JP2009543552A5 - - Google Patents
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- JP2009543552A5 JP2009543552A5 JP2009519525A JP2009519525A JP2009543552A5 JP 2009543552 A5 JP2009543552 A5 JP 2009543552A5 JP 2009519525 A JP2009519525 A JP 2009519525A JP 2009519525 A JP2009519525 A JP 2009519525A JP 2009543552 A5 JP2009543552 A5 JP 2009543552A5
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- Prior art keywords
- mir
- colon cancer
- related disease
- gene product
- marker
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- 206010009944 Colon cancer Diseases 0.000 claims 57
- 208000029742 colonic neoplasm Diseases 0.000 claims 57
- 108091070501 miRNA Proteins 0.000 claims 52
- 201000010099 disease Diseases 0.000 claims 49
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 49
- 108090000623 proteins and genes Proteins 0.000 claims 45
- 239000000047 product Substances 0.000 claims 44
- 238000000034 method Methods 0.000 claims 39
- 239000003550 marker Substances 0.000 claims 27
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 25
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims 25
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 108091028141 MiR-203 Proteins 0.000 claims 19
- 108091049679 miR-20a stem-loop Proteins 0.000 claims 19
- 238000012360 testing method Methods 0.000 claims 19
- 108091043222 miR-181b stem-loop Proteins 0.000 claims 18
- 239000000523 sample Substances 0.000 claims 17
- 108091064157 miR-106a stem-loop Proteins 0.000 claims 16
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 230000002401 inhibitory effect Effects 0.000 claims 9
- 208000005623 Carcinogenesis Diseases 0.000 claims 8
- 230000036952 cancer formation Effects 0.000 claims 8
- 231100000504 carcinogenesis Toxicity 0.000 claims 8
- 238000004393 prognosis Methods 0.000 claims 8
- 230000004044 response Effects 0.000 claims 8
- 230000004083 survival effect Effects 0.000 claims 8
- 230000001105 regulatory effect Effects 0.000 claims 7
- 238000010171 animal model Methods 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 239000002679 microRNA Substances 0.000 claims 5
- 208000009956 adenocarcinoma Diseases 0.000 claims 4
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- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
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- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80730406P | 2006-07-13 | 2006-07-13 | |
| US60/807,304 | 2006-07-13 | ||
| US93273607P | 2007-06-01 | 2007-06-01 | |
| US60/932,736 | 2007-06-01 | ||
| PCT/US2007/015892 WO2008008430A2 (en) | 2006-07-13 | 2007-07-12 | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013056596A Division JP5778708B2 (ja) | 2006-07-13 | 2013-03-19 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009543552A JP2009543552A (ja) | 2009-12-10 |
| JP2009543552A5 true JP2009543552A5 (cg-RX-API-DMAC7.html) | 2011-08-11 |
| JP5230619B2 JP5230619B2 (ja) | 2013-07-10 |
Family
ID=38923889
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519525A Expired - Fee Related JP5230619B2 (ja) | 2006-07-13 | 2007-07-12 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| JP2013056596A Expired - Fee Related JP5778708B2 (ja) | 2006-07-13 | 2013-03-19 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| JP2015136948A Pending JP2015231376A (ja) | 2006-07-13 | 2015-07-08 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013056596A Expired - Fee Related JP5778708B2 (ja) | 2006-07-13 | 2013-03-19 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| JP2015136948A Pending JP2015231376A (ja) | 2006-07-13 | 2015-07-08 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (12) | US8084199B2 (cg-RX-API-DMAC7.html) |
| EP (11) | EP2436784B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5230619B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103589784A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007272947B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2657030A1 (cg-RX-API-DMAC7.html) |
| ES (9) | ES2562607T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008008430A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| AU2005333165B2 (en) | 2004-11-12 | 2012-07-19 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| CN102533966B (zh) | 2005-08-01 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| CA2845251A1 (en) | 2005-09-12 | 2007-03-22 | The Ohio State University Research Foundation | Compositions for the therapy of bcl2-associated cancers and methods of preparation thereof |
| EP2479286B1 (en) | 2006-01-05 | 2013-11-13 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| EP2514434B1 (en) | 2006-01-05 | 2015-10-21 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer |
| EP2591794A1 (en) | 2006-01-05 | 2013-05-15 | The Ohio State University Research Foundation | MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors |
| CA2646051A1 (en) | 2006-03-20 | 2007-09-27 | Carlo M. Croce | Microrna fingerprints during human megakaryocytopoiesis |
| ES2562607T3 (es) | 2006-07-13 | 2016-03-07 | The Ohio State University Research Foundation | MIR-21 para el diagnóstico de adenocarcinoma de colon con mal pronóstico de supervivencia |
| CN101535505A (zh) | 2006-09-19 | 2009-09-16 | 俄亥俄州立大学研究基金会 | 慢性淋巴细胞性白血病(CLL)中受miR-29和miR-181调控的TCL1的表达 |
| AU2007299828C1 (en) * | 2006-09-19 | 2014-07-17 | Interpace Diagnostics, Llc | MicroRNAs differentially expressed in pancreatic diseases and uses thereof |
| AU2007314212B2 (en) | 2006-11-01 | 2014-05-29 | The Govt. Of The Usa As Represented By The Secretary Of The Department Of Health And Human Services | MicroRNA expression signature for predicting survival and metastases in Hepatocellular carcinoma |
| CN103555825B (zh) | 2007-01-31 | 2015-09-30 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| US20090099034A1 (en) * | 2007-06-07 | 2009-04-16 | Wisconsin Alumni Research Foundation | Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers |
| AU2008262252B2 (en) | 2007-06-08 | 2013-09-12 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells |
| AU2008266014B2 (en) | 2007-06-15 | 2013-06-06 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing |
| WO2009018303A2 (en) | 2007-07-31 | 2009-02-05 | The Ohio State University Research Foundation | Methods for reverting methylation by targeting dnmt3a and dnmt3b |
| CA2695514A1 (en) | 2007-08-03 | 2009-02-12 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncrnas |
| AU2008288806B2 (en) | 2007-08-22 | 2014-11-27 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias |
| EP2198050A1 (en) | 2007-09-14 | 2010-06-23 | Asuragen, INC. | Micrornas differentially expressed in cervical cancer and uses thereof |
| JP2011504093A (ja) | 2007-10-26 | 2011-02-03 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 脆弱性ヒスチジン三連構造（ｆｈｉｔ）相互作用を同定するための方法およびその使用 |
| WO2009058907A2 (en) | 2007-10-29 | 2009-05-07 | Isis Pharmaceuticals, Inc. | Targeting micrornas for the treatment of liver cancer |
| DE102007052114B4 (de) | 2007-10-30 | 2011-01-05 | T2Cure Gmbh | Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle |
| US8071562B2 (en) | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
| JP5116026B2 (ja) * | 2008-01-23 | 2013-01-09 | 富士フイルム株式会社 | 癌の検出方法および癌抑制剤 |
| WO2009105520A2 (en) * | 2008-02-19 | 2009-08-27 | University Of Georgia Research Foundation | Methods, devices, and compositions for the highly-sensitive detection and identification of diverse molecular entities |
| US20110034538A1 (en) * | 2008-02-28 | 2011-02-10 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Gastric Cancer |
| US20090220589A1 (en) * | 2008-03-01 | 2009-09-03 | Abraxis Bioscience, Llc | Treatment, diagnostic, and method for discovering antagonist using sparc specific mirnas |
| WO2009111643A2 (en) * | 2008-03-06 | 2009-09-11 | Asuragen, Inc. | Microrna markers for recurrence of colorectal cancer |
| EP2990487A1 (en) | 2008-05-08 | 2016-03-02 | Asuragen, INC. | Compositions and methods related to mirna modulation of neovascularization or angiogenesis |
| EP2334805A1 (en) * | 2008-06-04 | 2011-06-22 | Andor Pivarcsi | Skin cancer associated micrornas |
| AU2009257410B2 (en) | 2008-06-11 | 2014-03-06 | Fudan University | Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| EP2853601B1 (en) * | 2008-07-18 | 2016-09-21 | TrovaGene, Inc. | Methods for PCR-based detection of "ultra short" nucleic acid sequences |
| JP2012500389A (ja) * | 2008-08-12 | 2012-01-05 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法 |
| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| CN102078621B (zh) * | 2009-11-27 | 2013-04-10 | 中国科学院上海生命科学研究院 | 调控浆细胞样树突状细胞i型干扰素表达的方法和组合物 |
| WO2011076147A1 (en) * | 2009-12-24 | 2011-06-30 | Fudan University | Plasma-based micro-rna biomarkers and methods for early detection of colorectal cancer |
| CN102770560B (zh) * | 2009-12-24 | 2015-11-25 | 复旦大学 | 用于早期检测结直肠癌的基于血浆的微rna生物标记及方法 |
| CN102933719B (zh) * | 2009-12-24 | 2015-05-06 | 复旦大学 | 用于结直肠癌血浆中的微rna表达谱分析的组合物和方法 |
| WO2011076142A1 (en) * | 2009-12-24 | 2011-06-30 | Fudan University | Compositions and methods for microrna expession profiling in plasma of colorectal cancer |
| US8841269B2 (en) * | 2010-02-23 | 2014-09-23 | Creighton University | Polynucleotides for use in treating and diagnosing cancers |
| CN101831461B (zh) * | 2010-04-30 | 2012-01-04 | 浙江大学 | 一种人小RNA-148a表达载体及应用 |
| EP2625293A4 (en) * | 2010-10-08 | 2014-03-19 | Baylor Res Inst | Micrornas (mirna) as biomakers for the identification of familial and non-familial colorectal cancer |
| CA2816603A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| BR112013011942A2 (pt) | 2010-11-15 | 2016-11-01 | Univ Michigan | formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida. |
| EP2942403B1 (en) * | 2010-12-01 | 2017-04-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting the outcome of a cancer by analysing mirna expression |
| SG189505A1 (en) * | 2011-01-13 | 2013-05-31 | Ind Tech Res Inst | Biomarkers for recurrence prediction of colorectal cancer |
| KR20140008375A (ko) | 2011-02-17 | 2014-01-21 | 노오쓰웨스턴 유니버시티 | 초미세 구조 및 분자 마커의 검출에 의한 암 스크리닝 |
| EP2683387A4 (en) | 2011-03-07 | 2014-09-03 | Univ Ohio State | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
| CN102899392A (zh) * | 2011-07-28 | 2013-01-30 | 上海生物芯片有限公司 | 用于肠癌诊断的一组miRNA的检测方法和应用 |
| EP3156505B1 (en) * | 2011-08-19 | 2019-07-17 | Hummingbird Diagnostics GmbH | Complex sets of mirnas as non-invasive biomarkers for colon cancer |
| US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| HK1197273A1 (en) | 2011-10-14 | 2015-01-09 | The Ohio State University | Methods and materials related to ovarian cancer |
| US9481885B2 (en) * | 2011-12-13 | 2016-11-01 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| CN102443644A (zh) * | 2011-12-20 | 2012-05-09 | 苏州福英基因科技有限公司 | 结肠癌病理演变前期microrna-29a水平原位杂交检测试剂盒及检测方法和应用 |
| US10174314B2 (en) * | 2011-12-22 | 2019-01-08 | Interna Technologies B.V. | MiRNA for treating head and neck cancer |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| WO2014100216A1 (en) * | 2012-12-19 | 2014-06-26 | The Regents Of The University Of California | Cancer-Associated MicroRNAs and Related Antibodies |
| CN105209881B (zh) | 2013-03-13 | 2021-01-22 | 迈阿密大学 | 从细胞培养上清液和生物流体分离并纯化微泡的方法 |
| MX2015014486A (es) | 2013-04-15 | 2016-07-21 | Regeneron Pharma | Marcadores de respuesta de células tumorales a la terapia. |
| US20160289763A1 (en) * | 2013-11-13 | 2016-10-06 | The Texas A&M University System | Micro-rnas that modulate lymphangiogenesis and inflammatory pathways in lymphatic vessel cells |
| WO2015126886A1 (en) | 2014-02-18 | 2015-08-27 | Baylor Research Institute | Mir-320e and colorectal cancer |
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