JP2009533369A5 - - Google Patents
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- Publication number
- JP2009533369A5 JP2009533369A5 JP2009504637A JP2009504637A JP2009533369A5 JP 2009533369 A5 JP2009533369 A5 JP 2009533369A5 JP 2009504637 A JP2009504637 A JP 2009504637A JP 2009504637 A JP2009504637 A JP 2009504637A JP 2009533369 A5 JP2009533369 A5 JP 2009533369A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- protecting group
- give
- boc protecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 35
- 125000006239 protecting group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- -1 C 1 -C 7 -alkyl Chemical group 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- GXHFUVWIGNLZSC-UHFFFAOYSA-N Meldrum's acid Chemical compound CC1(C)OC(=O)CC(=O)O1 GXHFUVWIGNLZSC-UHFFFAOYSA-N 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 230000000875 corresponding Effects 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 238000006460 hydrolysis reaction Methods 0.000 claims 2
- CZRKBWYUKKBUMS-HNNXBMFYSA-N (4R)-4-[[3,5-bis(trifluoromethyl)benzoyl]-methylamino]-5-(3,4-dichlorophenyl)pent-2-enoic acid Chemical compound C([C@@H](N(C)C(=O)C=1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)C=CC(O)=O)C1=CC=C(Cl)C(Cl)=C1 CZRKBWYUKKBUMS-HNNXBMFYSA-N 0.000 claims 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N Sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 0 *CC1CCCC1 Chemical compound *CC1CCCC1 0.000 description 2
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0607532.9 | 2006-04-13 | ||
GB0607532A GB0607532D0 (en) | 2006-04-13 | 2006-04-13 | Organic compounds |
GB0610244A GB0610244D0 (en) | 2006-05-23 | 2006-05-23 | Organic compounds |
GB0610244.6 | 2006-05-23 | ||
PCT/EP2007/003213 WO2007118651A1 (en) | 2006-04-13 | 2007-04-11 | Synthesis of acylaminoalkenylene amides useful as substance p antagonists |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009533369A JP2009533369A (ja) | 2009-09-17 |
JP2009533369A5 true JP2009533369A5 (US20040106767A1-20040603-C00005.png) | 2011-02-17 |
JP5208917B2 JP5208917B2 (ja) | 2013-06-12 |
Family
ID=38324102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009504637A Expired - Fee Related JP5208917B2 (ja) | 2006-04-13 | 2007-04-11 | サブスタンスpアンタゴニストとして有用なアシルアミノアルケニレンアミドの合成 |
Country Status (29)
Families Citing this family (80)
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US8349817B2 (en) | 2007-04-25 | 2013-01-08 | Concert Pharmaceuticals, Inc. | Analogues of cilostazol |
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DK3825306T3 (da) | 2007-05-01 | 2023-09-11 | Sun Pharmaceutical Ind Inc | Morphinanforbindelser |
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US7820666B2 (en) | 2007-05-08 | 2010-10-26 | Concert Pharmaceuticals, Inc. | Tetrahydrotriazolopyrazine derivatives and uses thereof |
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US7687509B2 (en) | 2007-07-09 | 2010-03-30 | Concert Pharmaceuticals Inc. | Pyrimidinecarboxamide derivatives |
WO2009023233A1 (en) | 2007-08-14 | 2009-02-19 | Concert Pharmaceuticals, Inc. | Substituted oxazolidinone derivatives |
JP2010537717A (ja) | 2007-08-28 | 2010-12-09 | エフ エム シー コーポレーション | 遅効性自己ゲル化アルギネートシステムおよびその用途 |
ES2406479T3 (es) | 2007-09-12 | 2013-06-07 | Concert Pharmaceuticals Inc. | Derivado deuterado de 4-oxoquinolina para el tratamiento de la infección por VIH |
CN101855218A (zh) | 2007-09-13 | 2010-10-06 | 康塞特医药品有限公司 | 氘化的儿茶酚和苯并[d][1,3]间二氧杂环戊烯及其衍生物的合成 |
WO2009051782A1 (en) | 2007-10-18 | 2009-04-23 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
US8592487B2 (en) | 2007-10-26 | 2013-11-26 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
US8084464B2 (en) | 2007-12-18 | 2011-12-27 | Concert Pharmaceuticals, Inc. | Tetrahydroisoquinoline derivatives |
WO2009094210A1 (en) | 2008-01-22 | 2009-07-30 | Concert Pharmaceuticals Inc. | Vandetanib derivatives |
WO2009094216A1 (en) | 2008-01-22 | 2009-07-30 | Concert Pharmaceuticals Inc. | Derivatives of gefitinib |
CA2716788C (en) | 2008-02-29 | 2016-08-16 | Concert Pharmaceuticals, Inc. | Deuterium-substituted xanthine derivatives |
US8367674B2 (en) | 2008-04-17 | 2013-02-05 | Concert Pharmaceuticals, Inc. | Piperazine derivatives |
WO2009154754A2 (en) | 2008-06-17 | 2009-12-23 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated morpholine derivatives |
KR20110063479A (ko) | 2008-08-29 | 2011-06-10 | 콘서트 파마슈티컬즈, 인크. | 치환된 트리아졸로-피리다진 유도체 |
US8704001B2 (en) | 2008-09-16 | 2014-04-22 | Concert Pharmaceuticals, Inc. | Deuterated 2-amino-3-hydroxypropanoic acid derivatives |
EP2805950B1 (en) | 2008-09-19 | 2017-11-08 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds |
US9045453B2 (en) | 2008-11-14 | 2015-06-02 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
US20120077803A1 (en) * | 2009-02-24 | 2012-03-29 | Novartis Ag | Uses Of NK Receptor Antagonists |
US8952016B2 (en) | 2009-02-27 | 2015-02-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
DE102009001446A1 (de) | 2009-03-10 | 2010-09-23 | Evonik Rohmax Additives Gmbh | Verwendung von Kammpolymeren als Antifatigue-Additive |
BRPI1009199A2 (pt) | 2009-03-17 | 2016-03-08 | Concert Pharmaceuticals Inc | compostos de pirazinoisoquinolina |
WO2010108103A1 (en) * | 2009-03-19 | 2010-09-23 | Concert Pharmaceuticals, Inc. | Azepan-2-one derivatives |
DK2421808T3 (da) | 2009-04-23 | 2013-11-04 | Concert Pharmaceuticals Inc | 4-Hydroxysmørsyreanaloger |
WO2010135579A1 (en) | 2009-05-22 | 2010-11-25 | Concert Pharmaceuticals, Inc. | Fluorinated diaryl urea derivatives |
AU2010260249B2 (en) | 2009-06-18 | 2013-09-05 | Concert Pharmaceuticals, Inc. | Deuterated isoindoline-1,3-dione derivatives as PDE4 and TNF-alpha inhibitors |
WO2011005520A1 (en) | 2009-06-23 | 2011-01-13 | Concert Pharmaceuticals, Inc. | Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators |
EP2464355A4 (en) | 2009-08-14 | 2013-01-02 | Concert Pharmaceuticals Inc | SUBSTITUTED TRIAZOLPHTHALAZINE DERIVATIVES |
WO2011028820A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds |
WO2011047315A1 (en) | 2009-10-15 | 2011-04-21 | Concert Pharmaceuticals, Inc. | Subsitituted benzimidazoles |
WO2011063001A1 (en) | 2009-11-18 | 2011-05-26 | Concert Pharmaceuticals, Inc. | Niacin prodrugs and deuterated versions thereof |
DE102010001040A1 (de) | 2010-01-20 | 2011-07-21 | Evonik RohMax Additives GmbH, 64293 | (Meth)acrylat-Polymere zur Verbesserung des Viskositätsindexes |
WO2011109464A1 (en) | 2010-03-02 | 2011-09-09 | Concert Pharmaceuticals Inc. | Deuterated tetrahydronaphthalene derivatives |
US8575361B2 (en) | 2010-03-02 | 2013-11-05 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
US9226801B2 (en) * | 2010-03-08 | 2016-01-05 | Ibur, Llc | Custom linkable imaging and multifunctional tray |
US8575221B2 (en) | 2010-03-17 | 2013-11-05 | Concert Pharmaceuticals, Inc. | Derivatives of dimethylcurcumin |
US9107922B2 (en) | 2010-07-16 | 2015-08-18 | Concert Pharmaceuticals, Inc. | Pyrimidinecarboxamide derivatives |
US9085788B2 (en) | 2010-09-01 | 2015-07-21 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
US9074233B2 (en) | 2010-09-01 | 2015-07-07 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
CN103370289B (zh) | 2011-02-14 | 2015-09-09 | 康塞特医药品有限公司 | 4-羟基丁酸氘化类似物 |
US9145390B2 (en) | 2011-03-03 | 2015-09-29 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
WO2012122028A2 (en) | 2011-03-04 | 2012-09-13 | Concert Pharmaceuticals Inc. | Pyrazinoisoquinoline compounds |
HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
CN104364255A (zh) | 2012-04-13 | 2015-02-18 | 康塞特医药品有限公司 | 取代的黄嘌呤衍生物 |
US9249093B2 (en) | 2012-04-20 | 2016-02-02 | Concert Pharmaceuticals, Inc. | Deuterated rigosertib |
US20150197525A1 (en) | 2012-06-15 | 2015-07-16 | Concert Pharmaceuticals, Inc. | Deuterated derivatives of ruxolitinib |
US9181190B2 (en) | 2012-07-04 | 2015-11-10 | Concert Pharmaceuticals, Inc. | Deuterated vercirnon |
ES2694202T3 (es) | 2012-07-12 | 2018-12-19 | Concert Pharmaceuticals, Inc. | Idebenona deuterada |
EA201590296A1 (ru) | 2012-07-30 | 2015-07-30 | Консерт Фармасьютикалс Инк. | Дейтерированный ибрутиниб |
EP2885303B1 (en) | 2012-08-17 | 2018-12-26 | CoNCERT Pharmaceuticals, Inc. | Deuterated baricitinib |
WO2014066243A1 (en) | 2012-10-22 | 2014-05-01 | Concert Pharmaceuticals, Inc. | Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2yl)(piperidine-3,4,4,5,5-d5)-2,6-dione} |
ES2672468T3 (es) | 2013-01-09 | 2018-06-14 | Concert Pharmaceuticals Inc. | Momelotinib deuterado |
WO2014150043A1 (en) | 2013-03-15 | 2014-09-25 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
WO2015031741A1 (en) | 2013-08-30 | 2015-03-05 | Concert Pharmaceuticals, Inc. | Deuterated derivatives of a thienotriazolodiazapine bromodomain-containing protein inhibitor |
CN106459056A (zh) | 2014-02-10 | 2017-02-22 | 康塞特医药品公司 | 经取代的三唑苯二氮卓 |
US10160778B2 (en) | 2014-10-27 | 2018-12-25 | Concert Pharmaceuticals, Inc. | Pyrimidine phosphonic acid esters |
US10196384B2 (en) | 2015-03-31 | 2019-02-05 | Vertex Pharmaceuticals (Europe) Limited | Deuterated CFTR modulators |
WO2016176335A1 (en) | 2015-04-27 | 2016-11-03 | Concert Pharmaceuticals, Inc. | Deuterated otx-015 |
CA2999529A1 (en) | 2015-09-25 | 2017-03-30 | Vertex Pharmaceuticals (Europe) Limited | Deuterated cftr potentiators |
US11267777B2 (en) | 2015-11-19 | 2022-03-08 | Concert Pharmaceuticals, Inc. | Deuterated EPI-743 |
US10442761B2 (en) | 2016-02-16 | 2019-10-15 | Concert Pharmaceuticals, Inc. | Deuterated GFT-505 |
WO2019104179A1 (en) | 2017-11-22 | 2019-05-31 | Concert Pharmaceuticals, Inc. | Deuterated analogs of d-serine and uses thereof |
WO2019109021A1 (en) | 2017-12-01 | 2019-06-06 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA002348B1 (ru) | 1995-02-22 | 2002-04-25 | Новартис Аг | Соединения 1-арил-2-ациламиноэтана и их применение в качестве антагонистов нейрокинина, в частности нейрокинина 1 |
MY132550A (en) * | 1996-08-22 | 2007-10-31 | Novartis Ag | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists |
GB0010958D0 (en) * | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2007
- 2007-04-10 JO JO2007129A patent/JO2630B1/en active
- 2007-04-11 AR ARP070101533A patent/AR060506A1/es not_active Application Discontinuation
- 2007-04-11 WO PCT/EP2007/003213 patent/WO2007118651A1/en active Application Filing
- 2007-04-11 SI SI200730483T patent/SI2010498T1/sl unknown
- 2007-04-11 PT PT07724154T patent/PT2010498E/pt unknown
- 2007-04-11 US US12/296,969 patent/US8008479B2/en not_active Expired - Fee Related
- 2007-04-11 PL PL07724154T patent/PL2010498T3/pl unknown
- 2007-04-11 CA CA2645362A patent/CA2645362C/en not_active Expired - Fee Related
- 2007-04-11 AU AU2007237482A patent/AU2007237482B2/en not_active Ceased
- 2007-04-11 RU RU2008145102/04A patent/RU2433122C2/ru not_active IP Right Cessation
- 2007-04-11 MX MX2008013117A patent/MX2008013117A/es active IP Right Grant
- 2007-04-11 EP EP07724154A patent/EP2010498B1/en active Active
- 2007-04-11 NZ NZ571142A patent/NZ571142A/en not_active IP Right Cessation
- 2007-04-11 PE PE2007000444A patent/PE20071223A1/es not_active Application Discontinuation
- 2007-04-11 DE DE602007010269T patent/DE602007010269D1/de active Active
- 2007-04-11 JP JP2009504637A patent/JP5208917B2/ja not_active Expired - Fee Related
- 2007-04-11 AT AT07724154T patent/ATE486853T1/de active
- 2007-04-11 KR KR1020087024839A patent/KR20080108291A/ko not_active Application Discontinuation
- 2007-04-11 DK DK07724154.5T patent/DK2010498T3/da active
- 2007-04-12 TW TW096112886A patent/TW200815358A/zh unknown
- 2007-04-12 CL CL200701040A patent/CL2007001040A1/es unknown
-
2008
- 2008-10-08 MY MYPI20083997A patent/MY145069A/en unknown
- 2008-10-10 GT GT200800209A patent/GT200800209A/es unknown
- 2008-10-13 EC EC2008008820A patent/ECSP088820A/es unknown
- 2008-11-03 MA MA31347A patent/MA30394B1/fr unknown
- 2008-11-12 NO NO20084783A patent/NO20084783L/no not_active Application Discontinuation
-
2009
- 2009-05-15 HK HK09104457.9A patent/HK1125640A1/xx not_active IP Right Cessation
-
2011
- 2011-01-21 HR HR20110045T patent/HRP20110045T1/hr unknown
- 2011-01-26 CY CY20111100082T patent/CY1111294T1/el unknown
- 2011-07-22 US US13/188,795 patent/US20110282053A1/en not_active Abandoned
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