JP2010120959A5 - - Google Patents
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- Publication number
- JP2010120959A5 JP2010120959A5 JP2010031733A JP2010031733A JP2010120959A5 JP 2010120959 A5 JP2010120959 A5 JP 2010120959A5 JP 2010031733 A JP2010031733 A JP 2010031733A JP 2010031733 A JP2010031733 A JP 2010031733A JP 2010120959 A5 JP2010120959 A5 JP 2010120959A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- sarpogrelate hydrochloride
- tablet
- manufactured
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229950005789 sarpogrelate Drugs 0.000 claims description 26
- FFYNAVGJSYHHFO-UHFFFAOYSA-N sarpogrelate Chemical compound COC1=CC=CC(CCC=2C(=CC=CC=2)OCC(CN(C)C)OC(=O)CCC(O)=O)=C1 FFYNAVGJSYHHFO-UHFFFAOYSA-N 0.000 claims description 26
- 238000002360 preparation method Methods 0.000 claims description 24
- 239000011248 coating agent Substances 0.000 claims description 20
- 238000000576 coating method Methods 0.000 claims description 20
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- 239000001913 cellulose Substances 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
- 239000008187 granular material Substances 0.000 description 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 12
- 238000004090 dissolution Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 238000000748 compression moulding Methods 0.000 description 6
- 238000005469 granulation Methods 0.000 description 6
- 230000003179 granulation Effects 0.000 description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 229960003511 macrogol Drugs 0.000 description 6
- 235000019359 magnesium stearate Nutrition 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- 239000000454 talc Substances 0.000 description 6
- 229910052623 talc Inorganic materials 0.000 description 6
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229920002785 Croscarmellose sodium Polymers 0.000 description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 5
- 238000013019 agitation Methods 0.000 description 5
- 229960001681 croscarmellose sodium Drugs 0.000 description 5
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000007922 dissolution test Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229950008138 carmellose Drugs 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 229940069328 povidone Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Images
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010031733A JP4901966B2 (ja) | 2005-07-29 | 2010-02-16 | 小型化塩酸サルポグレラート経口投与製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005219766 | 2005-07-29 | ||
| JP2005219766 | 2005-07-29 | ||
| JP2010031733A JP4901966B2 (ja) | 2005-07-29 | 2010-02-16 | 小型化塩酸サルポグレラート経口投与製剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006205560A Division JP4567640B2 (ja) | 2005-07-29 | 2006-07-28 | 小型化塩酸サルポグレラート経口投与製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011241715A Division JP2012056957A (ja) | 2005-07-29 | 2011-11-02 | 小型化塩酸サルポグレラート経口投与製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010120959A JP2010120959A (ja) | 2010-06-03 |
| JP2010120959A5 true JP2010120959A5 (enrdf_load_stackoverflow) | 2012-02-02 |
| JP4901966B2 JP4901966B2 (ja) | 2012-03-21 |
Family
ID=37672642
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010031733A Active JP4901966B2 (ja) | 2005-07-29 | 2010-02-16 | 小型化塩酸サルポグレラート経口投与製剤 |
| JP2011241715A Pending JP2012056957A (ja) | 2005-07-29 | 2011-11-02 | 小型化塩酸サルポグレラート経口投与製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011241715A Pending JP2012056957A (ja) | 2005-07-29 | 2011-11-02 | 小型化塩酸サルポグレラート経口投与製剤 |
Country Status (3)
| Country | Link |
|---|---|
| JP (2) | JP4901966B2 (enrdf_load_stackoverflow) |
| KR (1) | KR101384827B1 (enrdf_load_stackoverflow) |
| CN (1) | CN1903182B (enrdf_load_stackoverflow) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101384827B1 (ko) * | 2005-07-29 | 2014-04-15 | 미쓰비시 타나베 파마 코퍼레이션 | 소형화 염산 사포그릴레이트 경구 투여 제제 |
| KR101320802B1 (ko) * | 2010-02-16 | 2013-10-23 | 주식회사 드림파마 | 방출 제어형 사포그릴레이트 염산염 함유 다층 정제 |
| KR101534606B1 (ko) * | 2011-11-08 | 2015-07-10 | 알보젠코리아 주식회사 | 사포그릴레이트의 안정화된 지속 방출 제제 |
| CN102552165B (zh) * | 2012-01-05 | 2014-07-16 | 金陵药业股份有限公司 | 一种盐酸沙格雷酯缓释微丸及其制备方法 |
| CN105769800B (zh) * | 2014-12-22 | 2018-07-27 | 山东金诃药物研究开发有限公司 | 一种盐酸沙格雷酯片及其制备方法 |
| CN106580909B (zh) * | 2016-12-21 | 2020-08-21 | 天津红日药业股份有限公司 | 一种含有盐酸沙格雷酯固体药物组合物 |
| CN108524462A (zh) * | 2018-06-15 | 2018-09-14 | 天津田边制药有限公司 | 一种盐酸沙格雷酯片剂制备工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4063341B2 (ja) * | 1994-07-06 | 2008-03-19 | メイ株式会社 | 緑内障治療剤及び眼圧降下剤 |
| JP4253371B2 (ja) * | 1998-07-17 | 2009-04-08 | 博道 萩原 | 筋クランプ治療剤 |
| JP2000034228A (ja) | 1998-07-17 | 2000-02-02 | Mitsubishi Chemicals Corp | 頚椎捻挫治療剤 |
| JP2000063270A (ja) * | 1998-08-20 | 2000-02-29 | Mitsubishi Chemicals Corp | 膵炎の予防・治療剤 |
| JP2000219626A (ja) * | 1999-01-29 | 2000-08-08 | Mitsubishi Chemicals Corp | ケロイドおよび／または肥厚性瘢痕の治療剤 |
| JP2000239163A (ja) * | 1999-02-19 | 2000-09-05 | Mitsubishi Chemicals Corp | 腸疾患の治療剤 |
| KR101384827B1 (ko) * | 2005-07-29 | 2014-04-15 | 미쓰비시 타나베 파마 코퍼레이션 | 소형화 염산 사포그릴레이트 경구 투여 제제 |
-
2006
- 2006-07-28 KR KR1020060071188A patent/KR101384827B1/ko active Active
- 2006-07-31 CN CN2006100991777A patent/CN1903182B/zh active Active
-
2010
- 2010-02-16 JP JP2010031733A patent/JP4901966B2/ja active Active
-
2011
- 2011-11-02 JP JP2011241715A patent/JP2012056957A/ja active Pending
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