JP5468900B2 - 置換されたアニリン誘導体 - Google Patents

置換されたアニリン誘導体 Download PDF

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Publication number
JP5468900B2
JP5468900B2 JP2009521335A JP2009521335A JP5468900B2 JP 5468900 B2 JP5468900 B2 JP 5468900B2 JP 2009521335 A JP2009521335 A JP 2009521335A JP 2009521335 A JP2009521335 A JP 2009521335A JP 5468900 B2 JP5468900 B2 JP 5468900B2
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JP
Japan
Prior art keywords
alkyl
compound
hydrogen
group
halogen
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JP2009521335A
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English (en)
Japanese (ja)
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JP2009544676A (ja
JP2009544676A5 (enExample
Inventor
アンドリュー・デイビッド・カー
ジュディ・シャーロット・ノイス
マイケル・グレン・オーチャード
デイビッド・ウィリアム・ポーター
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ユセベ ファルマ ソシエテ アノニム
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Priority claimed from GB0614678A external-priority patent/GB0614678D0/en
Priority claimed from GB0614677A external-priority patent/GB0614677D0/en
Priority claimed from GB0704648A external-priority patent/GB0704648D0/en
Priority claimed from GB0704645A external-priority patent/GB0704645D0/en
Application filed by ユセベ ファルマ ソシエテ アノニム filed Critical ユセベ ファルマ ソシエテ アノニム
Publication of JP2009544676A publication Critical patent/JP2009544676A/ja
Publication of JP2009544676A5 publication Critical patent/JP2009544676A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2009521335A 2006-07-24 2007-07-24 置換されたアニリン誘導体 Expired - Fee Related JP5468900B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0614678A GB0614678D0 (en) 2006-07-24 2006-07-24 Substituted aniline derivatives
GB0614677A GB0614677D0 (en) 2006-07-24 2006-07-24 Substituted Aniline Derivatives
GB0614678.1 2006-07-24
GB0614677.3 2006-07-24
GB0704645.1 2007-03-09
GB0704648A GB0704648D0 (en) 2007-03-09 2007-03-09 Substituted aniline derivatives
GB0704645A GB0704645D0 (en) 2007-03-09 2007-03-09 Substituted aniline derivatives
GB0704648.5 2007-03-09
PCT/GB2007/002815 WO2008012524A1 (en) 2006-07-24 2007-07-24 Substituted aniline derivatives

Publications (3)

Publication Number Publication Date
JP2009544676A JP2009544676A (ja) 2009-12-17
JP2009544676A5 JP2009544676A5 (enExample) 2013-07-04
JP5468900B2 true JP5468900B2 (ja) 2014-04-09

Family

ID=38484243

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009521335A Expired - Fee Related JP5468900B2 (ja) 2006-07-24 2007-07-24 置換されたアニリン誘導体

Country Status (6)

Country Link
US (3) US7678785B2 (enExample)
EP (1) EP2046739B1 (enExample)
JP (1) JP5468900B2 (enExample)
AU (1) AU2007279092B2 (enExample)
CA (1) CA2658913C (enExample)
WO (1) WO2008012524A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007279092B2 (en) * 2006-07-24 2012-12-13 Ucb Pharma S.A. Substituted aniline derivatives
MX2009004619A (es) * 2006-10-31 2009-05-15 Cadila Healthcare Ltd Agonistas selectivos del receptor tiroideo (tr) beta 1.
TWI386204B (zh) * 2008-04-10 2013-02-21 Mitsubishi Tanabe Pharma Corp 高半胱胺酸合成酶抑制劑
EP2297102A1 (en) * 2008-06-16 2011-03-23 F. Hoffmann-La Roche AG Heteroaromatic monoamides as orexinin receptor antagonists
WO2011043480A1 (ja) * 2009-10-09 2011-04-14 田辺三菱製薬株式会社 ホモシステイン合成酵素阻害薬
US20130316029A1 (en) * 2010-12-21 2013-11-28 Nestec S.A. Methods and compositions suitable for managing blood glucose in animals
RU2541532C2 (ru) * 2012-10-16 2015-02-20 Федеральное Государственное Бюджетное Учреждение Науки Институт Нефтехимии И Катализа Ран Ди-[4-(диметиламинометилсульфанил)-фениловый] эфир щавелевокислый - водорастворимое средство для борьбы с почвенной и поверхностно-семенной инфекцией
CN106563929B (zh) 2015-10-08 2019-09-17 利宝地工程有限公司 修复和制造涡轮发动机部件的方法及涡轮发动机部件
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
CN108172553A (zh) * 2018-01-17 2018-06-15 杭州暖芯迦电子科技有限公司 一种视网膜假体植入芯片的封装结构及其封装方法
CN116947678B (zh) * 2023-07-24 2025-07-08 河南大学 一类氮原子双取代芳香环类小分子有机化合物及其衍生物及其在制备抗菌药物中的应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2676188A (en) * 1950-12-16 1954-04-20 American Home Prod Acylated glycinamides
US4205168A (en) * 1973-09-24 1980-05-27 Chevron Research Company N-Carbamylalkyl-2,6-dialkyl-α-haloacetanilides
JPS51125741A (en) * 1974-10-17 1976-11-02 Chevron Res Weed killer
US3944607A (en) * 1974-10-17 1976-03-16 Chevron Research Company Herbicidal N-(N'-alkynylcarbamylmethyl)-2,6-dialkyl-α-haloacetanilides
LU78804A1 (de) * 1977-12-30 1979-07-20 Byk Gulden Lomberg Chem Fab N-substituierte w-aminoalkanoyl-w-aminoalkansaeuren,ihre verwendung und verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE3114351A1 (de) * 1981-04-09 1982-11-04 Hoechst Ag, 6000 Frankfurt "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung"
JPS58154567A (ja) * 1982-03-09 1983-09-14 Teikoku Chem Ind Corp Ltd チオフエノ−ル誘導体及びその製造方法
US4736066A (en) * 1982-07-19 1988-04-05 E. R. Squibb & Sons, Inc. Intermediate for substituted peptide compounds
JPH01211560A (ja) * 1988-02-18 1989-08-24 Sagami Chem Res Center β−ラクタム誘導体の製造方法
IT1224627B (it) * 1988-04-12 1990-10-04 Guidotti & C Spa Labor Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.
ES2087038B1 (es) * 1994-11-07 1997-03-16 Uriach & Cia Sa J Nuevas piperidinas con actividad antagonista del paf.
US6350761B1 (en) * 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
JP4751567B2 (ja) * 2000-09-14 2011-08-17 田辺三菱製薬株式会社 新規アミド誘導体およびその医薬としての用途
RU2247716C2 (ru) 2003-03-27 2005-03-10 Российский химико-технологический университет им. Д.И. Менделеева (РХТУ) Замещенные метил-n-амидооксамоил-n-фенил-d, l-аланинаты и их способы получения
US7932272B2 (en) * 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
JP2005202314A (ja) * 2004-01-19 2005-07-28 Fuji Photo Film Co Ltd 重合性組成物及びそれを用いた画像形成材料
WO2005077948A1 (ja) * 2004-02-16 2005-08-25 Daiichi Pharmaceutical Co., Ltd. 抗真菌作用複素環化合物
WO2006012441A1 (en) * 2004-07-23 2006-02-02 Susan Marie Royalty Peptidase inhibitors
WO2006106711A1 (ja) * 2005-03-30 2006-10-12 Eisai R & D Management Co., Ltd. ピリジン誘導体を含有する抗真菌剤
US7737166B2 (en) * 2005-08-17 2010-06-15 Daiichi Sankyo Company, Limited Antifungal bicyclic hetero ring compounds
AU2007279092B2 (en) 2006-07-24 2012-12-13 Ucb Pharma S.A. Substituted aniline derivatives

Also Published As

Publication number Publication date
EP2046739A1 (en) 2009-04-15
EP2046739B1 (en) 2015-08-26
JP2009544676A (ja) 2009-12-17
US20120029188A1 (en) 2012-02-02
WO2008012524A1 (en) 2008-01-31
US7678785B2 (en) 2010-03-16
AU2007279092A1 (en) 2008-01-31
CA2658913C (en) 2015-07-21
AU2007279092B2 (en) 2012-12-13
CA2658913A1 (en) 2008-01-31
US8624022B2 (en) 2014-01-07
US20110014271A1 (en) 2011-01-20
US20080045497A1 (en) 2008-02-21
US8071582B2 (en) 2011-12-06

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