KR101421063B1 - 안전성이 개선된 발현 벡터 - Google Patents

안전성이 개선된 발현 벡터 Download PDF

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KR101421063B1
KR101421063B1 KR1020097007572A KR20097007572A KR101421063B1 KR 101421063 B1 KR101421063 B1 KR 101421063B1 KR 1020097007572 A KR1020097007572 A KR 1020097007572A KR 20097007572 A KR20097007572 A KR 20097007572A KR 101421063 B1 KR101421063 B1 KR 101421063B1
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KR20090092755A (ko
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김선영
김수정
이준태
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주식회사 바이로메드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020097007572A 2006-10-10 2007-10-10 안전성이 개선된 발현 벡터 Expired - Fee Related KR101421063B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85026906P 2006-10-10 2006-10-10
US60/850,269 2006-10-10
PCT/KR2007/004940 WO2008044869A1 (en) 2006-10-10 2007-10-10 Expression vectors with improved safety

Publications (2)

Publication Number Publication Date
KR20090092755A KR20090092755A (ko) 2009-09-01
KR101421063B1 true KR101421063B1 (ko) 2014-07-21

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KR1020097007572A Expired - Fee Related KR101421063B1 (ko) 2006-10-10 2007-10-10 안전성이 개선된 발현 벡터

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Country Link
US (1) US8105575B2 (enExample)
EP (2) EP2082043A4 (enExample)
JP (2) JP2010505442A (enExample)
KR (1) KR101421063B1 (enExample)
CN (1) CN101522899B (enExample)
WO (1) WO2008044869A1 (enExample)

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WO2010085660A2 (en) * 2009-01-23 2010-07-29 Roger Williams Hospital Viral vectors encoding multiple highly homologous non-viral polypeptides and the use of same
CN101864420B (zh) * 2009-05-06 2012-05-23 中国人民解放军军事医学科学院生物工程研究所 一种用于hek293细胞高效表达外源基因的表达载体
FR2986536A1 (fr) * 2012-02-08 2013-08-09 Lfb Biotechnologies Unites de transcription et leur utilisation dans des vecteurs d'expression (cho)
WO2014099671A1 (en) * 2012-12-20 2014-06-26 Bluebird Bio, Inc. Chimeric antigen receptors and immune cells targeting b cell malignancies
CN103074374B (zh) * 2013-01-16 2014-04-02 薛博夫 人β-NGF的重组表达载体及含该载体的重组细胞株
EP3143146B1 (en) * 2014-05-14 2020-05-20 Esteve Pharmaceuticals, S.A. Adenoassociated virus vectors for the treatment of lysosomal storage disorders
WO2016176152A2 (en) * 2015-04-25 2016-11-03 Washington State University Re-targeted foamy virus vectors
US11976302B2 (en) 2017-05-06 2024-05-07 Upside Foods, Inc. Compositions and methods for increasing the culture density of a cellular biomass within a cultivation infrastructure
US11479792B2 (en) 2017-07-13 2022-10-25 Upside Foods, Inc. Compositions and methods for increasing the efficiency of cell cultures used for food production
WO2020014222A2 (en) * 2018-07-09 2020-01-16 Arizona Board Of Regents On Behalf Of The University Of Arizona Viral promoters and compositions and methods of use thereof
KR20220133854A (ko) 2019-09-30 2022-10-05 어플라이드 제네틱스 테크놀로지스 코퍼레이션 유전적 청력 상실 치료를 위한 아데노 관련 바이러스(aav) 시스템
WO2021136347A1 (zh) * 2019-12-30 2021-07-08 南京金斯瑞生物科技有限公司 一种哺乳动物表达系统使用的高表达载体
CN112250751B (zh) * 2020-10-22 2022-06-03 济南市中心医院 LENG8作为mRNA转录调控蛋白及线粒体活性调控蛋白的应用
US20250281641A1 (en) * 2020-12-18 2025-09-11 Usmedigene Inc. Vectors for delivery of human growth hormone gene and multiple therapeutic genes into central nervous system by crossing blood brain barrier

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US5583024A (en) 1985-12-02 1996-12-10 The Regents Of The University Of California Recombinant expression of Coleoptera luciferase
DE69123241T2 (de) 1990-12-14 1997-04-17 Cell Genesys Inc Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen
AT401526B (de) 1993-02-10 1996-09-25 Scheirer Winfried Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung
US5976796A (en) 1996-10-04 1999-11-02 Loma Linda University Construction and expression of renilla luciferase and green fluorescent protein fusion genes
JP4390860B2 (ja) 1997-05-13 2009-12-24 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル レンチウイルスをベースにした遺伝子転移ベクター
US6074859A (en) 1997-07-08 2000-06-13 Kikkoman Corporation Mutant-type bioluminescent protein, and process for producing the mutant-type bioluminescent protein
KR20000006334A (ko) 1998-06-26 2000-01-25 이선경 바이러스코딩염기서열이전혀없는고효율레트로바이러스벡터
KR20000046969A (ko) 1998-12-31 2000-07-25 이선경 이종 유전자 유래의 유전자 발현 조절요소를 포함하는 강력한전사 활성을 가진 진핵세포 발현벡더
KR100373821B1 (ko) * 2000-09-08 2003-02-26 주식회사 바이로메드 세포에서 유래한 변형된 비코딩 서열을 갖는 개선된고효율 레트로바이러스 벡터
US7575924B2 (en) * 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
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US20070161031A1 (en) * 2005-12-16 2007-07-12 The Board Of Trustees Of The Leland Stanford Junior University Functional arrays for high throughput characterization of gene expression regulatory elements

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Also Published As

Publication number Publication date
CN101522899A (zh) 2009-09-02
WO2008044869A1 (en) 2008-04-17
US8105575B2 (en) 2012-01-31
EP2261360A1 (en) 2010-12-15
KR20090092755A (ko) 2009-09-01
CN101522899B (zh) 2012-07-25
EP2261360B1 (en) 2014-04-23
EP2082043A1 (en) 2009-07-29
US20080153770A1 (en) 2008-06-26
JP2010505442A (ja) 2010-02-25
EP2082043A4 (en) 2010-03-24
JP5760023B2 (ja) 2015-08-05
JP2013143947A (ja) 2013-07-25

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