JP2009534018A5 - - Google Patents
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- Publication number
- JP2009534018A5 JP2009534018A5 JP2009505698A JP2009505698A JP2009534018A5 JP 2009534018 A5 JP2009534018 A5 JP 2009534018A5 JP 2009505698 A JP2009505698 A JP 2009505698A JP 2009505698 A JP2009505698 A JP 2009505698A JP 2009534018 A5 JP2009534018 A5 JP 2009534018A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- sweetness
- compounds
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 117
- 238000000034 method Methods 0.000 claims 38
- 108091005708 gustatory receptors Proteins 0.000 claims 33
- 235000003599 food sweetener Nutrition 0.000 claims 25
- 239000000203 mixture Substances 0.000 claims 25
- 239000003765 sweetening agent Substances 0.000 claims 25
- 101000659765 Homo sapiens Taste receptor type 1 member 2 Proteins 0.000 claims 19
- 102100035948 Taste receptor type 1 member 2 Human genes 0.000 claims 19
- 102000004169 proteins and genes Human genes 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 18
- 102000005962 receptors Human genes 0.000 claims 18
- 108020003175 receptors Proteins 0.000 claims 18
- 101000659774 Homo sapiens Taste receptor type 1 member 3 Proteins 0.000 claims 17
- 102100035942 Taste receptor type 1 member 3 Human genes 0.000 claims 17
- 238000003556 assay Methods 0.000 claims 16
- GHBNZZJYBXQAHG-KUVSNLSMSA-N (2r,3r,4s,5s,6r)-2-[[(2r,3s,4s,5r,6r)-6-[[(3s,8s,9r,10r,11r,13r,14s,17r)-17-[(2r,5r)-5-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-3-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H](CC[C@@H](C)[C@@H]1[C@]2(C[C@@H](O)[C@@]3(C)[C@H]4C(C([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]6[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O6)O)O5)O)CC4)(C)C)=CC[C@H]3[C@]2(C)CC1)C)C(C)(C)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GHBNZZJYBXQAHG-KUVSNLSMSA-N 0.000 claims 15
- 239000001512 FEMA 4601 Substances 0.000 claims 15
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 claims 15
- 235000009508 confectionery Nutrition 0.000 claims 15
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 claims 15
- TVJXHJAWHUMLLG-UHFFFAOYSA-N mogroside V Natural products CC(CCC(OC1OC(COC2OC(CO)C(O)C(O)C2OC3OC(CO)C(O)C(O)C3O)C(O)C(O)C1O)C(C)(C)O)C4CCC5(C)C6CC=C7C(CCC(OC8OC(COC9OC(CO)C(O)C(O)C9O)C(O)C(O)C8O)C7(C)C)C6(C)C(O)CC45C TVJXHJAWHUMLLG-UHFFFAOYSA-N 0.000 claims 15
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims 15
- 235000019203 rebaudioside A Nutrition 0.000 claims 15
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 14
- 229930006000 Sucrose Natural products 0.000 claims 14
- 239000005720 sucrose Substances 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 13
- 239000001329 FEMA 3811 Substances 0.000 claims 11
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 claims 11
- 229940089953 neohesperidin dihydrochalcone Drugs 0.000 claims 11
- 235000010434 neohesperidine DC Nutrition 0.000 claims 11
- 239000000126 substance Substances 0.000 claims 11
- 239000001183 FEMA 4495 Substances 0.000 claims 10
- CWBZAESOUBENAP-QVNVHUMTSA-N Naringin dihydrochalcone Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C(O)C(C(=O)CCC=3C=CC(O)=CC=3)=C(O)C=2)O[C@H](CO)[C@@H](O)[C@@H]1O CWBZAESOUBENAP-QVNVHUMTSA-N 0.000 claims 10
- 239000000654 additive Substances 0.000 claims 10
- 230000000996 additive effect Effects 0.000 claims 10
- 241000208713 Dionaea Species 0.000 claims 9
- YMHOBZXQZVXHBM-UHFFFAOYSA-N 2,5-dimethoxy-4-bromophenethylamine Chemical compound COC1=CC(CCN)=C(OC)C=C1Br YMHOBZXQZVXHBM-UHFFFAOYSA-N 0.000 claims 7
- 241000545067 Venus Species 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 238000001514 detection method Methods 0.000 claims 7
- ZWKNLRXFUTWSOY-QPJJXVBHSA-N (e)-3-phenylprop-2-enenitrile Chemical compound N#C\C=C\C1=CC=CC=C1 ZWKNLRXFUTWSOY-QPJJXVBHSA-N 0.000 claims 6
- JRHHJNMASOIRDS-UHFFFAOYSA-N 4-ethoxybenzaldehyde Chemical compound CCOC1=CC=C(C=O)C=C1 JRHHJNMASOIRDS-UHFFFAOYSA-N 0.000 claims 6
- YWPVROCHNBYFTP-UHFFFAOYSA-N Rubusoside Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC1OC(CO)C(O)C(O)C1O YWPVROCHNBYFTP-UHFFFAOYSA-N 0.000 claims 6
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- YWPVROCHNBYFTP-OSHKXICASA-N rubusoside Chemical compound O([C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YWPVROCHNBYFTP-OSHKXICASA-N 0.000 claims 6
- 229940013618 stevioside Drugs 0.000 claims 6
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims 6
- 235000019202 steviosides Nutrition 0.000 claims 6
- 108091006027 G proteins Proteins 0.000 claims 5
- 102000030782 GTP binding Human genes 0.000 claims 5
- 108091000058 GTP-Binding Proteins 0.000 claims 5
- 229940109275 cyclamate Drugs 0.000 claims 5
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- 238000005259 measurement Methods 0.000 claims 5
- -1 perilartin Chemical compound 0.000 claims 5
- 102000027583 GPCRs class C Human genes 0.000 claims 4
- 108091008882 GPCRs class C Proteins 0.000 claims 4
- 108700010039 chimeric receptor Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000005481 NMR spectroscopy Methods 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 238000002306 biochemical method Methods 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 2
- 239000000539 dimer Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 238000001506 fluorescence spectroscopy Methods 0.000 claims 2
- 239000007790 solid phase Substances 0.000 claims 2
- 102000015130 taste receptor activity proteins Human genes 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 1
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- XCOJIVIDDFTHGB-UEUZTHOGSA-N Perillartine Chemical compound CC(=C)[C@H]1CCC(\C=N\O)=CC1 XCOJIVIDDFTHGB-UEUZTHOGSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000003012 bilayer membrane Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 230000005714 functional activity Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 244000000013 helminth Species 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79352106P | 2006-04-20 | 2006-04-20 | |
| US79368606P | 2006-04-20 | 2006-04-20 | |
| US60/793,686 | 2006-04-20 | ||
| US60/793,521 | 2006-04-20 | ||
| US81486606P | 2006-06-19 | 2006-06-19 | |
| US60/814,866 | 2006-06-19 | ||
| US85382306P | 2006-10-24 | 2006-10-24 | |
| US85382106P | 2006-10-24 | 2006-10-24 | |
| US85381306P | 2006-10-24 | 2006-10-24 | |
| US60/853,823 | 2006-10-24 | ||
| US60/853,813 | 2006-10-24 | ||
| US60/853,821 | 2006-10-24 | ||
| US88140207P | 2007-01-19 | 2007-01-19 | |
| US60/881,402 | 2007-01-19 | ||
| PCT/CH2007/000190 WO2007121604A2 (en) | 2006-04-20 | 2007-04-20 | Method relating to sweetness enhancement |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013048518A Division JP2013172717A (ja) | 2006-04-20 | 2013-03-11 | 甘味増強に関する方法 |
| JP2014247195A Division JP6243831B2 (ja) | 2006-04-20 | 2014-12-05 | 甘味増強に関する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534018A JP2009534018A (ja) | 2009-09-24 |
| JP2009534018A5 true JP2009534018A5 (enExample) | 2012-08-02 |
| JP6095881B2 JP6095881B2 (ja) | 2017-03-15 |
Family
ID=38523418
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505698A Active JP6095881B2 (ja) | 2006-04-20 | 2007-04-20 | 甘味増強に関する方法 |
| JP2013048518A Withdrawn JP2013172717A (ja) | 2006-04-20 | 2013-03-11 | 甘味増強に関する方法 |
| JP2014247195A Active JP6243831B2 (ja) | 2006-04-20 | 2014-12-05 | 甘味増強に関する方法 |
| JP2017094295A Active JP6408643B2 (ja) | 2006-04-20 | 2017-05-10 | 甘味増強に関する方法 |
| JP2018175554A Active JP7018000B2 (ja) | 2006-04-20 | 2018-09-20 | 甘味増強に関する方法 |
| JP2021169287A Active JP7292347B2 (ja) | 2006-04-20 | 2021-10-15 | 甘味増強に関する方法 |
| JP2023093251A Pending JP2023161070A (ja) | 2006-04-20 | 2023-06-06 | 甘味増強に関する方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013048518A Withdrawn JP2013172717A (ja) | 2006-04-20 | 2013-03-11 | 甘味増強に関する方法 |
| JP2014247195A Active JP6243831B2 (ja) | 2006-04-20 | 2014-12-05 | 甘味増強に関する方法 |
| JP2017094295A Active JP6408643B2 (ja) | 2006-04-20 | 2017-05-10 | 甘味増強に関する方法 |
| JP2018175554A Active JP7018000B2 (ja) | 2006-04-20 | 2018-09-20 | 甘味増強に関する方法 |
| JP2021169287A Active JP7292347B2 (ja) | 2006-04-20 | 2021-10-15 | 甘味増強に関する方法 |
| JP2023093251A Pending JP2023161070A (ja) | 2006-04-20 | 2023-06-06 | 甘味増強に関する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8124361B2 (enExample) |
| EP (2) | EP2047254B1 (enExample) |
| JP (7) | JP6095881B2 (enExample) |
| KR (1) | KR101356914B1 (enExample) |
| WO (1) | WO2007121604A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2399059T3 (es) | 2005-05-23 | 2013-03-25 | Kraft Foods Global Brands Llc | Composiciones potenciadoras del dulzor |
| US7851005B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| US7851006B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| CN100482106C (zh) * | 2006-04-07 | 2009-04-29 | 哈尔滨三乐生物工程有限公司 | 活性肽果味啤酒样饮料及其制备方法 |
| EP2047254B1 (en) * | 2006-04-20 | 2015-10-28 | Givaudan SA | Method relating to sweetness enhancement |
| US20090162488A1 (en) * | 2007-12-21 | 2009-06-25 | The Concentrate Manufacturing Company Of Ireland | Beverage products and flavor systems having a non-sweetening amount of monatin |
| EP2298084B1 (de) | 2009-08-28 | 2011-10-19 | Symrise AG | Süßmittelreduzierte Produkte, Aromamischungen dafür sowie Verfahren zum Herstellen solcher Produkte |
| US10624372B2 (en) | 2009-08-28 | 2020-04-21 | Symrise Ag | Reduced-sweetener products, flavoring mixtures for said reduced-sweetener products and process for the production of products of this type |
| US20120232166A1 (en) * | 2009-10-12 | 2012-09-13 | Finley John W | Masking Bitter Flavors |
| JP5905187B2 (ja) * | 2009-12-02 | 2016-04-20 | 国立大学法人 東京大学 | 甘味受容体発現コンストラクト、これを発現させた細胞体、及びその利用 |
| JP2011116693A (ja) * | 2009-12-02 | 2011-06-16 | Univ Of Tokyo | 甘味物質に対するヒト甘味受容体作用性甘味調節物質 |
| MX2012007607A (es) | 2009-12-28 | 2012-07-20 | Coca Cola Co | Intensificadores de dulzor, composiciones de los mismos y metodos para su uso. |
| JP2011254783A (ja) * | 2010-06-11 | 2011-12-22 | Asahi Soft Drinks Co Ltd | 甘味増強剤、飲食品及び甘味増強方法 |
| MX365710B (es) | 2011-04-29 | 2019-06-11 | Intercontinental Great Brands Llc | Acido encapsulado, metodo para la preparacion del mismo y goma de mascar que comprende el mismo. |
| WO2013022948A1 (en) | 2011-08-08 | 2013-02-14 | The Coca-Cola Company | Cell lines comprising endogenous taste receptors and their uses |
| US20130040317A1 (en) | 2011-08-08 | 2013-02-14 | The University Of North Carolina At Chapel Hill | Cell lines comprising endogenous taste receptors and their uses |
| BR112014009376B1 (pt) * | 2011-10-24 | 2020-09-15 | Givaudan Sa | Composição consumível que compreende um adoçante e uma mistura que consiste essencialmente nos ingredientes individuais esteviosídeo e rebaudiosídeo a e método para adoçar a mesma |
| CN102838644B (zh) * | 2012-08-23 | 2015-06-03 | 湖南绿蔓生物科技股份有限公司 | 一种从甜茶叶中提取甜茶苷的生产方法 |
| MX384586B (es) | 2013-05-10 | 2025-03-14 | Pepsico Inc | Ensayo de internalización del receptor del gusto. |
| US10107794B2 (en) | 2013-05-10 | 2018-10-23 | Pepsico, Inc. | Methods of using U2-OS cells to identify potential sweet taste modulators |
| JP6347626B2 (ja) * | 2014-02-28 | 2018-06-27 | 三菱商事フードテック株式会社 | 甘味増強物質のスクリーニング方法 |
| CA2967999C (en) | 2014-12-10 | 2024-01-02 | Mars, Incorporated | Flavor compositions and pet food products containing the same |
| CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
| CA3066340A1 (en) | 2017-06-08 | 2018-12-13 | Suntory Holdings Limited | Food or beverage with increased sweetness |
| JP7173980B2 (ja) | 2017-10-23 | 2022-11-17 | 日本たばこ産業株式会社 | Ｇタンパク質共役受容体若しくはそのサブユニットを発現するためのコンストラクト及びその利用 |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| AU2019395196B2 (en) | 2018-12-07 | 2025-07-17 | Suntory Holdings Limited | Coffee beverage having improved quality of taste exhibited by sugar and sweetener |
| JP7114198B2 (ja) * | 2019-10-28 | 2022-08-08 | 長谷川香料株式会社 | ジヒドロカルコン類からなるアルコール感付与剤 |
| AU2021258138A1 (en) * | 2020-04-20 | 2022-12-01 | The Coca-Cola Company | Beverages comprising siamenoside i with enhanced flavor |
| KR102543061B1 (ko) | 2021-03-12 | 2023-06-15 | 중앙대학교 산학협력단 | 사카로미세스 세레비시아에서 브라제인을 고발현하기 위한 재조합 발현 벡터 및 이를 이용한 브라제인의 대량 생산방법 |
| CN113092651B (zh) * | 2021-03-29 | 2022-10-25 | 广州广电计量检测股份有限公司 | 一种乳或乳制品中甜味剂的检测方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
| US4612942A (en) * | 1984-03-08 | 1986-09-23 | Stevia Company, Inc. | Flavor enhancing and modifying materials |
| WO1990005745A1 (en) | 1988-11-18 | 1990-05-31 | The General Hospital Corporation | A cAMP-RESPONSIVE TRANSCRIPTIONAL ENHANCER BINDING PROTEIN |
| US5462856A (en) | 1990-07-19 | 1995-10-31 | Bunsen Rush Laboratories, Inc. | Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| DE69111050T2 (de) * | 1991-02-26 | 1995-11-23 | Zoster Sa | Verwendung von Neohesperidin-Dihydrochalcon zur Verstärkung des Körpers und des Mundgefühls von Nahrungsmitteln und Getränken. |
| NZ336326A (en) * | 1996-12-20 | 2001-02-23 | Nutrinova Gmbh | Method for increasing the sweetening power and enhancing the taste of a mixture of extremely powerful sweetening agents |
| JPH10262599A (ja) * | 1997-03-27 | 1998-10-06 | Nikken Chem Co Ltd | 味質が改良されたエリスリトールの製造方法 |
| JPH10276712A (ja) * | 1997-04-08 | 1998-10-20 | Nikken Kasei Kk | 甘味組成物の製造方法 |
| AU764180B2 (en) * | 1998-07-28 | 2003-08-14 | Regents Of The University Of California, The | Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction |
| US6368651B1 (en) * | 1999-05-13 | 2002-04-09 | The Nutrasweet Company | Use of additives to modify the taste characteristics of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester |
| WO2001018050A2 (en) | 1999-09-10 | 2001-03-15 | The Regents Of The University Of California | T2r taste receptor family |
| TW201022287A (en) | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US6955887B2 (en) * | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
| US7368285B2 (en) | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| WO2004055048A2 (en) * | 2002-12-18 | 2004-07-01 | Givaudan Sa | Chimeric alpha q-gustducin g-proteins |
| NZ619746A (en) * | 2003-08-06 | 2014-05-30 | Senomyx Inc | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
| US20050276839A1 (en) * | 2004-06-10 | 2005-12-15 | Rifkin Calman H | Appetite satiation and hydration beverage |
| US8796441B2 (en) | 2005-04-13 | 2014-08-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human sweet and umami taste receptor variants |
| EP2047254B1 (en) * | 2006-04-20 | 2015-10-28 | Givaudan SA | Method relating to sweetness enhancement |
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2007
- 2007-04-20 EP EP07720087.1A patent/EP2047254B1/en active Active
- 2007-04-20 EP EP15182783.9A patent/EP2995950B1/en active Active
- 2007-04-20 US US12/297,851 patent/US8124361B2/en active Active
- 2007-04-20 JP JP2009505698A patent/JP6095881B2/ja active Active
- 2007-04-20 WO PCT/CH2007/000190 patent/WO2007121604A2/en not_active Ceased
- 2007-04-20 KR KR1020087025407A patent/KR101356914B1/ko active Active
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2013
- 2013-03-11 JP JP2013048518A patent/JP2013172717A/ja not_active Withdrawn
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