JP2009530353A5 - - Google Patents

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Publication number
JP2009530353A5
JP2009530353A5 JP2009500873A JP2009500873A JP2009530353A5 JP 2009530353 A5 JP2009530353 A5 JP 2009530353A5 JP 2009500873 A JP2009500873 A JP 2009500873A JP 2009500873 A JP2009500873 A JP 2009500873A JP 2009530353 A5 JP2009530353 A5 JP 2009530353A5
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JP
Japan
Prior art keywords
biphenyl
benzimidazole
benzimidazol
methoxy
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009500873A
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English (en)
Japanese (ja)
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JP2009530353A (ja
JP5260489B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/052766 external-priority patent/WO2007110374A1/en
Publication of JP2009530353A publication Critical patent/JP2009530353A/ja
Publication of JP2009530353A5 publication Critical patent/JP2009530353A5/ja
Application granted granted Critical
Publication of JP5260489B2 publication Critical patent/JP5260489B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009500873A 2006-03-24 2007-03-22 ベンズイミダゾール誘導体、及びｇａｂａａ受容体複合体をモジュレートするためのその使用 Expired - Fee Related JP5260489B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US78527806P 2006-03-24 2006-03-24
DKPA200600426 2006-03-24
US60/785,278 2006-03-24
DKPA200600426 2006-03-24
DKPA200601327 2006-10-12
DKPA200601327 2006-10-12
US85128406P 2006-10-13 2006-10-13
US60/851,284 2006-10-13
PCT/EP2007/052766 WO2007110374A1 (en) 2006-03-24 2007-03-22 Benzimidazole derivatives and their use for modulating the gabaa receptor complex

Publications (3)

Publication Number Publication Date
JP2009530353A JP2009530353A (ja) 2009-08-27
JP2009530353A5 true JP2009530353A5 (https=) 2010-05-13
JP5260489B2 JP5260489B2 (ja) 2013-08-14

Family

ID=39456294

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009500873A Expired - Fee Related JP5260489B2 (ja) 2006-03-24 2007-03-22 ベンズイミダゾール誘導体、及びｇａｂａａ受容体複合体をモジュレートするためのその使用

Country Status (26)

Country Link
US (2) US7902230B2 (https=)
EP (2) EP2319837B1 (https=)
JP (1) JP5260489B2 (https=)
KR (1) KR20080111097A (https=)
CN (1) CN101384559B (https=)
AR (1) AR060084A1 (https=)
AT (1) ATE486856T1 (https=)
AU (1) AU2007229502B2 (https=)
BR (1) BRPI0710203A2 (https=)
CA (1) CA2647252A1 (https=)
CY (1) CY1111603T1 (https=)
DE (1) DE602007010261D1 (https=)
DK (1) DK2001855T3 (https=)
ES (1) ES2355163T3 (https=)
HR (1) HRP20100616T1 (https=)
IL (1) IL192297A (https=)
MX (1) MX2008010885A (https=)
MY (1) MY149855A (https=)
NO (1) NO20084481L (https=)
NZ (1) NZ569438A (https=)
PL (1) PL2001855T3 (https=)
PT (1) PT2001855E (https=)
RU (1) RU2435759C2 (https=)
SI (1) SI2001855T1 (https=)
TW (1) TWI391381B (https=)
WO (1) WO2007110374A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006233894A1 (en) 2005-04-13 2006-10-19 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABAA receptor complex
CA2632395A1 (en) 2005-12-05 2007-06-14 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TWI391381B (zh) * 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
JP2011507905A (ja) * 2007-12-21 2011-03-10 ワイス・エルエルシー ベンズイミダゾール化合物
WO2010055133A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TW201029987A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
WO2010055129A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
WO2010055130A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TW201029986A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
TW201029989A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
WO2011047315A1 (en) 2009-10-15 2011-04-21 Concert Pharmaceuticals, Inc. Subsitituted benzimidazoles
JP5947465B2 (ja) * 2012-10-01 2016-07-06 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｎｓ活性剤としてのベンズイミダゾール類
CN107445845A (zh) * 2017-08-24 2017-12-08 重庆沃肯精细化工有限公司 一种合成氯法齐明关键中间体n‑(4‑氯苯基)‑1，2‑苯二胺的方法
WO2019154257A1 (zh) * 2018-02-11 2019-08-15 江苏豪森药业集团有限公司 一种甾族类衍生物调节剂及其制备方法和应用
BR112021004661A2 (pt) * 2018-09-13 2021-06-01 Saniona A/S composto, composição farmacêutica, método para tratamento de dor neuropática e/ou prurido, e, uso do composto
KR102219563B1 (ko) * 2019-02-15 2021-02-24 에스티팜 주식회사 페나진 유도체 제조를 위한 중간체 및 그의 제조방법
CN120267677A (zh) * 2019-10-23 2025-07-08 纽罗塞克医疗公司 用gabaa受体调节剂的癫痫状况的治疗
EP4359381A4 (en) * 2021-06-21 2025-04-30 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
CN116693555B (zh) * 2022-02-25 2025-07-04 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
WO2025141131A1 (en) 2023-12-27 2025-07-03 Saniona A/S A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
AU675484B2 (en) * 1993-03-24 1997-02-06 Neurosearch A/S Benzimidazole compounds, their use and preparation
US5554630A (en) * 1993-03-24 1996-09-10 Neurosearch A/S Benzimidazole compounds
PL183853B1 (pl) * 1995-04-21 2002-07-31 Neurosearch As Nowa pochodna benzimidazolu i środek farmaceutyczny
BR9608056A (pt) * 1995-04-21 1999-11-30 Neurosearch As Compostos de benzimidazol, composições farmacêuticas contendo os compostos e sua utilização.
WO1998017651A1 (en) * 1996-10-21 1998-04-30 Neurosearch A/S 1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators
NZ503435A (en) 1997-10-10 2001-12-21 Neurosearch As Oxime substituted 1-(3-(heteroaryl)phenyl)-benzimidazole compounds having GABA activity
IL146403A0 (en) * 1999-06-22 2002-07-25 Neurosearch As Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
EP1613618A2 (en) * 2003-04-03 2006-01-11 Neurosearch A/S BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA- sb A /sb RECEPTOR COMPLEX
DE602004011914T2 (de) 2003-04-03 2008-06-12 Neurosearch A/S Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren
CA2589770A1 (en) * 2004-12-01 2006-06-08 Osi Pharmaceuticals, Inc. N-substituted benzimidazolyl c-kit inhibitors and combinatorial benzimidazole library
WO2006069381A2 (en) 2004-12-22 2006-06-29 Enterprise Integration Group Turn-taking confidence
AU2006233894A1 (en) 2005-04-13 2006-10-19 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABAA receptor complex
CA2632395A1 (en) 2005-12-05 2007-06-14 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TWI391381B (zh) * 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
WO2008008059A1 (en) 2006-07-12 2008-01-17 Locus Pharmaceuticals, Inc. Anti-cancer agents ans uses thereof

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