DE69024862T2 - Modifiziertes, biologisch aktives Protein - Google Patents

Modifiziertes, biologisch aktives Protein

Info

Publication number
DE69024862T2
DE69024862T2 DE69024862T DE69024862T DE69024862T2 DE 69024862 T2 DE69024862 T2 DE 69024862T2 DE 69024862 T DE69024862 T DE 69024862T DE 69024862 T DE69024862 T DE 69024862T DE 69024862 T2 DE69024862 T2 DE 69024862T2
Authority
DE
Germany
Prior art keywords
biologically active
active protein
modified
consisting essentially
chemical linkage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69024862T
Other languages
English (en)
Other versions
DE69024862D1 (de
Inventor
Yutaka Mizushima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTT Bio Pharma Co Ltd
Original Assignee
Asahi Glass Co Ltd
Seikagaku Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1310056A external-priority patent/JP2679852B2/ja
Application filed by Asahi Glass Co Ltd, Seikagaku Corp filed Critical Asahi Glass Co Ltd
Publication of DE69024862D1 publication Critical patent/DE69024862D1/de
Application granted granted Critical
Publication of DE69024862T2 publication Critical patent/DE69024862T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69024862T 1989-07-06 1990-07-03 Modifiziertes, biologisch aktives Protein Expired - Fee Related DE69024862T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17437189 1989-07-06
JP1310056A JP2679852B2 (ja) 1989-11-29 1989-11-29 経口及び局所投与用生物活性蛋白組成物

Publications (2)

Publication Number Publication Date
DE69024862D1 DE69024862D1 (de) 1996-02-29
DE69024862T2 true DE69024862T2 (de) 1996-09-05

Family

ID=26496004

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69024862T Expired - Fee Related DE69024862T2 (de) 1989-07-06 1990-07-03 Modifiziertes, biologisch aktives Protein

Country Status (8)

Country Link
US (3) US5109118A (de)
EP (1) EP0406804B1 (de)
AT (1) ATE133200T1 (de)
AU (1) AU647027B2 (de)
CA (1) CA2020439C (de)
DE (1) DE69024862T2 (de)
DK (1) DK0406804T3 (de)
ES (1) ES2084621T3 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869534A (en) * 1992-05-21 1999-02-09 The Picower Institute For Medical Research Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
DE69432930T2 (de) 1993-09-09 2004-05-06 Lorus Therapeutics Inc., Toronto Immunmodulierende zusammensetzungen aus galle
JPH08208511A (ja) * 1995-01-31 1996-08-13 Samu Kenkyusho:Kk 抗運動ニューロン疾患剤
CN1182368A (zh) 1995-03-16 1998-05-20 伊姆特克药物公司 来源于胆汁的治疗免疫系统紊乱的免疫调节组合物
AU721852C (en) * 1995-09-06 2001-08-30 Kyowa Hakko Kogyo Co. Ltd. Lipid metabolism improving agent
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
WO2001064742A1 (fr) * 2000-02-29 2001-09-07 Sumitomo Pharmaceuticals Company, Limited Bdnf modifie
US7910115B2 (en) 2003-04-30 2011-03-22 Shigekazu Nakatsugawa Polypeptide absorbable into digestive organs
KR101183856B1 (ko) * 2004-10-12 2012-09-19 가부시키가이샤 엘티티 바이오파마 레시틴화 수퍼옥사이드 디스뮤타아제 조성물 및 그 제조방법
US8052971B2 (en) * 2005-11-21 2011-11-08 MG Biologics Oral use of specific antibodies for intestinal health
KR100752990B1 (ko) * 2006-08-02 2007-08-30 주식회사 대웅 나노리포좀 및 천연 추출물을 포함하는 피부 질환의 예방또는 치료용 조성물
US8802681B2 (en) * 2008-10-17 2014-08-12 Signature Therapeutics, Inc. Pharmaceutical compositions with attenuated release of phenolic opioids
SG179026A1 (en) 2009-09-08 2012-04-27 Signature Therapeutics Inc Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof
WO2011133178A1 (en) 2010-04-21 2011-10-27 Pharmacofore, Inc Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug
DK2560486T3 (en) 2010-04-21 2019-02-04 Signature Therapeutics Inc COMPOSITIONS COMPREHENSIVE ENZYM-TENDABLE AMPHETAMINE PRODRUGS AND ITS INHIBITORS
US20110262355A1 (en) 2010-04-21 2011-10-27 Jenkins Thomas E Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
JP6016810B2 (ja) 2011-01-11 2016-10-26 シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. 酵素切断可能なオキシコドンプロドラッグを含んでなる組成物
WO2012122420A2 (en) 2011-03-09 2012-09-13 Pharmacofore, Inc. Opioid prodrugs with heterocyclic linkers
BR112013022946A2 (pt) 2011-03-09 2017-07-18 Signature Therapeutics Inc pró-fármacos de agentes ativos com ligantes heterocíclocos

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3476770D1 (en) * 1983-04-11 1989-03-23 Meito Sangyo Kk Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
US4560599A (en) * 1984-02-13 1985-12-24 Marquette University Assembling multilayers of polymerizable surfactant on a surface of a solid material
US4957740A (en) * 1984-10-31 1990-09-18 Centerchem, Inc. Composition for preventing or alleviating skin irritation by formulations containing superoxide dismutase
EP0211042A1 (de) * 1985-01-18 1987-02-25 Cooper-Lipotech, Inc. Liposomenzusammensetzungen und verfahren
JPS63135395A (ja) * 1986-11-28 1988-06-07 Nippon Oil & Fats Co Ltd リン脂質誘導体及びその製造方法
JPS63253031A (ja) * 1987-04-09 1988-10-20 Yutaka Mizushima ス−パ−オキサイドジスムタ−ゼ結合リピツドマイクロスフエア−および該リピツドマイクロスフエア−を含有する脂肪乳剤
IE64284B1 (en) * 1987-08-03 1995-07-26 Ddi Pharmaceuticals Conjugates of superoxide dismutase
US5080833A (en) * 1987-09-21 1992-01-14 Kabushiki Kaisha Toshiba Immobilization of bioactive substance on lipid composition containing modified lipid compound
JPH01235593A (ja) * 1988-03-15 1989-09-20 Fuji Photo Film Co Ltd 機能性有機薄膜
JPH04504258A (ja) * 1989-03-29 1992-07-30 アルコン　ラボラトリーズ　インコーポレイテッド モノアシルホスホグリセリド類を使用して眼薬の角膜への浸透を増強する方法
DE3919982A1 (de) * 1989-06-19 1990-12-20 Liedtke Pharmed Gmbh Orale lipidarzneiform

Also Published As

Publication number Publication date
ES2084621T3 (es) 1996-05-16
AU647027B2 (en) 1994-03-17
US5362491A (en) 1994-11-08
DK0406804T3 (da) 1996-06-10
EP0406804B1 (de) 1996-01-17
EP0406804A3 (en) 1992-04-01
US5109118A (en) 1992-04-28
AU5865290A (en) 1991-01-10
CA2020439C (en) 1998-11-24
CA2020439A1 (en) 1991-01-07
EP0406804A2 (de) 1991-01-09
DE69024862D1 (de) 1996-02-29
US5310958A (en) 1994-05-10
ATE133200T1 (de) 1996-02-15

Similar Documents

Publication Publication Date Title
DE69024862T2 (de) Modifiziertes, biologisch aktives Protein
ES2087056T3 (es) 2-pirimidinaminas sustituidas en las posiciones 4, 5 y 6.
DE3768589D1 (de) Zusammengestelltes leichtgewichtmaterial.
DE3586206D1 (de) Metoprololsuccinat und dieses enthaltende pharmazeutische zusammensetzung.
DE3850719D1 (de) Direkt angetriebenes Servoventil.
DE3884791D1 (de) Begasungs-Brutschrank.
FI91160B (fi) Menetelmä modifioidun ihmisen t-PA-proteiinin valmistamiseksi
ES2043609T3 (es) Composiciones de interleucina-2.
FI864552A (fi) Human-lysozym.
IT1212143B (it) Composizione ad attivita'tricogena.
DK109590A (da) Biologisk aktivt protein
DE3768160D1 (de) Nadel-traktor.
DK614489D0 (da) Peptidderivater
DK191089D0 (da) Biologisk aktive forbindelser
FI900794A0 (fi) Anordning foer att avlaegsna avbrutna tunnband i en bal's bandning.
ATE30966T1 (de) Lagerstabiles universalkontrollserum.
DE3888440T2 (de) Optisch aktive 2-Biphenylpyridine.
DE3782199T2 (de) Biologisch aktive peptide tan-866.
DE3771379D1 (de) Optisch aktive hydantoine.
DE3773322D1 (de) Pharmazeutische zubereitungen mit heilender aktivitaet.
NO884864D0 (no) Blodplate-relatent vekstregulator.
NO875477D0 (no) Rekombinant alveolaert overflateaktivt protein.
NO890669D0 (no) Sammenklappbart taktelt for kjoeretoey.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LTT INSTITUTE CO.,LTD., TOKYO, JP IGARASHI, RIE, K

8327 Change in the person/name/address of the patent owner

Owner name: LTT BIO-PHARMA CO., LTD., TOKIO/TOKYO, JP

8339 Ceased/non-payment of the annual fee