JP2009541204A5 - - Google Patents
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- Publication number
- JP2009541204A5 JP2009541204A5 JP2008558572A JP2008558572A JP2009541204A5 JP 2009541204 A5 JP2009541204 A5 JP 2009541204A5 JP 2008558572 A JP2008558572 A JP 2008558572A JP 2008558572 A JP2008558572 A JP 2008558572A JP 2009541204 A5 JP2009541204 A5 JP 2009541204A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- chain
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 41
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 13
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 4
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 4
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 4
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 206010042863 synovial sarcoma Diseases 0.000 claims 4
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 238000011503 in vivo imaging Methods 0.000 claims 2
- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- ZCYVEMRRCGMTRW-YPZZEJLDSA-N iodine-125 Chemical group [125I] ZCYVEMRRCGMTRW-YPZZEJLDSA-N 0.000 claims 1
- 229940044173 iodine-125 Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81525706P | 2006-06-21 | 2006-06-21 | |
| US60/815,257 | 2006-06-21 | ||
| PCT/JP2006/317155 WO2007148417A1 (en) | 2006-06-21 | 2006-08-24 | Tumor-targeting monoclonal antibodies to fzd10 and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009541204A JP2009541204A (ja) | 2009-11-26 |
| JP2009541204A5 true JP2009541204A5 (enExample) | 2011-07-28 |
| JP5028635B2 JP5028635B2 (ja) | 2012-09-19 |
Family
ID=37616924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008558572A Active JP5028635B2 (ja) | 2006-06-21 | 2006-08-24 | Ｆｚｄ１０に対する腫瘍標的化モノクローナル抗体とその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8221751B2 (enExample) |
| EP (2) | EP2386577A3 (enExample) |
| JP (1) | JP5028635B2 (enExample) |
| KR (1) | KR101351208B1 (enExample) |
| CN (1) | CN101573383B (enExample) |
| BR (1) | BRPI0621800B8 (enExample) |
| CA (1) | CA2655289C (enExample) |
| ES (1) | ES2405618T3 (enExample) |
| RU (1) | RU2412203C2 (enExample) |
| WO (1) | WO2007148417A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2500360B1 (en) | 2005-10-31 | 2015-08-05 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| CA2668714A1 (en) * | 2006-11-14 | 2008-05-22 | Novartis Ag | Methods of treating, diagnosing or detecting cancer |
| SG186017A1 (en) | 2007-11-30 | 2012-12-28 | Kalobios Pharmaceuticals Inc | Antibodies to the pcrv antigen of pseudomonas aeruginosa |
| EP2331136B1 (en) | 2008-09-26 | 2018-01-10 | OncoMed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| JP5407042B2 (ja) * | 2009-12-16 | 2014-02-05 | 公益財団法人ヒューマンサイエンス振興財団 | セセルニン−１の使用、滑膜肉腫の予後予測方法及び検査用試薬キット |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| CN102971337B (zh) | 2010-04-01 | 2016-09-21 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
| EP2720721B1 (en) | 2011-06-17 | 2017-08-30 | President and Fellows of Harvard College | Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer |
| WO2013025446A2 (en) * | 2011-08-12 | 2013-02-21 | Omeros Corporation | Anti-fzd10 monoclonal antibodies and methods for their use |
| USRE49477E1 (en) | 2012-04-20 | 2023-03-28 | Thomas Jefferson University | Engineered antibody for inhibition of fibrosis |
| JP2015536933A (ja) | 2012-10-23 | 2015-12-24 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法 |
| CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| JP6796059B2 (ja) | 2014-09-12 | 2020-12-02 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｗｎｔシグナリングアゴニスト分子 |
| ES2826566T3 (es) | 2014-11-21 | 2021-05-18 | Bristol Myers Squibb Co | Anticuerpos que comprenden regiones constantes pesadas modificadas |
| JP6805142B2 (ja) | 2014-11-21 | 2020-12-23 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｃｄ７３に対する抗体およびその使用 |
| JP6829469B2 (ja) * | 2015-08-10 | 2021-02-10 | 国立大学法人富山大学 | 抗原特異的モノクローナル抗体作製方法 |
| WO2017070567A1 (en) * | 2015-10-21 | 2017-04-27 | The Research Foundation For The State University Of New York | Klebsiella pneumoniae antibodies and methods to treat klebsiella pneumoniae infections |
| CN113082201B (zh) * | 2016-04-01 | 2024-07-05 | 上海斯丹赛生物技术有限公司 | 刺激t细胞介导的对表达抗原的细胞群的免疫应答的方法 |
| US10654934B2 (en) | 2016-04-01 | 2020-05-19 | Innovative Cellular Therapeutics CO., LTD. | Use of chimeric antigen receptor modified cells to treat cancer |
| TWI762516B (zh) * | 2016-10-06 | 2022-05-01 | 日商腫瘤療法 科學股份有限公司 | 針對ｆｚｄ１０之單株抗體及其用途 |
| JP7617603B2 (ja) | 2017-01-11 | 2025-01-20 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｒ－スポンジン（ｒｓｐｏ）サロゲート分子 |
| AU2018211985B2 (en) | 2017-01-26 | 2025-02-13 | Surrozen Operating, Inc. | Tissue-specific Wnt signal enhancing molecules and uses thereof |
| JP7418332B2 (ja) | 2017-12-19 | 2024-01-19 | スロゼン オペレーティング， インコーポレイテッド | 抗フリズルド抗体及び使用方法 |
| CN118271444A (zh) | 2017-12-19 | 2024-07-02 | 瑟罗泽恩奥普瑞汀公司 | Wnt替代分子和其用途 |
| CN111699003B (zh) | 2017-12-19 | 2024-05-03 | 瑟罗泽恩奥普瑞汀公司 | 抗lrp5/6抗体和使用方法 |
| AU2019297522B2 (en) | 2018-07-05 | 2026-04-23 | Surrozen Operating, Inc. | Multi-specific Wnt surrogate molecules and uses thereof |
| JP2021530223A (ja) | 2018-07-09 | 2021-11-11 | スロゼン， インコーポレイテッド | 組織特異性Ｗｎｔシグナル増強分子及びその使用 |
| WO2022104280A1 (en) | 2020-11-16 | 2022-05-19 | Surrozen Operating, Inc. | Liver-specific wnt signal enhancing molecules and uses thereof |
| CN115724977B (zh) * | 2022-11-04 | 2025-06-13 | 中国科学技术大学 | 针对人卷曲受体的单克隆抗体及其用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB9009548D0 (en) | 1990-04-27 | 1990-06-20 | Celltech Ltd | Chimeric antibody and method |
| AU668349B2 (en) | 1991-04-25 | 1996-05-02 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin 6 receptor |
| US5648267A (en) | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
| ATE340590T1 (de) | 1994-07-13 | 2006-10-15 | Chugai Pharmaceutical Co Ltd | Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper |
| GB9414580D0 (en) | 1994-07-19 | 1994-09-07 | Cancer Res Campaign Tech | Materials and methods relating to the diagnosis of synovial sarcomas |
| US5994098A (en) * | 1997-06-02 | 1999-11-30 | Smithkline Beecham Corporation | Human 7-TM receptor similar to murine frizzled-6 gene |
| EP0943684A3 (en) | 1998-03-10 | 2002-01-23 | Smithkline Beecham Plc | Frizzled-like polypeptides and polynucleotides |
| GB9819681D0 (en) | 1998-09-09 | 1998-11-04 | Smithkline Beecham Plc | Novel compounds |
| WO2001074405A1 (en) | 2000-03-31 | 2001-10-11 | Gene Logic, Inc. | Gene expression profiles in esophageal tissue |
| CA2456008A1 (en) | 2000-08-19 | 2002-02-28 | Axordia Limited | Stem cell differentiation |
| US6964849B2 (en) * | 2001-01-11 | 2005-11-15 | Curagen Corporation | Proteins and nucleic acids encoding same |
| EP1358327A2 (en) | 2001-01-11 | 2003-11-05 | Curagen Corporation | Proteins and nucleic acids encoding same |
| CA2444691A1 (en) | 2001-04-18 | 2002-10-31 | Protein Design Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
| AU2002308557A1 (en) | 2001-05-01 | 2002-11-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
| US20030044409A1 (en) * | 2001-05-01 | 2003-03-06 | Carson Dennis A. | Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens |
| WO2003004045A2 (en) | 2001-07-05 | 2003-01-16 | Xenon Genetics, Inc. | Methods for identifying therapeutic agents for treating diseases involving wnt polypeptides and wnt receptors |
| AU2003256079A1 (en) | 2002-08-30 | 2004-03-19 | Japan As Represented By President Of The University Of Tokyo | Method for treating synovial sarcoma |
| EP1549144A4 (en) | 2002-10-04 | 2010-01-06 | Univ California | METHOD FOR THE TREATMENT OF CANCER BY INHIBITION OF THE WNT SIGNALING LINE |
| JP4691626B2 (ja) * | 2003-07-11 | 2011-06-01 | オンコセラピー・サイエンス株式会社 | 滑膜肉腫の治療方法 |
| EP1789549A1 (en) | 2004-08-05 | 2007-05-30 | The University of Tokyo | Method for treating synovial sarcoma using sirna for fzd10 |
-
2006
- 2006-08-24 US US12/308,095 patent/US8221751B2/en active Active
- 2006-08-24 WO PCT/JP2006/317155 patent/WO2007148417A1/en not_active Ceased
- 2006-08-24 JP JP2008558572A patent/JP5028635B2/ja active Active
- 2006-08-24 CN CN200680055625.1A patent/CN101573383B/zh active Active
- 2006-08-24 RU RU2009101788/10A patent/RU2412203C2/ru active
- 2006-08-24 EP EP11170198A patent/EP2386577A3/en not_active Withdrawn
- 2006-08-24 BR BRPI0621800A patent/BRPI0621800B8/pt not_active IP Right Cessation
- 2006-08-24 KR KR1020097001229A patent/KR101351208B1/ko not_active Expired - Fee Related
- 2006-08-24 ES ES06783136T patent/ES2405618T3/es active Active
- 2006-08-24 CA CA2655289A patent/CA2655289C/en active Active
- 2006-08-24 EP EP06783136A patent/EP2044123B1/en active Active
-
2012
- 2012-06-12 US US13/494,822 patent/US9139655B2/en active Active