JP2009507471A5 - - Google Patents
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- Publication number
- JP2009507471A5 JP2009507471A5 JP2008527056A JP2008527056A JP2009507471A5 JP 2009507471 A5 JP2009507471 A5 JP 2009507471A5 JP 2008527056 A JP2008527056 A JP 2008527056A JP 2008527056 A JP2008527056 A JP 2008527056A JP 2009507471 A5 JP2009507471 A5 JP 2009507471A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cancer
- monoclonal antibody
- amino acids
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims 24
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 230000027455 binding Effects 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 230000026731 phosphorylation Effects 0.000 claims 4
- 238000006366 phosphorylation reaction Methods 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 2
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 1
- 108010001127 Insulin Receptor Proteins 0.000 claims 1
- 102100036721 Insulin receptor Human genes 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 102000004584 Somatomedin Receptors Human genes 0.000 claims 1
- 108010017622 Somatomedin Receptors Proteins 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000009087 cell motility Effects 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 230000002608 insulinlike Effects 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70922605P | 2005-08-17 | 2005-08-17 | |
| US60/709,226 | 2005-08-17 | ||
| US79881706P | 2006-05-08 | 2006-05-08 | |
| US60/798,817 | 2006-05-08 | ||
| PCT/US2006/031814 WO2007022172A1 (en) | 2005-08-17 | 2006-08-15 | Human monoclonal antibodies that specifically bind igf-ii |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009507471A JP2009507471A (ja) | 2009-02-26 |
| JP2009507471A5 true JP2009507471A5 (enExample) | 2009-09-24 |
| JP5149800B2 JP5149800B2 (ja) | 2013-02-20 |
Family
ID=37564252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008527056A Expired - Fee Related JP5149800B2 (ja) | 2005-08-17 | 2006-08-15 | Ｉｇｆ−ｉｉに特異的に結合するヒトモノクローナル抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8105598B2 (enExample) |
| EP (1) | EP1924604B1 (enExample) |
| JP (1) | JP5149800B2 (enExample) |
| AT (1) | ATE535546T1 (enExample) |
| AU (1) | AU2006279633B2 (enExample) |
| CA (1) | CA2618920C (enExample) |
| WO (1) | WO2007022172A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG179291A1 (en) | 2003-06-18 | 2012-04-27 | Genelux Corp | Modified recombinant vaccinia viruses and other microorganisms, uses thereof |
| US7939637B2 (en) | 2005-12-13 | 2011-05-10 | Medimmune Limited | Insulin-like growth factor antibodies and uses thereof |
| WO2009137758A2 (en) | 2008-05-09 | 2009-11-12 | Dyax Corp. | Igf-ii/gf-iie binding proteins |
| WO2010045315A1 (en) | 2008-10-14 | 2010-04-22 | Dyax Corp. | Use of igf-ii/igf-iie binding for the treatment and prevention of systemic sclerosis associated pulmonary fibrosis |
| CZ2008697A3 (cs) * | 2008-11-03 | 2010-04-28 | Univerzita Karlova v Praze, 1. Lékarská fakulta | Kombinace monoklonálních protilátek nebo jejich Fab fragmentu pro použití jako lécivo a farmaceutický prípravek tyto protilátky nebo jejich Fab fragmenty obsahující |
| US9150644B2 (en) | 2011-04-12 | 2015-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
| US9127056B2 (en) | 2011-10-17 | 2015-09-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monospecific and bispecific human monoclonal antibodies targeting insulin-like growth factor II (IGF-II) |
| US9546219B2 (en) | 2012-02-08 | 2017-01-17 | North Carolina State University | Treatment of allergic diseases with recombinant antibodies |
| CN106519024A (zh) * | 2015-09-15 | 2017-03-22 | 三生国健药业（上海）股份有限公司 | 一种用于去除单克隆抗体中异构体的复性液及复性方法 |
| EP3538558A4 (en) | 2016-11-09 | 2020-07-15 | North Carolina State University | TREATMENT OF ALLERGIC DISEASES USING CHIMERIC PROTEIN |
| WO2019183437A1 (en) | 2018-03-23 | 2019-09-26 | North Carolina State University | Methods and compositions for antibody to high affinity receptor for ige |
-
2006
- 2006-08-15 EP EP06789775A patent/EP1924604B1/en not_active Not-in-force
- 2006-08-15 CA CA2618920A patent/CA2618920C/en active Active
- 2006-08-15 AT AT06789775T patent/ATE535546T1/de active
- 2006-08-15 JP JP2008527056A patent/JP5149800B2/ja not_active Expired - Fee Related
- 2006-08-15 WO PCT/US2006/031814 patent/WO2007022172A1/en not_active Ceased
- 2006-08-15 AU AU2006279633A patent/AU2006279633B2/en not_active Ceased
-
2010
- 2010-09-23 US US12/889,345 patent/US8105598B2/en not_active Expired - Fee Related
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