CN107810200B - 结合mcm5的单克隆抗体 - Google Patents

结合mcm5的单克隆抗体 Download PDF

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Publication number
CN107810200B
CN107810200B CN201680033481.3A CN201680033481A CN107810200B CN 107810200 B CN107810200 B CN 107810200B CN 201680033481 A CN201680033481 A CN 201680033481A CN 107810200 B CN107810200 B CN 107810200B
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CN
China
Prior art keywords
antibody
seq
sequence
mcm5
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201680033481.3A
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English (en)
Chinese (zh)
Other versions
CN107810200A (zh
Inventor
R·A·拉斯基
K·斯托伯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arquer Diagnostics Ltd
Original Assignee
Arquer Diagnostics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CN107810200A publication Critical patent/CN107810200A/zh
Application granted granted Critical
Publication of CN107810200B publication Critical patent/CN107810200B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4706—Regulators; Modulating activity stimulating, promoting or activating activity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680033481.3A 2015-06-08 2016-06-01 结合mcm5的单克隆抗体 Expired - Fee Related CN107810200B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1509907.0 2015-06-08
GBGB1509907.0A GB201509907D0 (en) 2015-06-08 2015-06-08 Antibodies
PCT/GB2016/051609 WO2016198834A1 (en) 2015-06-08 2016-06-01 Monoclonal antibodies binding mcm5

Publications (2)

Publication Number Publication Date
CN107810200A CN107810200A (zh) 2018-03-16
CN107810200B true CN107810200B (zh) 2021-04-06

Family

ID=53785114

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680033481.3A Expired - Fee Related CN107810200B (zh) 2015-06-08 2016-06-01 结合mcm5的单克隆抗体

Country Status (8)

Country Link
US (2) US20180186892A1 (enExample)
EP (1) EP3221352B1 (enExample)
JP (3) JP2018520127A (enExample)
CN (1) CN107810200B (enExample)
ES (1) ES2678049T3 (enExample)
GB (1) GB201509907D0 (enExample)
TR (1) TR201808196T4 (enExample)
WO (1) WO2016198834A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201509907D0 (en) * 2015-06-08 2015-07-22 Urosens Ltd Antibodies
GB201820867D0 (en) * 2018-12-20 2019-02-06 Arquer Diagnostics Ltd Detection method
GB201820868D0 (en) * 2018-12-20 2019-02-06 Arquer Diagnostics Ltd Detection method
GB201912605D0 (en) * 2019-09-02 2019-10-16 Arquer Diagnostics Ltd Cancer assay
CN118359714B (zh) * 2024-06-14 2024-10-22 浙江莱阅病理诊断科技有限公司 一种抗mcm2鼠单克隆抗体及其制备方法和免疫组化试剂的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021014A1 (en) * 1997-10-21 1999-04-29 Cancer Research Campaign Technology Limited Determination of cellular growth abnormality

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005026211A2 (en) * 2003-09-05 2005-03-24 Eli Lilly And Company Anti-ghrelin antibodies
GB0708002D0 (en) * 2007-04-25 2007-06-06 Univ Sheffield Antibodies
GB201509907D0 (en) * 2015-06-08 2015-07-22 Urosens Ltd Antibodies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021014A1 (en) * 1997-10-21 1999-04-29 Cancer Research Campaign Technology Limited Determination of cellular growth abnormality

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Diagnosis of Genito-Urinary Tract Cancer by Detection of Minichromosome Maintenance 5 Protein in Urine Sediments;Kai et al;《Journal of the National Cancer Institute》;20020717;摘要，第1072页左栏第3段-第1078页右栏第3段 *
Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments;T J DUDDERIDGE et al;《BRITISH JOURNAL OF CANCER》;20100804;701-707 *

Also Published As

Publication number Publication date
WO2016198834A1 (en) 2016-12-15
US20180186892A1 (en) 2018-07-05
JP2022165963A (ja) 2022-11-01
JP2020156486A (ja) 2020-10-01
TR201808196T4 (tr) 2018-07-23
US20210277142A1 (en) 2021-09-09
EP3221352A1 (en) 2017-09-27
EP3221352B1 (en) 2018-05-09
CN107810200A (zh) 2018-03-16
ES2678049T3 (es) 2018-08-08
GB201509907D0 (en) 2015-07-22
JP2018520127A (ja) 2018-07-26

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Granted publication date: 20210406