JP2010533478A5 - - Google Patents
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- Publication number
- JP2010533478A5 JP2010533478A5 JP2010516305A JP2010516305A JP2010533478A5 JP 2010533478 A5 JP2010533478 A5 JP 2010533478A5 JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010533478 A5 JP2010533478 A5 JP 2010533478A5
- Authority
- JP
- Japan
- Prior art keywords
- gamma secretase
- seq
- ledaefrhds
- lvml
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94973807P | 2007-07-13 | 2007-07-13 | |
| US12/172,978 US20090023158A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase |
| PCT/US2008/070012 WO2009012237A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533478A JP2010533478A (ja) | 2010-10-28 |
| JP2010533478A5 true JP2010533478A5 (https=) | 2011-09-01 |
Family
ID=39739883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010516305A Withdrawn JP2010533478A (ja) | 2007-07-13 | 2008-07-14 | ガンマセクレターゼの阻害剤の基質特異性を同定するための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20090023158A1 (https=) |
| EP (1) | EP2183598A1 (https=) |
| JP (1) | JP2010533478A (https=) |
| CA (1) | CA2692604A1 (https=) |
| WO (1) | WO2009012237A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7910324B2 (en) * | 2007-06-08 | 2011-03-22 | Eisai R&D Management Co., Ltd. | Method of screening for compounds which affect the processing of EphA4 by γ-secretase |
| US20090191580A1 (en) * | 2007-07-19 | 2009-07-30 | Eisai R & D Management Co., Ltd. | METHOD OF SCREENING USING c-MET, A NOVEL SUBSTRATE FOR GAMMA-SECRETASE |
| JPWO2009017234A1 (ja) * | 2007-08-01 | 2010-10-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ｃ−Ｒｅｔを利用したスクリーニング方法 |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
| JP5580598B2 (ja) * | 2007-11-15 | 2014-08-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ＥｐｈＡ７を利用したスクリーニング方法 |
| US7892769B2 (en) * | 2007-11-30 | 2011-02-22 | Eisai R&D Management Co., Ltd. | Processing of EphA4 polypeptide by γ-secretase activity |
| JP6059017B2 (ja) | 2010-12-17 | 2017-01-11 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ゼラチナーゼによるＥｐｈＡ４の切断反応を指標としたスクリーニング方法 |
| JP5961608B2 (ja) | 2011-04-25 | 2016-08-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ＥｐｈＡ４細胞外ドメインの測定による認知機能障害を伴う神経系疾患の検出方法 |
| ES2660969T5 (es) | 2012-06-22 | 2021-09-03 | Gentium S R L | Método basado en euglobulina para determinar la actividad biológica de defibrotida |
| EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| US11732260B2 (en) * | 2018-03-02 | 2023-08-22 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-β precursor protein |
| AR119303A1 (es) | 2019-07-01 | 2021-12-09 | Eisai R&D Man Co Ltd | Anticuerpo anti-epha4 humano |
| WO2021174075A1 (en) * | 2020-02-27 | 2021-09-02 | Adeptrix Corp. | Multiplexed bead-based analytical assays |
| US20230174612A1 (en) * | 2020-04-09 | 2023-06-08 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| CA3189922A1 (en) | 2020-07-28 | 2022-02-03 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing app expression |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604102A (en) | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| US5441870A (en) | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5605811A (en) | 1992-10-26 | 1997-02-25 | Athena Neurosciences, Inc. | Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein |
| AU702293B2 (en) | 1993-10-27 | 1999-02-18 | Athena Neurosciences, Inc. | Transgenic animals harboring APP allele having Swedish mutation |
| DE10131899A1 (de) * | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| WO2007058987A1 (en) * | 2005-11-10 | 2007-05-24 | Bristol-Myers Squibb Company | Methods of identifying compounds that inhibit notch cleavage |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
-
2008
- 2008-07-14 CA CA 2692604 patent/CA2692604A1/en not_active Abandoned
- 2008-07-14 JP JP2010516305A patent/JP2010533478A/ja not_active Withdrawn
- 2008-07-14 WO PCT/US2008/070012 patent/WO2009012237A1/en not_active Ceased
- 2008-07-14 US US12/172,978 patent/US20090023158A1/en not_active Abandoned
- 2008-07-14 EP EP08826401A patent/EP2183598A1/en not_active Withdrawn
-
2011
- 2011-03-08 US US13/043,278 patent/US20110306071A1/en not_active Abandoned
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