JP2009538877A - 変性疾患及び炎症性疾患の治療に有用なトリアゾロピラジン化合物 - Google Patents

変性疾患及び炎症性疾患の治療に有用なトリアゾロピラジン化合物 Download PDF

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JP2009538877A
JP2009538877A JP2009512585A JP2009512585A JP2009538877A JP 2009538877 A JP2009538877 A JP 2009538877A JP 2009512585 A JP2009512585 A JP 2009512585A JP 2009512585 A JP2009512585 A JP 2009512585A JP 2009538877 A JP2009538877 A JP 2009538877A
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triazolo
pyrazin
substituted
pyrazol
compound
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Abandoned
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JP2009538877A5 (enExample
Inventor
ジャメス イングリス アンドレウス マルチン
エドワルドス パウル
ストウアルト チャムベルス マルク
スクフミドト ウオルフガング
アンドレウ クラセ ジュハ
バル グレゴリ
ロウイセ ヒルスト キム
マクレオド アングス
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Galapagos NV
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Publication of JP2009538877A publication Critical patent/JP2009538877A/ja
Publication of JP2009538877A5 publication Critical patent/JP2009538877A5/ja
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009512585A 2006-05-31 2007-05-30 変性疾患及び炎症性疾患の治療に有用なトリアゾロピラジン化合物 Abandoned JP2009538877A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US80355206P 2006-05-31 2006-05-31
US93176407P 2007-05-25 2007-05-25
US93176307P 2007-05-25 2007-05-25
US93184407P 2007-05-25 2007-05-25
US93210007P 2007-05-29 2007-05-29
PCT/EP2007/055246 WO2007138072A2 (en) 2006-05-31 2007-05-30 Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases

Publications (2)

Publication Number Publication Date
JP2009538877A true JP2009538877A (ja) 2009-11-12
JP2009538877A5 JP2009538877A5 (enExample) 2010-08-26

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ID=38618932

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JP2009512585A Abandoned JP2009538877A (ja) 2006-05-31 2007-05-30 変性疾患及び炎症性疾患の治療に有用なトリアゾロピラジン化合物

Country Status (20)

Country Link
US (3) US7501411B2 (enExample)
JP (1) JP2009538877A (enExample)
KR (1) KR20090026288A (enExample)
AT (1) ATE465164T1 (enExample)
AU (1) AU2007267121A1 (enExample)
BR (1) BRPI0712531A2 (enExample)
CA (1) CA2653506A1 (enExample)
CR (1) CR10458A (enExample)
DE (1) DE602007006010D1 (enExample)
DK (1) DK2029602T3 (enExample)
EA (1) EA200870592A1 (enExample)
EC (1) ECSP088923A (enExample)
HR (1) HRP20100378T1 (enExample)
IL (1) IL195033A0 (enExample)
MX (1) MX2008015057A (enExample)
NI (1) NI200800299A (enExample)
NO (1) NO20084703L (enExample)
NZ (1) NZ573015A (enExample)
PT (1) PT2029602E (enExample)
WO (1) WO2007138072A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522222A (ja) * 2010-03-10 2013-06-13 カリプシス，インク 疾患の治療のためのヒスタミン受容体の複素環阻害薬
JP2016525072A (ja) * 2013-06-19 2016-08-22 ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． 炎症性障害の治療のための新規化合物及びその医薬組成物
JP2021516695A (ja) * 2018-03-27 2021-07-08 北京大学Ｐｅｋｉｎｇ Ｕｎｉｖｅｒｓｉｔｙ 腫瘍転移の薬物治療における標的、及びその使用
JP2023516893A (ja) * 2020-02-27 2023-04-21 エスアンドティー バイオメッド カンパニー リミテッド マトリックスメタロプロテアーゼ１のモノクローナル抗体、その検出キット及び検出方法

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US7893058B2 (en) * 2006-05-15 2011-02-22 Janssen Pharmaceutica Nv Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
HRP20100378T1 (hr) * 2006-05-31 2010-08-31 Galapagos N.V. Spojevi triazolopirazina učinkoviti za tretman degenerativnih i upalnih bolesti
ATE495743T1 (de) 2006-12-01 2011-02-15 Galapagos Nv Triazolopyridinverbindungen zur behandlung von degenerations- und entzündungskrankheiten
US8148369B2 (en) 2007-05-10 2012-04-03 Janssen Pharmaceutica Nv Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
WO2008138843A1 (en) * 2007-05-10 2008-11-20 Galapagos N.V. Imidazopyridines and triazolopyrimidines useful for the treatment of joint degenerative & inflammatory diseases
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522222A (ja) * 2010-03-10 2013-06-13 カリプシス，インク 疾患の治療のためのヒスタミン受容体の複素環阻害薬
JP2016525072A (ja) * 2013-06-19 2016-08-22 ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． 炎症性障害の治療のための新規化合物及びその医薬組成物
JP2021516695A (ja) * 2018-03-27 2021-07-08 北京大学Ｐｅｋｉｎｇ Ｕｎｉｖｅｒｓｉｔｙ 腫瘍転移の薬物治療における標的、及びその使用
JP7138973B2 (ja) 2018-03-27 2022-09-20 北京大学 腫瘍転移の薬物治療における標的、及びその使用
JP2023516893A (ja) * 2020-02-27 2023-04-21 エスアンドティー バイオメッド カンパニー リミテッド マトリックスメタロプロテアーゼ１のモノクローナル抗体、その検出キット及び検出方法
JP7515204B2 (ja) 2020-02-27 2024-07-12 エスアンドティー バイオメッド カンパニー リミテッド マトリックスメタロプロテアーゼ１のモノクローナル抗体、その検出キット及び検出方法
JP2024120937A (ja) * 2020-02-27 2024-09-05 エスアンドティー バイオメッド カンパニー リミテッド マトリックスメタロプロテアーゼ１のモノクローナル抗体
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US7915256B2 (en) 2011-03-29
US7501411B2 (en) 2009-03-10
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