JP2009535462A - 化学的に異なる末端基を含むポリ(エチレングリコール) - Google Patents

化学的に異なる末端基を含むポリ(エチレングリコール) Download PDF

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JP2009535462A
JP2009535462A JP2009507852A JP2009507852A JP2009535462A JP 2009535462 A JP2009535462 A JP 2009535462A JP 2009507852 A JP2009507852 A JP 2009507852A JP 2009507852 A JP2009507852 A JP 2009507852A JP 2009535462 A JP2009535462 A JP 2009535462A
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aliphatic
nhc
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ring
optionally substituted
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JP2009535462A5 (enExample
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カート ブライテンカンプ,
ケビン エヌ. シル,
ハビブ スカッフ,
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インテザイン テクノロジーズ, インコーポレイテッド
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021004256A (ja) * 2015-01-30 2021-01-14 パリオン・サイエンシィズ・インコーポレーテッド 新規モノチオール粘液溶解剤
JP2023530622A (ja) * 2020-06-29 2023-07-19 コンパニー ゼネラール デ エタブリッスマン ミシュラン エポキシド基を含む化合物

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI341836B (en) * 2004-03-11 2011-05-11 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
US7560588B2 (en) 2006-04-27 2009-07-14 Intezyne Technologies, Inc. Poly(ethylene glycol) containing chemically disparate endgroups
US8212083B2 (en) 2006-04-27 2012-07-03 Intezyne Technologies, Inc. Heterobifunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof
WO2008006097A2 (en) * 2006-07-07 2008-01-10 Intezyne Technologies Llc Covalent modification of metal surfaces
US8188046B2 (en) 2006-10-16 2012-05-29 University Of South Florida Amyloid beta peptides and methods of use
WO2008106657A2 (en) * 2007-03-01 2008-09-04 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
WO2008134734A2 (en) * 2007-04-30 2008-11-06 Intezyne Technologies, Inc. Encapsulated contrast agents
MX2009011479A (es) * 2007-04-30 2010-02-01 Intezyne Technologies Inc Micelas de copolimero de bloque hibrido con estereoquimica mezclada para encapsulacion de hidrofobos.
JP5600063B2 (ja) 2007-10-19 2014-10-01 セルジーン アビロミクス リサーチ, インコーポレイテッド ヘテロアリール化合物およびその使用
US7989465B2 (en) 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
US8870847B2 (en) * 2007-11-27 2014-10-28 Abbott Cardiovascular Systems Inc. Blood vessel permeability-enhancement for the treatment of vascular diseases
US8034396B2 (en) * 2008-04-01 2011-10-11 Tyco Healthcare Group Lp Bioadhesive composition formed using click chemistry
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
US8658735B2 (en) 2008-08-28 2014-02-25 Tokyo University Of Science Educational Foundation Administrative Organization Polymerizable monomer, graft copolymer, and surface modifier
JP5594715B2 (ja) * 2008-09-08 2014-09-24 学校法人東京理科大学 重合性モノマーの製造方法及びグラフト共重合体
CA2753179A1 (en) 2009-02-21 2010-08-26 Sofradim Production Crosslinked fibers and method of making same by extrusion
US9273191B2 (en) 2009-02-21 2016-03-01 Sofradim Production Medical devices with an activated coating
US8877170B2 (en) * 2009-02-21 2014-11-04 Sofradim Production Medical device with inflammatory response-reducing coating
CA2753171A1 (en) 2009-02-21 2010-08-26 Sofradim Production Crosslinked fibers and method of making same using uv radiation
US8535477B2 (en) 2009-02-21 2013-09-17 Sofradim Production Medical devices incorporating functional adhesives
WO2010095052A2 (en) 2009-02-21 2010-08-26 Sofradim Production Compounds and medical devices activated with solvophobic linkers
US9039979B2 (en) 2009-02-21 2015-05-26 Sofradim Production Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices
EP2398584A2 (en) 2009-02-21 2011-12-28 Sofradim Production Apparatus and method of reaching polymers by exposure to uv radiation to produce injectable medical devices
US8512728B2 (en) 2009-02-21 2013-08-20 Sofradim Production Method of forming a medical device on biological tissue
EP2398523B1 (en) 2009-02-21 2018-04-04 Covidien LP Medical devices having activated surfaces
US8968733B2 (en) * 2009-02-21 2015-03-03 Sofradim Production Functionalized surgical adhesives
EP2398524B1 (en) 2009-02-21 2017-07-12 Covidien LP Medical devices having activated surfaces
US8956603B2 (en) 2009-02-21 2015-02-17 Sofradim Production Amphiphilic compounds and self-assembling compositions made therefrom
US8663689B2 (en) * 2009-02-21 2014-03-04 Sofradim Production Functionalized adhesive medical gel
US8435488B2 (en) * 2009-02-27 2013-05-07 Genentech, Inc. Methods and compositions for protein labelling
WO2010127271A1 (en) 2009-04-30 2010-11-04 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
US8524784B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
WO2011088405A1 (en) * 2010-01-15 2011-07-21 Intezyne Technologies, Incorporated Plasma modification of metal surfaces
WO2011112969A1 (en) * 2010-03-11 2011-09-15 Intezyne Technologies, Inc. Poly(ethylene glycol) derivatives for metal-free click chemistry
CN102191224A (zh) * 2010-03-12 2011-09-21 复旦大学 一种单纯疱疹病毒的重靶向修饰方法及其应用
CA2794336A1 (en) 2010-03-25 2011-09-29 Sofradim Production Surgical fasteners and methods for sealing wounds
US8795331B2 (en) 2010-03-25 2014-08-05 Covidien Lp Medical devices incorporating functional adhesives
GB201008902D0 (en) 2010-05-27 2010-07-14 Imp Innovations Ltd Membrane enhanced polymer sythesis
EP2588525A4 (en) 2010-06-29 2015-06-10 Covidien Lp MICROWAVE POWERED REACTOR AND IN SITU IMPLANT TRAINING METHOD
US8865857B2 (en) 2010-07-01 2014-10-21 Sofradim Production Medical device with predefined activated cellular integration
WO2012014080A2 (en) 2010-07-27 2012-02-02 Sofradim Production Polymeric fibers having tissue reactive members
BR112013010564B1 (pt) 2010-11-01 2021-09-21 Celgene Car Llc Compostos heterocíclicos e composições compreendendo os mesmos
EP2637502B1 (en) 2010-11-10 2018-01-10 Celgene CAR LLC Mutant-selective egfr inhibitors and uses thereof
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012166555A1 (en) * 2011-05-27 2012-12-06 Nektar Therapeutics Water - soluble polymer - linked binding moiety and drug compounds
FR2977162B1 (fr) * 2011-06-28 2013-07-12 Centre Nat Rech Scient Nanovecteurs ou particules polymeres et leur utilisation comme medicament et/ou agent de diagnostic
CN107315086B (zh) 2011-06-29 2019-09-10 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
US20130178600A1 (en) * 2012-01-09 2013-07-11 Intezyne Technologies, Inc. Poly(ethylene glycol) derivatives for click chemistry
US8993614B2 (en) 2012-03-15 2015-03-31 F. Hoffmann-La Roche Ag Substituted pyrrolidine-2-carboxamides
JP6317320B2 (ja) 2012-03-15 2018-04-25 セルジーン シーエーアール エルエルシー 上皮成長因子受容体キナーゼ阻害剤の塩
US20130288980A1 (en) * 2012-04-02 2013-10-31 Buck Institute For Research On Aging Targeting senescent and cancer cells for selective killing by interference with foxo4
US9212255B2 (en) * 2012-05-07 2015-12-15 Nissan Chemical Industries, Ltd. Resist underlayer film-forming composition
US9155804B2 (en) * 2012-09-26 2015-10-13 General Electric Company Contrast enhancement agents and method of use thereof
CN103044677A (zh) * 2012-12-28 2013-04-17 上海景宇生物科技有限公司 一种异端基遥爪聚乙二醇及其制备方法
CN105188371A (zh) 2013-02-08 2015-12-23 西建阿维拉米斯研究公司 Erk抑制剂及其用途
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
GB201315335D0 (en) * 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
US10173357B2 (en) 2013-09-26 2019-01-08 Northwestern University Poly(ethylene glycol) cross-linking of soft materials to tailor viscoelastic properties for bioprinting
EP3052136A4 (en) * 2013-10-02 2017-06-21 University of Massachusetts Surface functionalized, host-guest polymer nano-assemblies and methods thereof
WO2015065168A1 (en) * 2013-10-28 2015-05-07 Universiti Malaya Oligo-ethylene glycol based phosphonate surface modification reagents and use thereof
CN104926989B (zh) * 2014-03-20 2017-05-17 中国石油化工股份有限公司 一种丙烯酰胺型聚合物及其制备方法和应用
CN104926678B (zh) * 2014-03-20 2017-02-08 中国石油化工股份有限公司 一种n‑端胺基聚醚基丙烯酰胺单体及其制备方法
JP6277381B2 (ja) * 2014-03-27 2018-02-14 Kjケミカルズ株式会社 グリシジル基含有(メタ)アクリルアミド
TW201623605A (zh) 2014-04-01 2016-07-01 中央研究院 用於癌症診斷及預後之方法及系統
WO2016025561A1 (en) 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Forms and compositions of an erk inhibitor
US10112198B2 (en) 2014-08-26 2018-10-30 Academia Sinica Collector architecture layout design
SMT202100406T1 (it) * 2015-12-11 2021-09-14 Eth Zuerich Derivati di inositolo per l'uso nella cristallizzazione patologica
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
US11149058B2 (en) * 2016-03-18 2021-10-19 Department Of Biotechnology Multi-functional chemical agents, and the method for protein modification
KR20220147719A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
WO2019191650A1 (en) * 2018-03-29 2019-10-03 Children's Medical Center Corporation Compositions and methods for targeting cells
CN111748087B (zh) * 2020-07-20 2022-06-21 国科温州研究院(温州生物材料与工程研究所) 一种染料修饰peg及其在酸性光亮镀铜中的应用
WO2022263944A1 (en) * 2021-06-16 2022-12-22 3M Innovative Properties Company Azido-containing monomers, polymers, and articles
CN114085233B (zh) * 2021-10-08 2024-12-20 苏州凯润纳米材料有限公司 一种用于蛋白质修饰的聚乙二醇链接剂及其合成方法
US20260042880A1 (en) * 2024-08-09 2026-02-12 The Boeing Company Controllable extension of flexible oligomeric diols and methods thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000584A2 (en) * 1998-06-26 2000-01-06 University Of Utah Research Foundation Immobilized reagents for kinase assays
US20060142506A1 (en) * 2004-10-25 2006-06-29 Kurt Breitenkamp Heterobifunctional poly(ethylene glycol) and uses thereof

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL101813C (enExample) 1955-04-09
CH425237A (de) 1963-12-12 1966-11-30 Ciba Geigy Verfahren zur Emulsionspolymerisation von ungesättigten polymerisierbaren Verbindungen
JPH01104782A (ja) * 1987-07-02 1989-04-21 Fuji Photo Film Co Ltd 無電解メッキ用触媒材料およびそれを用いた金属化材料
US4847325A (en) 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
JPH01301869A (ja) * 1988-05-27 1989-12-06 Dai Ichi Kogyo Seiyaku Co Ltd ニッチング促進添加剤
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
JPH0668118B2 (ja) * 1990-08-06 1994-08-31 第一工業製薬株式会社 洗浄剤組成物
US5824701A (en) 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
US5965566A (en) 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US6160054A (en) 1995-05-08 2000-12-12 Fmc Corporation Hetero-telechelic polymers and processes for making same
WO1995033490A1 (en) 1994-06-02 1995-12-14 Enzon, Inc. Method of solubilizing substantially water insoluble materials
US6180092B1 (en) * 1994-11-10 2001-01-30 Arlene Lagin Dissolvable air freshener
US5756593A (en) 1995-05-15 1998-05-26 Enzon, Inc. Method of preparing polyalkyene oxide carboxylic acids
US6448369B1 (en) 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US6180095B1 (en) 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6251382B1 (en) 1998-04-17 2001-06-26 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
CA2394980C (en) 1999-12-22 2008-05-13 Shearwater Corporation Sterically hindered derivatives of water soluble polymers
US6413507B1 (en) 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
US6777387B2 (en) 2000-03-31 2004-08-17 Enzon Pharmaceuticals, Inc. Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
EP1363953A2 (en) 2001-02-01 2003-11-26 Fmc Corporation Functionalized initiators for anionic polymerization, protected funtionalized polymers, deprotected analogues thereof, and methods of making the same
EP1446438A2 (en) 2001-11-07 2004-08-18 Nektar Therapeutics Al, Corporation Branched polymers and their conjugates
AU2002363334A1 (en) 2001-11-09 2003-05-19 Enzon, Inc. Polymeric thiol-linked prodrugs
US6608076B1 (en) 2002-05-16 2003-08-19 Enzon, Inc. Camptothecin derivatives and polymeric conjugates thereof
JP2004010479A (ja) 2002-06-03 2004-01-15 Japan Science & Technology Corp ブロック共重合体とアンスラサイクリン系抗癌剤を含む新規固型製剤及びその製造法
US7569214B2 (en) 2002-09-09 2009-08-04 Nektar Therapeutics Al, Corporation Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid
JP4764630B2 (ja) 2002-09-09 2011-09-07 ネクター セラピューティックス 水溶性ポリマーアルカナール
US6649778B1 (en) 2002-09-20 2003-11-18 Enzon, Inc. Methods of preparing amino acid taxane derivatives and polymer conjugates containing the same
US7208145B2 (en) 2002-12-31 2007-04-24 Nektar Therapeutics Al, Corporation Polymeric reagents comprising a ketone or a related functional group
PL1656410T3 (pl) 2003-07-22 2010-08-31 Nektar Therapeutics Sposób wytwarzania sfunkcjonalizowanych polimerów z polimerycznych alkoholi
EP1663469A4 (en) * 2003-09-05 2009-01-07 Univ Massachusetts AMPHIPHILIC POLYMER CAPSULES AND ASSOCIATED METHODS OF INTERFACIAL ASSEMBLY
US20070034606A1 (en) * 2003-09-30 2007-02-15 Basf Aktiengesellschaft Patents, Trademarks And Licenses Method for pickling metallic surfaces by using alkoxylated alkynols
FR2860516B1 (fr) 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
EP1675620B1 (en) 2003-10-09 2019-05-08 Ambrx, Inc. Polymer derivatives
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
ITPD20040159A1 (it) * 2004-06-21 2004-09-21 Univ Degli Studi Trieste Derivati bifunzionali del polietilenglicole loro preparazione e uso.
EP1833958A4 (en) 2005-01-04 2009-01-14 Intezyne Technologies Inc SYNTHESIS OF HYBRID BLOCK COPOLYMERS AND USES THEREOF
CA2597378A1 (en) 2005-02-11 2006-08-17 Intezyne Technologies, Incorporated Synthesis of homopolymers and block copolymers
US20060216238A1 (en) * 2005-02-28 2006-09-28 Marianne Manchester Compositions and methods for targeting or imaging a tissue in a vertebrate subject
KR101288729B1 (ko) 2005-04-01 2013-07-23 인터자인 테크놀로지스, 인코포레이티드 약물 전달용 중합체성 마이셀
US7560588B2 (en) 2006-04-27 2009-07-14 Intezyne Technologies, Inc. Poly(ethylene glycol) containing chemically disparate endgroups
US8212083B2 (en) 2006-04-27 2012-07-03 Intezyne Technologies, Inc. Heterobifunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof
WO2008006097A2 (en) 2006-07-07 2008-01-10 Intezyne Technologies Llc Covalent modification of metal surfaces
WO2008106657A2 (en) 2007-03-01 2008-09-04 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
WO2008134734A2 (en) 2007-04-30 2008-11-06 Intezyne Technologies, Inc. Encapsulated contrast agents
US20090110662A1 (en) 2007-04-30 2009-04-30 Intezyne Technologies, Inc. Modification of biological targeting groups for the treatment of cancer
MX2009011479A (es) 2007-04-30 2010-02-01 Intezyne Technologies Inc Micelas de copolimero de bloque hibrido con estereoquimica mezclada para encapsulacion de hidrofobos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000584A2 (en) * 1998-06-26 2000-01-06 University Of Utah Research Foundation Immobilized reagents for kinase assays
US20060142506A1 (en) * 2004-10-25 2006-06-29 Kurt Breitenkamp Heterobifunctional poly(ethylene glycol) and uses thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021004256A (ja) * 2015-01-30 2021-01-14 パリオン・サイエンシィズ・インコーポレーテッド 新規モノチオール粘液溶解剤
JP7112464B2 (ja) 2015-01-30 2022-08-03 パリオン・サイエンシィズ・インコーポレーテッド 新規モノチオール粘液溶解剤
JP2023530622A (ja) * 2020-06-29 2023-07-19 コンパニー ゼネラール デ エタブリッスマン ミシュラン エポキシド基を含む化合物
JP7703578B2 (ja) 2020-06-29 2025-07-07 コンパニー ゼネラール デ エタブリッスマン ミシュラン エポキシド基を含む化合物

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