JP2010500353A5 - - Google Patents

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Publication number
JP2010500353A5
JP2010500353A5 JP2009523806A JP2009523806A JP2010500353A5 JP 2010500353 A5 JP2010500353 A5 JP 2010500353A5 JP 2009523806 A JP2009523806 A JP 2009523806A JP 2009523806 A JP2009523806 A JP 2009523806A JP 2010500353 A5 JP2010500353 A5 JP 2010500353A5
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JP
Japan
Prior art keywords
ring
aliphatic
hydrogen
optionally substituted
compound
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JP2009523806A
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English (en)
Japanese (ja)
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JP2010500353A (ja
JP5274460B2 (ja
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Priority claimed from PCT/US2007/017463 external-priority patent/WO2008019124A1/en
Publication of JP2010500353A publication Critical patent/JP2010500353A/ja
Publication of JP2010500353A5 publication Critical patent/JP2010500353A5/ja
Application granted granted Critical
Publication of JP5274460B2 publication Critical patent/JP5274460B2/ja
Expired - Fee Related legal-status Critical Current
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JP2009523806A 2006-08-08 2007-08-06 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 Expired - Fee Related JP5274460B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83615806P 2006-08-08 2006-08-08
US60/836,158 2006-08-08
PCT/US2007/017463 WO2008019124A1 (en) 2006-08-08 2007-08-06 Heteroaryl compounds useful as inhibitors of e1 activating enzymes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013039252A Division JP2013100368A (ja) 2006-08-08 2013-02-28 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物

Publications (3)

Publication Number Publication Date
JP2010500353A JP2010500353A (ja) 2010-01-07
JP2010500353A5 true JP2010500353A5 (https=) 2010-09-24
JP5274460B2 JP5274460B2 (ja) 2013-08-28

Family

ID=38669274

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009523806A Expired - Fee Related JP5274460B2 (ja) 2006-08-08 2007-08-06 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2013039252A Withdrawn JP2013100368A (ja) 2006-08-08 2013-02-28 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2014214207A Active JP5906297B2 (ja) 2006-08-08 2014-10-21 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2016058336A Withdrawn JP2016106157A (ja) 2006-08-08 2016-03-23 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2013039252A Withdrawn JP2013100368A (ja) 2006-08-08 2013-02-28 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2014214207A Active JP5906297B2 (ja) 2006-08-08 2014-10-21 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2016058336A Withdrawn JP2016106157A (ja) 2006-08-08 2016-03-23 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物

Country Status (29)

Country Link
EP (1) EP2049491B1 (https=)
JP (4) JP5274460B2 (https=)
KR (3) KR101555258B1 (https=)
CN (2) CN101516850B (https=)
AR (1) AR062270A1 (https=)
AT (1) ATE485276T1 (https=)
AU (1) AU2007281993B2 (https=)
BR (1) BRPI0715176A8 (https=)
CA (1) CA2659894C (https=)
CO (1) CO6150159A2 (https=)
CY (1) CY1111121T1 (https=)
DE (1) DE602007009998D1 (https=)
DK (1) DK2049491T3 (https=)
EA (2) EA024793B1 (https=)
ES (1) ES2354925T3 (https=)
HR (1) HRP20110017T1 (https=)
IL (4) IL196845A (https=)
ME (1) ME02789B (https=)
MX (1) MX2009001309A (https=)
MY (1) MY157177A (https=)
NO (1) NO20090434L (https=)
NZ (1) NZ574513A (https=)
PL (1) PL2049491T3 (https=)
PT (1) PT2049491E (https=)
RS (1) RS51549B (https=)
SI (1) SI2049491T1 (https=)
TW (2) TWI472516B (https=)
WO (1) WO2008019124A1 (https=)
ZA (1) ZA200900670B (https=)

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ES2665277T3 (es) 2009-03-13 2018-04-25 Katholieke Universiteit Leuven K.U. Leuven R&D Análogos de purina y su uso como agentes inmunosupresores
EP2430026A1 (en) 2009-05-14 2012-03-21 Millennium Pharmaceuticals, Inc. Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate
CA2793024A1 (en) * 2010-03-17 2011-09-22 F. Hoffmann-La Roche Ag Imidazopyridine compounds, compositions and methods of use
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
US8815881B2 (en) 2010-08-09 2014-08-26 Hoffmann-La Roche Inc. 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
JP6038150B2 (ja) * 2011-08-24 2016-12-07 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｎｅｄｄ８活性化酵素阻害剤
WO2013052814A2 (en) * 2011-10-07 2013-04-11 Millennium Pharmaceuticals, Inc. E1 enzyme mutants and uses thereof
EP2771489B1 (en) 2011-10-28 2018-07-04 Millennium Pharmaceuticals, Inc. Biomarkers of response to nae inhibitors
MY176125A (en) * 2011-11-03 2020-07-24 Takeda Pharmaceuticals Co Administration of nedd8-activating enzyme inhibitor and hypomethylating agent
UA117095C2 (uk) 2011-12-22 2018-06-25 Аліос Біофарма, Інк. Нуклеозидна сполука або її фармацевтично прийнятна сіль
EP2814791A4 (en) 2012-02-17 2015-08-19 Millennium Pharm Inc PYRAZOLOPYRIMIDINYL INHIBITORS OF ACTIVATION ENZYME OF UBIQUITIN
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP2674432A1 (en) 2012-06-14 2013-12-18 LEK Pharmaceuticals d.d. New synthetic route for the preparation of ß aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]pyrazin-7-yl compounds
WO2014055543A2 (en) 2012-10-01 2014-04-10 Millennium Pharmaceuticals, Inc. Biomarkers and methods to predict response to inhibitors and uses thereof
WO2014075392A1 (en) * 2012-11-16 2014-05-22 Merck Sharp & Dohme Corp. Purine inhibitors of human phosphatidylinositol 3-kinase delta
EP2764866A1 (en) * 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
CA2923752A1 (en) 2013-05-14 2014-11-20 Millennium Pharmaceuticals, Inc. Administration of nedd8-activating enzyme inhibitor and chemotherapeutic agents
JP6378759B2 (ja) * 2013-07-02 2018-08-22 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｓｕｍｏ活性化酵素阻害剤として有用なヘテロアリール化合物
US9334273B1 (en) 2014-03-05 2016-05-10 University Of Georgia Research Foundation, Inc. Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA)
SG11201610476VA (en) * 2014-07-01 2017-01-27 Millennium Pharm Inc Heteroaryl compounds useful as inhibitors of sumo activating enzyme
CN105085279A (zh) * 2015-08-26 2015-11-25 吴玲 制备r-5-氯-1-氨基茚满
CN105111091A (zh) * 2015-08-26 2015-12-02 吴玲 制备s-3-甲基-1-氨基茚满的方法
CN105061220A (zh) * 2015-08-26 2015-11-18 吴玲 一种制备r-3-甲基-1-氨基茚满的方法
CN105130824A (zh) * 2015-08-31 2015-12-09 吴玲 一种制备s-5-溴-1-氨基茚满的方法
WO2019109016A1 (en) 2017-12-01 2019-06-06 Millennium Pharmaceuticals, Inc. Biomarkers and methods for treatment with nae inhibitors
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
AU2020256166A1 (en) 2019-04-02 2021-10-14 Aligos Therapeutics, Inc. Compounds targeting PRMT5
CN110229067A (zh) * 2019-06-05 2019-09-13 南京焕然生物科技有限公司 一种2-氨基茚制备方法
CN112079836B (zh) 2019-06-13 2022-12-13 中国科学院上海药物研究所 三唑并嘧啶类化合物及其盐、组合物和应用
US11540867B2 (en) 2019-08-13 2023-01-03 Pioneer Surgical Technology, Inc. Driver for a bone screw
CN110563655A (zh) * 2019-09-24 2019-12-13 上海毕得医药科技有限公司 一种5-（2-溴乙基）嘧啶的制备方法
CA3164134A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
CN115485025A (zh) * 2020-02-28 2022-12-16 雷密克斯医疗公司 用于调节剪接的化合物和方法
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
WO2023021498A1 (en) * 2021-08-16 2023-02-23 Moya Bio Ltd. Fused azole and furan based nucleoside analogs and uses thereof
CN115124534B (zh) * 2021-11-23 2023-09-15 中山大学 非核苷酸类prmt5小分子抑制剂、制备方法及用途
US20260035382A1 (en) * 2022-09-30 2026-02-05 Wigen Biomedicine Technology (shanghai) Co., Ltd. Compounds as sumo activating enzyme inhibitors
CN120112536A (zh) * 2022-11-11 2025-06-06 微境生物医药科技(上海)有限公司 作为sumo活化酶抑制剂的化合物
CN118812375A (zh) * 2023-04-17 2024-10-22 中国科学院大连化学物理研究所 二芳基硼酸催化环氧化物立体选择性开环的方法
CN119306612B (zh) * 2023-07-14 2026-03-20 中国科学院大连化学物理研究所 一种反式氨基茚满的制备方法

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