JP2009531390A - 有機化合物 - Google Patents
有機化合物 Download PDFInfo
- Publication number
- JP2009531390A JP2009531390A JP2009502104A JP2009502104A JP2009531390A JP 2009531390 A JP2009531390 A JP 2009531390A JP 2009502104 A JP2009502104 A JP 2009502104A JP 2009502104 A JP2009502104 A JP 2009502104A JP 2009531390 A JP2009531390 A JP 2009531390A
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- JP
- Japan
- Prior art keywords
- alkyl
- heterocyclyl
- compound
- group
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002894 organic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 318
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 378
- -1 substituted Chemical class 0.000 claims description 154
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 143
- 229910052739 hydrogen Inorganic materials 0.000 claims description 137
- 239000001257 hydrogen Substances 0.000 claims description 134
- 229910052736 halogen Inorganic materials 0.000 claims description 108
- 150000002367 halogens Chemical class 0.000 claims description 108
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 106
- 125000000623 heterocyclic group Chemical group 0.000 claims description 103
- 125000003545 alkoxy group Chemical group 0.000 claims description 101
- 150000003839 salts Chemical class 0.000 claims description 95
- 125000001424 substituent group Chemical group 0.000 claims description 82
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 76
- 239000000203 mixture Substances 0.000 claims description 76
- 229940002612 prodrug Drugs 0.000 claims description 59
- 239000000651 prodrug Substances 0.000 claims description 59
- 125000004043 oxo group Chemical group O=* 0.000 claims description 58
- 125000003118 aryl group Chemical group 0.000 claims description 54
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 47
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 44
- 125000001072 heteroaryl group Chemical group 0.000 claims description 43
- 229910052757 nitrogen Inorganic materials 0.000 claims description 38
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 37
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 31
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- 125000002757 morpholinyl group Chemical group 0.000 claims description 30
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 28
- 125000003386 piperidinyl group Chemical group 0.000 claims description 28
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 23
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 20
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 18
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 17
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- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims description 16
- 125000002541 furyl group Chemical group 0.000 claims description 16
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 12
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- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 8
- PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical compound C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 claims description 8
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- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims description 8
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 8
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims description 8
- 125000004429 atom Chemical group 0.000 claims description 7
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Landscapes
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Applications Claiming Priority (2)
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| US78829406P | 2006-03-31 | 2006-03-31 | |
| PCT/EP2007/053064 WO2007113226A1 (en) | 2006-03-31 | 2007-03-29 | Organic compounds |
Publications (2)
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| JP2009531390A true JP2009531390A (ja) | 2009-09-03 |
| JP2009531390A5 JP2009531390A5 (enExample) | 2010-05-20 |
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| JP2009502104A Pending JP2009531390A (ja) | 2006-03-31 | 2007-03-29 | 有機化合物 |
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| US (2) | US8097617B2 (enExample) |
| EP (1) | EP2004643A1 (enExample) |
| JP (1) | JP2009531390A (enExample) |
| KR (1) | KR20080104351A (enExample) |
| CN (1) | CN101410397A (enExample) |
| AU (1) | AU2007233709A1 (enExample) |
| BR (1) | BRPI0710110A2 (enExample) |
| CA (1) | CA2644963A1 (enExample) |
| MX (1) | MX2008012617A (enExample) |
| RU (1) | RU2008143179A (enExample) |
| WO (1) | WO2007113226A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| JP2014509616A (ja) * | 2011-03-31 | 2014-04-21 | エーエムベーエルエーエム テクノロジー トランスファー ゲーエムベーハー | 治療用イミダゾ［１，２−ａ］ピリジン化合物 |
| JP2015522051A (ja) * | 2012-07-13 | 2015-08-03 | ユーシービー バイオファルマ エスピーアールエル | Ｔｎｆ活性の調節物質としてのイミダゾピリジン誘導体 |
| JPWO2014157740A1 (ja) * | 2013-03-29 | 2017-02-16 | 帝人ファーマ株式会社 | ピラゾール誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0710110A2 (pt) | 2011-08-02 |
| KR20080104351A (ko) | 2008-12-02 |
| CA2644963A1 (en) | 2007-10-11 |
| US8097617B2 (en) | 2012-01-17 |
| WO2007113226A1 (en) | 2007-10-11 |
| CN101410397A (zh) | 2009-04-15 |
| EP2004643A1 (en) | 2008-12-24 |
| US20090253689A1 (en) | 2009-10-08 |
| US20120077787A1 (en) | 2012-03-29 |
| AU2007233709A1 (en) | 2007-10-11 |
| RU2008143179A (ru) | 2010-05-10 |
| MX2008012617A (es) | 2008-10-10 |
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