JP2018520127A5 - - Google Patents

Info

Publication number

JP2018520127A5

JP2018520127A5 JP2017564337A JP2017564337A JP2018520127A5 JP 2018520127 A5 JP2018520127 A5 JP 2018520127A5 JP 2017564337 A JP2017564337 A JP 2017564337A JP 2017564337 A JP2017564337 A JP 2017564337A JP 2018520127 A5 JP2018520127 A5 JP 2018520127A5

Authority

JP

Japan

Prior art keywords

seq

antibody

nucleic acid

sequence

acid sequence

Prior art date

2016-06-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000007523 nucleic acids Chemical class 0.000 claims description 46
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 27
• 101150002398 MCM5 gene Proteins 0.000 claims description 26
• 238000000034 method Methods 0.000 claims description 22
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 21
• 108020004707 nucleic acids Proteins 0.000 claims description 18
• 102000039446 nucleic acids Human genes 0.000 claims description 18
• 230000002285 radioactive effect Effects 0.000 claims description 11
• 210000004027 cell Anatomy 0.000 claims description 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 7
• 238000002965 ELISA Methods 0.000 claims description 6
• 229910052693 Europium Inorganic materials 0.000 claims description 4
• OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 claims description 4
• 239000007787 solid Substances 0.000 claims description 4
• 241000588724 Escherichia coli Species 0.000 claims description 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 2
• 230000001268 conjugating effect Effects 0.000 claims description 2
• 238000001514 detection method Methods 0.000 claims description 2
• 230000003100 immobilizing effect Effects 0.000 claims description 2
• 238000002372 labelling Methods 0.000 claims description 2
• 238000006467 substitution reaction Methods 0.000 description 12
• 108090000765 processed proteins & peptides Proteins 0.000 description 7
• 210000004408 hybridoma Anatomy 0.000 description 6
• 102000004196 processed proteins & peptides Human genes 0.000 description 6
• 229920001184 polypeptide Polymers 0.000 description 5
• 108091033319 polynucleotide Proteins 0.000 description 4
• 102000040430 polynucleotide Human genes 0.000 description 4
• 239000002157 polynucleotide Substances 0.000 description 4
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
• 238000003556 assay Methods 0.000 description 1
• 238000010166 immunofluorescence Methods 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 238000002493 microarray Methods 0.000 description 1
• 229940126619 mouse monoclonal antibody Drugs 0.000 description 1