fermentation process |
| EP2281844A1 (en) * | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
| CA2844543A1 (en) * | 2011-08-22 | 2013-02-28 | Glycotope Gmbh | Microorganisms carrying a tumor antigen |
-
2006
- 2006-11-10 EP EP06090209A patent/EP1920782A1/en not_active Withdrawn
- 2006-11-10 EP EP06090208.7A patent/EP1920781B1/en active Active
- 2006-11-10 PL PL06090208T patent/PL1920781T3/pl unknown
-
2007
- 2007-11-12 KR KR1020097011972A patent/KR20090080554A/ko not_active Abandoned
- 2007-11-12 RU RU2009122204/10A patent/RU2460074C2/ru not_active IP Right Cessation
- 2007-11-12 JP JP2009535632A patent/JP5771355B2/ja not_active Expired - Fee Related
- 2007-11-12 CN CN200780049283.7A patent/CN101573138B/zh not_active Expired - Fee Related
- 2007-11-12 CA CA002668704A patent/CA2668704A1/en not_active Abandoned
- 2007-11-12 EA EA200970471A patent/EA025395B1/ru not_active IP Right Cessation
- 2007-11-12 KR KR1020157011383A patent/KR20150054014A/ko not_active Abandoned
- 2007-11-12 AU AU2007316819A patent/AU2007316819B2/en not_active Ceased
- 2007-11-12 MX MX2009005004A patent/MX2009005004A/es active IP Right Grant
- 2007-11-12 EP EP07819754A patent/EP2101814A1/en not_active Withdrawn
- 2007-11-12 ES ES07819755T patent/ES2715045T3/es active Active
- 2007-11-12 CA CA002668603A patent/CA2668603A1/en not_active Abandoned
- 2007-11-12 JP JP2009535633A patent/JP2010508834A/ja not_active Withdrawn
- 2007-11-12 BR BRPI0718796-3A2A patent/BRPI0718796A2/pt not_active IP Right Cessation
- 2007-11-12 US US12/514,200 patent/US8592165B2/en not_active Expired - Fee Related
- 2007-11-12 BR BRPI0719005-0A patent/BRPI0719005A2/pt not_active IP Right Cessation
- 2007-11-12 WO PCT/EP2007/009765 patent/WO2008055702A1/en not_active Ceased
- 2007-11-12 EP EP07819755.5A patent/EP2099480B2/en active Active
- 2007-11-12 WO PCT/EP2007/009766 patent/WO2008055703A2/en not_active Ceased
- 2007-11-12 AU AU2007316820A patent/AU2007316820B2/en not_active Ceased
- 2007-11-12 NZ NZ577559A patent/NZ577559A/en not_active IP Right Cessation
- 2007-11-12 US US12/514,248 patent/US9494587B2/en not_active Expired - Fee Related
-
2009
- 2009-05-04 NO NO20091748A patent/NO20091748L/no not_active Application Discontinuation
- 2009-05-05 IL IL198567A patent/IL198567A0/en unknown
- 2009-05-07 IL IL198626A patent/IL198626A/en not_active IP Right Cessation
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2015
- 2015-04-01 JP JP2015075105A patent/JP2015134813A/ja not_active Withdrawn
- 2015-04-01 JP JP2015074801A patent/JP2015133979A/ja not_active Withdrawn
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