KR20090026288A - 퇴행성 및 염증성 질환의 치료에 유용한 트리아졸로피라진 화합물 - Google Patents
퇴행성 및 염증성 질환의 치료에 유용한 트리아졸로피라진 화합물 Download PDFInfo
- Publication number
- KR20090026288A KR20090026288A KR1020087030751A KR20087030751A KR20090026288A KR 20090026288 A KR20090026288 A KR 20090026288A KR 1020087030751 A KR1020087030751 A KR 1020087030751A KR 20087030751 A KR20087030751 A KR 20087030751A KR 20090026288 A KR20090026288 A KR 20090026288A
- Authority
- KR
- South Korea
- Prior art keywords
- triazolo
- pyrazin
- compound
- substituted
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Images
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| US7893058B2 (en) * | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
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| DE602007012133D1 (de) | 2006-12-01 | 2011-03-03 | Andrew Burritt | Triazolopyridinverbindungen zur behandlung von degenerations- und entzündungskrankheiten |
| US8133895B2 (en) * | 2007-05-10 | 2012-03-13 | Janssen Pharmaceutica N.V. | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2008138842A1 (en) * | 2007-05-10 | 2008-11-20 | Galapagos N.V. | Imidazopyrazines and triazolopyrazine for the treatment of joint degenerative and inflammatory diseases |
| DE102007060172A1 (de) | 2007-12-13 | 2009-06-25 | Bayer Healthcare Ag | Triazolotriazine und Triazolopyrazine und ihre Verwendung |
| DE102008035209A1 (de) | 2008-07-29 | 2010-02-04 | Bayer Schering Pharma Aktiengesellschaft | Triazolotriazine und Triazolopyrazine und ihre Verwendung |
| AR071619A1 (es) * | 2008-05-07 | 2010-06-30 | Galapagos Nv | Compuestos de pirazina fusionados utiles para el tratamiento de enfermedades degenerativas e inflamatorias y composiciones farmaceuticas que los contienen. |
| DE102008023801A1 (de) | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| MX2011011025A (es) | 2009-04-20 | 2011-11-02 | Osi Pharmaceuticals Llc | Preparacion de c-piracin-metilaminas. |
| WO2010129740A1 (en) * | 2009-05-07 | 2010-11-11 | Osi Pharmaceuticals, Inc. | Use of osi-906 for treating adrenocortical carcinoma |
| TW201120043A (en) * | 2009-11-05 | 2011-06-16 | Galapagos Nv | Fused pyrazine compounds as their salts, useful for the treatment of degenerative and inflammatory diseases |
| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| TW201200518A (en) * | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| EP2825540B1 (en) | 2012-03-14 | 2016-09-14 | Bayer Intellectual Property GmbH | Substituted imidazopyridazines |
| US9586958B2 (en) | 2013-06-11 | 2017-03-07 | Bayer Pharma Aktiengesellschaft | Prodrug derivatives of substituted triazolopyridines |
| EP3010922B1 (en) * | 2013-06-19 | 2017-03-15 | Galapagos NV | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| RU2016131792A (ru) | 2014-01-03 | 2018-02-06 | Байер Энимэл Хельс ГмбХ | Новые пиразолил-гетероариламиды в качестве средств для борьбы с вредителями |
| WO2015166370A1 (en) | 2014-04-28 | 2015-11-05 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| WO2016208592A1 (ja) | 2015-06-22 | 2016-12-29 | 大日本住友製薬株式会社 | 二環性複素環アミド誘導体 |
| PT3319959T (pt) | 2015-07-06 | 2021-12-06 | Alkermes Inc | Inibidores hetero-halo de histona desacetilase |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| WO2017146128A1 (ja) * | 2016-02-26 | 2017-08-31 | 大日本住友製薬株式会社 | イミダゾリルアミド誘導体 |
| WO2018013597A1 (en) | 2016-07-12 | 2018-01-18 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| CA3049443A1 (en) | 2017-01-11 | 2018-07-19 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
| BR112019014527A2 (pt) | 2017-01-23 | 2020-02-27 | Revolution Medicines, Inc. | Compostos de piridina como inibidores de shp2 alostéricos |
| AR110740A1 (es) | 2017-01-23 | 2019-05-02 | Revolution Medicines Inc | Compuestos bicíclicos como inhibidores alostéricos de shp2 |
| CN109206357A (zh) * | 2017-07-04 | 2019-01-15 | 浙江九洲药业股份有限公司 | 一种格列齐特中间体的通式化合物及其制备方法和应用 |
| JP7152471B2 (ja) | 2017-08-07 | 2022-10-12 | ロダン・セラピューティクス，インコーポレーテッド | ヒストン脱アセチル化酵素の二環阻害剤 |
| CN111212834B (zh) | 2017-10-12 | 2024-01-19 | 锐新医药公司 | 作为变构shp2抑制剂的吡啶、吡嗪和三嗪化合物 |
| BR112020009757A2 (pt) | 2017-12-15 | 2020-11-03 | Revolution Medicines, Inc. | compostos policíclicos como inibidores alostéricos de shp2 |
| JP7474709B2 (ja) | 2018-02-27 | 2024-04-25 | インサイト・コーポレイション | Ａ２ａ／ａ２ｂ阻害剤としてのイミダゾピリミジン及びトリアゾロピリミジン |
| CN108379583B (zh) * | 2018-03-27 | 2021-08-17 | 北京大学 | 一种肿瘤转移药物治疗的靶标及其应用 |
| MA52940A (fr) | 2018-05-18 | 2021-04-28 | Incyte Corp | Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b |
| AU2019297361B2 (en) | 2018-07-05 | 2024-06-27 | Incyte Corporation | Fused pyrazine derivatives as A2A / A2B inhibitors |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| CN114945598B (zh) * | 2020-02-27 | 2023-12-01 | 世延生医股份有限公司 | 基质金属蛋白酶1的单克隆抗体、其检测试剂盒及其检测方法 |
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| CA2376951A1 (en) * | 1999-06-30 | 2001-01-04 | Peter J. Sinclair | Src kinase inhibitor compounds |
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-
2007
- 2007-05-30 WO PCT/EP2007/055246 patent/WO2007138072A2/en not_active Ceased
- 2007-05-30 NZ NZ573015A patent/NZ573015A/en not_active IP Right Cessation
- 2007-05-30 KR KR1020087030751A patent/KR20090026288A/ko not_active Withdrawn
- 2007-05-30 AT AT07729660T patent/ATE465164T1/de active
- 2007-05-30 DK DK07729660.6T patent/DK2029602T3/da active
- 2007-05-30 AU AU2007267121A patent/AU2007267121A1/en not_active Abandoned
- 2007-05-30 MX MX2008015057A patent/MX2008015057A/es active IP Right Grant
- 2007-05-30 US US11/809,294 patent/US7501411B2/en not_active Expired - Fee Related
- 2007-05-30 CA CA002653506A patent/CA2653506A1/en not_active Abandoned
- 2007-05-30 JP JP2009512585A patent/JP2009538877A/ja not_active Abandoned
- 2007-05-30 BR BRPI0712531-3A patent/BRPI0712531A2/pt not_active IP Right Cessation
- 2007-05-30 PT PT07729660T patent/PT2029602E/pt unknown
- 2007-05-30 EA EA200870592A patent/EA200870592A1/ru unknown
- 2007-05-30 DE DE602007006010T patent/DE602007006010D1/de active Active
- 2007-05-30 HR HR20100378T patent/HRP20100378T1/hr unknown
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2008
- 2008-10-30 IL IL195033A patent/IL195033A0/en unknown
- 2008-11-10 NO NO20084703A patent/NO20084703L/no not_active Application Discontinuation
- 2008-11-20 NI NI200800299A patent/NI200800299A/es unknown
- 2008-11-25 CR CR10458A patent/CR10458A/es unknown
- 2008-11-28 EC EC2008008923A patent/ECSP088923A/es unknown
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2009
- 2009-03-08 US US12/399,979 patent/US7915256B2/en not_active Expired - Fee Related
-
2011
- 2011-01-09 US US12/987,129 patent/US20110178067A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110178067A1 (en) | 2011-07-21 |
| HRP20100378T1 (hr) | 2010-08-31 |
| WO2007138072A3 (en) | 2008-02-14 |
| CA2653506A1 (en) | 2007-12-06 |
| BRPI0712531A2 (pt) | 2012-12-25 |
| EA200870592A1 (ru) | 2009-08-28 |
| JP2009538877A (ja) | 2009-11-12 |
| US20100298300A1 (en) | 2010-11-25 |
| MX2008015057A (es) | 2008-12-10 |
| ECSP088923A (es) | 2009-01-30 |
| US7501411B2 (en) | 2009-03-10 |
| AU2007267121A1 (en) | 2007-12-06 |
| NZ573015A (en) | 2010-11-26 |
| US7915256B2 (en) | 2011-03-29 |
| PT2029602E (pt) | 2010-07-08 |
| NO20084703L (no) | 2009-02-19 |
| IL195033A0 (en) | 2009-08-03 |
| US20080090818A1 (en) | 2008-04-17 |
| WO2007138072A2 (en) | 2007-12-06 |
| CR10458A (es) | 2009-02-26 |
| DE602007006010D1 (de) | 2010-06-02 |
| DK2029602T3 (da) | 2010-08-09 |
| ATE465164T1 (de) | 2010-05-15 |
| NI200800299A (es) | 2010-05-25 |
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