JP2017538439A5 - - Google Patents
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- JP2017538439A5 JP2017538439A5 JP2017538915A JP2017538915A JP2017538439A5 JP 2017538439 A5 JP2017538439 A5 JP 2017538439A5 JP 2017538915 A JP2017538915 A JP 2017538915A JP 2017538915 A JP2017538915 A JP 2017538915A JP 2017538439 A5 JP2017538439 A5 JP 2017538439A5
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- JP
- Japan
- Prior art keywords
- antibody
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- seq
- nodal
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000026310 Breast neoplasm Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
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- 239000012634 fragment Substances 0.000 claims description 7
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- 239000012472 biological sample Substances 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 5
- 206010005003 Bladder cancer Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 4
- 206010029260 Neuroblastoma Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
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- 201000005112 urinary bladder cancer Diseases 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 3
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- 206010036790 Productive cough Diseases 0.000 claims description 3
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- 102000039446 nucleic acids Human genes 0.000 description 23
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- 230000019491 signal transduction Effects 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- 101000835745 Homo sapiens Teratocarcinoma-derived growth factor 1 Proteins 0.000 description 3
- 206010027480 Metastatic malignant melanoma Diseases 0.000 description 3
- 102100026404 Teratocarcinoma-derived growth factor 1 Human genes 0.000 description 3
- 208000021039 metastatic melanoma Diseases 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
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- 238000000338 in vitro Methods 0.000 description 2
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- 238000003127 radioimmunoassay Methods 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 101150101604 ACVR1B gene Proteins 0.000 description 1
- 102000002092 Left-Right Determination Factor Human genes 0.000 description 1
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 101710143123 Mothers against decapentaplegic homolog 2 Proteins 0.000 description 1
- 101000967919 Mus musculus Left-right determination factor 1 Proteins 0.000 description 1
- 102000044547 Nodal Human genes 0.000 description 1
- 108700024442 Nodal Proteins 0.000 description 1
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 description 1
- 102000057208 Smad2 Human genes 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
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- 238000003745 diagnosis Methods 0.000 description 1
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- 230000001939 inductive effect Effects 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462060974P | 2014-10-07 | 2014-10-07 | |
| US62/060,974 | 2014-10-07 | ||
| PCT/US2015/054515 WO2016057683A2 (en) | 2014-10-07 | 2015-10-07 | Novel anti-nodal antibodies and methods of using same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017538439A JP2017538439A (ja) | 2017-12-28 |
| JP2017538439A5 true JP2017538439A5 (enExample) | 2018-11-08 |
| JP6574257B2 JP6574257B2 (ja) | 2019-09-11 |
Family
ID=55653941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017538915A Active JP6574257B2 (ja) | 2014-10-07 | 2015-10-07 | 新規の抗Ｎｏｄａｌ抗体及びその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9688750B2 (enExample) |
| EP (1) | EP3204414B1 (enExample) |
| JP (1) | JP6574257B2 (enExample) |
| WO (1) | WO2016057683A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014147129A1 (en) | 2013-03-21 | 2014-09-25 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
| EP2976331B1 (en) | 2013-03-21 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Synthesis of hydantoin containing peptide products |
| WO2016057683A2 (en) | 2014-10-07 | 2016-04-14 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Novel anti-nodal antibodies and methods of using same |
| WO2018127494A1 (en) * | 2017-01-03 | 2018-07-12 | Deinobiotics | Methods of producing lipolanthipeptides |
| US11331019B2 (en) | 2017-08-07 | 2022-05-17 | The Research Foundation For The State University Of New York | Nanoparticle sensor having a nanofibrous membrane scaffold |
| WO2019236769A1 (en) * | 2018-06-05 | 2019-12-12 | University Of Mississippi Medical Center | Production of sized macro- and micro- elp particles for drug delivery |
| KR20210038592A (ko) | 2018-07-23 | 2021-04-07 | 더 거버너스 오브 더 유니버시티 오브 알버타 | 유전자 인코딩된 이환형 펩타이드 라이브러리 |
| US20200239561A1 (en) * | 2019-01-26 | 2020-07-30 | Tairx Inc. | Nodal regulation of cancer drug resistance gene |
| US20230310478A1 (en) * | 2020-09-02 | 2023-10-05 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Methods and compositions for the treatment of pulmonary hypertension and cancer |
| KR102763290B1 (ko) * | 2021-09-16 | 2025-02-05 | 동아대학교 산학협력단 | 신규한 샤르코-마리-투스병 제1a형 진단 또는 예후 예측용 바이오마커 및 이의 용도 |
| CN119592689A (zh) * | 2024-11-19 | 2025-03-11 | 北京肿瘤医院(北京大学肿瘤医院) | SMAD2、p38 MAPK作为评估免疫治疗黏膜黑色素瘤效果的标志物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| ATE175997T1 (de) | 1991-08-10 | 1999-02-15 | Medical Res Council | Behandlung von zellpopulationen |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| DK0672142T3 (da) | 1992-12-04 | 2001-06-18 | Medical Res Council | Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse |
| US20020086351A1 (en) | 1998-08-20 | 2002-07-04 | Reinhard Ebner | Human nodal and lefty homologues |
| US7666423B2 (en) | 2006-07-28 | 2010-02-23 | Children's Memorial Hospital | Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells |
| CA2702880A1 (en) * | 2007-10-19 | 2009-04-23 | Immunas Pharma, Inc. | Antibody capable of specifically binding to a beta oligomer, and use thereof |
| WO2009080773A1 (en) | 2007-12-24 | 2009-07-02 | Dsm Ip Assets B.V. | Convergent synthesis of renin inhibitors and intermediates useful therein |
| EP4083072A1 (en) * | 2008-10-06 | 2022-11-02 | Minerva Biotechnologies Corporation | Muc1* antibodies |
| IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
| DK2488867T3 (da) * | 2009-10-14 | 2020-11-09 | Janssen Biotech Inc | Fremgangsmåder til affinitetsmodning af antistoffer |
| KR102099073B1 (ko) * | 2012-02-24 | 2020-04-10 | 애브비 스템센트알엑스 엘엘씨 | 항 ｓｅｚ6 항체들 및 사용 방법 |
| WO2016057683A2 (en) | 2014-10-07 | 2016-04-14 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Novel anti-nodal antibodies and methods of using same |
-
2015
- 2015-10-07 WO PCT/US2015/054515 patent/WO2016057683A2/en not_active Ceased
- 2015-10-07 US US14/877,617 patent/US9688750B2/en active Active
- 2015-10-07 EP EP15849199.3A patent/EP3204414B1/en active Active
- 2015-10-07 JP JP2017538915A patent/JP6574257B2/ja active Active
-
2017
- 2017-06-27 US US15/634,355 patent/US10508147B2/en active Active
-
2018
- 2018-02-13 US US15/895,771 patent/US10494428B2/en active Active
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