JP2009531036A - Ｖｅｇｆ受容体融合タンパク質およびそれらの使用 - Google Patents
Ｖｅｇｆ受容体融合タンパク質およびそれらの使用 Download PDFInfo
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100662572A CN100502945C (zh) | 2006-03-31 | 2006-03-31 | Vegf受体融合蛋白在治疗眼睛疾病中的应用 |
| PCT/CN2007/001021 WO2007112675A1 (fr) | 2006-03-31 | 2007-03-29 | Protéine de fusion du récepteur du vegf et son utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009531036A true JP2009531036A (ja) | 2009-09-03 |
| JP2009531036A5 JP2009531036A5 (https=) | 2009-12-17 |
Family
ID=37736587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501824A Pending JP2009531036A (ja) | 2006-03-31 | 2007-03-29 | Ｖｅｇｆ受容体融合タンパク質およびそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090264358A1 (https=) |
| EP (1) | EP2000483A4 (https=) |
| JP (1) | JP2009531036A (https=) |
| KR (1) | KR20090010030A (https=) |
| CN (1) | CN100502945C (https=) |
| AU (1) | AU2007234272A1 (https=) |
| BR (1) | BRPI0710223A2 (https=) |
| CA (1) | CA2647142A1 (https=) |
| RU (1) | RU2008136655A (https=) |
| WO (1) | WO2007112675A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013516169A (ja) * | 2009-12-31 | 2013-05-13 | インダストリー−ユニバーシティー コーポレーション ファウンデーション ハンヤン ユニバーシティー | 抗血管新生活性を有する組換えアデノウイルス |
| JP2016037488A (ja) * | 2014-08-11 | 2016-03-22 | 日本化薬株式会社 | ＴＧＦβ阻害機能を持つキメラタンパク質 |
| JP2021534825A (ja) * | 2018-12-07 | 2021-12-16 | 榮昌生物制薬(烟台)股▲フン▼有限公司Remegen Co., Ltd. | 二機能血管新生阻害剤及びその用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614134B (zh) | 2005-03-25 | 2016-09-07 | 瑞泽恩制药公司 | Vegf拮抗剂制剂 |
| US7608261B2 (en) | 2006-06-16 | 2009-10-27 | Regeneron Pharmacuticals, Inc. | VEGF antagonist formulations suitable for intravitreal administration |
| CN101279092B (zh) * | 2007-04-02 | 2010-10-27 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗与血管生成有关的疾病中的应用 |
| CN101721699B (zh) * | 2008-10-13 | 2012-11-07 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗伴随vegf升高的炎症反应的药物中的应用 |
| CN102233132B (zh) * | 2010-04-28 | 2013-10-23 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备抑制眼表新生血管生长的药物中的应用 |
| CN102380096B (zh) * | 2010-08-31 | 2014-04-30 | 成都康弘生物科技有限公司 | 一种含有抑制血管增生的融合蛋白的药物组合物及用途 |
| CN103816115B (zh) * | 2010-08-31 | 2017-06-27 | 成都康弘生物科技有限公司 | 一种含有抑制血管增生的融合蛋白的药物组合物及用途 |
| KR20260004598A (ko) | 2011-01-13 | 2026-01-08 | 리제너론 파아마슈티컬스, 인크. | 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
| KR102049990B1 (ko) | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| PT3230316T (pt) | 2014-12-11 | 2022-02-24 | Bayer Healthcare Llc | Ratamento de degenerescência macular relacionada com a idade com uma pequena lesão de neovascularização coroideia ativa |
| WO2017046140A1 (en) | 2015-09-18 | 2017-03-23 | Bayer Pharma Aktiengesellschaft | Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia |
| EP4122486A1 (en) | 2017-11-30 | 2023-01-25 | Regeneron Pharmaceuticals, Inc. | Use of a vegf antagonist to treat diabetic retinopathy |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| US11103552B2 (en) | 2018-05-10 | 2021-08-31 | Regeneron Pharmaceuticals, Inc. | High concentration VEGF receptor fusion protein containing formulations |
| CN118718181A (zh) | 2019-06-05 | 2024-10-01 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| WO2021108530A1 (en) * | 2019-11-26 | 2021-06-03 | University Of Massachusetts | Recombinant adeno-associated virus for delivery of kh902 (conbercept) and uses thereof |
| US11180540B2 (en) | 2019-12-06 | 2021-11-23 | Regeneron Pharmaceuticals, Inc. | Anti-VEGF protein compositions and methods for producing the same |
| JP2023525034A (ja) | 2020-05-08 | 2023-06-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｖｅｇｆトラップおよびミニトラップならびに眼障害およびがんの治療方法 |
| IL308505A (en) | 2021-05-17 | 2024-01-01 | Regeneron Pharma | Continuous high-dose VEGF antagonist regimens for the treatment of angiogenic ocular disorders |
| AU2023233561A1 (en) | 2022-03-15 | 2024-09-19 | Bayer Healthcare Llc | Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders |
| CN119365206A (zh) | 2022-03-15 | 2025-01-24 | 瑞泽恩制药公司 | 用于治疗血管生成性眼病的延长的高剂量vegf拮抗剂方案 |
| CN119584953A (zh) | 2022-09-16 | 2025-03-07 | 齐鲁制药有限公司 | 一种稳定的高浓度自缓冲药物组合物 |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| WO2024263995A1 (en) | 2023-06-23 | 2024-12-26 | Regeneron Pharmaceuticals, Inc. | Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders |
| CN120204358A (zh) * | 2023-12-27 | 2025-06-27 | 成都康弘生物科技有限公司 | 一种含有抗vegf的融合蛋白的药物组合物 |
| WO2025217334A1 (en) | 2024-04-09 | 2025-10-16 | Regeneron Pharmaceuticals, Inc. | Low concentration vegf receptor fusion protein containing formulations |
| CN118108862B (zh) * | 2024-04-29 | 2024-08-09 | 上海鼎新基因科技有限公司 | 抗血管新生的融合蛋白及其应用 |
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| WO2005000895A2 (en) * | 2003-06-30 | 2005-01-06 | Regeneron Pharmaceuticals, Inc. | Vegf traps and therapeutic uses thereof |
| CN1706867A (zh) * | 2004-06-08 | 2005-12-14 | 成都康弘科技实业（集团）有限公司 | 抑制血管新生的融合蛋白质及其用途 |
| WO2005121176A1 (en) * | 2004-06-08 | 2005-12-22 | Chengdu Kanghong Biotechnologies Co. Ltd | Angiogenesis-inhibiting chimeric protein and the use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100523187C (zh) * | 1999-06-08 | 2009-08-05 | 里珍纳龙药品有限公司 | 具有改善的药物动力学特性的修饰嵌合多肽 |
| BRPI0414604A (pt) * | 2003-09-23 | 2006-11-07 | Novartis Ag | combinações de um inibiddor do receptor de vegf com outros agentes terapêuticos |
-
2006
- 2006-03-31 CN CNB2006100662572A patent/CN100502945C/zh not_active Expired - Lifetime
-
2007
- 2007-03-29 BR BRPI0710223-2A patent/BRPI0710223A2/pt not_active IP Right Cessation
- 2007-03-29 CA CA002647142A patent/CA2647142A1/en not_active Abandoned
- 2007-03-29 JP JP2009501824A patent/JP2009531036A/ja active Pending
- 2007-03-29 KR KR1020087025464A patent/KR20090010030A/ko not_active Withdrawn
- 2007-03-29 WO PCT/CN2007/001021 patent/WO2007112675A1/zh not_active Ceased
- 2007-03-29 RU RU2008136655/13A patent/RU2008136655A/ru not_active Application Discontinuation
- 2007-03-29 AU AU2007234272A patent/AU2007234272A1/en not_active Abandoned
- 2007-03-29 EP EP07720595A patent/EP2000483A4/en not_active Withdrawn
-
2008
- 2008-09-29 US US12/241,017 patent/US20090264358A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005000895A2 (en) * | 2003-06-30 | 2005-01-06 | Regeneron Pharmaceuticals, Inc. | Vegf traps and therapeutic uses thereof |
| CN1706867A (zh) * | 2004-06-08 | 2005-12-14 | 成都康弘科技实业（集团）有限公司 | 抑制血管新生的融合蛋白质及其用途 |
| WO2005121176A1 (en) * | 2004-06-08 | 2005-12-22 | Chengdu Kanghong Biotechnologies Co. Ltd | Angiogenesis-inhibiting chimeric protein and the use |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013516169A (ja) * | 2009-12-31 | 2013-05-13 | インダストリー−ユニバーシティー コーポレーション ファウンデーション ハンヤン ユニバーシティー | 抗血管新生活性を有する組換えアデノウイルス |
| JP2016037488A (ja) * | 2014-08-11 | 2016-03-22 | 日本化薬株式会社 | ＴＧＦβ阻害機能を持つキメラタンパク質 |
| JP2021534825A (ja) * | 2018-12-07 | 2021-12-16 | 榮昌生物制薬(烟台)股▲フン▼有限公司Remegen Co., Ltd. | 二機能血管新生阻害剤及びその用途 |
| JP2023052623A (ja) * | 2018-12-07 | 2023-04-11 | 榮昌生物制薬（烟台）股▲フン▼有限公司 | 二機能血管新生阻害剤及びその用途 |
| JP7516381B2 (ja) | 2018-12-07 | 2024-07-16 | 榮昌生物制薬（烟台）股▲フン▼有限公司 | 二機能血管新生阻害剤及びその用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2000483A9 (en) | 2009-03-18 |
| CN1915427A (zh) | 2007-02-21 |
| AU2007234272A1 (en) | 2007-10-11 |
| BRPI0710223A2 (pt) | 2011-08-02 |
| WO2007112675A1 (fr) | 2007-10-11 |
| EP2000483A2 (en) | 2008-12-10 |
| US20090264358A1 (en) | 2009-10-22 |
| EP2000483A4 (en) | 2009-10-28 |
| CA2647142A1 (en) | 2007-10-11 |
| WO2007112675A8 (fr) | 2009-07-09 |
| RU2008136655A (ru) | 2010-05-10 |
| KR20090010030A (ko) | 2009-01-28 |
| CN100502945C (zh) | 2009-06-24 |
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