JP2009531036A5 - - Google Patents
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- Publication number
- JP2009531036A5 JP2009531036A5 JP2009501824A JP2009501824A JP2009531036A5 JP 2009531036 A5 JP2009531036 A5 JP 2009531036A5 JP 2009501824 A JP2009501824 A JP 2009501824A JP 2009501824 A JP2009501824 A JP 2009501824A JP 2009531036 A5 JP2009531036 A5 JP 2009531036A5
- Authority
- JP
- Japan
- Prior art keywords
- vegf receptor
- domain
- kdr
- receptor fusion
- flt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100662572A CN100502945C (zh) | 2006-03-31 | 2006-03-31 | Vegf受体融合蛋白在治疗眼睛疾病中的应用 |
| PCT/CN2007/001021 WO2007112675A1 (fr) | 2006-03-31 | 2007-03-29 | Protéine de fusion du récepteur du vegf et son utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009531036A JP2009531036A (ja) | 2009-09-03 |
| JP2009531036A5 true JP2009531036A5 (https=) | 2009-12-17 |
Family
ID=37736587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501824A Pending JP2009531036A (ja) | 2006-03-31 | 2007-03-29 | Ｖｅｇｆ受容体融合タンパク質およびそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090264358A1 (https=) |
| EP (1) | EP2000483A4 (https=) |
| JP (1) | JP2009531036A (https=) |
| KR (1) | KR20090010030A (https=) |
| CN (1) | CN100502945C (https=) |
| AU (1) | AU2007234272A1 (https=) |
| BR (1) | BRPI0710223A2 (https=) |
| CA (1) | CA2647142A1 (https=) |
| RU (1) | RU2008136655A (https=) |
| WO (1) | WO2007112675A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614134B (zh) | 2005-03-25 | 2016-09-07 | 瑞泽恩制药公司 | Vegf拮抗剂制剂 |
| US7608261B2 (en) | 2006-06-16 | 2009-10-27 | Regeneron Pharmacuticals, Inc. | VEGF antagonist formulations suitable for intravitreal administration |
| CN101279092B (zh) * | 2007-04-02 | 2010-10-27 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗与血管生成有关的疾病中的应用 |
| CN101721699B (zh) * | 2008-10-13 | 2012-11-07 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗伴随vegf升高的炎症反应的药物中的应用 |
| KR101248912B1 (ko) * | 2009-12-31 | 2013-03-29 | 한양대학교 산학협력단 | 항혈관신생 활성을 가지는 재조합 아데노바이러스 |
| CN102233132B (zh) * | 2010-04-28 | 2013-10-23 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备抑制眼表新生血管生长的药物中的应用 |
| CN102380096B (zh) * | 2010-08-31 | 2014-04-30 | 成都康弘生物科技有限公司 | 一种含有抑制血管增生的融合蛋白的药物组合物及用途 |
| CN103816115B (zh) * | 2010-08-31 | 2017-06-27 | 成都康弘生物科技有限公司 | 一种含有抑制血管增生的融合蛋白的药物组合物及用途 |
| KR20260004598A (ko) | 2011-01-13 | 2026-01-08 | 리제너론 파아마슈티컬스, 인크. | 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
| KR102049990B1 (ko) | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| JP6631865B2 (ja) * | 2014-08-11 | 2020-01-15 | 日本化薬株式会社 | ＴＧＦβ阻害機能を持つキメラタンパク質 |
| PT3230316T (pt) | 2014-12-11 | 2022-02-24 | Bayer Healthcare Llc | Ratamento de degenerescência macular relacionada com a idade com uma pequena lesão de neovascularização coroideia ativa |
| WO2017046140A1 (en) | 2015-09-18 | 2017-03-23 | Bayer Pharma Aktiengesellschaft | Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia |
| EP4122486A1 (en) | 2017-11-30 | 2023-01-25 | Regeneron Pharmaceuticals, Inc. | Use of a vegf antagonist to treat diabetic retinopathy |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| US11103552B2 (en) | 2018-05-10 | 2021-08-31 | Regeneron Pharmaceuticals, Inc. | High concentration VEGF receptor fusion protein containing formulations |
| CN111328336B (zh) | 2018-12-07 | 2024-01-30 | 荣昌生物制药(烟台)股份有限公司 | 一种双功能血管生成抑制剂及其用途 |
| CN118718181A (zh) | 2019-06-05 | 2024-10-01 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| WO2021108530A1 (en) * | 2019-11-26 | 2021-06-03 | University Of Massachusetts | Recombinant adeno-associated virus for delivery of kh902 (conbercept) and uses thereof |
| US11180540B2 (en) | 2019-12-06 | 2021-11-23 | Regeneron Pharmaceuticals, Inc. | Anti-VEGF protein compositions and methods for producing the same |
| JP2023525034A (ja) | 2020-05-08 | 2023-06-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｖｅｇｆトラップおよびミニトラップならびに眼障害およびがんの治療方法 |
| IL308505A (en) | 2021-05-17 | 2024-01-01 | Regeneron Pharma | Continuous high-dose VEGF antagonist regimens for the treatment of angiogenic ocular disorders |
| AU2023233561A1 (en) | 2022-03-15 | 2024-09-19 | Bayer Healthcare Llc | Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders |
| CN119365206A (zh) | 2022-03-15 | 2025-01-24 | 瑞泽恩制药公司 | 用于治疗血管生成性眼病的延长的高剂量vegf拮抗剂方案 |
| CN119584953A (zh) | 2022-09-16 | 2025-03-07 | 齐鲁制药有限公司 | 一种稳定的高浓度自缓冲药物组合物 |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| WO2024263995A1 (en) | 2023-06-23 | 2024-12-26 | Regeneron Pharmaceuticals, Inc. | Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders |
| CN120204358A (zh) * | 2023-12-27 | 2025-06-27 | 成都康弘生物科技有限公司 | 一种含有抗vegf的融合蛋白的药物组合物 |
| WO2025217334A1 (en) | 2024-04-09 | 2025-10-16 | Regeneron Pharmaceuticals, Inc. | Low concentration vegf receptor fusion protein containing formulations |
| CN118108862B (zh) * | 2024-04-29 | 2024-08-09 | 上海鼎新基因科技有限公司 | 抗血管新生的融合蛋白及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| CN100523187C (zh) * | 1999-06-08 | 2009-08-05 | 里珍纳龙药品有限公司 | 具有改善的药物动力学特性的修饰嵌合多肽 |
| BRPI0414604A (pt) * | 2003-09-23 | 2006-11-07 | Novartis Ag | combinações de um inibiddor do receptor de vegf com outros agentes terapêuticos |
| KR100897379B1 (ko) * | 2004-06-08 | 2009-05-14 | 쳉두 캉홍 바이오테크놀로지스 코. 리미티드 | 혈관신생-저해 키메릭 단백질 및 그 사용 |
| CN1304427C (zh) * | 2004-06-08 | 2007-03-14 | 成都康弘生物科技有限公司 | 抑制血管新生的融合蛋白质及其用途 |
-
2006
- 2006-03-31 CN CNB2006100662572A patent/CN100502945C/zh not_active Expired - Lifetime
-
2007
- 2007-03-29 BR BRPI0710223-2A patent/BRPI0710223A2/pt not_active IP Right Cessation
- 2007-03-29 CA CA002647142A patent/CA2647142A1/en not_active Abandoned
- 2007-03-29 JP JP2009501824A patent/JP2009531036A/ja active Pending
- 2007-03-29 KR KR1020087025464A patent/KR20090010030A/ko not_active Withdrawn
- 2007-03-29 WO PCT/CN2007/001021 patent/WO2007112675A1/zh not_active Ceased
- 2007-03-29 RU RU2008136655/13A patent/RU2008136655A/ru not_active Application Discontinuation
- 2007-03-29 AU AU2007234272A patent/AU2007234272A1/en not_active Abandoned
- 2007-03-29 EP EP07720595A patent/EP2000483A4/en not_active Withdrawn
-
2008
- 2008-09-29 US US12/241,017 patent/US20090264358A1/en not_active Abandoned
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