JP2010115195A5 - - Google Patents
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- JP2010115195A5 JP2010115195A5 JP2009253394A JP2009253394A JP2010115195A5 JP 2010115195 A5 JP2010115195 A5 JP 2010115195A5 JP 2009253394 A JP2009253394 A JP 2009253394A JP 2009253394 A JP2009253394 A JP 2009253394A JP 2010115195 A5 JP2010115195 A5 JP 2010115195A5
- Authority
- JP
- Japan
- Prior art keywords
- mammal
- test sample
- immune response
- detecting
- tissue cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000124008 Mammalia Species 0.000 claims 24
- 210000001519 tissues Anatomy 0.000 claims 18
- 201000010099 disease Diseases 0.000 claims 10
- 230000028993 immune response Effects 0.000 claims 10
- 230000002757 inflammatory Effects 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 102000004965 antibodies Human genes 0.000 claims 8
- 108090001123 antibodies Proteins 0.000 claims 8
- 230000015572 biosynthetic process Effects 0.000 claims 8
- 238000005755 formation reaction Methods 0.000 claims 8
- 230000021633 leukocyte mediated immunity Effects 0.000 claims 4
- 230000001404 mediated Effects 0.000 claims 4
- 206010021425 Immune system disease Diseases 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
Claims (14)
- 哺乳動物の免疫関連疾患の検出方法であって、（ａ）哺乳動物から採取した組織細胞の試験試料中、及び（ｂ）同じ細胞型の既知の正常組織細胞のコントロール試料中における、配列番号１１３６に示すアミノ酸配列を有するポリペプチドをコードする遺伝子の発現レベルを検出することを含み、このときコントロール試料と比較して試験試料中における該遺伝子の発現レベルが高いか又は低いことにより、試験組織細胞が採取された哺乳動物における免疫関連疾患の存在が示される方法。
- 哺乳動物の免疫関連疾患の検出方法であって、（ａ）哺乳動物から採取した組織細胞の試験試料と、配列番号１１３６に示すアミノ酸配列に結合する抗体とを接触させることと、（ｂ）抗体と試験試料中のポリペプチドとの間の複合体の形成を検出することを含み、このとき該複合体の形成により、試験組織細胞が採取された哺乳動物における免疫関連疾患の存在が示される方法。
- 免疫関連疾患がＴ細胞媒介性免疫疾患である、請求項１又は２に記載の方法。
- 哺乳動物の炎症性免疫反応の検出方法であって、（ａ）哺乳動物から採取した組織細胞の試験試料中、及び（ｂ）同じ細胞型の既知の正常組織細胞のコントロール試料中における、配列番号１１３６に示すアミノ酸配列を有するポリペプチドをコードする遺伝子の発現レベルを検出することを含み、このときコントロール試料と比較して試験試料中における該遺伝子の発現レベルが高いか又は低いことにより、試験組織細胞が採取された哺乳動物における炎症性免疫反応の存在が示される方法。
- 哺乳動物の炎症性免疫反応の検出方法であって、（ａ）哺乳動物から採取した組織細胞の試験試料と、配列番号１１３６に示すアミノ酸配列に結合する抗体とを接触させることと、（ｂ）抗体と試験試料中のポリペプチドとの間の複合体の形成を検出することを含み、このとき該複合体の形成により、試験組織細胞が採取された哺乳動物における炎症性免疫反応の存在が示される方法。
- 炎症性免疫反応がＴ細胞媒介性免疫反応である、請求項４又は５に記載の方法。
- Ｔ細胞媒介性免疫反応がＣＤ４５ＲＯ Ｔ細胞媒介性反応である、請求項６に記載の方法。
- 哺乳動物の免疫関連疾患を診断するためのキットであって、（ａ）哺乳動物から採取した組織細胞の試験試料中、及び（ｂ）同じ細胞型の既知の正常組織細胞のコントロール試料中における、配列番号１１３６に示すアミノ酸配列を有するポリペプチドをコードする遺伝子の発現レベルを検出するための手段を具備し、このときコントロール試料と比較して試験試料中における該遺伝子の発現レベルが高いか又は低いことにより、試験組織細胞が採取された哺乳動物における免疫関連疾患の存在が示されるキット。
- 哺乳動物の免疫関連疾患を診断するためのキットであって、（ａ）哺乳動物から採取した組織細胞の試験試料と、配列番号１１３６に示すアミノ酸配列を有するポリペプチドに結合する抗体とを接触させるための手段と、（ｂ）抗体と試験試料中のポリペプチドとの間の複合体の形成を検出するための手段とを具備し、このとき該複合体の形成により、試験組織細胞が採取された哺乳動物における免疫関連疾患の存在が示されるキット。
- 免疫関連疾患がＴ細胞媒介性免疫疾患である、請求項８又は９に記載のキット。
- 哺乳動物の炎症性免疫反応を診断するためのキットであって、（ａ）哺乳動物から採取した組織細胞の試験試料中、及び（ｂ）同じ細胞型の既知の正常組織細胞のコントロール試料中における、配列番号１１３６に示すアミノ酸配列を有するポリペプチドをコードする遺伝子の発現レベルを検出するための手段を具備し、このときコントロール試料と比較して試験試料中における該遺伝子の発現レベルが高いか又は低いことにより、試験組織細胞が採取された哺乳動物における炎症性免疫反応の存在が示されるキット。
- 哺乳動物の炎症性免疫反応を診断するためのキットであって、（ａ）哺乳動物から採取した組織細胞の試験試料と、配列番号１１３６に示すアミノ酸配列を有するポリペプチドに結合する抗体とを接触させるための手段と、（ｂ）抗体と試験試料中のポリペプチドとの間の複合体の形成を検出するための手段とを具備し、このとき該複合体の形成により、試験組織細胞が採取された哺乳動物における炎症性免疫反応の存在が示されるキット。
- 炎症性免疫反応がＴ細胞媒介性免疫反応である、請求項１１又は１２に記載のキット。
- Ｔ細胞媒介性免疫反応がＣＤ４５ＲＯ Ｔ細胞媒介性反応である、請求項１３に記載のキット。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42247202P | 2002-10-29 | 2002-10-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004548574A Division JP2006517785A (ja) | 2002-10-29 | 2003-10-28 | 免疫関連疾患の治療のための新規組成物と方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012187148A Division JP2012254093A (ja) | 2002-10-29 | 2012-08-28 | 免疫関連疾患の治療のための新規組成物と方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010115195A JP2010115195A (ja) | 2010-05-27 |
| JP2010115195A5 true JP2010115195A5 (ja) | 2011-04-14 |
Family
ID=32230357
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004548574A Pending JP2006517785A (ja) | 2002-10-29 | 2003-10-28 | 免疫関連疾患の治療のための新規組成物と方法 |
| JP2009253394A Pending JP2010115195A (ja) | 2002-10-29 | 2009-11-04 | 免疫関連疾患の治療のための新規組成物と方法 |
| JP2012187148A Pending JP2012254093A (ja) | 2002-10-29 | 2012-08-28 | 免疫関連疾患の治療のための新規組成物と方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004548574A Pending JP2006517785A (ja) | 2002-10-29 | 2003-10-28 | 免疫関連疾患の治療のための新規組成物と方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012187148A Pending JP2012254093A (ja) | 2002-10-29 | 2012-08-28 | 免疫関連疾患の治療のための新規組成物と方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20070185017A1 (ja) |
| EP (5) | EP2322200A3 (ja) |
| JP (3) | JP2006517785A (ja) |
| AU (2) | AU2003298607B9 (ja) |
| CA (1) | CA2503330A1 (ja) |
| WO (1) | WO2004039956A2 (ja) |
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-
2003
- 2003-10-28 EP EP10195510A patent/EP2322200A3/en not_active Ceased
- 2003-10-28 EP EP10195513A patent/EP2322202A3/en not_active Ceased
- 2003-10-28 US US10/533,069 patent/US20070185017A1/en not_active Abandoned
- 2003-10-28 EP EP10195512A patent/EP2322201A3/en not_active Ceased
- 2003-10-28 EP EP03796358A patent/EP1576137A4/en not_active Withdrawn
- 2003-10-28 EP EP10195515A patent/EP2322203A3/en not_active Ceased
- 2003-10-28 AU AU2003298607A patent/AU2003298607B9/en not_active Ceased
- 2003-10-28 WO PCT/US2003/034381 patent/WO2004039956A2/en active Application Filing
- 2003-10-28 CA CA002503330A patent/CA2503330A1/en not_active Abandoned
- 2003-10-28 JP JP2004548574A patent/JP2006517785A/ja active Pending
-
2009
- 2009-11-04 JP JP2009253394A patent/JP2010115195A/ja active Pending
- 2009-12-24 AU AU2009251206A patent/AU2009251206B2/en not_active Ceased
-
2011
- 2011-02-23 US US13/033,177 patent/US20110245096A1/en not_active Abandoned
-
2012
- 2012-08-28 JP JP2012187148A patent/JP2012254093A/ja active Pending
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