JP2011518125A5 - - Google Patents
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- Publication number
- JP2011518125A5 JP2011518125A5 JP2011501904A JP2011501904A JP2011518125A5 JP 2011518125 A5 JP2011518125 A5 JP 2011518125A5 JP 2011501904 A JP2011501904 A JP 2011501904A JP 2011501904 A JP2011501904 A JP 2011501904A JP 2011518125 A5 JP2011518125 A5 JP 2011518125A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fab fragment
- heavy chain
- light chain
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3990708P | 2008-03-27 | 2008-03-27 | |
| US61/039,907 | 2008-03-27 | ||
| PCT/US2009/037349 WO2009120530A1 (en) | 2008-03-27 | 2009-03-17 | Glucagon receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518125A JP2011518125A (ja) | 2011-06-23 |
| JP2011518125A5 true JP2011518125A5 (https=) | 2012-04-12 |
| JP5438095B2 JP5438095B2 (ja) | 2014-03-12 |
Family
ID=40794248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501904A Expired - Fee Related JP5438095B2 (ja) | 2008-03-27 | 2009-03-17 | グルカゴン受容体アンタゴニスト |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7968686B2 (https=) |
| EP (1) | EP2268670A1 (https=) |
| JP (1) | JP5438095B2 (https=) |
| KR (1) | KR101235934B1 (https=) |
| CN (1) | CN101983208A (https=) |
| AR (1) | AR070844A1 (https=) |
| AU (1) | AU2009228866A1 (https=) |
| BR (1) | BRPI0910118A2 (https=) |
| CA (1) | CA2719761A1 (https=) |
| CL (1) | CL2009000586A1 (https=) |
| EA (1) | EA201071126A1 (https=) |
| MX (1) | MX2010010517A (https=) |
| PE (1) | PE20091674A1 (https=) |
| TW (1) | TW201000126A (https=) |
| WO (1) | WO2009120530A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120056800A (ko) * | 2009-09-08 | 2012-06-04 | (주)네오팜 | 글루글루카곤 수용체에 대한 항체와 이의 사용 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| JO3756B1 (ar) * | 2010-11-23 | 2021-01-31 | Regeneron Pharma | اجسام مضادة بشرية لمستقبلات الجلوكاجون |
| US8771696B2 (en) | 2010-11-23 | 2014-07-08 | Regeneron Pharmaceuticals, Inc. | Method of reducing the severity of stress hyperglycemia with human antibodies to the glucagon receptor |
| EP3604339B1 (en) | 2011-01-14 | 2021-03-10 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013059531A1 (en) * | 2011-10-20 | 2013-04-25 | Genentech, Inc. | Anti-gcgr antibodies and uses thereof |
| EP2785740A1 (en) | 2011-12-02 | 2014-10-08 | Eli Lilly and Company | Anti-glucagon antibodies and uses thereof |
| WO2014181229A2 (en) * | 2013-05-07 | 2014-11-13 | Rinat Neuroscience Corp. | Anti-glucagon receptor antibodies and methods of use thereof |
| WO2015189698A2 (en) * | 2014-06-08 | 2015-12-17 | Beijing Cosci-Remd Bio Med Tech Company Ltd | Methods for treating type 1 diabetes using glucagon receptor antagonistic antibodies |
| NZ750953A (en) | 2016-08-30 | 2026-02-27 | Regeneron Pharma | Methods of treating severe insulin resistance by interfering with glucagon receptor signaling |
| US20190248888A1 (en) | 2016-10-20 | 2019-08-15 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
| EP3573651A4 (en) * | 2017-01-27 | 2020-10-14 | NGM Biopharmaceuticals, Inc. | GLUCAGON RECEPTOR BINDING PROTEINS AND METHODS OF USE |
| CA3071387A1 (en) | 2017-08-22 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Methods of treating urea cycle disorders by interfering with glucagon receptor signaling |
| CN110357959B (zh) | 2018-04-10 | 2023-02-28 | 鸿运华宁（杭州）生物医药有限公司 | Gcgr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用 |
| EP3829636A1 (en) | 2018-07-27 | 2021-06-09 | NGM Biopharmaceuticals, Inc. | Use of glucagon receptor antagonists with immunotherapeutic agent |
| CN115947849A (zh) | 2018-12-21 | 2023-04-11 | 江苏恒瑞医药股份有限公司 | 双特异性蛋白 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776725A (en) | 1992-08-28 | 1998-07-07 | Zymogenetics, Inc. | Recombinant production of glucagon receptors |
| HU219674B (hu) | 1992-08-28 | 2001-06-28 | Novo Nordisk A/S | Glukagon-receptort kódoló DNS-molekulák, glukagon-receptor peptidek, glukagon-receptort blokkoló monoklonális ellenanyagok, és eljárások előállításukra |
| AU2002239538A1 (en) | 2000-12-06 | 2002-06-18 | Deltagen, Inc. | Transgenic mice containing glucagon receptor gene disruptions |
| AR036711A1 (es) * | 2001-10-05 | 2004-09-29 | Bayer Corp | Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico |
| US7399853B2 (en) | 2003-04-28 | 2008-07-15 | Isis Pharmaceuticals | Modulation of glucagon receptor expression |
| WO2006005469A2 (en) | 2004-07-15 | 2006-01-19 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with glucagon receptor (gcgr) |
| WO2008003641A1 (en) | 2006-07-04 | 2008-01-10 | Bracco Imaging S.P.A. | Device for localized thermal ablation of biological tissue, particularly tumoral tissues or the like |
| CL2007002668A1 (es) * | 2006-09-20 | 2008-05-09 | Amgen Inc | Proteina de union a antigeno que se une al receptor de glucagon humano; acido nucleico que la codifica; metodo de produccion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir la diabetes tipo 2. |
-
2009
- 2009-03-12 AR ARP090100889A patent/AR070844A1/es unknown
- 2009-03-12 CL CL2009000586A patent/CL2009000586A1/es unknown
- 2009-03-12 PE PE2009000369A patent/PE20091674A1/es not_active Application Discontinuation
- 2009-03-13 TW TW098108296A patent/TW201000126A/zh unknown
- 2009-03-17 MX MX2010010517A patent/MX2010010517A/es not_active Application Discontinuation
- 2009-03-17 WO PCT/US2009/037349 patent/WO2009120530A1/en not_active Ceased
- 2009-03-17 EA EA201071126A patent/EA201071126A1/ru unknown
- 2009-03-17 AU AU2009228866A patent/AU2009228866A1/en not_active Abandoned
- 2009-03-17 KR KR1020107021297A patent/KR101235934B1/ko not_active Expired - Fee Related
- 2009-03-17 BR BRPI0910118A patent/BRPI0910118A2/pt not_active IP Right Cessation
- 2009-03-17 JP JP2011501904A patent/JP5438095B2/ja not_active Expired - Fee Related
- 2009-03-17 US US12/405,458 patent/US7968686B2/en not_active Expired - Fee Related
- 2009-03-17 EP EP09726006A patent/EP2268670A1/en not_active Withdrawn
- 2009-03-17 CN CN2009801107130A patent/CN101983208A/zh active Pending
- 2009-03-17 CA CA2719761A patent/CA2719761A1/en not_active Abandoned
-
2011
- 2011-05-16 US US13/108,073 patent/US20110212092A1/en not_active Abandoned
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