JP2009531036A5 - - Google Patents
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- Publication number
- JP2009531036A5 JP2009531036A5 JP2009501824A JP2009501824A JP2009531036A5 JP 2009531036 A5 JP2009531036 A5 JP 2009531036A5 JP 2009501824 A JP2009501824 A JP 2009501824A JP 2009501824 A JP2009501824 A JP 2009501824A JP 2009531036 A5 JP2009531036 A5 JP 2009531036A5
- Authority
- JP
- Japan
- Prior art keywords
- vegf receptor
- domain
- kdr
- receptor fusion
- flt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000037865 fusion proteins Human genes 0.000 claims 7
- 108020001507 fusion proteins Proteins 0.000 claims 7
- 108091008605 VEGF receptors Proteins 0.000 claims 6
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 4
- 230000033115 angiogenesis Effects 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 101100381481 Caenorhabditis elegans baz-2 gene Proteins 0.000 claims 2
- 208000022873 Ocular disease Diseases 0.000 claims 2
- 101100372762 Rattus norvegicus Flt1 gene Proteins 0.000 claims 2
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 claims 2
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010058202 Cystoid macular oedema Diseases 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 208000001344 Macular Edema Diseases 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010038903 Retinal vascular occlusion Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 201000010206 cystoid macular edema Diseases 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001976 enzyme digestion Methods 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100662572A CN100502945C (zh) | 2006-03-31 | 2006-03-31 | Vegf受体融合蛋白在治疗眼睛疾病中的应用 |
| PCT/CN2007/001021 WO2007112675A1 (fr) | 2006-03-31 | 2007-03-29 | Protéine de fusion du récepteur du vegf et son utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009531036A JP2009531036A (ja) | 2009-09-03 |
| JP2009531036A5 true JP2009531036A5 (enExample) | 2009-12-17 |
Family
ID=37736587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501824A Pending JP2009531036A (ja) | 2006-03-31 | 2007-03-29 | Ｖｅｇｆ受容体融合タンパク質およびそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090264358A1 (enExample) |
| EP (1) | EP2000483A4 (enExample) |
| JP (1) | JP2009531036A (enExample) |
| KR (1) | KR20090010030A (enExample) |
| CN (1) | CN100502945C (enExample) |
| AU (1) | AU2007234272A1 (enExample) |
| BR (1) | BRPI0710223A2 (enExample) |
| CA (1) | CA2647142A1 (enExample) |
| RU (1) | RU2008136655A (enExample) |
| WO (1) | WO2007112675A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2586459T (lt) | 2005-03-25 | 2017-09-25 | Regeneron Pharmaceuticals, Inc. | Vegf antagonisto kompozicijos |
| CN104434770A (zh) | 2006-06-16 | 2015-03-25 | 瑞泽恩制药公司 | 适合玻璃体内施用的vegf拮抗剂的制剂 |
| CN101279092B (zh) * | 2007-04-02 | 2010-10-27 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗与血管生成有关的疾病中的应用 |
| CN101721699B (zh) * | 2008-10-13 | 2012-11-07 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗伴随vegf升高的炎症反应的药物中的应用 |
| KR101248912B1 (ko) * | 2009-12-31 | 2013-03-29 | 한양대학교 산학협력단 | 항혈관신생 활성을 가지는 재조합 아데노바이러스 |
| CN102233132B (zh) * | 2010-04-28 | 2013-10-23 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备抑制眼表新生血管生长的药物中的应用 |
| CN102380096B (zh) * | 2010-08-31 | 2014-04-30 | 成都康弘生物科技有限公司 | 一种含有抑制血管增生的融合蛋白的药物组合物及用途 |
| CN103816115B (zh) * | 2010-08-31 | 2017-06-27 | 成都康弘生物科技有限公司 | 一种含有抑制血管增生的融合蛋白的药物组合物及用途 |
| JP2014503555A (ja) | 2011-01-13 | 2014-02-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 血管新生眼疾患を処置するためのｖｅｇｆアンタゴニストの使用 |
| KR102049990B1 (ko) | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| JP6631865B2 (ja) * | 2014-08-11 | 2020-01-15 | 日本化薬株式会社 | ＴＧＦβ阻害機能を持つキメラタンパク質 |
| EP3985023A1 (en) | 2014-12-11 | 2022-04-20 | Bayer Healthcare LLC | Treatment of age related macular degeneration with a small active choroidal neovascularization lesion |
| WO2017046140A1 (en) | 2015-09-18 | 2017-03-23 | Bayer Pharma Aktiengesellschaft | Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia |
| ES2927049T3 (es) | 2017-11-30 | 2022-11-02 | Regeneron Pharma | Uso de un antagonista del VEGF para tratar trastornos oculares angiogénicos |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| PT4364724T (pt) | 2018-05-10 | 2025-12-16 | Regeneron Pharma | Formulações contendo uma proteína de fusão do recetor do vegf de concentração elevada |
| EP3812402B1 (en) * | 2018-12-07 | 2024-11-20 | RemeGen Co., Ltd. | Bifunctional angiogenesis inhibitor and use thereof |
| CN115335529A (zh) * | 2019-11-26 | 2022-11-11 | 马萨诸塞大学 | 用于递送kh902(康柏西普)的重组腺相关病毒及其用途 |
| EP3906303A1 (en) | 2019-12-06 | 2021-11-10 | Regeneron Pharmaceuticals, Inc. | Anti-vegf protein compositions and methods for producing the same |
| CA3182893A1 (en) | 2020-05-08 | 2021-11-11 | Regeneron Pharmaceuticals, Inc. | Vegf traps and mini-traps and methods for treating ocular disorders and cancer |
| ES3041647T3 (en) | 2021-05-17 | 2025-11-13 | Regeneron Pharma | Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders |
| IL315347A (en) | 2022-03-15 | 2024-11-01 | Regeneron Pharma | Prolonged high-dose VEGF antagonist regimens for the treatment of angiogenic ocular disorders |
| CN119136823A (zh) | 2022-03-15 | 2024-12-13 | 瑞泽恩制药公司 | 用于治疗血管生成性眼病的延长的高剂量vegf拮抗剂方案 |
| KR20250065646A (ko) | 2022-09-16 | 2025-05-13 | 치루 파머수티컬 컴퍼니 리미티드 | 안정적인 고농도 자가완충식 약물 조성물 |
| WO2024263995A1 (en) | 2023-06-23 | 2024-12-26 | Regeneron Pharmaceuticals, Inc. | Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders |
| WO2025140553A1 (zh) * | 2023-12-27 | 2025-07-03 | 成都康弘生物科技有限公司 | 一种含有抗vegf的融合蛋白的药物组合物 |
| WO2025217334A1 (en) | 2024-04-09 | 2025-10-16 | Regeneron Pharmaceuticals, Inc. | Low concentration vegf receptor fusion protein containing formulations |
| CN118108862B (zh) * | 2024-04-29 | 2024-08-09 | 上海鼎新基因科技有限公司 | 抗血管新生的融合蛋白及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| CN100523187C (zh) * | 1999-06-08 | 2009-08-05 | 里珍纳龙药品有限公司 | 具有改善的药物动力学特性的修饰嵌合多肽 |
| AU2004273619A1 (en) * | 2003-09-23 | 2005-03-31 | Novartis Ag | Combinations of a VEGF receptor inhibitor with other therapeutic agents |
| EP1767546B1 (en) * | 2004-06-08 | 2012-03-07 | Chengdu Kanghong Biotechnologies Co., Ltd. | Angiogenesis-inhibiting chimeric protein and the use |
| CN1304427C (zh) * | 2004-06-08 | 2007-03-14 | 成都康弘生物科技有限公司 | 抑制血管新生的融合蛋白质及其用途 |
-
2006
- 2006-03-31 CN CNB2006100662572A patent/CN100502945C/zh active Active
-
2007
- 2007-03-29 EP EP07720595A patent/EP2000483A4/en not_active Withdrawn
- 2007-03-29 KR KR1020087025464A patent/KR20090010030A/ko not_active Withdrawn
- 2007-03-29 CA CA002647142A patent/CA2647142A1/en not_active Abandoned
- 2007-03-29 BR BRPI0710223-2A patent/BRPI0710223A2/pt not_active IP Right Cessation
- 2007-03-29 WO PCT/CN2007/001021 patent/WO2007112675A1/zh not_active Ceased
- 2007-03-29 AU AU2007234272A patent/AU2007234272A1/en not_active Abandoned
- 2007-03-29 RU RU2008136655/13A patent/RU2008136655A/ru not_active Application Discontinuation
- 2007-03-29 JP JP2009501824A patent/JP2009531036A/ja active Pending
-
2008
- 2008-09-29 US US12/241,017 patent/US20090264358A1/en not_active Abandoned
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