JP2010504909A - 長期持続性の医薬製剤 - Google Patents

長期持続性の医薬製剤 Download PDF

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JP2010504909A
JP2010504909A JP2009528264A JP2009528264A JP2010504909A JP 2010504909 A JP2010504909 A JP 2010504909A JP 2009528264 A JP2009528264 A JP 2009528264A JP 2009528264 A JP2009528264 A JP 2009528264A JP 2010504909 A JP2010504909 A JP 2010504909A
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vector
formulation
nucleic acid
organ
micro
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JP2010504909A5 (https=
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パールマン,アンドリュー・エル
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メドジェニクス・メディカル・イスラエル・リミテッド
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    • C12N2710/10343Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
JP2009528264A 2006-09-14 2007-09-12 長期持続性の医薬製剤 Pending JP2010504909A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84435106P 2006-09-14 2006-09-14
PCT/US2007/019774 WO2008033375A2 (en) 2006-09-14 2007-09-12 Long lasting drug formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014168085A Division JP6039617B2 (ja) 2006-09-14 2014-08-21 長期持続性の医薬製剤

Publications (2)

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JP2010504909A true JP2010504909A (ja) 2010-02-18
JP2010504909A5 JP2010504909A5 (https=) 2010-08-05

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009528264A Pending JP2010504909A (ja) 2006-09-14 2007-09-12 長期持続性の医薬製剤
JP2014168085A Expired - Fee Related JP6039617B2 (ja) 2006-09-14 2014-08-21 長期持続性の医薬製剤
JP2016216033A Pending JP2017048231A (ja) 2006-09-14 2016-11-04 長期持続性の医薬製剤

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JP2014168085A Expired - Fee Related JP6039617B2 (ja) 2006-09-14 2014-08-21 長期持続性の医薬製剤
JP2016216033A Pending JP2017048231A (ja) 2006-09-14 2016-11-04 長期持続性の医薬製剤

Country Status (9)

Country Link
US (3) US9155749B2 (https=)
EP (1) EP2061515A4 (https=)
JP (3) JP2010504909A (https=)
KR (2) KR101470472B1 (https=)
CN (2) CN102886052B (https=)
AU (1) AU2007294858B2 (https=)
CA (1) CA2664318C (https=)
IL (3) IL197557A (https=)
WO (1) WO2008033375A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013532152A (ja) * 2010-06-15 2013-08-15 メドジェニクス・メディカル・イスラエル・リミテッド 長期持続性の医薬製剤
JP2015520161A (ja) * 2012-05-18 2015-07-16 ユニバーシティー オブ アイオワ リサーチ ファウンデーション アミロイドの沈着を処置するための方法および組成物
JP2019205473A (ja) * 2015-05-28 2019-12-05 コーネル ユニヴァーシティー 血管性浮腫の治療としてのc1eiのアデノ随伴ウイルス介在性送達

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468242B2 (en) 2001-11-05 2008-12-23 Medgenics, Inc. Dermal micro organs, methods and apparatuses for producing and using the same
US8501396B2 (en) 2001-11-05 2013-08-06 Medgenics Medical Israel Ltd. Dermal micro-organs, methods and apparatuses for producing and using the same
HRP20120673T1 (hr) 2003-05-01 2012-10-31 Medgenics, Inc. Uporaba dermalnih mikroorgana
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
CN102886052B (zh) 2006-09-14 2014-07-30 迈德詹尼克斯医疗以色列有限公司 长效药物制剂
US20130171107A1 (en) * 2006-09-14 2013-07-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
EP2446034A4 (en) * 2009-06-22 2013-11-27 Ipca Lab Ltd NEW POLYNUCLEOTIDE MOLECULES FOR IMPROVED GENE EXPRESSION
WO2013069016A2 (en) * 2011-11-09 2013-05-16 Medgenics Medical Israel Ltd. Long lasting drug formulations
US20160122713A1 (en) * 2014-10-14 2016-05-05 Medgenics Medical Israel Ltd. Genetically-modified micro-organ secreting a therapeutic peptide and methods of use thereof
US20190030128A1 (en) * 2016-01-11 2019-01-31 Medgenics Medical Israel Ltd. Compositions and Methods for Treatment of Central Nervous System Diseases
JP7674628B2 (ja) 2016-02-19 2025-05-12 イーアイティー・ファーマ・インコーポレイテッド インターフェロンラムダによるデルタ型肝炎ウイルス感染の処置
US20190142901A1 (en) * 2017-11-16 2019-05-16 Claresa Levetan Compositions and methods for treating or preventing type 1 diabetes using a biologic response modifier in combination with one or more islet or beta cell regeneration or replacement therapies
CN111118016B (zh) * 2018-10-30 2022-04-15 上海朗昇生物科技有限公司 治疗视网膜色素变性疾病的基因治疗载体

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63185396A (ja) * 1986-09-15 1988-07-30 インテグレイテッド ジェネティックス,インコーポレイテッド 組換ヒトエリスロポエチン(epo)
JP2001502540A (ja) * 1996-10-18 2001-02-27 カンジ,インコーポレイテッド インターフェロン―α核酸の送達および発現のための方法および組成物
WO2004099363A2 (en) * 2003-05-01 2004-11-18 Medgenics Inc. Dermal micro organs, methods and apparatuses for producing and using the same
JP2005511709A (ja) * 2001-11-05 2005-04-28 メドジニックス・インコーポレイテッド 治療組織用の密閉された自動システム、及び治療組織の投与方法
WO2006013103A2 (de) * 2004-08-03 2006-02-09 Geneart Ag Induzierbare genexpression
JP2006506097A (ja) * 2002-11-18 2006-02-23 マキシジェン, インコーポレイテッド インターフェロン−αのポリペプチドおよび結合体

Family Cites Families (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US376511A (en) 1888-01-17 James d
US1516071A (en) * 1921-11-02 1924-11-18 Stanley L Apolant Method of performing skin-grafting operations and surgical instrument used therefor
US3076461A (en) * 1956-12-31 1963-02-05 Meek Cicero Parker Microdermatome
US3470782A (en) * 1966-01-03 1969-10-07 Eric O Acker Slitting machine
US3613242A (en) * 1966-12-29 1971-10-19 Michigan Research Corp Skin graft cutter
CA992255A (en) * 1971-01-25 1976-07-06 Cutter Laboratories Prosthesis for spinal repair
DE7235643U (de) * 1972-09-28 1974-06-27 Fischer A Hüftgelenkkopfprothese
US4115346A (en) * 1974-02-12 1978-09-19 Kulzer & Co. Gmbh Hydroxy group containing diesters of acrylic acids and their use in dental material
US4043343A (en) * 1975-08-01 1977-08-23 Williams Robert W Forceps
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
DE2939057C3 (de) 1979-09-27 1982-02-25 Aesculap-Werke Ag Vormals Jetter & Scheerer, 7200 Tuttlingen Schneidvorrichtung zum Einbringen von Schnitten in die Haut
SE420009B (sv) * 1979-12-21 1981-09-07 Ericsson Telefon Ab L M Expanderskruv for fastsettning i en halighet
US4369788A (en) * 1980-01-31 1983-01-25 Goald Harold J Reversed forceps for microdisc surgery
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
DE3247387C2 (de) * 1982-12-22 1984-11-22 Rolf Prof. Dr.med. 7400 Tübingen Hettich Verfahren zur Herstellung eines Transplantats und Vorrichtung zur Durchführung des Verfahrens
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
DE3432897C2 (de) 1984-09-07 1986-07-03 Aesculap-Werke Ag Vormals Jetter & Scheerer, 7200 Tuttlingen Hautnetz-Dermatom
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JPS61233694A (ja) 1985-04-08 1986-10-17 Morinaga & Co Ltd ウシ脾臓中に含まれる成長因子及びその単離方法
US4667016A (en) * 1985-06-20 1987-05-19 Kirin-Amgen, Inc. Erythropoietin purification
US4966849A (en) * 1985-09-20 1990-10-30 President And Fellows Of Harvard College CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
EP0260032B1 (en) 1986-09-08 1994-01-26 Ajinomoto Co., Inc. Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
US5804178A (en) 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US4883666A (en) * 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
DE3854823T2 (de) 1987-05-01 1996-05-23 Stratagene Inc Mutagenesetest durch Verwendung von nicht menschlichen Lebewesen, die Test-DNS-Sequenzen enthalten
US4951684A (en) * 1987-05-15 1990-08-28 Syntex (U.S.A.) Inc. Device for collecting biological material
JPS63185396U (https=) 1987-05-21 1988-11-29
US5175385A (en) 1987-09-03 1992-12-29 Ohio University/Edison Animal Biotechnolgy Center Virus-resistant transgenic mice
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
ATE151467T1 (de) 1987-11-30 1997-04-15 Univ Iowa Res Found Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene
US5024841A (en) 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5221778A (en) 1988-08-24 1993-06-22 Yale University Multiplex gene regulation
CA2000181A1 (en) 1988-10-14 1990-04-14 Chung-Faye Chao Process for producing cultured epidermal sheet, product and method of use
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5175383A (en) 1989-02-17 1992-12-29 President And Fellows Of Harvard College Animal model for benign prostatic disease
US5256775A (en) 1989-06-05 1993-10-26 Gilead Sciences, Inc. Exonuclease-resistant oligonucleotides
US5043711A (en) 1989-06-09 1991-08-27 Xerox Corporation Representation of polygons defined by non-zero winding numbers
US4973301A (en) * 1989-07-11 1990-11-27 Israel Nissenkorn Catheter and method of using same
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5012841A (en) * 1989-08-24 1991-05-07 Keystone International Holdings Corp. Pressure reducing and conditioning valves
JPH0390237A (ja) 1989-08-31 1991-04-16 Matsutani Seisakusho Co Ltd アイレス縫合針の加工方法
DE3936703A1 (de) * 1989-11-03 1991-05-08 Lutz Biedermann Knochenschraube
US5059193A (en) * 1989-11-20 1991-10-22 Spine-Tech, Inc. Expandable spinal implant and surgical method
CH680564A5 (https=) * 1989-12-07 1992-09-30 Experimentelle Chirurgie Schwe
US5623065A (en) 1990-08-13 1997-04-22 Isis Pharmaceuticals, Inc. Gapped 2' modified oligonucleotides
DE4104092A1 (de) 1990-02-13 1991-08-14 Christoph Dr Med Rieger Von einem flexiblen kunststoffschlauch ueberzogene metallkanuele
US5220007A (en) 1990-02-15 1993-06-15 The Worcester Foundation For Experimental Biology Method of site-specific alteration of RNA and production of encoded polypeptides
US5149797A (en) 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
RU2135191C1 (ru) * 1990-04-24 1999-08-27 Ортек Интернэшнл, Инк. Композиционный эквивалент живой кожи, способ его получения, тест-набор
ES2217250T3 (es) 1990-06-15 2004-11-01 Scios Inc. Mamifero transgenico, no humano que muestra la patologia de formacion amiloides de la enfermedad de alzheimer.
US5236445A (en) * 1990-07-02 1993-08-17 American Cyanamid Company Expandable bone anchor and method of anchoring a suture to a bone
US5725529A (en) * 1990-09-25 1998-03-10 Innovasive Devices, Inc. Bone fastener
EP0557306B1 (en) * 1990-09-25 1998-12-23 Innovasive Devices, Inc. Bone fastener
US5288846A (en) 1990-10-19 1994-02-22 The General Hospital Corporation Cell specific gene regulators
US5720753A (en) * 1991-03-22 1998-02-24 United States Surgical Corporation Orthopedic fastener
ATE156344T1 (de) 1991-04-25 1997-08-15 Univ Brown Res Found Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
JP2576302B2 (ja) * 1991-04-26 1997-01-29 ヤマハ株式会社 楽音合成装置
GB9112898D0 (en) * 1991-06-14 1991-07-31 Digital Equipment Int Communication networks
DE69231250T2 (de) * 1991-10-21 2001-03-15 Cell Genesys, Inc. Kombinierte zelluläre und immunsuppressive therapien
US5298422A (en) 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
US5700922A (en) 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
AU671093B2 (en) 1992-01-07 1996-08-15 Elan Pharmaceuticals, Inc. Transgenic animal models for alzheimer's disease
US5360735A (en) 1992-01-08 1994-11-01 Synaptic Pharmaceutical Corporation DNA encoding a human 5-HT1F receptor, vectors, and host cells
US5958764A (en) * 1992-04-30 1999-09-28 Baylor College Of Medicine Specific expression vectors and methods of use
WO1993022430A1 (en) 1992-04-30 1993-11-11 Baylor College Of Medicine Development of a vector to target gene expression to the epidermis of transgenic animals
JP2660641B2 (ja) * 1992-07-22 1997-10-08 株式会社東洋設計 ロール混練機の材料巻込み機構
US5652355A (en) 1992-07-23 1997-07-29 Worcester Foundation For Experimental Biology Hybrid oligonucleotide phosphorothioates
EP0663952A4 (en) 1992-09-11 1997-06-11 Univ California Transgenic non-human animals having targeted lymphocyte transduction genes.
US5888720A (en) * 1992-10-27 1999-03-30 Yissum Research And Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs
US5423330A (en) * 1993-03-10 1995-06-13 The University Of Miami Capsule suction punch instrument and method of use
JPH09501065A (ja) 1993-03-16 1997-02-04 フォトジェネシス インコーポレイテッド 渦巻き状移植片の調製および移植法並びにそのための外科用機器
WO1994023049A2 (en) 1993-04-02 1994-10-13 The Johns Hopkins University The introduction and expression of large genomic sequences in transgenic animals
US6664107B1 (en) 1993-05-26 2003-12-16 Ontario Cancer Institute, University Health Network CD45 disrupted nucleic acid
US5423850A (en) * 1993-10-01 1995-06-13 Berger; J. Lee Balloon compressor for internal fixation of bone fractures
US5480400A (en) * 1993-10-01 1996-01-02 Berger; J. Lee Method and device for internal fixation of bone fractures
DE733059T1 (de) 1993-12-09 1997-08-28 Univ Jefferson Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen
JP3333211B2 (ja) * 1994-01-26 2002-10-15 レイリー,マーク・エイ 骨の治療に関する外科的方法で使用される、改良に係る拡張可能な装置
US6248110B1 (en) * 1994-01-26 2001-06-19 Kyphon, Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
US5477862A (en) * 1994-03-14 1995-12-26 Haaga; John R. Cutting tip for biopsy needle
US6485721B1 (en) * 1994-04-25 2002-11-26 Research Development Corporation Of Japan Biologically active substance-secreting hybrid gel
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US5622866A (en) * 1994-06-23 1997-04-22 Merck & Co., Inc. Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces
US5693064A (en) 1994-11-04 1997-12-02 Arnold; James E. Dermal punch for hair transplantation and methods
US20030157074A1 (en) * 1994-11-16 2003-08-21 Mitrani Eduardo N. Vitro micro-organs, and uses related thereto
US6472200B1 (en) 1999-07-23 2002-10-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Device and method for performing a biological modification of a fluid
WO2003035851A1 (en) 2001-10-23 2003-05-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
JP3091113B2 (ja) 1994-11-22 2000-09-25 科学技術振興事業団 生理活性物質分泌性のハイブリッド型ゲル
US5782851A (en) * 1996-04-10 1998-07-21 Rassman; William R. Hair transplantation system
US5652256A (en) 1995-06-06 1997-07-29 Knowles; W. Roy Topical composition for fungal treatment
US5985653A (en) * 1995-06-07 1999-11-16 Aastrom Biosciences, Inc. Incubator apparatus for use in a system for maintaining and growing biological cells
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US5591444A (en) 1995-07-28 1997-01-07 Isolagen Technologies, Inc. Use of autologous dermal fibroblasts for the repair of skin and soft tissue defects
CA2230263A1 (en) 1995-08-25 1997-03-06 Lifecell Corporation Reconstituted skin
US5857982A (en) * 1995-09-08 1999-01-12 United States Surgical Corporation Apparatus and method for removing tissue
US6090618A (en) 1996-10-07 2000-07-18 Arch Development Corporation DNA constructs and viral vectors comprising a smooth muscle promoter
US5782830A (en) * 1995-10-16 1998-07-21 Sdgi Holdings, Inc. Implant insertion device
JP3452366B2 (ja) 1995-10-20 2003-09-29 トランスティッシュウ テクノロジーズ ゲーエムベーハー 新規人工組織、その製法およびその使用
US6071284A (en) * 1995-10-30 2000-06-06 Biomedical Enterprises, Inc. Materials collection system and uses thereof
DE19607517C1 (de) * 1996-02-28 1997-04-10 Lutz Biedermann Knochenschraube
AU722375B2 (en) * 1996-09-06 2000-08-03 Trustees Of The University Of Pennsylvania, The Methods using cre-lox for production of recombinant adeno-associated viruses
NL1004276C2 (nl) 1996-10-15 1998-04-20 Willem Marie Ysebaert Werkwijzen voor het vervaardigen van huideilandjes, voor het verplaatsen van huid of huideilandjes, voor het spreiden van huideilandjes en het aanbrengen hiervan op een brandwond, alsmede een houder, snijraam, snijtafel, contradrager, klemorgaan, membraan, transportorgaan en spreidingsorgaan om te worden toegepast voor dergelijke werkwijzen.
CA2279996A1 (en) 1997-01-16 1998-07-16 Yissum Research Development Company Of The Hebrew University In Jerusale M A device and method for performing a biological modification of a fluid
US5817120A (en) 1997-02-10 1998-10-06 Rassman; William R. Hair implanting instrument
US6486133B1 (en) 1997-03-07 2002-11-26 The Wistar Institute Of Anatomy And Biology Methods for inducing localized vascular development and enhancing the repair of a wound in the mammamian dermis
US6110459A (en) 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
US5972015A (en) * 1997-08-15 1999-10-26 Kyphon Inc. Expandable, asymetric structures for deployment in interior body regions
US6171812B1 (en) 1997-07-15 2001-01-09 The National Institute Of Biogerontology, Inc. Combined perfusion and mechanical loading system for explanted bone
JP2001511462A (ja) 1997-07-31 2001-08-14 セント エリザベス メディカル センター オブ ボストン インク. 移植片処置法
GB9716198D0 (en) 1997-07-31 1997-10-08 Plessey Telecomm RAP routeing for ISO 10589
CN1275050A (zh) 1997-08-15 2000-11-29 路德维格癌症研究所 内皮蛋白酶解活性和/或血管生成活性的刺激、调节和/或抑制
EP1014859A4 (en) 1997-08-19 2007-05-02 Philipp Lang MEASUREMENT OF INTERSTITIAL CAPILLARY FLUID BY MEANS OF ULTRASONIC METHOD AND DEVICES
JP3059127B2 (ja) 1997-09-02 2000-07-04 藤村 昭夫 組織工学を応用した人工臓器
US20040019923A1 (en) * 1997-10-16 2004-01-29 Ivarie Robert D. Exogenous proteins expressed in avians and their eggs
AU1114699A (en) 1997-10-24 1999-05-17 Children's Medical Center Corporation Methods for promoting cell transfection (in vivo)
US7687057B2 (en) * 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US6533807B2 (en) 1998-02-05 2003-03-18 Medtronic, Inc. Radially-expandable stent and delivery system
AU6664998A (en) 1998-02-24 1999-09-15 Gerigene Medical Corporation Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects
US6331166B1 (en) * 1998-03-03 2001-12-18 Senorx, Inc. Breast biopsy system and method
DE69903800T2 (de) * 1998-03-18 2003-10-02 Massachusetts Institute Of Technology, Cambridge Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
CA2323604A1 (en) * 1998-03-19 1999-09-23 Valentis, Inc. Interferon alpha plasmids and delivery systems, and methods of making and using the same
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US5944673A (en) * 1998-05-14 1999-08-31 Ethicon Endo-Surgery, Inc. Biopsy instrument with multi-port needle
US6027512A (en) 1998-05-28 2000-02-22 Bridges; Ronzee M. Hair follicle harvesting device
EP1110113A4 (en) 1998-06-29 2005-03-09 Univ Syracuse Method of fabricating a cylindrical optical fiber containing an optically active film
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
AU5690799A (en) 1998-08-25 2000-03-14 Avigenics, Inc. Direct oviduct transgenesis
WO2000047720A2 (en) 1999-02-10 2000-08-17 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
US6264659B1 (en) * 1999-02-22 2001-07-24 Anthony C. Ross Method of treating an intervertebral disk
US6245101B1 (en) * 1999-05-03 2001-06-12 William J. Drasler Intravascular hinge stent
RU2262510C9 (ru) 1999-05-19 2006-04-20 Лексиген Фармасьютикэлс Корп. Слитый белок, обладающий биологической активностью интерферона-альфа, димерный слитый белок, фармацевтическая композиция, их содержащая, молекула днк (варианты) и способ адресования интерферона-альфа в ткани печени
US20030152562A1 (en) * 2001-10-23 2003-08-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Vitro micro-organs, and uses related thereto
US20060127366A1 (en) 1999-06-25 2006-06-15 Mitrani Eduardo N Method and device for inducing biological processes by micro-organs
JP2003535025A (ja) * 1999-06-25 2003-11-25 イッサム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム 微小器官で血管新生を誘発する方法
US20030129736A1 (en) 1999-07-15 2003-07-10 Eduardo Mitrani Device and method for performing a biological modification of a fluid
CA2379663A1 (en) 1999-07-28 2001-02-08 Jamie M. Grooms Cartilage or bone matrix as a nucleic acid delivery vehicle
JP2005098702A (ja) 1999-10-07 2005-04-14 Seitai Kagaku Kenkyusho:Kk 生物組織試料作製方法および器具
EP1237582B1 (en) * 1999-12-10 2011-09-14 AntiCancer, Inc. Methods for introducing genes into mammalian subjects
WO2001042796A1 (en) 1999-12-13 2001-06-14 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health High-throughput tissue microarray technology and applications
US6893462B2 (en) 2000-01-11 2005-05-17 Regeneration Technologies, Inc. Soft and calcified tissue implants
CA2399224A1 (en) 2000-02-18 2001-08-23 Regeneration Technologies, Inc. Implantable tissues infused with growth factors and other additives
WO2001071018A2 (en) * 2000-03-22 2001-09-27 Board Of Trustees Of The University Of Arkansas Secreting products from skin by adeno-associated virus (aav) gene transfer
US20020154114A1 (en) * 2000-11-30 2002-10-24 Christensen Thomas Kragh Method and system for customising build-to-order products
ES2184623B1 (es) 2001-06-29 2004-09-16 Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas (C.I.E.M.A.T.) Piel artificial autologa secretora de leptina y metodo de obtencion.
WO2003006669A2 (en) * 2001-07-09 2003-01-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Efficient methods for assessing and validating candidate protein-based therapeutic molecules encoded by nucleic acid sequences of interest
AU2002325758A1 (en) * 2001-09-20 2003-04-01 Centre For Translational Research In Cancer Cultured stromal cells and uses thereof
JP2005506084A (ja) 2001-10-23 2005-03-03 イッサム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム インビトロにおけるマイクロ器官、およびそれに関する用途
US7468242B2 (en) * 2001-11-05 2008-12-23 Medgenics, Inc. Dermal micro organs, methods and apparatuses for producing and using the same
DK2298301T3 (en) 2001-12-06 2018-10-01 Fibrogen Inc MEDICINALS FOR TREATMENT OF ANEMIA ASSOCIATED WITH Kidney Disease
JP3806900B2 (ja) 2001-12-11 2006-08-09 独立行政法人産業技術総合研究所 育毛剤
US7297540B2 (en) 2002-01-15 2007-11-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
US7666134B2 (en) 2002-09-28 2010-02-23 Kci Licensing, Inc. System and method for transplantation of dermal tissue
US20040091961A1 (en) * 2002-11-08 2004-05-13 Evans Glen A. Enhanced variants of erythropoietin and methods of use
US7708746B2 (en) 2003-02-27 2010-05-04 Wright Medical Technology, Inc. Method and apparatus for processing dermal tissue
US7625384B2 (en) * 2003-02-27 2009-12-01 Wright Medical Technology, Inc. Method and apparatus for processing dermal tissue
WO2004078916A2 (en) 2003-03-03 2004-09-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US20050090777A1 (en) * 2003-10-23 2005-04-28 Carter Travis S. Surgical irrigation system
WO2006110843A2 (en) 2005-04-12 2006-10-19 Applied Tissue Technologies Llc Engineered deremal tissue particles and transplantation methods
US7785339B2 (en) 2005-08-09 2010-08-31 Innovia, Llc Tool for coring portions of one or more hair follicles
JP4600373B2 (ja) * 2006-09-12 2010-12-15 株式会社デンソー 車両用交流発電機
US8454948B2 (en) * 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
CN102886052B (zh) * 2006-09-14 2014-07-30 迈德詹尼克斯医疗以色列有限公司 长效药物制剂
CA2802726A1 (en) * 2010-06-15 2011-12-22 Medgenics Medical Israel Ltd. Long lasting drug formulations

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63185396A (ja) * 1986-09-15 1988-07-30 インテグレイテッド ジェネティックス,インコーポレイテッド 組換ヒトエリスロポエチン(epo)
JP2001502540A (ja) * 1996-10-18 2001-02-27 カンジ,インコーポレイテッド インターフェロン―α核酸の送達および発現のための方法および組成物
JP2005511709A (ja) * 2001-11-05 2005-04-28 メドジニックス・インコーポレイテッド 治療組織用の密閉された自動システム、及び治療組織の投与方法
JP2006506097A (ja) * 2002-11-18 2006-02-23 マキシジェン, インコーポレイテッド インターフェロン−αのポリペプチドおよび結合体
WO2004099363A2 (en) * 2003-05-01 2004-11-18 Medgenics Inc. Dermal micro organs, methods and apparatuses for producing and using the same
WO2006013103A2 (de) * 2004-08-03 2006-02-09 Geneart Ag Induzierbare genexpression

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
JPN6012033413; 大井一輝 外1名: '臨床経験 "保存期糖尿病性腎不全に対するrecombinant human erythropoietin (rEPO) の投与経験"' 治療 Vol.73,No.6, 199106, P.1251-1257 *
JPN6012033414; 平方秀樹: '特集/慢性腎不全-初期から末期まで "末期腎不全の病態と治療方針 貧血治療の適応と目標"' 臨牀と研究 Vol.76,No.8, 199908, P.1551-1558 *
JPN6012033415; 日野一成 外9名: '"ウイルス肝炎に対するインターフェロンalpha-2b療法 -日米欧間の比較-"' 川崎医会誌 Vol.18,No.3, 1992, P.157-161 *
JPN6012033416; 中原紀元 外1名: '解説 "インターフェロンによる遺伝子治療"' 綜合臨牀 Vol.52,No.9, 200309, P.2514-2521 *
JPN6013030713; 三谷幸之介: '新しい遺伝子治療"ヘルパー依存型アデノウイルスベクター -免疫原性が低く36k塩基対までDNAを導入' 医学のあゆみ Vol.203,No.5, 20021102, P.379-383, 医歯薬出版 *
JPN6013030717; 木脇弘二 外1名: '遺伝子治療の理論"オルニチントランスカルバミラーゼ欠損症の遺伝子治療"' 医学のあゆみ Vol.175,No.9, 19951202, P.655-659, 医歯薬出版 *
JPN6013030719; 斎藤泉: '"2. アデノウイルス・ベクター"' ウイルス Vol.44,No.1, 199406, P.100-104, 日本ウイルス学会 *
JPN6013030722; Kim,C.H. et al.: 'Codon optimization for high-level expression of human erythropoietin(EPO) in mammalian cells' GENE Vol.199,No.1-2, 19971015, P.293-301 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013532152A (ja) * 2010-06-15 2013-08-15 メドジェニクス・メディカル・イスラエル・リミテッド 長期持続性の医薬製剤
JP2015520161A (ja) * 2012-05-18 2015-07-16 ユニバーシティー オブ アイオワ リサーチ ファウンデーション アミロイドの沈着を処置するための方法および組成物
JP2019205473A (ja) * 2015-05-28 2019-12-05 コーネル ユニヴァーシティー 血管性浮腫の治療としてのc1eiのアデノ随伴ウイルス介在性送達
JP2022091764A (ja) * 2015-05-28 2022-06-21 コーネル ユニヴァーシティー 血管性浮腫の治療としてのc1eiのアデノ随伴ウイルス介在性送達
JP7321513B2 (ja) 2015-05-28 2023-08-07 コーネル ユニヴァーシティー 血管性浮腫の治療としてのc1eiのアデノ随伴ウイルス介在性送達
JP7417303B2 (ja) 2015-05-28 2024-01-18 コーネル ユニヴァーシティー 血管性浮腫の治療としてのc1eiのアデノ随伴ウイルス介在性送達

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