JP2009511579A5 - - Google Patents
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- Publication number
- JP2009511579A5 JP2009511579A5 JP2008535569A JP2008535569A JP2009511579A5 JP 2009511579 A5 JP2009511579 A5 JP 2009511579A5 JP 2008535569 A JP2008535569 A JP 2008535569A JP 2008535569 A JP2008535569 A JP 2008535569A JP 2009511579 A5 JP2009511579 A5 JP 2009511579A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- myostatin
- antibody
- monoclonal antibody
- muscle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72573805P | 2005-10-12 | 2005-10-12 | |
| US60/725,738 | 2005-10-12 | ||
| PCT/US2006/038817 WO2007047112A2 (en) | 2005-10-12 | 2006-10-05 | Anti-myostatin antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511579A JP2009511579A (ja) | 2009-03-19 |
| JP2009511579A5 true JP2009511579A5 (https=) | 2009-11-05 |
| JP5031756B2 JP5031756B2 (ja) | 2012-09-26 |
Family
ID=37681692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008535569A Expired - Fee Related JP5031756B2 (ja) | 2005-10-12 | 2006-10-05 | 抗ミオスタチン抗体 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7632499B2 (https=) |
| EP (2) | EP1951755B1 (https=) |
| JP (1) | JP5031756B2 (https=) |
| KR (1) | KR101128548B1 (https=) |
| CN (1) | CN101282992B (https=) |
| AU (1) | AU2006303921B2 (https=) |
| BR (1) | BRPI0617345A2 (https=) |
| CA (1) | CA2624935C (https=) |
| DK (2) | DK2816058T3 (https=) |
| EA (1) | EA015903B1 (https=) |
| ES (2) | ES2533462T3 (https=) |
| HR (1) | HRP20150176T1 (https=) |
| HU (1) | HUE036566T2 (https=) |
| IL (1) | IL189580A (https=) |
| LT (1) | LT2816058T (https=) |
| NO (1) | NO20082167L (https=) |
| PL (2) | PL1951755T3 (https=) |
| PT (2) | PT2816058T (https=) |
| RS (2) | RS56755B1 (https=) |
| SI (2) | SI2816058T1 (https=) |
| UA (1) | UA92504C2 (https=) |
| WO (1) | WO2007047112A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101287484B (zh) | 2002-12-20 | 2012-10-10 | 安姆根有限公司 | 抑制肌肉生长抑制素的结合剂 |
| BRPI0616923A2 (pt) * | 2005-10-06 | 2011-07-05 | Lilly Co Eli | anticorpos monoclonais, seus usos e composição farmacêutica |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| ES2892925T3 (es) | 2006-03-31 | 2022-02-07 | Chugai Pharmaceutical Co Ltd | Métodos para controlar la farmacocinética en sangre de anticuerpos |
| CA2661836A1 (en) * | 2006-09-05 | 2008-03-13 | Eli Lilly And Company | Anti-myostatin antibodies |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| PE20091163A1 (es) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| MX345039B (es) | 2008-06-25 | 2017-01-16 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles que inhiben el tnfa. |
| CN104004094B (zh) * | 2008-06-25 | 2017-09-22 | 艾斯巴技术-诺华有限责任公司 | 使用通用抗体构架进行的兔抗体的人源化 |
| AR074777A1 (es) * | 2008-12-19 | 2011-02-09 | Glaxo Group Ltd | Proteinas de union a antigeno |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| UY33421A (es) | 2010-06-03 | 2011-12-30 | Glaxo Wellcome House | Proteinas de union al antígeno humanizados |
| US8999343B2 (en) * | 2010-08-16 | 2015-04-07 | Amgen Inc. | Antibodies that bind myostatin, compositions and methods |
| AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
| TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| JP6130307B2 (ja) | 2011-03-17 | 2017-05-17 | ザ ユニバーシティ オブ バーミンガム | 再指向性免疫療法 |
| EP2554353B1 (de) | 2011-08-05 | 2017-06-07 | Trisa Holding AG | Verfahren zur Herstellung einer Zahnbürste und Zahnbürste |
| AU2012339722B2 (en) | 2011-11-14 | 2017-09-14 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and/or Activin A |
| EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
| TW202237660A (zh) | 2012-08-24 | 2022-10-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| TWI633117B (zh) | 2012-09-13 | 2018-08-21 | 必治妥美雅史谷比公司 | 結合至肌肉生長抑制素（ｍｙｏｓｔａｔｉｎ）以纖維連接蛋白爲主之支架結構域蛋白質 |
| AU2013334660B2 (en) | 2012-10-24 | 2018-08-09 | Celgene Corporation | Methods for treating anemia |
| WO2014119634A1 (ja) * | 2013-01-30 | 2014-08-07 | 独立行政法人国立精神・神経医療研究センター | 筋増加剤及びそれを含む医薬組成物 |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| HRP20251426T1 (hr) | 2013-05-06 | 2026-01-02 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| US20170248609A1 (en) | 2014-01-27 | 2017-08-31 | Novartis Ag | Biomarkers predictive of muscle atrophy, method and use |
| HK1243940A1 (zh) | 2014-11-06 | 2018-07-27 | Scholar Rock, Inc. | 抗原肌肉生长抑制素/潜在肌肉生长抑制素的抗体及其用途 |
| WO2016073879A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related antibodies and uses thereof |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| EP3256148A1 (en) | 2015-02-12 | 2017-12-20 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease |
| WO2016168613A1 (en) * | 2015-04-15 | 2016-10-20 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with gdf8 inhibitors |
| LT3350220T (lt) | 2015-09-15 | 2021-09-27 | Scholar Rock, Inc. | Anti pro/latentinio miostatino antikūnai ir jų panaudojimas |
| TWI605057B (zh) | 2015-12-18 | 2017-11-11 | 中外製藥股份有限公司 | 抗肌抑素抗體、含變異ｆｃ區之多肽及使用方法 |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CN115814077A (zh) | 2016-01-08 | 2023-03-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
| AU2017283546C1 (en) | 2016-06-13 | 2020-11-19 | Scholar Rock, Inc. | Use of myostatin inhibitors and combination therapies |
| KR102306744B1 (ko) | 2016-06-17 | 2021-09-28 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체 및 사용 방법 |
| TWI693940B (zh) | 2016-08-05 | 2020-05-21 | 日商中外製藥股份有限公司 | Ｉｌ-８相關疾病之治療用或預防用組成物 |
| ES2944357T3 (es) | 2017-01-06 | 2023-06-20 | Scholar Rock Inc | Tratamiento de enfermedades metabólicas inhibiendo la activación de miostatina |
| CN111787981B (zh) | 2018-03-01 | 2025-12-30 | 瑞泽恩制药公司 | 增加肌肉量和减少脂肪量的方法 |
| DK3773713T3 (da) | 2018-04-06 | 2025-08-18 | Regeneron Pharma | Leptinreceptoragonistantistof til anvendelse i forøgelse af knoglemasse hos et individ, der lider af metabolisk dysfunktion eller hypoleptinæmI |
| CA3120800A1 (en) | 2018-12-17 | 2020-06-25 | Revitope Limited | Twin immune cell engager |
| KR20210104744A (ko) | 2018-12-18 | 2021-08-25 | 리제너론 파마슈티칼스 인코포레이티드 | 렙틴 수용체, gdf8 및 액티빈 a에 대한 길항제를 사용하여 체중 및 제지방 근육량을 향상시키기 위한 조성물 및 방법 |
| CN120187750A (zh) | 2022-09-21 | 2025-06-20 | 瑞泽恩制药公司 | 治疗肥胖、糖尿病和肝功能障碍的方法 |
| IL321628A (en) | 2022-12-22 | 2025-08-01 | Scholar Rock Inc | Selective and potent inhibitory antibodies for myostatin activation |
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| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
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| CN101287484B (zh) | 2002-12-20 | 2012-10-10 | 安姆根有限公司 | 抑制肌肉生长抑制素的结合剂 |
| BRPI0410927A (pt) | 2003-06-02 | 2006-06-27 | Wyeth Corp | métodos terapêuticos e profiláticos para distúrbios neuromusculares |
| EP1644416A4 (en) | 2003-06-30 | 2007-08-29 | Centocor Inc | ANTI-TARGET AND GENETICALLY MODIFIED IMMUNOGLOBULIN-DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES |
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| ATE557042T1 (de) | 2004-03-23 | 2012-05-15 | Lilly Co Eli | Anti-myostatin-antikörper |
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| NL1031674C2 (nl) | 2005-04-25 | 2007-04-26 | Pfizer | Antilichamen tegen myostatine. |
| US20090215671A1 (en) | 2005-05-27 | 2009-08-27 | The Regents Of The University Of California | Compositions And Methods For Treatment of Neural Disorders Using Transforming Growth Factor-Beta Superfamily Proteins And Their Antagonists |
| ES2534760T3 (es) | 2005-08-19 | 2015-04-28 | Wyeth Llc | Anticuerpos antagonistas contra GDF-8 y sus usos en el tratamiento de ELA y otros trastornos asociados con GDF-8 |
| BRPI0616923A2 (pt) | 2005-10-06 | 2011-07-05 | Lilly Co Eli | anticorpos monoclonais, seus usos e composição farmacêutica |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| JP2009518422A (ja) | 2005-12-06 | 2009-05-07 | アムジェン インコーポレイテッド | ミオスタチン・アンタゴニストの使用 |
| US20070190056A1 (en) | 2006-02-07 | 2007-08-16 | Ravi Kambadur | Muscle regeneration compositions and uses therefor |
| CA2661836A1 (en) | 2006-09-05 | 2008-03-13 | Eli Lilly And Company | Anti-myostatin antibodies |
| TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
-
2006
- 2006-05-10 UA UAA200803004A patent/UA92504C2/ru unknown
- 2006-10-05 RS RS20180031A patent/RS56755B1/sr unknown
- 2006-10-05 EP EP06816225.4A patent/EP1951755B1/en active Active
- 2006-10-05 KR KR1020087008707A patent/KR101128548B1/ko not_active Expired - Fee Related
- 2006-10-05 PL PL06816225T patent/PL1951755T3/pl unknown
- 2006-10-05 BR BRPI0617345-4A patent/BRPI0617345A2/pt not_active Application Discontinuation
- 2006-10-05 SI SI200632235T patent/SI2816058T1/en unknown
- 2006-10-05 JP JP2008535569A patent/JP5031756B2/ja not_active Expired - Fee Related
- 2006-10-05 DK DK14181801.3T patent/DK2816058T3/en active
- 2006-10-05 HU HUE14181801A patent/HUE036566T2/hu unknown
- 2006-10-05 AU AU2006303921A patent/AU2006303921B2/en not_active Ceased
- 2006-10-05 HR HRP20150176TT patent/HRP20150176T1/hr unknown
- 2006-10-05 ES ES06816225.4T patent/ES2533462T3/es active Active
- 2006-10-05 US US12/066,838 patent/US7632499B2/en not_active Expired - Fee Related
- 2006-10-05 EP EP14181801.3A patent/EP2816058B1/en active Active
- 2006-10-05 PT PT141818013T patent/PT2816058T/pt unknown
- 2006-10-05 PT PT06816225T patent/PT1951755E/pt unknown
- 2006-10-05 RS RS20150157A patent/RS54046B1/sr unknown
- 2006-10-05 WO PCT/US2006/038817 patent/WO2007047112A2/en not_active Ceased
- 2006-10-05 PL PL14181801T patent/PL2816058T3/pl unknown
- 2006-10-05 DK DK06816225.4T patent/DK1951755T3/en active
- 2006-10-05 EA EA200801065A patent/EA015903B1/ru not_active IP Right Cessation
- 2006-10-05 CA CA2624935A patent/CA2624935C/en active Active
- 2006-10-05 CN CN2006800375720A patent/CN101282992B/zh not_active Expired - Fee Related
- 2006-10-05 ES ES14181801.3T patent/ES2657292T3/es active Active
- 2006-10-05 SI SI200631876T patent/SI1951755T1/sl unknown
- 2006-10-05 LT LTEP14181801.3T patent/LT2816058T/lt unknown
-
2008
- 2008-02-18 IL IL189580A patent/IL189580A/en not_active IP Right Cessation
- 2008-05-09 NO NO20082167A patent/NO20082167L/no not_active Application Discontinuation
-
2009
- 2009-11-03 US US12/611,470 patent/US8066995B2/en not_active Expired - Fee Related
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