CN100502945C - Vegf受体融合蛋白在治疗眼睛疾病中的应用 - Google Patents

Vegf受体融合蛋白在治疗眼睛疾病中的应用 Download PDF

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Publication number
CN100502945C
CN100502945C CNB2006100662572A CN200610066257A CN100502945C CN 100502945 C CN100502945 C CN 100502945C CN B2006100662572 A CNB2006100662572 A CN B2006100662572A CN 200610066257 A CN200610066257 A CN 200610066257A CN 100502945 C CN100502945 C CN 100502945C
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vegf
application
sequence
fusion protein
preparation
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Expired - Lifetime
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CNB2006100662572A
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English (en)
Chinese (zh)
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CN1915427A (zh
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俞德超
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Chengdu Kanghong Biotechnologies Co Ltd
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Chengdu Kanghong Biotechnologies Co Ltd
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Priority to CNB2006100662572A priority Critical patent/CN100502945C/zh
Publication of CN1915427A publication Critical patent/CN1915427A/zh
Priority to AU2007234272A priority patent/AU2007234272A1/en
Priority to CA002647142A priority patent/CA2647142A1/en
Priority to PCT/CN2007/001021 priority patent/WO2007112675A1/zh
Priority to KR1020087025464A priority patent/KR20090010030A/ko
Priority to RU2008136655/13A priority patent/RU2008136655A/ru
Priority to EP07720595A priority patent/EP2000483A4/en
Priority to JP2009501824A priority patent/JP2009531036A/ja
Priority to BRPI0710223-2A priority patent/BRPI0710223A2/pt
Priority to US12/241,017 priority patent/US20090264358A1/en
Priority to US12/457,478 priority patent/US8216575B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB2006100662572A 2006-03-31 2006-03-31 Vegf受体融合蛋白在治疗眼睛疾病中的应用 Expired - Lifetime CN100502945C (zh)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CNB2006100662572A CN100502945C (zh) 2006-03-31 2006-03-31 Vegf受体融合蛋白在治疗眼睛疾病中的应用
EP07720595A EP2000483A4 (en) 2006-03-31 2007-03-29 VEGF RECEPTOR FUSION PROTEIN AND APPLICATION THEREOF
BRPI0710223-2A BRPI0710223A2 (pt) 2006-03-31 2007-03-29 proteìnas de fusão de receptor de vegf e seu uso
PCT/CN2007/001021 WO2007112675A1 (fr) 2006-03-31 2007-03-29 Protéine de fusion du récepteur du vegf et son utilisation
KR1020087025464A KR20090010030A (ko) 2006-03-31 2007-03-29 Ｖｅｇｆ 수용체 융합 단백질 및 그의 용도
RU2008136655/13A RU2008136655A (ru) 2006-03-31 2007-03-29 Гибридные белки рецептора vegf, их фармацевтические композиции и терапевтическое применение при заболеваниях глаз
AU2007234272A AU2007234272A1 (en) 2006-03-31 2007-03-29 VEGF receptor fusion protein and use thereof
JP2009501824A JP2009531036A (ja) 2006-03-31 2007-03-29 Ｖｅｇｆ受容体融合タンパク質およびそれらの使用
CA002647142A CA2647142A1 (en) 2006-03-31 2007-03-29 Vegf receptor fusion protein and use thereof
US12/241,017 US20090264358A1 (en) 2006-03-31 2008-09-29 Vegf receptor fusion proteins, their pharmaceutical compositions and therapeutic applications for the eye diseases
US12/457,478 US8216575B2 (en) 2006-03-31 2009-06-11 Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB2006100662572A CN100502945C (zh) 2006-03-31 2006-03-31 Vegf受体融合蛋白在治疗眼睛疾病中的应用

Related Child Applications (1)

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CNB2008101608428A Division CN100567325C (zh) 2006-03-31 2006-03-31 Vegf受体融合蛋白及其在制备治疗眼睛疾病的药物中的应用

Publications (2)

Publication Number Publication Date
CN1915427A CN1915427A (zh) 2007-02-21
CN100502945C true CN100502945C (zh) 2009-06-24

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CNB2006100662572A Expired - Lifetime CN100502945C (zh) 2006-03-31 2006-03-31 Vegf受体融合蛋白在治疗眼睛疾病中的应用

Country Status (10)

Country Link
US (1) US20090264358A1 (https=)
EP (1) EP2000483A4 (https=)
JP (1) JP2009531036A (https=)
KR (1) KR20090010030A (https=)
CN (1) CN100502945C (https=)
AU (1) AU2007234272A1 (https=)
BR (1) BRPI0710223A2 (https=)
CA (1) CA2647142A1 (https=)
RU (1) RU2008136655A (https=)
WO (1) WO2007112675A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11253572B2 (en) 2011-01-13 2022-02-22 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
US11732024B2 (en) 2006-06-16 2023-08-22 Regeneron Pharmaceuticals, Inc. VEGF antagonist formulations suitable for intravitreal administration
US11806398B2 (en) 2005-03-25 2023-11-07 Regeneron Pharmaceuticals, Inc. Citrate buffered VEGF antagonist formulations
US12103960B2 (en) 2020-05-08 2024-10-01 Regeneron Pharmaceuticals, Inc. VEGF traps and mini-traps and methods for treating ocular disorders and cancer
US12280093B2 (en) 2017-11-30 2025-04-22 Regenron Pharmaceuticals, Inc. Use of a VEGF receptor-based fusion protein antagonist to treat nonproliferative diabetic retinopathy

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101279092B (zh) * 2007-04-02 2010-10-27 成都康弘生物科技有限公司 Vegf受体融合蛋白在制备治疗与血管生成有关的疾病中的应用
CN101721699B (zh) * 2008-10-13 2012-11-07 成都康弘生物科技有限公司 Vegf受体融合蛋白在制备治疗伴随vegf升高的炎症反应的药物中的应用
KR101248912B1 (ko) * 2009-12-31 2013-03-29 한양대학교 산학협력단 항혈관신생 활성을 가지는 재조합 아데노바이러스
CN102233132B (zh) * 2010-04-28 2013-10-23 成都康弘生物科技有限公司 Vegf受体融合蛋白在制备抑制眼表新生血管生长的药物中的应用
CN102380096B (zh) * 2010-08-31 2014-04-30 成都康弘生物科技有限公司 一种含有抑制血管增生的融合蛋白的药物组合物及用途
CN103816115B (zh) * 2010-08-31 2017-06-27 成都康弘生物科技有限公司 一种含有抑制血管增生的融合蛋白的药物组合物及用途
KR102049990B1 (ko) 2013-03-28 2019-12-03 삼성전자주식회사 c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
JP6631865B2 (ja) * 2014-08-11 2020-01-15 日本化薬株式会社 ＴＧＦβ阻害機能を持つキメラタンパク質
PT3230316T (pt) 2014-12-11 2022-02-24 Bayer Healthcare Llc Ratamento de degenerescência macular relacionada com a idade com uma pequena lesão de neovascularização coroideia ativa
WO2017046140A1 (en) 2015-09-18 2017-03-23 Bayer Pharma Aktiengesellschaft Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
MX2020009152A (es) 2018-03-02 2020-11-09 Kodiak Sciences Inc Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos.
US11103552B2 (en) 2018-05-10 2021-08-31 Regeneron Pharmaceuticals, Inc. High concentration VEGF receptor fusion protein containing formulations
CN111328336B (zh) 2018-12-07 2024-01-30 荣昌生物制药(烟台)股份有限公司 一种双功能血管生成抑制剂及其用途
CN118718181A (zh) 2019-06-05 2024-10-01 里珍纳龙药品有限公司 用于精确剂量递送的装置及方法
WO2021108530A1 (en) * 2019-11-26 2021-06-03 University Of Massachusetts Recombinant adeno-associated virus for delivery of kh902 (conbercept) and uses thereof
US11180540B2 (en) 2019-12-06 2021-11-23 Regeneron Pharmaceuticals, Inc. Anti-VEGF protein compositions and methods for producing the same
IL308505A (en) 2021-05-17 2024-01-01 Regeneron Pharma Continuous high-dose VEGF antagonist regimens for the treatment of angiogenic ocular disorders
AU2023233561A1 (en) 2022-03-15 2024-09-19 Bayer Healthcare Llc Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders
CN119365206A (zh) 2022-03-15 2025-01-24 瑞泽恩制药公司 用于治疗血管生成性眼病的延长的高剂量vegf拮抗剂方案
CN119584953A (zh) 2022-09-16 2025-03-07 齐鲁制药有限公司 一种稳定的高浓度自缓冲药物组合物
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
WO2024263995A1 (en) 2023-06-23 2024-12-26 Regeneron Pharmaceuticals, Inc. Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders
CN120204358A (zh) * 2023-12-27 2025-06-27 成都康弘生物科技有限公司 一种含有抗vegf的融合蛋白的药物组合物
WO2025217334A1 (en) 2024-04-09 2025-10-16 Regeneron Pharmaceuticals, Inc. Low concentration vegf receptor fusion protein containing formulations
CN118108862B (zh) * 2024-04-29 2024-08-09 上海鼎新基因科技有限公司 抗血管新生的融合蛋白及其应用

Citations (2)

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WO2005027973A2 (en) * 2003-09-23 2005-03-31 Novartis Ag Combinations of a vegf receptor inhibitor with other therapeutic agents
CN1706867A (zh) * 2004-06-08 2005-12-14 成都康弘科技实业（集团）有限公司 抑制血管新生的融合蛋白质及其用途

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US7087411B2 (en) * 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
CN100523187C (zh) * 1999-06-08 2009-08-05 里珍纳龙药品有限公司 具有改善的药物动力学特性的修饰嵌合多肽
KR100897379B1 (ko) * 2004-06-08 2009-05-14 쳉두 캉홍 바이오테크놀로지스 코. 리미티드 혈관신생-저해 키메릭 단백질 및 그 사용

Patent Citations (2)

* Cited by examiner, † Cited by third party
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WO2005027973A2 (en) * 2003-09-23 2005-03-31 Novartis Ag Combinations of a vegf receptor inhibitor with other therapeutic agents
CN1706867A (zh) * 2004-06-08 2005-12-14 成都康弘科技实业（集团）有限公司 抑制血管新生的融合蛋白质及其用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
血管内皮生长因子及其受体与眼内新生血管性疾病. 赵世红综述，何守志审校.眼科研究，第21卷第1期. 2003 *
血管内皮生长因子受体的结构与功能. 张曼等.生物化学与生物物理进展，第24卷第1期. 1997 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11806398B2 (en) 2005-03-25 2023-11-07 Regeneron Pharmaceuticals, Inc. Citrate buffered VEGF antagonist formulations
US11732024B2 (en) 2006-06-16 2023-08-22 Regeneron Pharmaceuticals, Inc. VEGF antagonist formulations suitable for intravitreal administration
US12331099B2 (en) 2006-06-16 2025-06-17 Regeneron Pharmaceuticals, Inc. VEGF antagonist formulations suitable for intravitreal administration
US11253572B2 (en) 2011-01-13 2022-02-22 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
US11559564B2 (en) 2011-01-13 2023-01-24 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
US11707506B2 (en) 2011-01-13 2023-07-25 Regeneren Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
US11730794B2 (en) 2011-01-13 2023-08-22 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
US11975045B2 (en) 2011-01-13 2024-05-07 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
US11986511B2 (en) 2011-01-13 2024-05-21 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
US12268730B2 (en) 2011-01-13 2025-04-08 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
US12280093B2 (en) 2017-11-30 2025-04-22 Regenron Pharmaceuticals, Inc. Use of a VEGF receptor-based fusion protein antagonist to treat nonproliferative diabetic retinopathy
US12103960B2 (en) 2020-05-08 2024-10-01 Regeneron Pharmaceuticals, Inc. VEGF traps and mini-traps and methods for treating ocular disorders and cancer

Also Published As

Publication number Publication date
EP2000483A9 (en) 2009-03-18
CN1915427A (zh) 2007-02-21
AU2007234272A1 (en) 2007-10-11
BRPI0710223A2 (pt) 2011-08-02
WO2007112675A1 (fr) 2007-10-11
EP2000483A2 (en) 2008-12-10
US20090264358A1 (en) 2009-10-22
EP2000483A4 (en) 2009-10-28
CA2647142A1 (en) 2007-10-11
WO2007112675A8 (fr) 2009-07-09
JP2009531036A (ja) 2009-09-03
RU2008136655A (ru) 2010-05-10
KR20090010030A (ko) 2009-01-28

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CI01 Publication of corrected invention patent application

Correction item: Applicant address

Correct: No. 36, Shu Shu West Road, Chengdu, Sichuan, Jinniu District

False: No. 36, Shu Shu West Road, Chengdu, Heilongjiang, Jinniu District

Number: 08

Volume: 23

CI02 Correction of invention patent application

Correction item: Applicant address

Correct: No. 36, Shu Shu West Road, Chengdu, Sichuan, Jinniu District

False: No. 36, Shu Shu West Road, Chengdu, Heilongjiang, Jinniu District

Number: 08

Page: The title page

Volume: 23

ERR Gazette correction

Free format text: CORRECT: APPLICANT ADDRESS; FROM: * ROAD, NO. 36, SHU ROAD(WEST), JINNIU DISTRICT, CHENGDU CITY, HEILONGJIANG PROVINCE TO: * ROAD, NO. 36, SHU ROAD(WEST), JINNIU DISTRICT, CHENGDU CITY, SICHUAN PROVINCE

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Granted publication date: 20090624