CN101384559B - 苯并咪唑衍生物及其在调节gabaa受体复合物中的应用 - Google Patents

苯并咪唑衍生物及其在调节gabaa受体复合物中的应用 Download PDF

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CN101384559B
CN101384559B CN2007800059554A CN200780005955A CN101384559B CN 101384559 B CN101384559 B CN 101384559B CN 2007800059554 A CN2007800059554 A CN 2007800059554A CN 200780005955 A CN200780005955 A CN 200780005955A CN 101384559 B CN101384559 B CN 101384559B
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biphenyl
benzimidazole
benzimidazol
phenyl
pyridin
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CN101384559A (zh
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J·S·拉森
L·图伯
P·K·阿灵
E·O·尼尔森
N·米尔扎
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Saniona AS
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Neurosearch AS
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CN2007800059554A 2006-03-24 2007-03-22 苯并咪唑衍生物及其在调节gabaa受体复合物中的应用 Expired - Fee Related CN101384559B (zh)

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Application Number Priority Date Filing Date Title
US78527806P 2006-03-24 2006-03-24
DKPA200600426 2006-03-24
DKPA200600426 2006-03-24
DKPA200601327 2006-10-12
DKPA200601327 2006-10-12
US85128406P 2006-10-13 2006-10-13
PCT/EP2007/052766 WO2007110374A1 (en) 2006-03-24 2007-03-22 Benzimidazole derivatives and their use for modulating the gabaa receptor complex

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CN101384559A CN101384559A (zh) 2009-03-11
CN101384559B true CN101384559B (zh) 2012-03-14

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US (2) US7902230B2 (https=)
EP (2) EP2319837B1 (https=)
JP (1) JP5260489B2 (https=)
KR (1) KR20080111097A (https=)
CN (1) CN101384559B (https=)
AR (1) AR060084A1 (https=)
AT (1) ATE486856T1 (https=)
AU (1) AU2007229502B2 (https=)
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TW201029986A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
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JP5947465B2 (ja) * 2012-10-01 2016-07-06 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｎｓ活性剤としてのベンズイミダゾール類
CN107445845A (zh) * 2017-08-24 2017-12-08 重庆沃肯精细化工有限公司 一种合成氯法齐明关键中间体n‑(4‑氯苯基)‑1，2‑苯二胺的方法
WO2019154257A1 (zh) * 2018-02-11 2019-08-15 江苏豪森药业集团有限公司 一种甾族类衍生物调节剂及其制备方法和应用
BR112021004661A2 (pt) * 2018-09-13 2021-06-01 Saniona A/S composto, composição farmacêutica, método para tratamento de dor neuropática e/ou prurido, e, uso do composto
KR102219563B1 (ko) * 2019-02-15 2021-02-24 에스티팜 주식회사 페나진 유도체 제조를 위한 중간체 및 그의 제조방법
CN120267677A (zh) * 2019-10-23 2025-07-08 纽罗塞克医疗公司 用gabaa受体调节剂的癫痫状况的治疗
EP4359381A4 (en) * 2021-06-21 2025-04-30 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
CN116693555B (zh) * 2022-02-25 2025-07-04 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
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AU2007229502A1 (en) 2007-10-04
DE602007010261D1 (de) 2010-12-16
EP2001855A1 (en) 2008-12-17
US7902230B2 (en) 2011-03-08
CN101384559A (zh) 2009-03-11
JP2009530353A (ja) 2009-08-27
US20110118259A1 (en) 2011-05-19
ES2355163T3 (es) 2011-03-23
BRPI0710203A2 (pt) 2011-05-24
IL192297A (en) 2013-11-28
JP5260489B2 (ja) 2013-08-14
CY1111603T1 (el) 2015-10-07
EP2319837B1 (en) 2012-10-31
WO2007110374A1 (en) 2007-10-04
RU2008129868A (ru) 2010-04-27
AU2007229502B2 (en) 2012-09-20
DK2001855T3 (da) 2011-02-07
AR060084A1 (es) 2008-05-21
PT2001855E (pt) 2011-01-17
US20090036476A1 (en) 2009-02-05
IL192297A0 (en) 2009-09-22
MX2008010885A (es) 2008-09-08
MY149855A (en) 2013-10-31
ATE486856T1 (de) 2010-11-15
CA2647252A1 (en) 2007-10-04
RU2435759C2 (ru) 2011-12-10
HRP20100616T1 (hr) 2011-02-28
EP2001855B1 (en) 2010-11-03
TW200811113A (en) 2008-03-01
KR20080111097A (ko) 2008-12-22
TWI391381B (zh) 2013-04-01
SI2001855T1 (sl) 2011-03-31
HK1132257A1 (en) 2010-02-19
US8288418B2 (en) 2012-10-16
PL2001855T3 (pl) 2011-04-29
NZ569438A (en) 2011-05-27
NO20084481L (no) 2008-12-18

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