JP2010505442A - 安全性の改善された発現ベクター - Google Patents
安全性の改善された発現ベクター Download PDFInfo
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- JP2010505442A JP2010505442A JP2009532294A JP2009532294A JP2010505442A JP 2010505442 A JP2010505442 A JP 2010505442A JP 2009532294 A JP2009532294 A JP 2009532294A JP 2009532294 A JP2009532294 A JP 2009532294A JP 2010505442 A JP2010505442 A JP 2010505442A
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- C12N15/09—Recombinant DNA-technology
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
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| US9206440B2 (en) * | 2009-01-23 | 2015-12-08 | Roger Williams Hospital | Viral vectors encoding multiple highly homologus non-viral polypeptides and the use of same |
| CN101864420B (zh) * | 2009-05-06 | 2012-05-23 | 中国人民解放军军事医学科学院生物工程研究所 | 一种用于hek293细胞高效表达外源基因的表达载体 |
| FR2986536A1 (fr) | 2012-02-08 | 2013-08-09 | Lfb Biotechnologies | Unites de transcription et leur utilisation dans des vecteurs d'expression (cho) |
| WO2014099671A1 (en) * | 2012-12-20 | 2014-06-26 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| CN103074374B (zh) * | 2013-01-16 | 2014-04-02 | 薛博夫 | 人β-NGF的重组表达载体及含该载体的重组细胞株 |
| MX383227B (es) * | 2014-05-14 | 2025-03-13 | UNIV AUTòNOMA DE BARCELONA | Vectores de virus adenoasociados para el tratamiento de trastornos de almacenamiento lisosomico. |
| WO2016176152A2 (en) * | 2015-04-25 | 2016-11-03 | Washington State University | Re-targeted foamy virus vectors |
| ES2985769T3 (es) | 2017-05-06 | 2024-11-07 | Upside Foods Inc | Composiciones y métodos para aumentar la densidad de cultivo de una biomasa celular dentro de una infraestructura de cultivo |
| WO2019014652A1 (en) | 2017-07-13 | 2019-01-17 | Memphis Meats, Inc. | COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CELL CULTURES USED IN FOOD PRODUCTION |
| WO2020014222A2 (en) * | 2018-07-09 | 2020-01-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Viral promoters and compositions and methods of use thereof |
| AU2020357740A1 (en) * | 2019-09-30 | 2022-04-28 | Eli Lilly And Company | Adeno-associated virus (AAV) systems for treatment of genetic hearing loss |
| WO2021136347A1 (zh) * | 2019-12-30 | 2021-07-08 | 南京金斯瑞生物科技有限公司 | 一种哺乳动物表达系统使用的高表达载体 |
| CN112250751B (zh) * | 2020-10-22 | 2022-06-03 | 济南市中心医院 | LENG8作为mRNA转录调控蛋白及线粒体活性调控蛋白的应用 |
| US20250281641A1 (en) * | 2020-12-18 | 2025-09-11 | Usmedigene Inc. | Vectors for delivery of human growth hormone gene and multiple therapeutic genes into central nervous system by crossing blood brain barrier |
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| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| AU643109B2 (en) | 1990-12-14 | 1993-11-04 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| AT401526B (de) | 1993-02-10 | 1996-09-25 | Scheirer Winfried | Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung |
| US5976796A (en) | 1996-10-04 | 1999-11-02 | Loma Linda University | Construction and expression of renilla luciferase and green fluorescent protein fusion genes |
| KR100556864B1 (ko) * | 1997-05-13 | 2006-03-10 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 렌티바이러스-기원 유전자 전달 벡터 |
| US6074859A (en) | 1997-07-08 | 2000-06-13 | Kikkoman Corporation | Mutant-type bioluminescent protein, and process for producing the mutant-type bioluminescent protein |
| KR20000006334A (ko) * | 1998-06-26 | 2000-01-25 | 이선경 | 바이러스코딩염기서열이전혀없는고효율레트로바이러스벡터 |
| KR20000046969A (ko) | 1998-12-31 | 2000-07-25 | 이선경 | 이종 유전자 유래의 유전자 발현 조절요소를 포함하는 강력한전사 활성을 가진 진핵세포 발현벡더 |
| KR100373821B1 (ko) * | 2000-09-08 | 2003-02-26 | 주식회사 바이로메드 | 세포에서 유래한 변형된 비코딩 서열을 갖는 개선된고효율 레트로바이러스 벡터 |
| US7575924B2 (en) * | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
| EP1858332A4 (en) | 2005-02-16 | 2011-06-22 | Lentigen Corp | LENTIVIRUS VECTORS AND ITS USE |
| GB0509965D0 (en) * | 2005-05-17 | 2005-06-22 | Ml Lab Plc | Improved expression elements |
| US20070161031A1 (en) * | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
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| WO2006078880A2 (en) * | 2005-01-21 | 2006-07-27 | Immusol Incorporated | Inducible sirna expression cassette and method of use |
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| JPN6012063291; Ｇｅｎｏｍｅ Ｒｅｓｅａｒｃｈ ｖｏｌ．１６, 200601, ｐｐ．１-１０ * |
| JPN6012063294; 'Ｃｏｍｐｒｅｈｅｎｓｉｖｅ ａｎａｌｙｓｉｓ ｏｆ ｔｒａｎｓｃｒｉｐｔｉｏｎａｌ ｐｒｏｍｏｔｅｒ ｓｔｒｕｃｔｕｒｅ ａｎｄ ｆｕｎｃｔｉｏｎ ｉｎ １％ ｏｆ ｔｈｅ ｈｕｍａｎ ｇｅｎｏｍｅ' Ｇｅｎｏｍｅ Ｒｅｓｅａｒｃｈ Ｓｕｐｐｌｅｍｅｎｔａｌ Ｒｅｓｅａｒｃｈ Ｄａｔａ , 200601, ｐｐ．１-５ * |
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| EP2082043A1 (en) | 2009-07-29 |
| CN101522899B (zh) | 2012-07-25 |
| KR101421063B1 (ko) | 2014-07-21 |
| WO2008044869A1 (en) | 2008-04-17 |
| EP2261360B1 (en) | 2014-04-23 |
| US8105575B2 (en) | 2012-01-31 |
| JP5760023B2 (ja) | 2015-08-05 |
| EP2261360A1 (en) | 2010-12-15 |
| EP2082043A4 (en) | 2010-03-24 |
| KR20090092755A (ko) | 2009-09-01 |
| JP2013143947A (ja) | 2013-07-25 |
| CN101522899A (zh) | 2009-09-02 |
| US20080153770A1 (en) | 2008-06-26 |
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