JP2010505442A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010505442A5 JP2010505442A5 JP2009532294A JP2009532294A JP2010505442A5 JP 2010505442 A5 JP2010505442 A5 JP 2010505442A5 JP 2009532294 A JP2009532294 A JP 2009532294A JP 2009532294 A JP2009532294 A JP 2009532294A JP 2010505442 A5 JP2010505442 A5 JP 2010505442A5
- Authority
- JP
- Japan
- Prior art keywords
- expression vector
- fragment
- vector
- rpl10
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013604 expression vector Substances 0.000 claims 39
- 239000012634 fragment Substances 0.000 claims 24
- 102100021546 60S ribosomal protein L10 Human genes 0.000 claims 18
- 101001108634 Homo sapiens 60S ribosomal protein L10 Proteins 0.000 claims 18
- 101001117935 Homo sapiens 60S ribosomal protein L15 Proteins 0.000 claims 18
- 101001007394 Homo sapiens Leukocyte receptor cluster member 8 Proteins 0.000 claims 17
- 102100028297 Leukocyte receptor cluster member 8 Human genes 0.000 claims 17
- 239000013598 vector Substances 0.000 claims 17
- 239000002773 nucleotide Substances 0.000 claims 15
- 125000003729 nucleotide group Chemical group 0.000 claims 15
- 108700009124 Transcription Initiation Site Proteins 0.000 claims 13
- 102100029861 Cytochrome b-c1 complex subunit 8 Human genes 0.000 claims 11
- 102100040002 Eukaryotic translation initiation factor 6 Human genes 0.000 claims 11
- 101000585358 Homo sapiens Cytochrome b-c1 complex subunit 8 Proteins 0.000 claims 11
- 101000959746 Homo sapiens Eukaryotic translation initiation factor 6 Proteins 0.000 claims 11
- 101000708470 Homo sapiens Sorting nexin-3 Proteins 0.000 claims 11
- 102100032829 Sorting nexin-3 Human genes 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 230000001177 retroviral effect Effects 0.000 claims 4
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241001430294 unidentified retrovirus Species 0.000 claims 3
- 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000002103 transcriptional effect Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 239000012212 insulator Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 230000008488 polyadenylation Effects 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000005758 transcription activity Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85026906P | 2006-10-10 | 2006-10-10 | |
| PCT/KR2007/004940 WO2008044869A1 (en) | 2006-10-10 | 2007-10-10 | Expression vectors with improved safety |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013042281A Division JP5760023B2 (ja) | 2006-10-10 | 2013-03-04 | 安全性の改善された発現ベクター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010505442A JP2010505442A (ja) | 2010-02-25 |
| JP2010505442A5 true JP2010505442A5 (enExample) | 2010-11-25 |
Family
ID=39283030
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009532294A Pending JP2010505442A (ja) | 2006-10-10 | 2007-10-10 | 安全性の改善された発現ベクター |
| JP2013042281A Expired - Fee Related JP5760023B2 (ja) | 2006-10-10 | 2013-03-04 | 安全性の改善された発現ベクター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013042281A Expired - Fee Related JP5760023B2 (ja) | 2006-10-10 | 2013-03-04 | 安全性の改善された発現ベクター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8105575B2 (enExample) |
| EP (2) | EP2261360B1 (enExample) |
| JP (2) | JP2010505442A (enExample) |
| KR (1) | KR101421063B1 (enExample) |
| CN (1) | CN101522899B (enExample) |
| WO (1) | WO2008044869A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9206440B2 (en) * | 2009-01-23 | 2015-12-08 | Roger Williams Hospital | Viral vectors encoding multiple highly homologus non-viral polypeptides and the use of same |
| CN101864420B (zh) * | 2009-05-06 | 2012-05-23 | 中国人民解放军军事医学科学院生物工程研究所 | 一种用于hek293细胞高效表达外源基因的表达载体 |
| FR2986536A1 (fr) | 2012-02-08 | 2013-08-09 | Lfb Biotechnologies | Unites de transcription et leur utilisation dans des vecteurs d'expression (cho) |
| WO2014099671A1 (en) * | 2012-12-20 | 2014-06-26 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| CN103074374B (zh) * | 2013-01-16 | 2014-04-02 | 薛博夫 | 人β-NGF的重组表达载体及含该载体的重组细胞株 |
| MX383227B (es) * | 2014-05-14 | 2025-03-13 | UNIV AUTòNOMA DE BARCELONA | Vectores de virus adenoasociados para el tratamiento de trastornos de almacenamiento lisosomico. |
| WO2016176152A2 (en) * | 2015-04-25 | 2016-11-03 | Washington State University | Re-targeted foamy virus vectors |
| ES2985769T3 (es) | 2017-05-06 | 2024-11-07 | Upside Foods Inc | Composiciones y métodos para aumentar la densidad de cultivo de una biomasa celular dentro de una infraestructura de cultivo |
| WO2019014652A1 (en) | 2017-07-13 | 2019-01-17 | Memphis Meats, Inc. | COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CELL CULTURES USED IN FOOD PRODUCTION |
| WO2020014222A2 (en) * | 2018-07-09 | 2020-01-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Viral promoters and compositions and methods of use thereof |
| AU2020357740A1 (en) * | 2019-09-30 | 2022-04-28 | Eli Lilly And Company | Adeno-associated virus (AAV) systems for treatment of genetic hearing loss |
| WO2021136347A1 (zh) * | 2019-12-30 | 2021-07-08 | 南京金斯瑞生物科技有限公司 | 一种哺乳动物表达系统使用的高表达载体 |
| CN112250751B (zh) * | 2020-10-22 | 2022-06-03 | 济南市中心医院 | LENG8作为mRNA转录调控蛋白及线粒体活性调控蛋白的应用 |
| US20250281641A1 (en) * | 2020-12-18 | 2025-09-11 | Usmedigene Inc. | Vectors for delivery of human growth hormone gene and multiple therapeutic genes into central nervous system by crossing blood brain barrier |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| AU643109B2 (en) | 1990-12-14 | 1993-11-04 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| AT401526B (de) | 1993-02-10 | 1996-09-25 | Scheirer Winfried | Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung |
| US5976796A (en) | 1996-10-04 | 1999-11-02 | Loma Linda University | Construction and expression of renilla luciferase and green fluorescent protein fusion genes |
| KR100556864B1 (ko) * | 1997-05-13 | 2006-03-10 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 렌티바이러스-기원 유전자 전달 벡터 |
| US6074859A (en) | 1997-07-08 | 2000-06-13 | Kikkoman Corporation | Mutant-type bioluminescent protein, and process for producing the mutant-type bioluminescent protein |
| KR20000006334A (ko) * | 1998-06-26 | 2000-01-25 | 이선경 | 바이러스코딩염기서열이전혀없는고효율레트로바이러스벡터 |
| KR20000046969A (ko) | 1998-12-31 | 2000-07-25 | 이선경 | 이종 유전자 유래의 유전자 발현 조절요소를 포함하는 강력한전사 활성을 가진 진핵세포 발현벡더 |
| KR100373821B1 (ko) * | 2000-09-08 | 2003-02-26 | 주식회사 바이로메드 | 세포에서 유래한 변형된 비코딩 서열을 갖는 개선된고효율 레트로바이러스 벡터 |
| US7575924B2 (en) * | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
| US20090133136A1 (en) * | 2005-01-21 | 2009-05-21 | Immusol Incorporated | Inducible SIRNA expression cassette and method of use |
| EP1858332A4 (en) | 2005-02-16 | 2011-06-22 | Lentigen Corp | LENTIVIRUS VECTORS AND ITS USE |
| GB0509965D0 (en) * | 2005-05-17 | 2005-06-22 | Ml Lab Plc | Improved expression elements |
| US20070161031A1 (en) * | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
-
2007
- 2007-10-10 WO PCT/KR2007/004940 patent/WO2008044869A1/en not_active Ceased
- 2007-10-10 CN CN2007800378795A patent/CN101522899B/zh not_active Expired - Fee Related
- 2007-10-10 EP EP10007115.8A patent/EP2261360B1/en not_active Not-in-force
- 2007-10-10 US US11/870,361 patent/US8105575B2/en not_active Expired - Fee Related
- 2007-10-10 JP JP2009532294A patent/JP2010505442A/ja active Pending
- 2007-10-10 KR KR1020097007572A patent/KR101421063B1/ko not_active Expired - Fee Related
- 2007-10-10 EP EP07833251A patent/EP2082043A4/en not_active Withdrawn
-
2013
- 2013-03-04 JP JP2013042281A patent/JP5760023B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010505442A5 (enExample) | ||
| Sinn et al. | Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors–design, biosafety, and production | |
| Hoffmann et al. | Detailed comparison of retroviral vectors and promoter configurations for stable and high transgene expression in human induced pluripotent stem cells | |
| EP0512017B1 (en) | Vaccines | |
| US8828718B2 (en) | Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements | |
| CN107794272A (zh) | 一种高特异性的crispr基因组编辑体系 | |
| RS56844B1 (sr) | Retrovirusni vektori sa modifikovanim polipurinskim nizom | |
| US11767530B2 (en) | Splice inhibiting oligonucleotides | |
| US20240200042A1 (en) | Limited self-replicating mrna molecular system, producing method and use | |
| JP6960409B2 (ja) | プロモーター | |
| JP2023504593A (ja) | 産生系 | |
| CN102250950A (zh) | 一种基于dna水平的乙型脑炎病毒复制子载体系统及其构建方法和应用 | |
| EP4326881A1 (en) | Dna amplification method using care elements | |
| CN102174649B (zh) | 快速检测锌指核酸酶介导基因定点整合的方法 | |
| WO2023062365A2 (en) | Lentiviral vectors | |
| Laham-Karam et al. | Transduction of human immunodeficiency virus type 1 vectors lacking encapsidation and dimerization signals | |
| US20250034589A1 (en) | Lentiviral Vectors | |
| Mao et al. | DNA context and promoter activity affect gene expression in lentiviral vectors | |
| Zenke et al. | Development of siRNA expression vector utilizing rock bream β-actin promoter: a potential therapeutic tool against viral infection in fish | |
| WO2023062366A1 (en) | Retroviral vectors | |
| Real et al. | Improvement of lentiviral transfer vectors using cis-acting regulatory elements for increased gene expression | |
| CN103642838B (zh) | 一种人类及哺乳动物细胞表达载体及其应用 | |
| CN110343752A (zh) | 一种研究PGCs分化过程中Wnt信号与组蛋白联合作用于靶基因机制的方法 | |
| EP4573112A1 (en) | Envelope proteins | |
| JP2017000015A (ja) | 目的遺伝子の発現誘導可能なウイルスベクター |