ES2084621T3 - Proteina biologicamente activa modificada. - Google Patents
Proteina biologicamente activa modificada.Info
- Publication number
- ES2084621T3 ES2084621T3 ES90112690T ES90112690T ES2084621T3 ES 2084621 T3 ES2084621 T3 ES 2084621T3 ES 90112690 T ES90112690 T ES 90112690T ES 90112690 T ES90112690 T ES 90112690T ES 2084621 T3 ES2084621 T3 ES 2084621T3
- Authority
- ES
- Spain
- Prior art keywords
- biologically active
- modified protein
- active modified
- active protein
- consisting essentially
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000035118 modified proteins Human genes 0.000 title 1
- 108091005573 modified proteins Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
- C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
- C12Y115/01001—Superoxide dismutase (1.15.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
UNA PROTEINA MODIFICADA, BIOLOGICAMENTE ACTIVA, QUE SE COMPONE ESENCIALMENTE DE UNA PROTEINA BIOLOGICAMENTE ACTIVA ENLAZADA CON LECITINA MEDIANTE UN FIJADOR QUIMICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17437189 | 1989-07-06 | ||
JP1310056A JP2679852B2 (ja) | 1989-11-29 | 1989-11-29 | 経口及び局所投与用生物活性蛋白組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084621T3 true ES2084621T3 (es) | 1996-05-16 |
Family
ID=26496004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90112690T Expired - Lifetime ES2084621T3 (es) | 1989-07-06 | 1990-07-03 | Proteina biologicamente activa modificada. |
Country Status (8)
Country | Link |
---|---|
US (3) | US5109118A (es) |
EP (1) | EP0406804B1 (es) |
AT (1) | ATE133200T1 (es) |
AU (1) | AU647027B2 (es) |
CA (1) | CA2020439C (es) |
DE (1) | DE69024862T2 (es) |
DK (1) | DK0406804T3 (es) |
ES (1) | ES2084621T3 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869534A (en) * | 1992-05-21 | 1999-02-09 | The Picower Institute For Medical Research | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
US6551623B1 (en) | 1993-09-09 | 2003-04-22 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
WO1995007089A1 (en) | 1993-09-09 | 1995-03-16 | Imutec Corporation | Immunomodulating compositions from bile |
JPH08208511A (ja) * | 1995-01-31 | 1996-08-13 | Samu Kenkyusho:Kk | 抗運動ニューロン疾患剤 |
AU711294B2 (en) | 1995-03-16 | 1999-10-07 | Erin Mills Biotech Inc. | Immunomodulating compositions from bile for the treatment of immune system disorders |
EP0790060B1 (en) * | 1995-09-06 | 2003-11-12 | Kyowa Hakko Kogyo Co., Ltd. | Substance ameliorant le metabolisme des graisses |
US20040101569A1 (en) * | 1996-05-16 | 2004-05-27 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
US6017545A (en) * | 1998-02-10 | 2000-01-25 | Modi; Pankaj | Mixed micellar delivery system and method of preparation |
US6221378B1 (en) | 1998-02-10 | 2001-04-24 | Generex Pharmaceuticals Incorporated | Mixed micellar delivery system and method of preparation |
US7070799B1 (en) * | 1998-02-10 | 2006-07-04 | Generex Pharmaceuticals, Inc. | Method for administering insulin to the buccal region |
AU2001234178A1 (en) * | 2000-02-29 | 2001-09-12 | Ltt Institute Co., Ltd. | Modified bdnf |
EP1627885B8 (en) * | 2003-04-30 | 2015-02-18 | Innovative Medicine and Any Peptide Pharmaceuticals Corp | Polypeptide capable of assisting digestive organ absorption |
CN100516208C (zh) * | 2004-10-12 | 2009-07-22 | 日本株式会社Ltt生物医药 | 卵磷脂化超氧化物歧化酶组合物及其制备方法 |
US8052971B2 (en) * | 2005-11-21 | 2011-11-08 | MG Biologics | Oral use of specific antibodies for intestinal health |
KR100752990B1 (ko) * | 2006-08-02 | 2007-08-30 | 주식회사 대웅 | 나노리포좀 및 천연 추출물을 포함하는 피부 질환의 예방또는 치료용 조성물 |
CA2739936C (en) | 2008-10-17 | 2017-12-12 | Pharmacofore, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
CA2773340C (en) | 2009-09-08 | 2019-07-23 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof |
ES2710617T3 (es) | 2010-04-21 | 2019-04-26 | Signature Therapeutics Inc | Composiciones que comprenden profármacos de anfetamina escindibles enzimáticamente e inhibidores de los mismos |
US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
WO2011133178A1 (en) | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
AU2012205733B2 (en) | 2011-01-11 | 2015-10-08 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
US8685916B2 (en) | 2011-03-09 | 2014-04-01 | Signature Therapeutics, Inc. | Opioid prodrugs with heterocyclic linkers |
WO2012122422A2 (en) | 2011-03-09 | 2012-09-13 | Signature Therapeutics, Inc. | Active agent prodrugs with heterocyclic linkers |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0122151B1 (en) * | 1983-04-11 | 1989-02-15 | Meito Sangyo Kabushiki Kaisha | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique |
US4560599A (en) * | 1984-02-13 | 1985-12-24 | Marquette University | Assembling multilayers of polymerizable surfactant on a surface of a solid material |
US4957740A (en) * | 1984-10-31 | 1990-09-18 | Centerchem, Inc. | Composition for preventing or alleviating skin irritation by formulations containing superoxide dismutase |
EP0211042A1 (en) * | 1985-01-18 | 1987-02-25 | Cooper-Lipotech, Inc. | Liposome composition and method |
JPS63135395A (ja) * | 1986-11-28 | 1988-06-07 | Nippon Oil & Fats Co Ltd | リン脂質誘導体及びその製造方法 |
JPS63253031A (ja) * | 1987-04-09 | 1988-10-20 | Yutaka Mizushima | ス−パ−オキサイドジスムタ−ゼ結合リピツドマイクロスフエア−および該リピツドマイクロスフエア−を含有する脂肪乳剤 |
IE64284B1 (en) * | 1987-08-03 | 1995-07-26 | Ddi Pharmaceuticals | Conjugates of superoxide dismutase |
US5080833A (en) * | 1987-09-21 | 1992-01-14 | Kabushiki Kaisha Toshiba | Immobilization of bioactive substance on lipid composition containing modified lipid compound |
JPH01235593A (ja) * | 1988-03-15 | 1989-09-20 | Fuji Photo Film Co Ltd | 機能性有機薄膜 |
JPH04504258A (ja) * | 1989-03-29 | 1992-07-30 | アルコン ラボラトリーズ インコーポレイテッド | モノアシルホスホグリセリド類を使用して眼薬の角膜への浸透を増強する方法 |
DE3919982A1 (de) * | 1989-06-19 | 1990-12-20 | Liedtke Pharmed Gmbh | Orale lipidarzneiform |
-
1990
- 1990-07-02 US US07/547,039 patent/US5109118A/en not_active Expired - Lifetime
- 1990-07-03 ES ES90112690T patent/ES2084621T3/es not_active Expired - Lifetime
- 1990-07-03 DK DK90112690.4T patent/DK0406804T3/da active
- 1990-07-03 DE DE69024862T patent/DE69024862T2/de not_active Expired - Fee Related
- 1990-07-03 AT AT90112690T patent/ATE133200T1/de not_active IP Right Cessation
- 1990-07-03 EP EP90112690A patent/EP0406804B1/en not_active Expired - Lifetime
- 1990-07-04 AU AU58652/90A patent/AU647027B2/en not_active Ceased
- 1990-07-04 CA CA002020439A patent/CA2020439C/en not_active Expired - Lifetime
-
1992
- 1992-02-07 US US07/832,585 patent/US5310958A/en not_active Expired - Lifetime
-
1994
- 1994-02-02 US US08/190,451 patent/US5362491A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0406804A2 (en) | 1991-01-09 |
ATE133200T1 (de) | 1996-02-15 |
CA2020439A1 (en) | 1991-01-07 |
AU647027B2 (en) | 1994-03-17 |
DE69024862D1 (de) | 1996-02-29 |
EP0406804B1 (en) | 1996-01-17 |
US5362491A (en) | 1994-11-08 |
US5310958A (en) | 1994-05-10 |
DE69024862T2 (de) | 1996-09-05 |
DK0406804T3 (da) | 1996-06-10 |
US5109118A (en) | 1992-04-28 |
EP0406804A3 (en) | 1992-04-01 |
CA2020439C (en) | 1998-11-24 |
AU5865290A (en) | 1991-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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