JP2011512817A5 - - Google Patents
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- Publication number
- JP2011512817A5 JP2011512817A5 JP2010548830A JP2010548830A JP2011512817A5 JP 2011512817 A5 JP2011512817 A5 JP 2011512817A5 JP 2010548830 A JP2010548830 A JP 2010548830A JP 2010548830 A JP2010548830 A JP 2010548830A JP 2011512817 A5 JP2011512817 A5 JP 2011512817A5
- Authority
- JP
- Japan
- Prior art keywords
- clostridium difficile
- binds
- isolated antibody
- protein
- acetylmuramoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004965 antibodies Human genes 0.000 claims 3
- 108090001123 antibodies Proteins 0.000 claims 3
- 241000193163 Clostridioides difficile Species 0.000 claims 2
- 241000423301 Clostridioides difficile 630 Species 0.000 claims 2
- 101710010750 XV Proteins 0.000 claims 2
- 101700079396 amiB Proteins 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 210000004215 spores Anatomy 0.000 claims 2
Claims (3)
- 配列番号１を有するクロストリジウム・ディフィシル株６３０の仮想上の（ｈｙｐｏｔｈｅｔｉｃａｌ）タンパク質ＣＤ１０２１又は前記仮想上のタンパク質ＣＤ１０２１の断片に結合する、単離された抗体。
- 配列番号５を有するクロストリジウム・ディフィシル株６３０の推定Ｎ−アセチルムラモイル−Ｌ−アラニンアミダーゼタンパク質又は前記推定Ｎ−アセチルムラモイル−Ｌ−アラニンアミダーゼタンパク質の断片に結合する、単離された抗体。
- サンプル中のクロストリジウム・ディフィシル胞子の存在を検出する方法であって、前記サンプルをクロストリジウム・ディフィシル胞子に結合する単離された抗体に接触させるステップを含む、方法。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3227008P | 2008-02-28 | 2008-02-28 | |
| PCT/US2009/035050 WO2009108652A1 (en) | 2008-02-28 | 2009-02-25 | Antibodies to clostridium difficile spores and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011512817A JP2011512817A (ja) | 2011-04-28 |
| JP2011512817A5 true JP2011512817A5 (ja) | 2012-04-12 |
Family
ID=41016450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010548830A Pending JP2011512817A (ja) | 2008-02-28 | 2009-02-25 | クロストリジウム・ディフィシル胞子に対する抗体及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8697374B2 (ja) |
| EP (1) | EP2271366A4 (ja) |
| JP (1) | JP2011512817A (ja) |
| KR (1) | KR20100126760A (ja) |
| CN (1) | CN101980723A (ja) |
| AU (1) | AU2009219358A1 (ja) |
| BR (1) | BRPI0906060A2 (ja) |
| CA (1) | CA2714720A1 (ja) |
| WO (1) | WO2009108652A1 (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2544435T3 (es) * | 2009-03-27 | 2015-08-31 | Gojo Industries, Inc. | Composiciones y métodos para examinar y usar compuestos que antagonizan interacciones espora-superficie |
| CN102533867A (zh) * | 2010-12-10 | 2012-07-04 | 西北民族大学 | 一种艰难梭菌a毒素的类毒素的制备方法 |
| US20120276059A1 (en) | 2011-04-29 | 2012-11-01 | Techlab, Inc. | Fecal lactoferrin as a biomarker for determining disease severity and for monitoring infection in patients with clostridium difficile disease |
| US10295535B2 (en) * | 2011-04-29 | 2019-05-21 | Techlab, Inc. | Clostridium difficile dehydrogenase and toxin as a biomarker for monitoring infection in patients with clostridium difficile disease and differentiating carrier state from active disease |
| EP2755681B1 (en) * | 2011-09-15 | 2018-06-27 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | IMMUNOTHERAPY AND DIAGNOSIS OF MUCORMYCOSIS USING CotH |
| KR20140063825A (ko) * | 2011-09-16 | 2014-05-27 | 유씨비 파마, 에스.에이. | 클로스트리듐 디피실의 주요 외독소 tcda 및 tcdb에 대한 중화 항체 |
| WO2013071409A1 (en) | 2011-11-18 | 2013-05-23 | National Research Council Of Canada (Nrc) | Clostridium difficile lipoteichoic acid and uses thereof |
| CN102590515B (zh) * | 2012-01-13 | 2014-07-30 | 张春华 | 艰难梭菌外毒素a检测试剂盒及组成该试剂盒的单克隆抗体 |
| WO2013130981A1 (en) | 2012-03-02 | 2013-09-06 | Regeneron Pharmaceuticals, Inc. | Human antibodies to clostridium difficile toxins |
| US9133527B2 (en) * | 2012-05-11 | 2015-09-15 | Techlab, Inc. | Cell wall protein CwpV (CD0514) as a diagnostic marker for Clostridium difficile ribotype 027 |
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| US9932374B2 (en) * | 2012-09-19 | 2018-04-03 | Glaxosmithkline Biologicals Sa | Clostridium difficile polypeptides as vaccine |
| CA2892973A1 (en) * | 2012-11-28 | 2014-06-05 | Cnj Holdings, Inc. | Antibodies against clostridium difficile |
| ES2940827T3 (es) * | 2013-04-19 | 2023-05-11 | Immuron Ltd | Procedimientos y composiciones para el tratamiento y/o la profilaxis de la enfermedad asociada a Clostridium difficile |
| WO2015150493A1 (en) * | 2014-04-01 | 2015-10-08 | Institut Pasteur | Predictive value of clostridium difficile-specific immune response for recurrence and disease outcome |
| CN106662529B (zh) | 2014-06-09 | 2019-08-30 | 3M创新有限公司 | 检测目标分析物的测定装置和方法 |
| US20180000793A1 (en) | 2015-02-06 | 2018-01-04 | Ernesto Abel-Santos | Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis |
| US20190059860A1 (en) * | 2015-09-21 | 2019-02-28 | 4C Diagnostics Ltd. | Stool specimen collecting, sampling and diagnosing means and methods thereof |
| CA3142278A1 (en) * | 2019-06-05 | 2020-12-10 | Liv Process, Inc. | Aptamers against clostridium difficile |
| CN111948388B (zh) * | 2020-08-18 | 2022-03-22 | 山东农业大学 | 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用 |
Family Cites Families (41)
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| US4530833A (en) | 1982-09-13 | 1985-07-23 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4533630A (en) | 1982-09-13 | 1985-08-06 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4879218A (en) | 1982-09-13 | 1989-11-07 | Virginia Tech Intellectual Properties, Inc. | Antibody for C.difficile |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| GB8426464D0 (en) | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
| US4863852A (en) | 1985-07-03 | 1989-09-05 | Virginia Tech Intellectual Properties, Inc. | Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors |
| US4956302A (en) | 1987-09-11 | 1990-09-11 | Abbott Laboratories | Lateral flow chromatographic binding assay device |
| AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
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| US5750373A (en) | 1990-12-03 | 1998-05-12 | Genentech, Inc. | Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants |
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| AU662148B2 (en) | 1991-04-10 | 1995-08-24 | Scripps Research Institute, The | Heterodimeric receptor libraries using phagemids |
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| US5610023A (en) | 1995-03-31 | 1997-03-11 | Lee Laboratories, Inc. | Method of purification of clostridium difficile toxin A and production of mono-specific antibodies |
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| WO1999002188A1 (en) * | 1997-07-11 | 1999-01-21 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Hen egg yolk antibodies to clostridium difficile antigens and use in therapy for pseudomembranous colitis |
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| US7074454B1 (en) | 1999-11-01 | 2006-07-11 | Mucovax Holding B.V. | Production of mammary secretion antibodies in farm animals |
| US6974573B2 (en) | 1999-11-01 | 2005-12-13 | Mucovax Holdings, B.V. | Antibody production in farm animals |
| KR100627635B1 (ko) | 1999-11-01 | 2006-09-25 | 뮤코 박스 홀딩 비.브이. | 가축에서 유선 분비 항체를 제조하는 방법 |
| US6509196B1 (en) | 2000-01-04 | 2003-01-21 | Response Biomedical Corp. | Compensation for non-specific signals in quantitative immunoassays |
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| ATE371015T1 (de) | 2001-11-30 | 2007-09-15 | California Inst Of Techn | Verbesserung in einem verfahren zur quantifizierung bakterieller endosporen mittels lanthaniddipicolinat-lumineszenz |
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| US20040014154A1 (en) | 2002-02-01 | 2004-01-22 | Adrian Ponce | Methods and apparatus for assays of bacterial spores |
| US20030175318A1 (en) | 2002-03-06 | 2003-09-18 | Schilling Amanda S. | Application of germination solution improved efficacy of biological decontamination |
| US20040033546A1 (en) | 2002-04-10 | 2004-02-19 | The Trustees Of Columbia University In The City Of New York | Novel microarrays and methods of use thereof |
| US7608419B2 (en) | 2003-11-13 | 2009-10-27 | California Institute Of Technology | Method and apparatus for detecting and quantifying bacterial spores on a surface |
| WO2004069848A2 (en) | 2003-01-28 | 2004-08-19 | Diversa Corporation | Amidases, nucleic acids encoding them and methods for making and using them |
| US7189522B2 (en) | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| US20060275920A1 (en) | 2005-06-01 | 2006-12-07 | Petrilla John F | Apparatus and method for discriminating among lateral flow assay test indicators |
-
2009
- 2009-02-25 CN CN2009801113555A patent/CN101980723A/zh active Pending
- 2009-02-25 KR KR1020107021314A patent/KR20100126760A/ko not_active Application Discontinuation
- 2009-02-25 WO PCT/US2009/035050 patent/WO2009108652A1/en active Application Filing
- 2009-02-25 JP JP2010548830A patent/JP2011512817A/ja active Pending
- 2009-02-25 BR BRPI0906060A patent/BRPI0906060A2/pt not_active IP Right Cessation
- 2009-02-25 EP EP09715042A patent/EP2271366A4/en not_active Withdrawn
- 2009-02-25 CA CA2714720A patent/CA2714720A1/en not_active Abandoned
- 2009-02-25 AU AU2009219358A patent/AU2009219358A1/en not_active Abandoned
- 2009-02-25 US US12/919,254 patent/US8697374B2/en not_active Expired - Fee Related
-
2014
- 2014-03-12 US US14/205,995 patent/US20140335543A1/en not_active Abandoned
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