JP2010065046A5 - - Google Patents
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- Publication number
- JP2010065046A5 JP2010065046A5 JP2009251464A JP2009251464A JP2010065046A5 JP 2010065046 A5 JP2010065046 A5 JP 2010065046A5 JP 2009251464 A JP2009251464 A JP 2009251464A JP 2009251464 A JP2009251464 A JP 2009251464A JP 2010065046 A5 JP2010065046 A5 JP 2010065046A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- amino acid
- sequence
- cell epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 230000003941 amyloidogenesis Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37391402P | 2002-04-19 | 2002-04-19 | |
| US60/373,914 | 2002-04-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586180A Division JP4662719B2 (ja) | 2002-04-19 | 2003-04-07 | アルツハイマー病の処置のための免疫学的方法および組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012249078A Division JP2013075898A (ja) | 2002-04-19 | 2012-11-13 | アルツハイマー病の処置のための免疫学的方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010065046A JP2010065046A (ja) | 2010-03-25 |
| JP2010065046A5 true JP2010065046A5 (https=) | 2010-11-25 |
| JP5345920B2 JP5345920B2 (ja) | 2013-11-20 |
Family
ID=29251102
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586180A Expired - Fee Related JP4662719B2 (ja) | 2002-04-19 | 2003-04-07 | アルツハイマー病の処置のための免疫学的方法および組成物 |
| JP2009251464A Expired - Fee Related JP5345920B2 (ja) | 2002-04-19 | 2009-10-30 | アルツハイマー病の処置のための免疫学的方法および組成物 |
| JP2012249078A Withdrawn JP2013075898A (ja) | 2002-04-19 | 2012-11-13 | アルツハイマー病の処置のための免疫学的方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586180A Expired - Fee Related JP4662719B2 (ja) | 2002-04-19 | 2003-04-07 | アルツハイマー病の処置のための免疫学的方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012249078A Withdrawn JP2013075898A (ja) | 2002-04-19 | 2012-11-13 | アルツハイマー病の処置のための免疫学的方法および組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20030232758A1 (https=) |
| EP (2) | EP1497321B1 (https=) |
| JP (3) | JP4662719B2 (https=) |
| KR (1) | KR100994748B1 (https=) |
| CN (1) | CN100360555C (https=) |
| AT (1) | ATE514707T1 (https=) |
| AU (1) | AU2003218560B2 (https=) |
| CA (1) | CA2481952C (https=) |
| ES (1) | ES2368907T3 (https=) |
| IL (3) | IL164643A0 (https=) |
| MX (1) | MXPA04010255A (https=) |
| NO (2) | NO335192B1 (https=) |
| NZ (1) | NZ536064A (https=) |
| PL (1) | PL209696B1 (https=) |
| SG (1) | SG173214A1 (https=) |
| WO (1) | WO2003089460A1 (https=) |
| ZA (1) | ZA200408811B (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2414772C (en) | 2000-07-07 | 2011-06-28 | Jan Naslund | Prevention and treatment of alzheimer's disease |
| CA2504349A1 (en) * | 2001-11-02 | 2003-05-15 | Diagenics International Corporation | Monoclonal antibodies specific for beta-amyloid |
| US20050106626A1 (en) * | 2002-10-20 | 2005-05-19 | George Pieczenik | Ligand binding of amyloid peptide protein epitope |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| US8193250B2 (en) | 2004-10-22 | 2012-06-05 | Mount Sinai School Of Medicine | Compositions and methods for treating alzheimer's disease and related disorders and promoting a healthy nervous system |
| US20090123952A1 (en) * | 2004-11-12 | 2009-05-14 | Pfizer, Inc. | Method of Measuring Amyloid-Beta Peptides |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| EP1959996A2 (en) | 2005-12-12 | 2008-08-27 | AC Immune S.A. | Monoclonal antibody |
| JP5097695B2 (ja) | 2006-02-22 | 2012-12-12 | 株式会社林原 | 抗アミロイドβペプチド抗体産生誘導用のペプチドワクチン |
| RU2429244C2 (ru) | 2006-03-23 | 2011-09-20 | Байоарктик Ньюросайенс Аб | Улучшенные селективные в отношении протофибрилл антитела и их применение |
| DE112007001030T5 (de) * | 2006-04-28 | 2009-02-26 | Kagoshima University | Amyloid-ß-Fibrillogenese-inhibierendes Peptid |
| EP2046833B9 (en) | 2006-07-14 | 2014-02-19 | AC Immune S.A. | Humanized antibody against amyloid beta |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008143708A2 (en) * | 2006-12-07 | 2008-11-27 | Mayo Foundation For Medical Education And Research | Methods and materials related to anti-amyloid antibodies |
| HRP20140049T1 (hr) * | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| AU2008311367B2 (en) | 2007-10-05 | 2014-11-13 | Ac Immune S.A. | Use of anti-amyloid beta antibody in ocular diseases |
| WO2010024927A2 (en) * | 2008-08-28 | 2010-03-04 | The Research Foundation Of State University Of New York | Treatment of amyloidoses using myelin basic protein and fragments thereof |
| US8912145B2 (en) | 2008-11-28 | 2014-12-16 | Hokko Chemical Industry Co., Ltd. | Vaccine composition for prophylaxis and/or therapy of Alzheimer's disease |
| WO2010061899A1 (ja) * | 2008-11-28 | 2010-06-03 | 北興化学工業株式会社 | ワクチンを蓄積する形質転換ダイズ植物およびその利用 |
| CN101797493B (zh) * | 2009-02-06 | 2014-05-21 | 上海抗体药物国家工程研究中心有限公司 | 一种在反应釜中制备亲和层析介质的方法 |
| CN101486768B (zh) * | 2009-02-25 | 2012-05-30 | 吉林大学 | 一种用于治疗阿尔茨海默氏病的抗原蛋白及蛋白基因 |
| WO2010124028A2 (en) * | 2009-04-21 | 2010-10-28 | Vasylyev Sergiy V | Light collection and illumination systems employing planar waveguide |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2598882B1 (en) | 2010-07-30 | 2017-07-26 | AC Immune S.A. | Safe and functional humanized antibodies for use in treating an amyloidosis |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| US20120328605A1 (en) * | 2010-10-27 | 2012-12-27 | Daniel Larocque | Compositions and uses |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| DE102011057019A1 (de) * | 2011-12-23 | 2013-06-27 | Forschungszentrum Jülich GmbH | Standard zur Quantifizierung von pathogenen Aggregaten aus körpereigenen Proteinen |
| CA2848994A1 (en) * | 2012-01-20 | 2013-07-25 | Ananth Annapragada | Methods and compositions for objectively characterizing medical images |
| US9534048B2 (en) * | 2012-08-24 | 2017-01-03 | University Health Network | Antibodies to TTR and methods of use |
| US9475866B2 (en) * | 2012-09-12 | 2016-10-25 | Neurimmune Holding Ag | Human islet amyloid polypeptide (hIAPP) specific antibodies and uses thereof |
| SMT202000340T1 (it) | 2012-10-15 | 2020-07-08 | Medimmune Ltd | Anticorpi contro il beta amiloide |
| US10195257B2 (en) | 2013-07-28 | 2019-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations comprising quillaja desacylsaponins and beta amyloid peptides or tau protein to induce a Th2 immune response |
| FI3137094T3 (fi) | 2014-04-29 | 2023-03-20 | Advantage Therapeutics Inc | Alzheimerin taudin (ad) hoitaminen ja ehkäiseminen |
| WO2016005466A2 (en) | 2014-07-10 | 2016-01-14 | Bioarctic Neuroscience Ab | IMPROVED Aß PROTOFIBRIL BINDING ANTIBODIES |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| AU2016353553B2 (en) * | 2015-11-09 | 2022-01-20 | The University Of British Columbia | Amyloid beta epitopes and antibodies thereto |
| WO2017098516A1 (en) * | 2015-12-10 | 2017-06-15 | The National Institute for Biotechnology in the Negev Ltd. | VARIANTS OF AMYLOID beta-PROTEIN PRECURSOR INHIBITOR DOMAIN |
| DK3425390T3 (da) * | 2016-11-25 | 2021-02-15 | Genuv Inc | Sammensætning til fremme af differentiering og beskyttelse af neurale stamceller og fremgangsmåde til induktion af neural regenerering ved anvendelse heraf |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| CN118370815A (zh) | 2017-08-22 | 2024-07-23 | 渤健马萨诸塞州股份有限公司 | 含有抗β淀粉样蛋白抗体的药物组合物 |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| CN111787942B (zh) | 2017-10-25 | 2024-03-29 | 杨森制药公司 | 磷酸化Tau肽的组合物及其用途 |
| WO2019218079A1 (en) * | 2018-05-18 | 2019-11-21 | Universite Laval | Use of nod2 agonist for the treatment, prophylaxis and/or delay of the onset of multiple sclerosis and alzheimer's disease |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| MY206596A (en) * | 2019-02-08 | 2024-12-25 | Janssen Pharmaceuticals Inc | Method of safe administration of phosphorylated tau peptide vaccine |
| JP7505713B2 (ja) | 2019-02-22 | 2024-06-25 | ロヨラ メリーマウント ユニバーシティ | アミロイドペプチドバリアント |
| JOP20210284A1 (ar) | 2019-04-24 | 2023-01-30 | Janssen Pharmaceuticals Inc | الإعطاء غير المتجانس للقاحات تاو |
| CN115066610A (zh) * | 2020-02-05 | 2022-09-16 | 住友制药株式会社 | 用于tau病变和痴呆相关疾病的确定试剂和确定方法 |
| TW202144387A (zh) * | 2020-02-11 | 2021-12-01 | 美商聯合生物醫學公司 | 針對胰島澱粉樣多肽（iapp）的胜肽免疫原及其預防和治療與聚集iapp相關疾病的製劑 |
| CA3183431A1 (en) * | 2020-05-15 | 2021-11-18 | Vib Vzw | Means and methods for the treatment of pathological aggregation |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| WO2023159970A1 (zh) * | 2022-02-28 | 2023-08-31 | 安域生物科技杭州有限公司 | 基于β-淀粉样蛋白修饰的抗原多肽及其应用 |
| CN115786260B (zh) * | 2022-12-26 | 2024-08-20 | 海南大学 | Aβ42-hIAPP共寡聚化物诱导的AD脑类器官病理模型方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| CA2138997C (en) | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Vaccine composition containing adjuvants |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5840294A (en) | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| US5759551A (en) | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| WO1994025060A1 (en) * | 1993-04-27 | 1994-11-10 | Ladd Anna E | Immunogenic lhrh peptide constructs and synthetic universal immune stimulators for vaccines |
| US5744144A (en) | 1993-07-30 | 1998-04-28 | University Of Pittsburgh University Patent Committee Policy And Procedures | Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| AU6728396A (en) | 1995-08-17 | 1997-03-12 | Ontario Cancer Institute, The | Protein fibril assembly assay |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6750324B1 (en) * | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| AU2001270377A1 (en) | 2000-06-20 | 2002-01-02 | The Governing Council Of The University Of Toronto | Transgenic animal model of neurodegenerative disorders |
| US6310810B1 (en) | 2000-07-14 | 2001-10-30 | Raj Kumar Jain | High-speed sense amplifier |
| US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
-
2003
- 2003-04-07 AT AT03711746T patent/ATE514707T1/de not_active IP Right Cessation
- 2003-04-07 KR KR1020047016794A patent/KR100994748B1/ko not_active Expired - Fee Related
- 2003-04-07 IL IL16464303A patent/IL164643A0/xx unknown
- 2003-04-07 CA CA2481952A patent/CA2481952C/en not_active Expired - Fee Related
- 2003-04-07 MX MXPA04010255A patent/MXPA04010255A/es unknown
- 2003-04-07 EP EP03711746A patent/EP1497321B1/en not_active Expired - Lifetime
- 2003-04-07 PL PL373450A patent/PL209696B1/pl unknown
- 2003-04-07 CN CNB038088584A patent/CN100360555C/zh not_active Expired - Fee Related
- 2003-04-07 WO PCT/CA2003/000502 patent/WO2003089460A1/en not_active Ceased
- 2003-04-07 JP JP2003586180A patent/JP4662719B2/ja not_active Expired - Fee Related
- 2003-04-07 AU AU2003218560A patent/AU2003218560B2/en not_active Ceased
- 2003-04-07 EP EP10182139.5A patent/EP2330113B1/en not_active Expired - Lifetime
- 2003-04-07 SG SG2006073324A patent/SG173214A1/en unknown
- 2003-04-07 ES ES03711746T patent/ES2368907T3/es not_active Expired - Lifetime
- 2003-04-07 NZ NZ536064A patent/NZ536064A/en not_active IP Right Cessation
- 2003-04-10 US US10/411,544 patent/US20030232758A1/en not_active Abandoned
-
2004
- 2004-10-17 IL IL164643A patent/IL164643A/en not_active IP Right Cessation
- 2004-11-01 ZA ZA2004/08811A patent/ZA200408811B/en unknown
- 2004-11-18 NO NO20045021A patent/NO335192B1/no not_active IP Right Cessation
-
2005
- 2005-07-13 US US11/180,225 patent/US20090041771A1/en not_active Abandoned
-
2009
- 2009-01-15 IL IL196532A patent/IL196532A/en not_active IP Right Cessation
- 2009-10-30 JP JP2009251464A patent/JP5345920B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-29 US US13/434,205 patent/US20120315321A1/en not_active Abandoned
- 2012-11-13 JP JP2012249078A patent/JP2013075898A/ja not_active Withdrawn
-
2013
- 2013-11-07 NO NO20131483A patent/NO20131483L/no not_active Application Discontinuation
-
2014
- 2014-04-07 US US14/246,830 patent/US20140212481A1/en not_active Abandoned
-
2016
- 2016-06-17 US US15/186,049 patent/US20160297876A1/en not_active Abandoned
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