ES2176286T3 - Esteres de metido de pentapeptidos inhibidoras del cancer de seres humanos. - Google Patents

Esteres de metido de pentapeptidos inhibidoras del cancer de seres humanos.

Info

Publication number
ES2176286T3
ES2176286T3 ES95305130T ES95305130T ES2176286T3 ES 2176286 T3 ES2176286 T3 ES 2176286T3 ES 95305130 T ES95305130 T ES 95305130T ES 95305130 T ES95305130 T ES 95305130T ES 2176286 T3 ES2176286 T3 ES 2176286T3
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ES
Spain
Prior art keywords
cbz
chem
esteres
pentapeptides
inhibiting
Prior art date
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Expired - Lifetime
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ES95305130T
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English (en)
Inventor
George R Pettit
Michael D Williams
Jayaram K Srirangam
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University of Arizona
Arizona's Public Universities
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University of Arizona
Arizona's Public Universities
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Publication of ES2176286T3 publication Critical patent/ES2176286T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTAN AQUI DENTRO VARIOS DERIVADOS DE ESTERES DE METILO DE PENTAPEPTIDOS DE DOLASTATINA 10, EN LOS QUE SE HAN UTILIZADO TANTO AMINOACIDOS QUE OCURREN DE FORMA NATURAL COMO MODIFICADOS. LOS AMINOACIDOS MODIFICADOS SELECCIONADOS SON CONSTITUYENTES DE LA DOLASTATINA 10 QUE ES UN PEPTIDO ESTRUCTURALMENTE DISTINTO CON UNA EXCELENTE ACTIVIDAD ANTINEOPLASTICA IN VITRO E IN VIVO. LAS ESTRUCTURAS DE ESTOS COMPUESTOS SON COMO SE MUESTRAN A CONTINUACION: 10A) R{SUB,1} = I-PR; R = -NH(ME){SUB,2}; R{SUB,2} = CH{SUB,2}CH{SUB,2}CH{SUB,2}NH-CBZ; 10B) R{SUB,1} = I-PR; R = -NH(ME){SUB,2}; 11A) R{SUB,1} = -(CH{SUB,2}){SUB,4}NH-CBZ; R = -NH (CBZ); 11B) R = -NH(CBZ); R{SUB,2} = -CH{SUB,2}CH{SUB,2}CH{SUB,2}NH-CBZ; 11C) R = -NH(CBZ); R{SUB,2} = -CH{SUB,2}-S-ME.
ES95305130T 1994-08-01 1995-07-21 Esteres de metido de pentapeptidos inhibidoras del cancer de seres humanos. Expired - Lifetime ES2176286T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/283,682 US5504191A (en) 1994-08-01 1994-08-01 Human cancer inhibitory pentapeptide methyl esters

Publications (1)

Publication Number Publication Date
ES2176286T3 true ES2176286T3 (es) 2002-12-01

Family

ID=23087105

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95305130T Expired - Lifetime ES2176286T3 (es) 1994-08-01 1995-07-21 Esteres de metido de pentapeptidos inhibidoras del cancer de seres humanos.

Country Status (9)

Country Link
US (1) US5504191A (es)
EP (1) EP0695759B1 (es)
JP (1) JP3579750B2 (es)
AT (1) ATE217884T1 (es)
CA (1) CA2154203A1 (es)
DE (1) DE69526757T2 (es)
DK (1) DK0695759T3 (es)
ES (1) ES2176286T3 (es)
PT (1) PT695759E (es)

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ATE217884T1 (de) 2002-06-15
EP0695759A3 (en) 1997-11-26
EP0695759A2 (en) 1996-02-07
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US5504191A (en) 1996-04-02
EP0695759B1 (en) 2002-05-22
DE69526757T2 (de) 2002-11-07

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