ATE486856T1 - Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexes - Google Patents
Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexesInfo
- Publication number
- ATE486856T1 ATE486856T1 AT07727240T AT07727240T ATE486856T1 AT E486856 T1 ATE486856 T1 AT E486856T1 AT 07727240 T AT07727240 T AT 07727240T AT 07727240 T AT07727240 T AT 07727240T AT E486856 T1 ATE486856 T1 AT E486856T1
- Authority
- AT
- Austria
- Prior art keywords
- modulating
- receptor complex
- benzimidazole derivatives
- gabaa receptor
- gabaa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pregnancy & Childbirth (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78527806P | 2006-03-24 | 2006-03-24 | |
DKPA200600426 | 2006-03-24 | ||
DKPA200601327 | 2006-10-12 | ||
US85128406P | 2006-10-13 | 2006-10-13 | |
PCT/EP2007/052766 WO2007110374A1 (en) | 2006-03-24 | 2007-03-22 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE486856T1 true ATE486856T1 (de) | 2010-11-15 |
Family
ID=39456294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07727240T ATE486856T1 (de) | 2006-03-24 | 2007-03-22 | Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexes |
Country Status (27)
Country | Link |
---|---|
US (2) | US7902230B2 (de) |
EP (2) | EP2319837B1 (de) |
JP (1) | JP5260489B2 (de) |
KR (1) | KR20080111097A (de) |
CN (1) | CN101384559B (de) |
AR (1) | AR060084A1 (de) |
AT (1) | ATE486856T1 (de) |
AU (1) | AU2007229502B2 (de) |
BR (1) | BRPI0710203A2 (de) |
CA (1) | CA2647252A1 (de) |
CY (1) | CY1111603T1 (de) |
DE (1) | DE602007010261D1 (de) |
DK (1) | DK2001855T3 (de) |
ES (1) | ES2355163T3 (de) |
HK (1) | HK1132257A1 (de) |
HR (1) | HRP20100616T1 (de) |
IL (1) | IL192297A (de) |
MX (1) | MX2008010885A (de) |
MY (1) | MY149855A (de) |
NO (1) | NO20084481L (de) |
NZ (1) | NZ569438A (de) |
PL (1) | PL2001855T3 (de) |
PT (1) | PT2001855E (de) |
RU (1) | RU2435759C2 (de) |
SI (1) | SI2001855T1 (de) |
TW (1) | TWI391381B (de) |
WO (1) | WO2007110374A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1877052B1 (de) | 2005-04-13 | 2009-07-22 | Neurosearch A/S | Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes |
DE602006010602D1 (de) | 2005-12-05 | 2009-12-31 | Neurosearch As | Benzimidazolderivate und ihre verwendung zur modulierung des gabaa-rezeptorkomplexes |
TWI391381B (zh) * | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
EP2231617A1 (de) * | 2007-12-21 | 2010-09-29 | Wyeth LLC | Benzimidazolverbindungen |
WO2010055133A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
TW201029987A (en) * | 2008-11-14 | 2010-08-16 | Neurosearch As | Novel compounds |
TW201029986A (en) * | 2008-11-14 | 2010-08-16 | Neurosearch As | Novel compounds |
WO2010055129A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
TW201029989A (en) * | 2008-11-14 | 2010-08-16 | Neurosearch As | Novel compounds |
WO2010055130A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
US8278460B2 (en) | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
EP2903980B1 (de) * | 2012-10-01 | 2017-07-19 | F. Hoffmann-La Roche AG | Benzimidazole verwendbar als zns-wirksame mittel |
CN107445845A (zh) * | 2017-08-24 | 2017-12-08 | 重庆沃肯精细化工有限公司 | 一种合成氯法齐明关键中间体n‑(4‑氯苯基)‑1,2‑苯二胺的方法 |
EP3849976B1 (de) | 2018-09-13 | 2022-10-26 | Saniona A/S | Gabaa-rezeptor-ligand |
KR102219563B1 (ko) * | 2019-02-15 | 2021-02-24 | 에스티팜 주식회사 | 페나진 유도체 제조를 위한 중간체 및 그의 제조방법 |
CN116693555A (zh) * | 2022-02-25 | 2023-09-05 | 上海赛默罗生物科技有限公司 | 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK40192D0 (da) | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
US5554630A (en) * | 1993-03-24 | 1996-09-10 | Neurosearch A/S | Benzimidazole compounds |
AU675484B2 (en) * | 1993-03-24 | 1997-02-06 | Neurosearch A/S | Benzimidazole compounds, their use and preparation |
WO1996033191A1 (en) * | 1995-04-21 | 1996-10-24 | Neurosearch A/S | Benzimidazole compounds and their use as modulators of the gabaa receptor complex |
CZ287545B6 (en) * | 1995-04-21 | 2000-12-13 | Neurosearch As | Benzimidazole derivatives, pharmaceutical preparation in which they are comprised and their use |
JP2001502675A (ja) * | 1996-10-21 | 2001-02-27 | ニューロサーチ・アクティーゼルスカブ | 1―フエニル―ベンズイミダゾール化合物及びこれをbaga▲下a▼―レセプターモデュレーターとして使用する方法 |
WO1999019323A1 (en) | 1997-10-10 | 1999-04-22 | Neurosearch A/S | Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use |
WO2000078728A1 (en) | 1999-06-22 | 2000-12-28 | Neurosearch A/S | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
EP1613618A2 (de) | 2003-04-03 | 2006-01-11 | Neurosearch A/S | Benzimidazol derivate und ihre verwendung als modulatoren des gaba-a rezeptoren komplexes |
US7335777B2 (en) * | 2003-04-03 | 2008-02-26 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
BRPI0518794A2 (pt) * | 2004-12-01 | 2008-12-09 | Osi Pharm Inc | composto, composiÇço, mÉtodo de tratamento de distérbio hiperproliferativo, e, biblioteca combinatorial |
US7809569B2 (en) | 2004-12-22 | 2010-10-05 | Enterprise Integration Group, Inc. | Turn-taking confidence |
EP1877052B1 (de) | 2005-04-13 | 2009-07-22 | Neurosearch A/S | Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes |
DE602006010602D1 (de) | 2005-12-05 | 2009-12-31 | Neurosearch As | Benzimidazolderivate und ihre verwendung zur modulierung des gabaa-rezeptorkomplexes |
TWI391381B (zh) * | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
WO2008008059A1 (en) | 2006-07-12 | 2008-01-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents ans uses thereof |
-
2007
- 2007-02-27 TW TW096106596A patent/TWI391381B/zh not_active IP Right Cessation
- 2007-03-22 JP JP2009500873A patent/JP5260489B2/ja not_active Expired - Fee Related
- 2007-03-22 EP EP10182058A patent/EP2319837B1/de active Active
- 2007-03-22 ES ES07727240T patent/ES2355163T3/es active Active
- 2007-03-22 BR BRPI0710203-8A patent/BRPI0710203A2/pt not_active IP Right Cessation
- 2007-03-22 AU AU2007229502A patent/AU2007229502B2/en not_active Ceased
- 2007-03-22 DE DE602007010261T patent/DE602007010261D1/de active Active
- 2007-03-22 US US12/279,511 patent/US7902230B2/en active Active
- 2007-03-22 CA CA002647252A patent/CA2647252A1/en not_active Abandoned
- 2007-03-22 NZ NZ569438A patent/NZ569438A/en not_active IP Right Cessation
- 2007-03-22 KR KR1020087026085A patent/KR20080111097A/ko not_active Application Discontinuation
- 2007-03-22 RU RU2008129868/04A patent/RU2435759C2/ru not_active IP Right Cessation
- 2007-03-22 SI SI200730455T patent/SI2001855T1/sl unknown
- 2007-03-22 CN CN2007800059554A patent/CN101384559B/zh not_active Expired - Fee Related
- 2007-03-22 DK DK07727240.9T patent/DK2001855T3/da active
- 2007-03-22 PT PT07727240T patent/PT2001855E/pt unknown
- 2007-03-22 MY MYPI20082972A patent/MY149855A/en unknown
- 2007-03-22 MX MX2008010885A patent/MX2008010885A/es active IP Right Grant
- 2007-03-22 PL PL07727240T patent/PL2001855T3/pl unknown
- 2007-03-22 EP EP07727240A patent/EP2001855B1/de active Active
- 2007-03-22 AT AT07727240T patent/ATE486856T1/de active
- 2007-03-22 WO PCT/EP2007/052766 patent/WO2007110374A1/en active Application Filing
- 2007-03-23 AR ARP070101206A patent/AR060084A1/es unknown
-
2008
- 2008-06-19 IL IL192297A patent/IL192297A/en not_active IP Right Cessation
- 2008-10-23 NO NO20084481A patent/NO20084481L/no not_active Application Discontinuation
-
2009
- 2009-09-10 HK HK09108282.1A patent/HK1132257A1/xx not_active IP Right Cessation
-
2010
- 2010-11-12 HR HR20100616T patent/HRP20100616T1/hr unknown
- 2010-12-09 CY CY20101101143T patent/CY1111603T1/el unknown
-
2011
- 2011-01-20 US US13/009,988 patent/US8288418B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE486856T1 (de) | Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexes | |
ATE531712T1 (de) | Substituierte aryloxazole und ihre verwendung | |
ATE543808T1 (de) | 5,6-ring-annelierte indolderivate und ihre verwendung | |
ATE548355T1 (de) | 4- (4-cyano-2-thioaryl) -dihydropyrimidinone und ihre verwendung | |
ATE509016T1 (de) | 2-aryl-5-heterocyclylcyclohexan-1,3- dionverbindungen und ihre verwendung als herbizide | |
ATE547002T1 (de) | Pestizide und ihre verwendung | |
DE602007013295D1 (de) | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren | |
ATE546433T1 (de) | Quinolinderivate und ihre verwendung als fungizide | |
DE602007013869D1 (de) | Substituierte imidazole und ihre verwendung als pestizide | |
DE102008063992A8 (de) | Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung | |
ATE454377T1 (de) | 2-phenyl-6-aminocarbonylpyrimidinderivate und ihre verwendung als antagonisten am p2y12- rezeptor | |
ATE478059T1 (de) | Cinnamoylpiperazinderivate und ihre verwendung als par-1-antagonisten | |
ATE544752T1 (de) | Aryloxyacetamidderivate und ihre verwendung als fungizide | |
BRPI0811094A2 (pt) | Derivados de heteroarilamida pirimidona | |
BRPI0821142A2 (pt) | derivados heterocíclicos bicíclicos | |
ATE513817T1 (de) | Pyrimidinderivate und ihre verwendung als pestizide | |
BRPI0820633A2 (pt) | antagonistas de receptores de il-4 muteína modificada | |
DE602006007976D1 (de) | Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes | |
DE602007010179D1 (de) | Piperidinylaminopyridazine und ihre verwendung als schnelldissoziierende antagonisten des dopamin-2-rezeptors | |
NO20073252L (no) | Fremgangsmate for kontinuerlig og proporsjonal kalktilsetting | |
DE602007008056D1 (de) | Esterverbindung und ihre verwendung | |
DE602007006314D1 (de) | Anzeigevorrichtung und ihre verwendung | |
DE602007014008D1 (de) | Neue verbindungen und ihre verwendung | |
ATE486868T1 (de) | Neue chromen-2-on-derivate und ihre verwendung als monoamin-neurotransmitter- wiederaufnahmeinhibitoren | |
ATE509012T1 (de) | Arylindenopyrimidine und ihre verwendung als adenosin-a2a-rezeptorantagonisten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 2001855 Country of ref document: EP |