JP2010090142A5 - - Google Patents
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- Publication number
- JP2010090142A5 JP2010090142A5 JP2009276500A JP2009276500A JP2010090142A5 JP 2010090142 A5 JP2010090142 A5 JP 2010090142A5 JP 2009276500 A JP2009276500 A JP 2009276500A JP 2009276500 A JP2009276500 A JP 2009276500A JP 2010090142 A5 JP2010090142 A5 JP 2010090142A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- group
- excipient base
- sucralose
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 12
- 239000000546 pharmaceutical excipient Substances 0.000 claims 12
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 8
- 239000004376 Sucralose Substances 0.000 claims 6
- 230000000954 anitussive effect Effects 0.000 claims 6
- 229940124584 antitussives Drugs 0.000 claims 6
- 239000003172 expectorant agent Substances 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 6
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims 6
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 6
- 235000019408 sucralose Nutrition 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- YQSHYGCCYVPRDI-UHFFFAOYSA-N (4-propan-2-ylphenyl)methanamine Chemical compound CC(C)C1=CC=C(CN)C=C1 YQSHYGCCYVPRDI-UHFFFAOYSA-N 0.000 claims 4
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 229940125715 antihistaminic agent Drugs 0.000 claims 4
- 239000000739 antihistaminic agent Substances 0.000 claims 4
- ZDIGNSYAACHWNL-UHFFFAOYSA-N brompheniramine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 ZDIGNSYAACHWNL-UHFFFAOYSA-N 0.000 claims 4
- 229960000725 brompheniramine Drugs 0.000 claims 4
- 229960003782 dextromethorphan hydrobromide Drugs 0.000 claims 4
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 claims 4
- 230000003419 expectorant effect Effects 0.000 claims 4
- 229940066493 expectorants Drugs 0.000 claims 4
- 229960002146 guaifenesin Drugs 0.000 claims 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 4
- 229960005489 paracetamol Drugs 0.000 claims 4
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 3
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims 3
- 229960003908 pseudoephedrine Drugs 0.000 claims 3
- DBGIVFWFUFKIQN-VIFPVBQESA-N (+)-Fenfluramine Chemical compound CCN[C@@H](C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-VIFPVBQESA-N 0.000 claims 2
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 claims 2
- BCXHDORHMMZBBZ-DORFAMGDSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;sulfuric acid Chemical compound OS(O)(=O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC BCXHDORHMMZBBZ-DORFAMGDSA-N 0.000 claims 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 2
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 2
- ISFHAYSTHMVOJR-UHFFFAOYSA-N Phenindamine Chemical compound C1N(C)CCC(C2=CC=CC=C22)=C1C2C1=CC=CC=C1 ISFHAYSTHMVOJR-UHFFFAOYSA-N 0.000 claims 2
- UFLGIAIHIAPJJC-UHFFFAOYSA-N Tripelennamine Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CC=C1 UFLGIAIHIAPJJC-UHFFFAOYSA-N 0.000 claims 2
- 230000000202 analgesic effect Effects 0.000 claims 2
- 229940035676 analgesics Drugs 0.000 claims 2
- 239000000730 antalgic agent Substances 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 229940034982 antineoplastic agent Drugs 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000003434 antitussive agent Substances 0.000 claims 2
- 229960000383 azatadine Drugs 0.000 claims 2
- SEBMTIQKRHYNIT-UHFFFAOYSA-N azatadine Chemical compound C1CN(C)CCC1=C1C2=NC=CC=C2CCC2=CC=CC=C21 SEBMTIQKRHYNIT-UHFFFAOYSA-N 0.000 claims 2
- 229960003166 bromazine Drugs 0.000 claims 2
- NUNIWXHYABYXKF-UHFFFAOYSA-N bromazine Chemical compound C=1C=C(Br)C=CC=1C(OCCN(C)C)C1=CC=CC=C1 NUNIWXHYABYXKF-UHFFFAOYSA-N 0.000 claims 2
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 claims 2
- 229960003291 chlorphenamine Drugs 0.000 claims 2
- RBNWAMSGVWEHFP-UHFFFAOYSA-N cis-p-Menthan-1,8-diol Natural products CC(C)(O)C1CCC(C)(O)CC1 RBNWAMSGVWEHFP-UHFFFAOYSA-N 0.000 claims 2
- 229960004415 codeine phosphate Drugs 0.000 claims 2
- 229960003871 codeine sulfate Drugs 0.000 claims 2
- 229960001140 cyproheptadine Drugs 0.000 claims 2
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 claims 2
- 239000000850 decongestant Substances 0.000 claims 2
- 229940124581 decongestants Drugs 0.000 claims 2
- SOYKEARSMXGVTM-HNNXBMFYSA-N dexchlorpheniramine Chemical compound C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Cl)C=C1 SOYKEARSMXGVTM-HNNXBMFYSA-N 0.000 claims 2
- 229960001882 dexchlorpheniramine Drugs 0.000 claims 2
- 229960004597 dexfenfluramine Drugs 0.000 claims 2
- 229960000520 diphenhydramine Drugs 0.000 claims 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 2
- 229960005178 doxylamine Drugs 0.000 claims 2
- HCFDWZZGGLSKEP-UHFFFAOYSA-N doxylamine Chemical compound C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 HCFDWZZGGLSKEP-UHFFFAOYSA-N 0.000 claims 2
- 229960001680 ibuprofen Drugs 0.000 claims 2
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 2
- 229960000991 ketoprofen Drugs 0.000 claims 2
- 229960000582 mepyramine Drugs 0.000 claims 2
- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 claims 2
- 229960002009 naproxen Drugs 0.000 claims 2
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 2
- 229930006948 p-menthane-3,8-diol Natural products 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229960003534 phenindamine Drugs 0.000 claims 2
- 229950010257 terpin Drugs 0.000 claims 2
- RBNWAMSGVWEHFP-WAAGHKOSSA-N terpin Chemical compound CC(C)(O)[C@H]1CC[C@@](C)(O)CC1 RBNWAMSGVWEHFP-WAAGHKOSSA-N 0.000 claims 2
- 229960003223 tripelennamine Drugs 0.000 claims 2
- 229960001128 triprolidine Drugs 0.000 claims 2
- CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 230000000118 anti-neoplastic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- UZLGHNUASUZUOR-UHFFFAOYSA-L dipotassium;3-carboxy-3-hydroxypentanedioate Chemical compound [K+].[K+].OC(=O)CC(O)(C([O-])=O)CC([O-])=O UZLGHNUASUZUOR-UHFFFAOYSA-L 0.000 claims 1
- 230000000873 masking effect Effects 0.000 claims 1
- 229960003975 potassium Drugs 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229960002635 potassium citrate Drugs 0.000 claims 1
- 239000001508 potassium citrate Substances 0.000 claims 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims 1
- 235000011082 potassium citrates Nutrition 0.000 claims 1
- 229960004839 potassium iodide Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30891201P | 2001-07-31 | 2001-07-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003516536A Division JP2004538309A (ja) | 2001-07-31 | 2002-07-31 | 不快な味覚をマスキングするためのスクラロース調合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010090142A JP2010090142A (ja) | 2010-04-22 |
| JP2010090142A5 true JP2010090142A5 (enExample) | 2012-03-01 |
Family
ID=23195896
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003516536A Pending JP2004538309A (ja) | 2001-07-31 | 2002-07-31 | 不快な味覚をマスキングするためのスクラロース調合物 |
| JP2009276500A Pending JP2010090142A (ja) | 2001-07-31 | 2009-12-04 | 不快な味覚をマスキングするためのスクラロース調合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003516536A Pending JP2004538309A (ja) | 2001-07-31 | 2002-07-31 | 不快な味覚をマスキングするためのスクラロース調合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20060121066A1 (enExample) |
| EP (1) | EP1411955A4 (enExample) |
| JP (2) | JP2004538309A (enExample) |
| AU (1) | AU2002324579B2 (enExample) |
| BR (1) | BR0211794A (enExample) |
| CA (1) | CA2455939C (enExample) |
| CL (1) | CL2004000208A1 (enExample) |
| CO (1) | CO5560580A2 (enExample) |
| CR (1) | CR7264A (enExample) |
| EC (1) | ECSP044995A (enExample) |
| MX (1) | MXPA04001026A (enExample) |
| NZ (1) | NZ530889A (enExample) |
| WO (1) | WO2003011306A1 (enExample) |
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| JP4814636B2 (ja) * | 2004-01-29 | 2011-11-16 | 大日本住友製薬株式会社 | ビグアナイド系薬物の内服製剤 |
| PL2486942T3 (pl) | 2004-11-24 | 2019-05-31 | Meda Pharmaceuticals Inc | Kompozycje zawierające azelastynę oraz sposoby ich stosowania |
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| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| ES2929945T3 (es) * | 2013-11-13 | 2022-12-05 | National Defense Education And Res Foundation | Nueva composición de un compuesto de acetaminofeno sin efectos secundarios sobre el hígado |
| JP6565334B2 (ja) * | 2014-06-18 | 2019-08-28 | 大正製薬株式会社 | 固形製剤 |
| CN105640956B (zh) * | 2014-11-14 | 2018-09-14 | 澳美制药厂有限公司 | 不含防腐剂的复方磷酸可待因组合口服液及其制备方法 |
| GR1009069B (el) * | 2015-01-05 | 2017-07-07 | Λαμδα Φαρμακευτικα Εργαστηρια Εφαρμοσμενης Ερευνας & Αναπτυξης Α.Ε. | Ποσιμα διαλυματα υψηλης συγκεντρωσης που περιεχουν υδροχλωρικη ρανιτιδινη |
| US20160317497A1 (en) * | 2015-05-01 | 2016-11-03 | Trinity Ent And Facial Aesthetics | Flavored analgesic and decongestant spray |
| JP6794758B2 (ja) * | 2015-10-21 | 2020-12-02 | 大正製薬株式会社 | 経口液体医薬組成物 |
| EP3181150A1 (de) * | 2015-12-19 | 2017-06-21 | Analyticon Discovery GmbH | Pharmazeutische zubereitungen |
| US10689324B2 (en) | 2015-12-22 | 2020-06-23 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| DK3800177T3 (da) | 2015-12-22 | 2025-03-31 | Zogenix International Ltd | Fenfluramin-sammensætninger og fremgangsmåder til fremstilling af samme |
| US9669008B1 (en) | 2016-03-18 | 2017-06-06 | Silvergate Pharmaceuticals, Inc. | Enalapril formulations |
| GB2551971B (en) * | 2016-06-29 | 2020-09-16 | Syri Ltd | Taste masked liquid pharmaceutical composition of mebeverine or pharmaceutically acceptable salts thereof |
| RU2021106383A (ru) | 2016-08-24 | 2021-04-05 | Зодженикс Интернэшнл Лимитед | Состав для ингибирования образования агонистов 5-ht2b и способы его применения |
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| JP6858729B2 (ja) * | 2018-05-25 | 2021-04-14 | ▲財▼▲団▼法人国防教育研究基金会Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成 |
| US10517841B1 (en) | 2018-06-14 | 2019-12-31 | Zogenix International Limited | Compositions and methods for treating respiratory depression with fenfluramine |
| WO2020105005A1 (en) | 2018-11-19 | 2020-05-28 | Zogenix International Limited | Methods of treating rett syndrome using fenfluramine |
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| CN110302149A (zh) * | 2019-08-07 | 2019-10-08 | 北京博达绿洲医药科技研究有限公司 | 一种适合4-11岁儿童服用抗感冒药物及其制备方法 |
| CN110279695B (zh) * | 2019-08-07 | 2022-04-08 | 北京博智绿洲医药科技有限公司 | 一种治疗流涕、鼻塞等感冒症状的药物组合物及其制备方法和用途 |
| CN110327339A (zh) * | 2019-08-07 | 2019-10-15 | 北京博达绿洲医药科技研究有限公司 | 一种复方右美沙芬口服溶液及其制备方法和用途 |
| CN112439072A (zh) * | 2019-08-29 | 2021-03-05 | 鲁南制药集团股份有限公司 | 一种掩味组合物及其制备方法、用途 |
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| CN117122562A (zh) * | 2022-05-21 | 2023-11-28 | 山东百诺医药股份有限公司 | 一种美芬那敏铵口服溶液 |
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| CN1211085C (zh) * | 1999-09-29 | 2005-07-20 | 宝洁公司 | 稳定性改善的组合物 |
| JP2001106639A (ja) * | 1999-10-04 | 2001-04-17 | Taisho Pharmaceut Co Ltd | 経口用組成物 |
| DE19961897A1 (de) * | 1999-12-20 | 2001-06-28 | Basf Ag | Verwendung eines Filmüberzuges als geschmacksmaskierendes Coating von pharmazeutischen Darreichungsformen |
-
2002
- 2002-07-31 EP EP02759229A patent/EP1411955A4/en not_active Ceased
- 2002-07-31 NZ NZ530889A patent/NZ530889A/en not_active IP Right Cessation
- 2002-07-31 CA CA2455939A patent/CA2455939C/en not_active Expired - Lifetime
- 2002-07-31 AU AU2002324579A patent/AU2002324579B2/en not_active Ceased
- 2002-07-31 MX MXPA04001026A patent/MXPA04001026A/es active IP Right Grant
- 2002-07-31 JP JP2003516536A patent/JP2004538309A/ja active Pending
- 2002-07-31 BR BR0211794-0A patent/BR0211794A/pt not_active Application Discontinuation
- 2002-07-31 WO PCT/US2002/024298 patent/WO2003011306A1/en not_active Ceased
-
2004
- 2004-02-06 CL CL200400208A patent/CL2004000208A1/es unknown
- 2004-02-23 CO CO04015498A patent/CO5560580A2/es not_active Application Discontinuation
- 2004-02-27 CR CR7264A patent/CR7264A/es unknown
- 2004-02-27 EC EC2004004995A patent/ECSP044995A/es unknown
-
2005
- 2005-01-27 US US10/485,858 patent/US20060121066A1/en not_active Abandoned
-
2009
- 2009-12-04 JP JP2009276500A patent/JP2010090142A/ja active Pending
-
2011
- 2011-02-01 US US13/018,932 patent/US20110136851A1/en not_active Abandoned
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