JP5149800B2 - Ｉｇｆ−ｉｉに特異的に結合するヒトモノクローナル抗体 - Google Patents

Ｉｇｆ−ｉｉに特異的に結合するヒトモノクローナル抗体 Download PDF

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Publication number
JP5149800B2
JP5149800B2 JP2008527056A JP2008527056A JP5149800B2 JP 5149800 B2 JP5149800 B2 JP 5149800B2 JP 2008527056 A JP2008527056 A JP 2008527056A JP 2008527056 A JP2008527056 A JP 2008527056A JP 5149800 B2 JP5149800 B2 JP 5149800B2
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Japan
Prior art keywords
cancer
igf
antibody
monoclonal antibody
variable region
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Expired - Fee Related
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JP2008527056A
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English (en)
Japanese (ja)
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JP2009507471A5 (enExample
JP2009507471A (ja
Inventor
ディミーター エス． ディミトロフ
ヤン フォン
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Government of the United States of America
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Government of the United States of America
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2008527056A 2005-08-17 2006-08-15 Ｉｇｆ−ｉｉに特異的に結合するヒトモノクローナル抗体 Expired - Fee Related JP5149800B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US70922605P 2005-08-17 2005-08-17
US60/709,226 2005-08-17
US79881706P 2006-05-08 2006-05-08
US60/798,817 2006-05-08
PCT/US2006/031814 WO2007022172A1 (en) 2005-08-17 2006-08-15 Human monoclonal antibodies that specifically bind igf-ii

Publications (3)

Publication Number Publication Date
JP2009507471A JP2009507471A (ja) 2009-02-26
JP2009507471A5 JP2009507471A5 (enExample) 2009-09-24
JP5149800B2 true JP5149800B2 (ja) 2013-02-20

Family

ID=37564252

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008527056A Expired - Fee Related JP5149800B2 (ja) 2005-08-17 2006-08-15 Ｉｇｆ−ｉｉに特異的に結合するヒトモノクローナル抗体

Country Status (7)

Country Link
US (1) US8105598B2 (enExample)
EP (1) EP1924604B1 (enExample)
JP (1) JP5149800B2 (enExample)
AT (1) ATE535546T1 (enExample)
AU (1) AU2006279633B2 (enExample)
CA (1) CA2618920C (enExample)
WO (1) WO2007022172A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG179291A1 (en) 2003-06-18 2012-04-27 Genelux Corp Modified recombinant vaccinia viruses and other microorganisms, uses thereof
US7939637B2 (en) 2005-12-13 2011-05-10 Medimmune Limited Insulin-like growth factor antibodies and uses thereof
WO2009137758A2 (en) 2008-05-09 2009-11-12 Dyax Corp. Igf-ii/gf-iie binding proteins
WO2010045315A1 (en) 2008-10-14 2010-04-22 Dyax Corp. Use of igf-ii/igf-iie binding for the treatment and prevention of systemic sclerosis associated pulmonary fibrosis
CZ2008697A3 (cs) * 2008-11-03 2010-04-28 Univerzita Karlova v Praze, 1. Lékarská fakulta Kombinace monoklonálních protilátek nebo jejich Fab fragmentu pro použití jako lécivo a farmaceutický prípravek tyto protilátky nebo jejich Fab fragmenty obsahující
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
US9127056B2 (en) 2011-10-17 2015-09-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monospecific and bispecific human monoclonal antibodies targeting insulin-like growth factor II (IGF-II)
US9546219B2 (en) 2012-02-08 2017-01-17 North Carolina State University Treatment of allergic diseases with recombinant antibodies
CN106519024A (zh) * 2015-09-15 2017-03-22 三生国健药业（上海）股份有限公司 一种用于去除单克隆抗体中异构体的复性液及复性方法
EP3538558A4 (en) 2016-11-09 2020-07-15 North Carolina State University TREATMENT OF ALLERGIC DISEASES USING CHIMERIC PROTEIN
WO2019183437A1 (en) 2018-03-23 2019-09-26 North Carolina State University Methods and compositions for antibody to high affinity receptor for ige

Also Published As

Publication number Publication date
AU2006279633B2 (en) 2011-03-03
CA2618920A1 (en) 2007-02-22
EP1924604B1 (en) 2011-11-30
US8105598B2 (en) 2012-01-31
JP2009507471A (ja) 2009-02-26
CA2618920C (en) 2015-03-24
EP1924604A1 (en) 2008-05-28
WO2007022172A1 (en) 2007-02-22
US20110008358A1 (en) 2011-01-13
ATE535546T1 (de) 2011-12-15
AU2006279633A1 (en) 2007-02-22

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