JP2009544676A5 - - Google Patents
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- Publication number
- JP2009544676A5 JP2009544676A5 JP2009521335A JP2009521335A JP2009544676A5 JP 2009544676 A5 JP2009544676 A5 JP 2009544676A5 JP 2009521335 A JP2009521335 A JP 2009521335A JP 2009521335 A JP2009521335 A JP 2009521335A JP 2009544676 A5 JP2009544676 A5 JP 2009544676A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- compound
- halogen
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 29
- 229910052739 hydrogen Inorganic materials 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 22
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 10
- -1 Butconazole Chemical compound 0.000 claims 3
- 241000222122 Candida albicans Species 0.000 claims 3
- 206010017533 Fungal infection Diseases 0.000 claims 3
- 208000031888 Mycoses Diseases 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 230000000843 anti-fungal effect Effects 0.000 claims 3
- 229940121375 antifungal agent Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241001225321 Aspergillus fumigatus Species 0.000 claims 2
- 229920001503 Glucan Polymers 0.000 claims 2
- 208000002474 Tinea Diseases 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 230000007774 longterm Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 150000003536 tetrazoles Chemical class 0.000 claims 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 1
- BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 claims 1
- MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 claims 1
- MPIPASJGOJYODL-SFHVURJKSA-N (R)-isoconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@@H](OCC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 MPIPASJGOJYODL-SFHVURJKSA-N 0.000 claims 1
- AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 claims 1
- ZCJYUTQZBAIHBS-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C=CC(SC=2C=CC=CC=2)=CC=1)CN1C=NC=C1 ZCJYUTQZBAIHBS-UHFFFAOYSA-N 0.000 claims 1
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 1
- QXHHHPZILQDDPS-UHFFFAOYSA-N 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound S1C=CC(COC(CN2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1Cl QXHHHPZILQDDPS-UHFFFAOYSA-N 0.000 claims 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
- MBRHNTMUYWQHMR-UHFFFAOYSA-N 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one Chemical compound NCCO.ON1C(=O)C=C(C)C=C1C1CCCCC1 MBRHNTMUYWQHMR-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
- 241000228212 Aspergillus Species 0.000 claims 1
- 206010005098 Blastomycosis Diseases 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 206010007134 Candida infections Diseases 0.000 claims 1
- 108010020326 Caspofungin Proteins 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000221204 Cryptococcus neoformans Species 0.000 claims 1
- 206010012504 Dermatophytosis Diseases 0.000 claims 1
- 208000014260 Fungal keratitis Diseases 0.000 claims 1
- CTETYYAZBPJBHE-UHFFFAOYSA-N Haloprogin Chemical compound ClC1=CC(Cl)=C(OCC#CI)C=C1Cl CTETYYAZBPJBHE-UHFFFAOYSA-N 0.000 claims 1
- 208000000816 Intravenous Substance Abuse Diseases 0.000 claims 1
- 206010062353 Keratitis fungal Diseases 0.000 claims 1
- 108010021062 Micafungin Proteins 0.000 claims 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims 1
- 241001460074 Microsporum distortum Species 0.000 claims 1
- 241001363490 Monilia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- AWGBZRVEGDNLDZ-UHFFFAOYSA-N Rimocidin Natural products C1C(C(C(O)C2)C(O)=O)OC2(O)CC(O)CCCC(=O)CC(O)C(CC)C(=O)OC(CCC)CC=CC=CC=CC=CC1OC1OC(C)C(O)C(N)C1O AWGBZRVEGDNLDZ-UHFFFAOYSA-N 0.000 claims 1
- AWGBZRVEGDNLDZ-JCUCCFEFSA-N Rimocidine Chemical compound O([C@H]1/C=C/C=C/C=C/C=C/C[C@H](OC(=O)[C@@H](CC)[C@H](O)CC(=O)CCC[C@H](O)C[C@@]2(O)O[C@H]([C@@H]([C@@H](O)C2)C(O)=O)C1)CCC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N)[C@@H]1O AWGBZRVEGDNLDZ-JCUCCFEFSA-N 0.000 claims 1
- 206010041736 Sporotrichosis Diseases 0.000 claims 1
- 241000893966 Trichophyton verrucosum Species 0.000 claims 1
- 229960003204 amorolfine Drugs 0.000 claims 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
- 229960003942 amphotericin b Drugs 0.000 claims 1
- 230000036436 anti-hiv Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 229960002206 bifonazole Drugs 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229960002962 butenafine Drugs 0.000 claims 1
- ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000003984 candidiasis Diseases 0.000 claims 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 claims 1
- JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 claims 1
- 229960003034 caspofungin Drugs 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960004375 ciclopirox olamine Drugs 0.000 claims 1
- 229960004022 clotrimazole Drugs 0.000 claims 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 claims 1
- 201000009861 cutaneous mycosis Diseases 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229960003913 econazole Drugs 0.000 claims 1
- 229960001274 fenticonazole Drugs 0.000 claims 1
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 claims 1
- 229960004413 flucytosine Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229960001235 gentian violet Drugs 0.000 claims 1
- 229960001906 haloprogin Drugs 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims 1
- 229960004849 isoconazole Drugs 0.000 claims 1
- 229960004130 itraconazole Drugs 0.000 claims 1
- 229960004125 ketoconazole Drugs 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 229960002159 micafungin Drugs 0.000 claims 1
- PIEUQSKUWLMALL-YABMTYFHSA-N micafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@H](O)CC(N)=O)[C@H](O)[C@@H](O)C=2C=C(OS(O)(=O)=O)C(O)=CC=2)[C@@H](C)O)=O)=NO1 PIEUQSKUWLMALL-YABMTYFHSA-N 0.000 claims 1
- 229960002509 miconazole Drugs 0.000 claims 1
- 229960004313 naftifine Drugs 0.000 claims 1
- OZGNYLLQHRPOBR-DHZHZOJOSA-N naftifine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)C\C=C\C1=CC=CC=C1 OZGNYLLQHRPOBR-DHZHZOJOSA-N 0.000 claims 1
- 229960003255 natamycin Drugs 0.000 claims 1
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 claims 1
- 235000010298 natamycin Nutrition 0.000 claims 1
- 239000004311 natamycin Substances 0.000 claims 1
- 229960000988 nystatin Drugs 0.000 claims 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229960003483 oxiconazole Drugs 0.000 claims 1
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960001589 posaconazole Drugs 0.000 claims 1
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 208000002491 severe combined immunodeficiency Diseases 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960002607 sulconazole Drugs 0.000 claims 1
- 229960002722 terbinafine Drugs 0.000 claims 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims 1
- 229960000580 terconazole Drugs 0.000 claims 1
- 229960004214 tioconazole Drugs 0.000 claims 1
- 229960004880 tolnaftate Drugs 0.000 claims 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 229960002703 undecylenic acid Drugs 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 1
- 229960004740 voriconazole Drugs 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0614678.1 | 2006-07-24 | ||
| GB0614677A GB0614677D0 (en) | 2006-07-24 | 2006-07-24 | Substituted Aniline Derivatives |
| GB0614677.3 | 2006-07-24 | ||
| GB0614678A GB0614678D0 (en) | 2006-07-24 | 2006-07-24 | Substituted aniline derivatives |
| GB0704648.5 | 2007-03-09 | ||
| GB0704648A GB0704648D0 (en) | 2007-03-09 | 2007-03-09 | Substituted aniline derivatives |
| GB0704645.1 | 2007-03-09 | ||
| GB0704645A GB0704645D0 (en) | 2007-03-09 | 2007-03-09 | Substituted aniline derivatives |
| PCT/GB2007/002815 WO2008012524A1 (en) | 2006-07-24 | 2007-07-24 | Substituted aniline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009544676A JP2009544676A (ja) | 2009-12-17 |
| JP2009544676A5 true JP2009544676A5 (enExample) | 2013-07-04 |
| JP5468900B2 JP5468900B2 (ja) | 2014-04-09 |
Family
ID=38484243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009521335A Expired - Fee Related JP5468900B2 (ja) | 2006-07-24 | 2007-07-24 | 置換されたアニリン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7678785B2 (enExample) |
| EP (1) | EP2046739B1 (enExample) |
| JP (1) | JP5468900B2 (enExample) |
| AU (1) | AU2007279092B2 (enExample) |
| CA (1) | CA2658913C (enExample) |
| WO (1) | WO2008012524A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7678785B2 (en) * | 2006-07-24 | 2010-03-16 | Ucb Pharma S.A. | Substituted aniline derivatives |
| NZ576324A (en) * | 2006-10-31 | 2011-08-26 | Cadila Healthcare Ltd | Selective tr-beta 1 agonist |
| TWI386204B (zh) * | 2008-04-10 | 2013-02-21 | Mitsubishi Tanabe Pharma Corp | 高半胱胺酸合成酶抑制劑 |
| CA2726703A1 (en) * | 2008-06-16 | 2009-12-23 | F. Hoffmann-La Roche Ag | Heteroaromatic monoamides as orexinin receptor antagonists |
| WO2011043480A1 (ja) * | 2009-10-09 | 2011-04-14 | 田辺三菱製薬株式会社 | ホモシステイン合成酵素阻害薬 |
| CA2821807A1 (en) * | 2010-12-21 | 2012-06-28 | Nestec S.A. | Methods and compositions suitable for managing blood glucose in animals |
| RU2541532C2 (ru) * | 2012-10-16 | 2015-02-20 | Федеральное Государственное Бюджетное Учреждение Науки Институт Нефтехимии И Катализа Ран | Ди-[4-(диметиламинометилсульфанил)-фениловый] эфир щавелевокислый - водорастворимое средство для борьбы с почвенной и поверхностно-семенной инфекцией |
| CN106563929B (zh) | 2015-10-08 | 2019-09-17 | 利宝地工程有限公司 | 修复和制造涡轮发动机部件的方法及涡轮发动机部件 |
| WO2018048882A1 (en) | 2016-09-06 | 2018-03-15 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN108172553A (zh) * | 2018-01-17 | 2018-06-15 | 杭州暖芯迦电子科技有限公司 | 一种视网膜假体植入芯片的封装结构及其封装方法 |
| CN116947678B (zh) * | 2023-07-24 | 2025-07-08 | 河南大学 | 一类氮原子双取代芳香环类小分子有机化合物及其衍生物及其在制备抗菌药物中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2676188A (en) * | 1950-12-16 | 1954-04-20 | American Home Prod | Acylated glycinamides |
| US4205168A (en) * | 1973-09-24 | 1980-05-27 | Chevron Research Company | N-Carbamylalkyl-2,6-dialkyl-α-haloacetanilides |
| US3944607A (en) * | 1974-10-17 | 1976-03-16 | Chevron Research Company | Herbicidal N-(N'-alkynylcarbamylmethyl)-2,6-dialkyl-α-haloacetanilides |
| JPS51125741A (en) * | 1974-10-17 | 1976-11-02 | Chevron Res | Weed killer |
| LU78804A1 (de) * | 1977-12-30 | 1979-07-20 | Byk Gulden Lomberg Chem Fab | N-substituierte w-aminoalkanoyl-w-aminoalkansaeuren,ihre verwendung und verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
| DE3114351A1 (de) * | 1981-04-09 | 1982-11-04 | Hoechst Ag, 6000 Frankfurt | "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung" |
| JPS58154567A (ja) * | 1982-03-09 | 1983-09-14 | Teikoku Chem Ind Corp Ltd | チオフエノ−ル誘導体及びその製造方法 |
| US4736066A (en) * | 1982-07-19 | 1988-04-05 | E. R. Squibb & Sons, Inc. | Intermediate for substituted peptide compounds |
| JPH01211560A (ja) * | 1988-02-18 | 1989-08-24 | Sagami Chem Res Center | β−ラクタム誘導体の製造方法 |
| IT1224627B (it) * | 1988-04-12 | 1990-10-04 | Guidotti & C Spa Labor | Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. |
| ES2087038B1 (es) * | 1994-11-07 | 1997-03-16 | Uriach & Cia Sa J | Nuevas piperidinas con actividad antagonista del paf. |
| US6350761B1 (en) * | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
| CN102050758A (zh) * | 2000-09-14 | 2011-05-11 | 田边三菱制药株式会社 | 酰胺衍生物及其制备药物的用途 |
| RU2247716C2 (ru) | 2003-03-27 | 2005-03-10 | Российский химико-технологический университет им. Д.И. Менделеева (РХТУ) | Замещенные метил-n-амидооксамоил-n-фенил-d, l-аланинаты и их способы получения |
| EP1669348A4 (en) * | 2003-09-30 | 2009-03-11 | Eisai R&D Man Co Ltd | NEW ANTIPILIC AGENT CONTAINING A HETEROCYCLIC COMPOUND |
| JP2005202314A (ja) * | 2004-01-19 | 2005-07-28 | Fuji Photo Film Co Ltd | 重合性組成物及びそれを用いた画像形成材料 |
| EP1717238A4 (en) * | 2004-02-16 | 2008-03-05 | Daiichi Seiyaku Co | FUNGICIDES HETEROCYCLIC COMPOUNDS |
| WO2006012441A1 (en) * | 2004-07-23 | 2006-02-02 | Susan Marie Royalty | Peptidase inhibitors |
| JP4874958B2 (ja) * | 2005-03-30 | 2012-02-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピリジン誘導体を含有する抗真菌剤 |
| US7737166B2 (en) * | 2005-08-17 | 2010-06-15 | Daiichi Sankyo Company, Limited | Antifungal bicyclic hetero ring compounds |
| US7678785B2 (en) | 2006-07-24 | 2010-03-16 | Ucb Pharma S.A. | Substituted aniline derivatives |
-
2007
- 2007-07-24 US US11/782,337 patent/US7678785B2/en not_active Expired - Fee Related
- 2007-07-24 EP EP07766352.4A patent/EP2046739B1/en not_active Not-in-force
- 2007-07-24 AU AU2007279092A patent/AU2007279092B2/en not_active Ceased
- 2007-07-24 JP JP2009521335A patent/JP5468900B2/ja not_active Expired - Fee Related
- 2007-07-24 WO PCT/GB2007/002815 patent/WO2008012524A1/en not_active Ceased
- 2007-07-24 CA CA2658913A patent/CA2658913C/en not_active Expired - Fee Related
-
2010
- 2010-01-13 US US12/687,008 patent/US8071582B2/en not_active Expired - Fee Related
-
2011
- 2011-10-07 US US13/269,321 patent/US8624022B2/en not_active Expired - Fee Related
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