JP2009537517A5 - - Google Patents
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- Publication number
- JP2009537517A5 JP2009537517A5 JP2009510923A JP2009510923A JP2009537517A5 JP 2009537517 A5 JP2009537517 A5 JP 2009537517A5 JP 2009510923 A JP2009510923 A JP 2009510923A JP 2009510923 A JP2009510923 A JP 2009510923A JP 2009537517 A5 JP2009537517 A5 JP 2009537517A5
- Authority
- JP
- Japan
- Prior art keywords
- furo
- azabicyclo
- spiro
- octane
- furyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 9
- 235000010299 hexamethylene tetramine Nutrition 0.000 claims 9
- 229960004011 methenamine Drugs 0.000 claims 9
- 238000001727 in vivo Methods 0.000 claims 7
- 239000002243 precursor Substances 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 206010057852 Nicotine dependence Diseases 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 239000001301 oxygen Chemical group 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 239000011593 sulfur Chemical group 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- IHIIIDMMCFNRSA-QFIPXVFZSA-N (3r)-5'-[5-(morpholin-4-ylmethyl)furan-2-yl]spiro[1-azabicyclo[2.2.2]octane-3,2'-3h-furo[2,3-b]pyridine] Chemical compound C=1C=C(C=2C=C3C[C@@]4(OC3=NC=2)C2CCN(CC2)C4)OC=1CN1CCOCC1 IHIIIDMMCFNRSA-QFIPXVFZSA-N 0.000 claims 1
- PFXZDYFCWCJPGP-QFIPXVFZSA-N (3r)-5'-[5-(morpholin-4-ylmethyl)furan-3-yl]spiro[1-azabicyclo[2.2.2]octane-3,2'-3h-furo[2,3-b]pyridine] Chemical compound C=1C(C=2C=C3C[C@@]4(OC3=NC=2)C2CCN(CC2)C4)=COC=1CN1CCOCC1 PFXZDYFCWCJPGP-QFIPXVFZSA-N 0.000 claims 1
- KQPRBJVDAZZSAU-QFIPXVFZSA-N (3r)-5'-[5-(pyrrolidin-1-ylmethyl)furan-2-yl]spiro[1-azabicyclo[2.2.2]octane-3,2'-3h-furo[2,3-b]pyridine] Chemical compound C=1C=C(C=2C=C3C[C@@]4(OC3=NC=2)C2CCN(CC2)C4)OC=1CN1CCCC1 KQPRBJVDAZZSAU-QFIPXVFZSA-N 0.000 claims 1
- VIJLMJSMFUQJTO-QFIPXVFZSA-N (3r)-5'-[5-(pyrrolidin-1-ylmethyl)furan-3-yl]spiro[1-azabicyclo[2.2.2]octane-3,2'-3h-furo[2,3-b]pyridine] Chemical compound C=1C(C=2C=C3C[C@@]4(OC3=NC=2)C2CCN(CC2)C4)=COC=1CN1CCCC1 VIJLMJSMFUQJTO-QFIPXVFZSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 201000006347 Intellectual Disability Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 208000020358 Learning disease Diseases 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 230000001713 cholinergic effect Effects 0.000 claims 1
- 230000007278 cognition impairment Effects 0.000 claims 1
- 235000019788 craving Nutrition 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 201000003723 learning disability Diseases 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- ZFLIWLTZPYHUBM-IBGZPJMESA-N n-methyl-1-[5-[(3r)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3h-furo[2,3-b]pyridine]-5'-yl]thiophen-2-yl]methanamine Chemical compound S1C(CNC)=CC=C1C1=CN=C(O[C@]2(C3)C4CCN(CC4)C2)C3=C1 ZFLIWLTZPYHUBM-IBGZPJMESA-N 0.000 claims 1
- UBBPGHMTJPPULM-QFIPXVFZSA-N n-methyl-n-[[4-[(3r)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3h-furo[2,3-b]pyridine]-5'-yl]furan-2-yl]methyl]cyclopropanamine Chemical compound C=1C(C=2C=C3C[C@@]4(OC3=NC=2)C2CCN(CC2)C4)=COC=1CN(C)C1CC1 UBBPGHMTJPPULM-QFIPXVFZSA-N 0.000 claims 1
- YICKPQPPCVYQKE-QFIPXVFZSA-N n-methyl-n-[[5-[(3r)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3h-furo[2,3-b]pyridine]-5'-yl]furan-2-yl]methyl]cyclopropanamine Chemical compound C=1C=C(C=2C=C3C[C@@]4(OC3=NC=2)C2CCN(CC2)C4)OC=1CN(C)C1CC1 YICKPQPPCVYQKE-QFIPXVFZSA-N 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000005586 smoking cessation Effects 0.000 claims 1
- 230000000946 synaptic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74747606P | 2006-05-17 | 2006-05-17 | |
| US82497506P | 2006-09-08 | 2006-09-08 | |
| PCT/SE2007/000485 WO2007133155A1 (en) | 2006-05-17 | 2007-05-16 | Nicotinic acetylcholine receptor ligands 101 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009537517A JP2009537517A (ja) | 2009-10-29 |
| JP2009537517A5 true JP2009537517A5 (enExample) | 2010-04-02 |
Family
ID=38694158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510923A Pending JP2009537517A (ja) | 2006-05-17 | 2007-05-16 | ニコチン性アセチルコリン受容体リガンド１０１ |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7842803B2 (enExample) |
| EP (1) | EP2019831B1 (enExample) |
| JP (1) | JP2009537517A (enExample) |
| KR (1) | KR20090007753A (enExample) |
| AR (1) | AR060914A1 (enExample) |
| AU (1) | AU2007250560B2 (enExample) |
| BR (1) | BRPI0711941A2 (enExample) |
| CA (1) | CA2652610A1 (enExample) |
| CL (1) | CL2007001405A1 (enExample) |
| EC (1) | ECSP088971A (enExample) |
| ES (1) | ES2392997T3 (enExample) |
| IL (1) | IL195019A0 (enExample) |
| MX (1) | MX2008014436A (enExample) |
| NO (1) | NO20084915L (enExample) |
| RU (1) | RU2441007C2 (enExample) |
| SA (1) | SA07280244B1 (enExample) |
| TW (1) | TW200813067A (enExample) |
| UY (1) | UY30349A1 (enExample) |
| WO (1) | WO2007133155A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| WO2009066107A1 (en) * | 2007-11-21 | 2009-05-28 | Astrazeneca Ab | Use of a nicotinic receptor agonist |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| US20140171448A1 (en) | 2011-01-27 | 2014-06-19 | Novartis Ag | Use of nicotinic acetylcholine receptor alpha 7 activators |
| CA2830458A1 (en) | 2011-03-18 | 2012-09-27 | Novartis Ag | Combinations of alpha 7 nicotinic acetylcholine receptor activators and mglur5 antagonists for use in dopamine induced dyskinesia in parkinson's disease |
| CA3083244C (en) | 2011-10-20 | 2023-01-03 | Novartis Ag | Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment |
| ES2661050T3 (es) | 2012-12-11 | 2018-03-27 | Novartis Ag | Biomarcador predictivo de la capacidad de respuesta a tratamiento con activador del receptor nicotínico de acetilcolina alfa-7 |
| WO2014111837A1 (en) | 2013-01-15 | 2014-07-24 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| BR112015016994A8 (pt) | 2013-01-15 | 2018-01-23 | Novartis Ag | uso de agonistas do receptor alfa 7 nicotínico de acetilcolina |
| ES2883232T3 (es) | 2013-01-15 | 2021-12-07 | Novartis Ag | Uso de agonistas del receptor nicotínico de acetilcolina alfa 7 |
| US11209254B2 (en) * | 2016-03-09 | 2021-12-28 | Msato, Llc | Pellet shaped marking round for air rifles and pistols |
| HU231333B1 (hu) * | 2018-07-13 | 2023-01-28 | Richter Gedeon Nyrt | Spirokromán származékok |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR013184A1 (es) * | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
| CN1294136C (zh) * | 2001-06-01 | 2007-01-10 | 阿斯特拉曾尼卡有限公司 | 用于治疗的烟碱乙酰胆碱受体新型配体 |
| AU2003224545B2 (en) * | 2002-04-18 | 2009-08-13 | Astrazeneca Ab | Thienyl compounds |
| CN1325500C (zh) * | 2002-04-18 | 2007-07-11 | 阿斯特拉曾尼卡有限公司 | 呋喃基化合物 |
| MXPA04010190A (es) * | 2002-04-18 | 2005-02-03 | Astrazeneca Ab | Compuestos heterociclicos. |
| CN1856497A (zh) * | 2003-09-25 | 2006-11-01 | 阿斯利康(瑞典)有限公司 | 配体 |
-
2007
- 2007-05-10 TW TW096116654A patent/TW200813067A/zh unknown
- 2007-05-14 AR ARP070102066A patent/AR060914A1/es not_active Application Discontinuation
- 2007-05-14 SA SA07280244A patent/SA07280244B1/ar unknown
- 2007-05-15 UY UY30349A patent/UY30349A1/es not_active Application Discontinuation
- 2007-05-16 AU AU2007250560A patent/AU2007250560B2/en not_active Ceased
- 2007-05-16 WO PCT/SE2007/000485 patent/WO2007133155A1/en not_active Ceased
- 2007-05-16 CL CL2007001405A patent/CL2007001405A1/es unknown
- 2007-05-16 KR KR1020087027857A patent/KR20090007753A/ko not_active Abandoned
- 2007-05-16 BR BRPI0711941-0A patent/BRPI0711941A2/pt not_active IP Right Cessation
- 2007-05-16 MX MX2008014436A patent/MX2008014436A/es not_active Application Discontinuation
- 2007-05-16 ES ES07748149T patent/ES2392997T3/es active Active
- 2007-05-16 CA CA002652610A patent/CA2652610A1/en not_active Abandoned
- 2007-05-16 RU RU2008143450/04A patent/RU2441007C2/ru not_active IP Right Cessation
- 2007-05-16 JP JP2009510923A patent/JP2009537517A/ja active Pending
- 2007-05-16 EP EP07748149A patent/EP2019831B1/en active Active
- 2007-05-17 US US11/749,820 patent/US7842803B2/en active Active
-
2008
- 2008-10-30 IL IL195019A patent/IL195019A0/en unknown
- 2008-11-21 NO NO20084915A patent/NO20084915L/no not_active Application Discontinuation
- 2008-12-12 EC EC2008008971A patent/ECSP088971A/es unknown
-
2010
- 2010-11-05 US US12/940,449 patent/US20110136804A1/en not_active Abandoned
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