JP2022115986A5 - - Google Patents
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- JP2022115986A5 JP2022115986A5 JP2022076621A JP2022076621A JP2022115986A5 JP 2022115986 A5 JP2022115986 A5 JP 2022115986A5 JP 2022076621 A JP2022076621 A JP 2022076621A JP 2022076621 A JP2022076621 A JP 2022076621A JP 2022115986 A5 JP2022115986 A5 JP 2022115986A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- variable region
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 40
- 238000000034 method Methods 0.000 claims 17
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 12
- 238000002965 ELISA Methods 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 238000002967 competitive immunoassay Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940043131 pyroglutamate Drugs 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416788P | 2016-11-03 | 2016-11-03 | |
| US62/416,788 | 2016-11-03 | ||
| JP2019522704A JP7071349B2 (ja) | 2016-11-03 | 2017-11-02 | ピログルタメートアミロイド－βに対する抗体及びその使用 |
| PCT/IB2017/056831 WO2018083628A1 (en) | 2016-11-03 | 2017-11-02 | ANTIBODIES TO PYROGLUTAMATE AMYLOID-β AND USES THEREOF |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522704A Division JP7071349B2 (ja) | 2016-11-03 | 2017-11-02 | ピログルタメートアミロイド－βに対する抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022115986A JP2022115986A (ja) | 2022-08-09 |
| JP2022115986A5 true JP2022115986A5 (enExample) | 2023-02-08 |
| JP7348987B2 JP7348987B2 (ja) | 2023-09-21 |
Family
ID=60473574
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522704A Active JP7071349B2 (ja) | 2016-11-03 | 2017-11-02 | ピログルタメートアミロイド－βに対する抗体及びその使用 |
| JP2022076621A Active JP7348987B2 (ja) | 2016-11-03 | 2022-05-06 | ピログルタメートアミロイド－βに対する抗体及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522704A Active JP7071349B2 (ja) | 2016-11-03 | 2017-11-02 | ピログルタメートアミロイド－βに対する抗体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10519223B2 (enExample) |
| EP (1) | EP3534937B1 (enExample) |
| JP (2) | JP7071349B2 (enExample) |
| CN (1) | CN109922826A (enExample) |
| AR (1) | AR110114A1 (enExample) |
| AU (1) | AU2017355596A1 (enExample) |
| CA (1) | CA3041969A1 (enExample) |
| ES (1) | ES2962767T3 (enExample) |
| MA (1) | MA46704A (enExample) |
| TW (1) | TW201827467A (enExample) |
| WO (1) | WO2018083628A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201827467A (zh) * | 2016-11-03 | 2018-08-01 | 比利時商健生藥品公司 | 焦穀胺酸類澱粉蛋白－β之抗體及其用途 |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| JP7110560B2 (ja) * | 2017-09-06 | 2022-08-02 | 株式会社三洋物産 | 遊技機 |
| JP7110561B2 (ja) * | 2017-09-06 | 2022-08-02 | 株式会社三洋物産 | 遊技機 |
| JP7110563B2 (ja) * | 2017-09-06 | 2022-08-02 | 株式会社三洋物産 | 遊技機 |
| JP2019136430A (ja) * | 2018-02-15 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136431A (ja) * | 2018-02-15 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| JP2019136429A (ja) * | 2018-02-15 | 2019-08-22 | 株式会社三洋物産 | 遊技機 |
| CN113597429A (zh) * | 2019-03-01 | 2021-11-02 | 株式会社岛津制作所 | App669-711测定方法及测定用试剂盒 |
| WO2020193644A1 (en) * | 2019-03-26 | 2020-10-01 | Janssen Pharmaceutica Nv | ANTIBODIES TO PYROGLUTAMATE AMYLOID-ß AND USES THEREOF |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
| JP2023535024A (ja) | 2020-07-23 | 2023-08-15 | オター プロシーナ リミテッド | 抗ａベータ抗体 |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
| JP2023105293A (ja) * | 2022-07-21 | 2023-07-28 | 株式会社三洋物産 | 遊技機 |
| JP2023105292A (ja) * | 2022-07-21 | 2023-07-28 | 株式会社三洋物産 | 遊技機 |
| EP4638494A1 (en) | 2022-12-22 | 2025-10-29 | BioArctic AB | Antibody which binds to abetape3 |
| WO2025037271A1 (en) | 2023-08-17 | 2025-02-20 | Janssen Pharmaceutica Nv | Plasma assay for detecting cns-derived tau peptides |
| CN118459582B (zh) * | 2024-07-11 | 2024-11-15 | 苏州近岸蛋白质科技股份有限公司 | 一种抗焦谷氨酸修饰的β淀粉样蛋白抗体及其用途 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| US5642870A (en) | 1992-08-05 | 1997-07-01 | Sargis; Ike | Switch stand |
| US5761894A (en) | 1996-09-25 | 1998-06-09 | Magic Circle Corporation | Grass striping attachment for lawn mowers |
| US9907485B2 (en) | 2004-10-15 | 2018-03-06 | Brainlab Ag | Targeted immunization and plaque destruction against Alzheimer's disease |
| KR20080090408A (ko) * | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| JP2011527338A (ja) | 2008-07-09 | 2011-10-27 | ユニバーシティー オブ チューリッヒ | 神経新生を促進する方法 |
| JP5828762B2 (ja) | 2008-07-21 | 2015-12-09 | プロビオドルグ エージー | 診断用抗体アッセイ |
| JP5769316B2 (ja) * | 2009-08-06 | 2015-08-26 | イムナス・ファーマ株式会社 | Ａβオリゴマーに特異的に結合する抗体およびその利用 |
| EP2576617B1 (en) * | 2010-06-04 | 2016-04-27 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin | MONOCLONAL ANTIBODIES TARGETING Aß OLIGOMERS |
| WO2012021475A2 (en) * | 2010-08-12 | 2012-02-16 | Eli Lilly And Company | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
| LT3042917T (lt) * | 2010-08-12 | 2018-05-10 | Eli Lilly And Company | Antikūnai prieš n3pglu beta amiloidinį peptidą ir jų panaudojimas |
| EP2511296A1 (en) | 2011-04-12 | 2012-10-17 | Araclón Biotech, S. L. | Antibody, kit and method for determination of amyloid peptides |
| ITRM20120383A1 (it) | 2012-03-20 | 2013-09-21 | Uni Degli Studi Di Milano B Icocca | Metodo e kit per la rivelazione di anticorpi. |
| WO2015175769A1 (en) * | 2014-05-15 | 2015-11-19 | Biogen Ma Inc. | Methods for the detection of amyloid beta oligomers in biological samples |
| WO2015191825A1 (en) | 2014-06-13 | 2015-12-17 | Biogen Ma Inc. | Methods for the detection and measurement of amyloid beta in biological samples |
| EP3234611A1 (en) | 2014-12-19 | 2017-10-25 | Probiodrug AG | Novel method for the detection of pglu-abeta peptides |
| KR102786380B1 (ko) | 2015-07-16 | 2025-03-26 | 비보리온 테라퓨틱스 엔.브이. | 항-피로글루타메이트화된 아밀로이드 베타 인간화 항체 |
| JOP20170004B1 (ar) | 2016-01-15 | 2022-09-15 | Lilly Co Eli | الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته |
| AR107774A1 (es) | 2016-03-16 | 2018-05-30 | Lilly Co Eli | Terapia de combinación, método para el tratamiento de la enfermedad de alzheimer |
| EP3249388A1 (en) | 2016-05-23 | 2017-11-29 | Raman Health Technologies, S.L | Method for diagnosing alzheimer´s disease |
| IL263433B2 (en) | 2016-06-07 | 2024-03-01 | Biogen Int Neuroscience Gmbh | Methods for treating alzheimer's disease |
| US10988529B2 (en) | 2016-08-09 | 2021-04-27 | Eli Lilly And Company | Combination therapy |
| TWI669119B (zh) | 2016-10-21 | 2019-08-21 | 美國禮來大藥廠 | 組合療法 |
| TW201827467A (zh) * | 2016-11-03 | 2018-08-01 | 比利時商健生藥品公司 | 焦穀胺酸類澱粉蛋白－β之抗體及其用途 |
| JOP20190247A1 (ar) | 2017-04-20 | 2019-10-20 | Lilly Co Eli | أجسام بيتا ببتيد النشوانية المضادة لـ N3pGlu واستخداماتها |
| SI3672631T1 (sl) | 2017-08-22 | 2023-06-30 | Biogen Ma Inc. | Farmacevtski sestavki, ki vsebujejo protitelesa proti beta amiloidu |
-
2017
- 2017-11-01 TW TW106137798A patent/TW201827467A/zh unknown
- 2017-11-02 JP JP2019522704A patent/JP7071349B2/ja active Active
- 2017-11-02 ES ES17804663T patent/ES2962767T3/es active Active
- 2017-11-02 WO PCT/IB2017/056831 patent/WO2018083628A1/en not_active Ceased
- 2017-11-02 AU AU2017355596A patent/AU2017355596A1/en not_active Abandoned
- 2017-11-02 CA CA3041969A patent/CA3041969A1/en active Pending
- 2017-11-02 MA MA046704A patent/MA46704A/fr unknown
- 2017-11-02 US US15/801,435 patent/US10519223B2/en active Active
- 2017-11-02 EP EP17804663.7A patent/EP3534937B1/en active Active
- 2017-11-02 CN CN201780067973.9A patent/CN109922826A/zh active Pending
- 2017-11-03 AR ARP170103056A patent/AR110114A1/es unknown
-
2019
- 2019-11-19 US US16/688,406 patent/US10851156B2/en active Active
-
2020
- 2020-11-25 US US17/104,848 patent/US11673943B2/en active Active
-
2022
- 2022-05-06 JP JP2022076621A patent/JP7348987B2/ja active Active
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