AU2007279092B2 - Substituted aniline derivatives - Google Patents

Substituted aniline derivatives Download PDF

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Publication number
AU2007279092B2
AU2007279092B2 AU2007279092A AU2007279092A AU2007279092B2 AU 2007279092 B2 AU2007279092 B2 AU 2007279092B2 AU 2007279092 A AU2007279092 A AU 2007279092A AU 2007279092 A AU2007279092 A AU 2007279092A AU 2007279092 B2 AU2007279092 B2 AU 2007279092B2
Authority
AU
Australia
Prior art keywords
alkyl
compound
hydrogen
compounds
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007279092A
Other languages
English (en)
Other versions
AU2007279092A1 (en
Inventor
Andrew David Carr
Judi Charlotte Neuss
Michael Glen Orchard
David William Porter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0614678A external-priority patent/GB0614678D0/en
Priority claimed from GB0614677A external-priority patent/GB0614677D0/en
Priority claimed from GB0704648A external-priority patent/GB0704648D0/en
Priority claimed from GB0704645A external-priority patent/GB0704645D0/en
Application filed by UCB SA filed Critical UCB SA
Publication of AU2007279092A1 publication Critical patent/AU2007279092A1/en
Application granted granted Critical
Publication of AU2007279092B2 publication Critical patent/AU2007279092B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
AU2007279092A 2006-07-24 2007-07-24 Substituted aniline derivatives Ceased AU2007279092B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0614678A GB0614678D0 (en) 2006-07-24 2006-07-24 Substituted aniline derivatives
GB0614677A GB0614677D0 (en) 2006-07-24 2006-07-24 Substituted Aniline Derivatives
GB0614678.1 2006-07-24
GB0614677.3 2006-07-24
GB0704645.1 2007-03-09
GB0704648A GB0704648D0 (en) 2007-03-09 2007-03-09 Substituted aniline derivatives
GB0704645A GB0704645D0 (en) 2007-03-09 2007-03-09 Substituted aniline derivatives
GB0704648.5 2007-03-09
PCT/GB2007/002815 WO2008012524A1 (en) 2006-07-24 2007-07-24 Substituted aniline derivatives

Publications (2)

Publication Number Publication Date
AU2007279092A1 AU2007279092A1 (en) 2008-01-31
AU2007279092B2 true AU2007279092B2 (en) 2012-12-13

Family

ID=38484243

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007279092A Ceased AU2007279092B2 (en) 2006-07-24 2007-07-24 Substituted aniline derivatives

Country Status (6)

Country Link
US (3) US7678785B2 (enExample)
EP (1) EP2046739B1 (enExample)
JP (1) JP5468900B2 (enExample)
AU (1) AU2007279092B2 (enExample)
CA (1) CA2658913C (enExample)
WO (1) WO2008012524A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007279092B2 (en) * 2006-07-24 2012-12-13 Ucb Pharma S.A. Substituted aniline derivatives
MX2009004619A (es) * 2006-10-31 2009-05-15 Cadila Healthcare Ltd Agonistas selectivos del receptor tiroideo (tr) beta 1.
TWI386204B (zh) * 2008-04-10 2013-02-21 Mitsubishi Tanabe Pharma Corp 高半胱胺酸合成酶抑制劑
EP2297102A1 (en) * 2008-06-16 2011-03-23 F. Hoffmann-La Roche AG Heteroaromatic monoamides as orexinin receptor antagonists
WO2011043480A1 (ja) * 2009-10-09 2011-04-14 田辺三菱製薬株式会社 ホモシステイン合成酵素阻害薬
US20130316029A1 (en) * 2010-12-21 2013-11-28 Nestec S.A. Methods and compositions suitable for managing blood glucose in animals
RU2541532C2 (ru) * 2012-10-16 2015-02-20 Федеральное Государственное Бюджетное Учреждение Науки Институт Нефтехимии И Катализа Ран Ди-[4-(диметиламинометилсульфанил)-фениловый] эфир щавелевокислый - водорастворимое средство для борьбы с почвенной и поверхностно-семенной инфекцией
CN106563929B (zh) 2015-10-08 2019-09-17 利宝地工程有限公司 修复和制造涡轮发动机部件的方法及涡轮发动机部件
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
CN108172553A (zh) * 2018-01-17 2018-06-15 杭州暖芯迦电子科技有限公司 一种视网膜假体植入芯片的封装结构及其封装方法
CN116947678B (zh) * 2023-07-24 2025-07-08 河南大学 一类氮原子双取代芳香环类小分子有机化合物及其衍生物及其在制备抗菌药物中的应用

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US4205168A (en) * 1973-09-24 1980-05-27 Chevron Research Company N-Carbamylalkyl-2,6-dialkyl-α-haloacetanilides
EP0062887B1 (de) * 1981-04-09 1984-07-11 Hoechst Aktiengesellschaft Oxindol-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel mit neuroanaboler Wirkung
US6350761B1 (en) * 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants

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US2676188A (en) * 1950-12-16 1954-04-20 American Home Prod Acylated glycinamides
JPS51125741A (en) * 1974-10-17 1976-11-02 Chevron Res Weed killer
US3944607A (en) * 1974-10-17 1976-03-16 Chevron Research Company Herbicidal N-(N'-alkynylcarbamylmethyl)-2,6-dialkyl-α-haloacetanilides
LU78804A1 (de) * 1977-12-30 1979-07-20 Byk Gulden Lomberg Chem Fab N-substituierte w-aminoalkanoyl-w-aminoalkansaeuren,ihre verwendung und verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
JPS58154567A (ja) * 1982-03-09 1983-09-14 Teikoku Chem Ind Corp Ltd チオフエノ−ル誘導体及びその製造方法
US4736066A (en) * 1982-07-19 1988-04-05 E. R. Squibb & Sons, Inc. Intermediate for substituted peptide compounds
JPH01211560A (ja) * 1988-02-18 1989-08-24 Sagami Chem Res Center β−ラクタム誘導体の製造方法
IT1224627B (it) * 1988-04-12 1990-10-04 Guidotti & C Spa Labor Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.
ES2087038B1 (es) * 1994-11-07 1997-03-16 Uriach & Cia Sa J Nuevas piperidinas con actividad antagonista del paf.
JP4751567B2 (ja) * 2000-09-14 2011-08-17 田辺三菱製薬株式会社 新規アミド誘導体およびその医薬としての用途
RU2247716C2 (ru) 2003-03-27 2005-03-10 Российский химико-технологический университет им. Д.И. Менделеева (РХТУ) Замещенные метил-n-амидооксамоил-n-фенил-d, l-аланинаты и их способы получения
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4205168A (en) * 1973-09-24 1980-05-27 Chevron Research Company N-Carbamylalkyl-2,6-dialkyl-α-haloacetanilides
EP0062887B1 (de) * 1981-04-09 1984-07-11 Hoechst Aktiengesellschaft Oxindol-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel mit neuroanaboler Wirkung
US6350761B1 (en) * 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants

Also Published As

Publication number Publication date
EP2046739A1 (en) 2009-04-15
EP2046739B1 (en) 2015-08-26
JP2009544676A (ja) 2009-12-17
US20120029188A1 (en) 2012-02-02
WO2008012524A1 (en) 2008-01-31
US7678785B2 (en) 2010-03-16
AU2007279092A1 (en) 2008-01-31
CA2658913C (en) 2015-07-21
CA2658913A1 (en) 2008-01-31
US8624022B2 (en) 2014-01-07
US20110014271A1 (en) 2011-01-20
JP5468900B2 (ja) 2014-04-09
US20080045497A1 (en) 2008-02-21
US8071582B2 (en) 2011-12-06

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired