DK0573551T3 - Serinrige peptidlinkere - Google Patents

Serinrige peptidlinkere

Info

Publication number
DK0573551T3
DK0573551T3 DK92907232T DK92907232T DK0573551T3 DK 0573551 T3 DK0573551 T3 DK 0573551T3 DK 92907232 T DK92907232 T DK 92907232T DK 92907232 T DK92907232 T DK 92907232T DK 0573551 T3 DK0573551 T3 DK 0573551T3
Authority
DK
Denmark
Prior art keywords
serine
peptide linkers
ser
rich peptide
domains
Prior art date
Application number
DK92907232T
Other languages
English (en)
Inventor
James S Huston
Hermann Oppermann
Serge N Timasheff
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Application granted granted Critical
Publication of DK0573551T3 publication Critical patent/DK0573551T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK92907232T 1991-02-27 1992-02-27 Serinrige peptidlinkere DK0573551T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66222691A 1991-02-27 1991-02-27
PCT/US1992/001478 WO1992015682A1 (en) 1991-02-27 1992-02-27 Serine-rich peptide linkers

Publications (1)

Publication Number Publication Date
DK0573551T3 true DK0573551T3 (da) 2003-08-04

Family

ID=24656899

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92907232T DK0573551T3 (da) 1991-02-27 1992-02-27 Serinrige peptidlinkere

Country Status (9)

Country Link
EP (1) EP0573551B1 (da)
JP (1) JPH06508985A (da)
AT (1) ATE241011T1 (da)
AU (1) AU664030B2 (da)
CA (1) CA2100671C (da)
DE (1) DE69233068T2 (da)
DK (1) DK0573551T3 (da)
ES (1) ES2194838T3 (da)
WO (1) WO1992015682A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0393438B1 (de) 1989-04-21 2005-02-16 Amgen Inc. TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs
US7264944B1 (en) 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
US6143866A (en) * 1989-07-18 2000-11-07 Amgen, Inc. Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc A method of producing a recombinant human necrotic factor absorber
US6025165A (en) * 1991-11-25 2000-02-15 Enzon, Inc. Methods for producing multivalent antigen-binding proteins
CA2129663C (en) * 1992-02-06 2005-07-05 James S. Huston Biosynthetic binding protein for cancer marker
AU5670194A (en) * 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
ES2263278T3 (es) 1998-07-10 2006-12-01 Scios Inc. Metodo para producir un peptido con un pl por encima de 8 o por debajo de 5.
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
PT1691833E (pt) 2003-11-28 2010-06-08 Micromet Ag Composições compreendendo polipéptidos
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
BRPI0716997B8 (pt) 2006-09-10 2021-05-25 Glycotope Gmbh proteína ou composição de moléculas de proteína, métodos para produção e uso da mesma
PL1920781T3 (pl) 2006-11-10 2015-06-30 Glycotope Gmbh Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów
ES2382058T3 (es) 2008-01-17 2012-06-04 Philogen S.P.A. Combinación de una proteína de fusión de un anticuerpo dirigido contra el EDB de la fibronectina-IL-2, y una molécula de unión a los linfocitos B, progenitores de los linfocitos B y/o sus homólogos cancerosos
EP2116555A1 (en) 2008-05-08 2009-11-11 Bayer Schering Pharma Aktiengesellschaft Use of a radioactively labelled molecule specifically binding to ED-B fibronectin in a method of treatment of Hodgkin lymphoma
US8927694B2 (en) 2008-11-18 2015-01-06 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
WO2011110490A1 (en) 2010-03-09 2011-09-15 Bayer Pharma Aktiengesellschaft Process for the production of radioactively labelled scfv antibody fragments, kits and compositions
WO2012085069A2 (en) * 2010-12-23 2012-06-28 Roche Diagnostics Gmbh Detection of a polypeptide dimer by a bivalent binding agent
WO2012085064A1 (en) * 2010-12-23 2012-06-28 Roche Diagnostics Gmbh Detection of a posttranslationally modified polypeptide by a bi-valent binding agent
EP2655414B1 (en) 2010-12-23 2018-08-29 Roche Diagniostics GmbH Bispecific binding agent
WO2012085111A1 (en) 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
CA2844543A1 (en) 2011-08-22 2013-02-28 Glycotope Gmbh Microorganisms carrying a tumor antigen
ES2626013T3 (es) 2011-09-06 2017-07-21 Novo Nordisk A/S Derivados de GLP-1
US20130344565A1 (en) * 2012-06-21 2013-12-26 Rapid Pathogen Screening, Inc. Optimization of Expression and Purification of Recombinant Human MxA Protein in E. Coli
US9345766B2 (en) 2012-08-30 2016-05-24 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-ERBB3 agents
CA3003399A1 (en) 2015-11-02 2017-05-11 Bioatla, Llc Conditionally active polypeptides
CN117815404A (zh) 2018-05-18 2024-04-05 第一三共株式会社 抗-muc1抗体-药物缀合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US831967A (en) * 1905-08-29 1906-09-25 Eugenie Mearis Table.
ES2055445T3 (es) * 1989-08-22 1994-08-16 Immunex Corp Proteinas de fusion que comprenden gm-csf e il-3.
CA2129663C (en) * 1992-02-06 2005-07-05 James S. Huston Biosynthetic binding protein for cancer marker

Also Published As

Publication number Publication date
CA2100671C (en) 1999-02-02
ATE241011T1 (de) 2003-06-15
JPH06508985A (ja) 1994-10-13
ES2194838T3 (es) 2003-12-01
AU664030B2 (en) 1995-11-02
DE69233068T2 (de) 2004-01-22
WO1992015682A1 (en) 1992-09-17
AU1440392A (en) 1992-10-06
DE69233068D1 (de) 2003-06-26
EP0573551A4 (en) 1994-06-08
EP0573551B1 (en) 2003-05-21
EP0573551A1 (en) 1993-12-15
CA2100671A1 (en) 1992-08-28

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